g(m1)-ganglioside and Thyroid-Neoplasms

g(m1)-ganglioside has been researched along with Thyroid-Neoplasms* in 2 studies

Other Studies

2 other study(ies) available for g(m1)-ganglioside and Thyroid-Neoplasms

Article	Year
Ganglioside reactive antibodies of IgG and IgM class in sera of patients with differentiated thyroid cancer. Immunology letters, 2002, Feb-01, Volume: 80, Issue:2 We searched for the presence of ganglioside reactive antibodies in sera of patients with differentiated thyroid cancer (DTC). Sera were screened by ELISA with plates coated with GM3(NeuAc), GM3(NeuGc), GM2, GM1, FucGM1, GD3, GD1a or GD1b gangliosides. Ganglioside reactive antibodies were detected more frequently in sera of patients with DTC than in sera of healthy persons, in keeping with the possibility of autoimmunization during carcinogenesis. Antibodies of IgM and IgG classes reactive with FucGM1 occurred most often. However, the infrequent occurrence of ganglioside reactive antibodies, their low titer and lack of correlation between their presence and clinical condition of the patients indicate that determination of these antibodies has no diagnostic value in DTC. Topics: Antigens, Differentiation; Dose-Response Relationship, Immunologic; G(M1) Ganglioside; Gangliosides; Humans; Immunoglobulin G; Immunoglobulin M; Neoplasm Metastasis; Thyroglobulin; Thyroid Neoplasms	2002
Antibodies to the ganglioside GD1b in a patient with motor neuron disease and thyroid adenoma. Archives of neurology, 1991, Volume: 48, Issue:11 Patients with motor neuron disease with thyroid disorders have been described, although the relationship between the two conditions is unclear. We treated a patient with amyotrophic lateral sclerosis who also had a follicular adenoma of the thyroid gland. Because thyroid gland plasma membranes contain high concentrations of complex gangliosides, such as GD1b, and some patients with motor neuron disease have IgM antibodies to GD1b, we decided to assay serum from this patient for the presence of antiganglioside antibodies. IgM antibodies to GD1b were detectable at serum dilutions of 1:500 and 1:1000 by enzyme-linked immunosorbent assay. While these titers are less than those usually described in patients with plasma cell dyscrasia, they are well in excess of normal values. Antibody to GM1 was also detectable at a lower (1:100) dilution. We do not know the importance of the anti-GD1b antibodies in this patient, but it is possible that antibodies to GD1b are involved in this and other cases of motor neuron disease associated with thyroid disease. Topics: Adenoma; Amyotrophic Lateral Sclerosis; Antibodies; G(M1) Ganglioside; Gangliosides; Humans; Male; Middle Aged; Thyroid Neoplasms	1991

Article

Year

Ganglioside reactive antibodies of IgG and IgM class in sera of patients with differentiated thyroid cancer.

Immunology letters, 2002, Feb-01, Volume: 80, Issue:2

We searched for the presence of ganglioside reactive antibodies in sera of patients with differentiated thyroid cancer (DTC). Sera were screened by ELISA with plates coated with GM3(NeuAc), GM3(NeuGc), GM2, GM1, FucGM1, GD3, GD1a or GD1b gangliosides. Ganglioside reactive antibodies were detected more frequently in sera of patients with DTC than in sera of healthy persons, in keeping with the possibility of autoimmunization during carcinogenesis. Antibodies of IgM and IgG classes reactive with FucGM1 occurred most often. However, the infrequent occurrence of ganglioside reactive antibodies, their low titer and lack of correlation between their presence and clinical condition of the patients indicate that determination of these antibodies has no diagnostic value in DTC.

Topics: Antigens, Differentiation; Dose-Response Relationship, Immunologic; G(M1) Ganglioside; Gangliosides; Humans; Immunoglobulin G; Immunoglobulin M; Neoplasm Metastasis; Thyroglobulin; Thyroid Neoplasms

2002

Antibodies to the ganglioside GD1b in a patient with motor neuron disease and thyroid adenoma.

Archives of neurology, 1991, Volume: 48, Issue:11

Patients with motor neuron disease with thyroid disorders have been described, although the relationship between the two conditions is unclear. We treated a patient with amyotrophic lateral sclerosis who also had a follicular adenoma of the thyroid gland. Because thyroid gland plasma membranes contain high concentrations of complex gangliosides, such as GD1b, and some patients with motor neuron disease have IgM antibodies to GD1b, we decided to assay serum from this patient for the presence of antiganglioside antibodies. IgM antibodies to GD1b were detectable at serum dilutions of 1:500 and 1:1000 by enzyme-linked immunosorbent assay. While these titers are less than those usually described in patients with plasma cell dyscrasia, they are well in excess of normal values. Antibody to GM1 was also detectable at a lower (1:100) dilution. We do not know the importance of the anti-GD1b antibodies in this patient, but it is possible that antibodies to GD1b are involved in this and other cases of motor neuron disease associated with thyroid disease.

Topics: Adenoma; Amyotrophic Lateral Sclerosis; Antibodies; G(M1) Ganglioside; Gangliosides; Humans; Male; Middle Aged; Thyroid Neoplasms

1991