g(m1)-ganglioside and Small-Cell-Lung-Carcinoma

g(m1)-ganglioside has been researched along with Small-Cell-Lung-Carcinoma* in 2 studies

Other Studies

2 other study(ies) available for g(m1)-ganglioside and Small-Cell-Lung-Carcinoma

Article	Year
Design, Synthesis, and Structure-Activity Relationships of Novel Tetrahydroisoquinolino Benzodiazepine Dimer Antitumor Agents and Their Application in Antibody-Drug Conjugates. Journal of medicinal chemistry, 2020, 11-25, Volume: 63, Issue:22 Topics: Animals; Antibodies, Monoclonal; Antineoplastic Agents; Apoptosis; Benzodiazepines; Cell Proliferation; Drug Design; Female; G(M1) Ganglioside; GPI-Linked Proteins; Humans; Immunoconjugates; Lung Neoplasms; Mesothelin; Mice; Mice, SCID; Small Cell Lung Carcinoma; Stomach Neoplasms; Structure-Activity Relationship; Tetrahydroisoquinolines; Tumor Cells, Cultured; Xenograft Model Antitumor Assays	2020
Subacute Sensorimotor Neuropathy Accompanied by Anti-ganglioside GM1 Antibody in a Patient with Lung Cancer. Internal medicine (Tokyo, Japan), 2018, Nov-15, Volume: 57, Issue:22 A 66-year-old man presented with subacute sensorimotor neuropathy in association with small cell lung cancer. Tests for the anti-ganglioside antibody GM1-IgM were positive. Chemotherapy and intravenous immunoglobulin treatment led to a slight improvement in neurological symptoms. Four additional cases of neuropathy accompanied by anti-ganglioside antibody and lung cancer have been reported. The most commonly reported pattern was subacute sensorimotor neuropathy. Patients died from cancer progression after 5 to 18 months. There is evidence that anti-ganglioside antibody inhibits tumor progression, prolonging the patient survival. However, severe neurological disturbance may offset the survival benefit of anti-ganglioside antibody in patients with paraneoplastic neurological syndrome. Topics: Aged; Autoantibodies; G(M1) Ganglioside; Guillain-Barre Syndrome; Humans; Immunoglobulins, Intravenous; Immunologic Factors; Lung Neoplasms; Male; Small Cell Lung Carcinoma; Tomography, X-Ray Computed	2018

Article

Year

Design, Synthesis, and Structure-Activity Relationships of Novel Tetrahydroisoquinolino Benzodiazepine Dimer Antitumor Agents and Their Application in Antibody-Drug Conjugates.

Journal of medicinal chemistry, 2020, 11-25, Volume: 63, Issue:22

Topics: Animals; Antibodies, Monoclonal; Antineoplastic Agents; Apoptosis; Benzodiazepines; Cell Proliferation; Drug Design; Female; G(M1) Ganglioside; GPI-Linked Proteins; Humans; Immunoconjugates; Lung Neoplasms; Mesothelin; Mice; Mice, SCID; Small Cell Lung Carcinoma; Stomach Neoplasms; Structure-Activity Relationship; Tetrahydroisoquinolines; Tumor Cells, Cultured; Xenograft Model Antitumor Assays

2020

Subacute Sensorimotor Neuropathy Accompanied by Anti-ganglioside GM1 Antibody in a Patient with Lung Cancer.

Internal medicine (Tokyo, Japan), 2018, Nov-15, Volume: 57, Issue:22

A 66-year-old man presented with subacute sensorimotor neuropathy in association with small cell lung cancer. Tests for the anti-ganglioside antibody GM1-IgM were positive. Chemotherapy and intravenous immunoglobulin treatment led to a slight improvement in neurological symptoms. Four additional cases of neuropathy accompanied by anti-ganglioside antibody and lung cancer have been reported. The most commonly reported pattern was subacute sensorimotor neuropathy. Patients died from cancer progression after 5 to 18 months. There is evidence that anti-ganglioside antibody inhibits tumor progression, prolonging the patient survival. However, severe neurological disturbance may offset the survival benefit of anti-ganglioside antibody in patients with paraneoplastic neurological syndrome.

Topics: Aged; Autoantibodies; G(M1) Ganglioside; Guillain-Barre Syndrome; Humans; Immunoglobulins, Intravenous; Immunologic Factors; Lung Neoplasms; Male; Small Cell Lung Carcinoma; Tomography, X-Ray Computed

2018