g(m1)-ganglioside and Protein-Aggregation--Pathological

In this perspective we summarize current knowledge of the effect of monosialoganglioside GM

Topics: Amyloid beta-Peptides; Brain; G(M1) Ganglioside; Humans; Protein Aggregation, Pathological

Amyloid aggregation and deposition of amyloid β-peptide (Aβ) are pathologic characteristics of Alzheimer's disease (AD). Recent reports have shown that the association of Aβ with membranes containing ganglioside GM1 (GM1) plays a pivotal role in amyloid deposition and the pathogenesis of AD. However, the molecular interactions responsible for membrane damage associated with Aβ deposition are not fully understood. In this study, we microscopically observed amyloid aggregation of Aβ in the presence of lipid vesicles and on a substrate-supported planar membrane containing raft components and GM1. The experimental system enabled us to observe lipid-associated aggregation of Aβ, uptake of the raft components into Aβ aggregates, and relevant membrane damage. The results indicate that uptake of raft components from the membrane into Aβ deposits induces macroscopic heterogeneity of the membrane structure.

Topics: Alzheimer Disease; Amyloid; Amyloid beta-Peptides; Animals; Cell Membrane; G(M1) Ganglioside; Humans; Liposomes; Membrane Microdomains; Peptide Fragments; Protein Aggregation, Pathological