g(m1)-ganglioside and Paraneoplastic-Syndromes

g(m1)-ganglioside has been researched along with Paraneoplastic-Syndromes* in 2 studies

Reviews

1 review(s) available for g(m1)-ganglioside and Paraneoplastic-Syndromes

Article	Year
Inflammatory neuropathy: pathogenesis and clinical features. Current opinion in neurology and neurosurgery, 1992, Volume: 5, Issue:5 The nature of the underlying mechanisms in inflammatory and immune-mediated neuropathies continues to represent an intensive area of research. Different auto-antibodies that are thought to cause specific neuropathic syndromes have been described. The involvement of T cells, cytokines, complement and class II molecules in the pathogenesis of these syndromes has also been studied. There is also intensive investigation into the area of immunotherapy, in particular in the use of intravenous immunoglobulin (Ig). Topics: Autoantibodies; Demyelinating Diseases; Electromyography; G(M1) Ganglioside; Humans; Myelin Proteins; Neurologic Examination; Paraneoplastic Syndromes; Polyneuropathies; Polyradiculoneuropathy	1992

Article

Year

Inflammatory neuropathy: pathogenesis and clinical features.

Current opinion in neurology and neurosurgery, 1992, Volume: 5, Issue:5

The nature of the underlying mechanisms in inflammatory and immune-mediated neuropathies continues to represent an intensive area of research. Different auto-antibodies that are thought to cause specific neuropathic syndromes have been described. The involvement of T cells, cytokines, complement and class II molecules in the pathogenesis of these syndromes has also been studied. There is also intensive investigation into the area of immunotherapy, in particular in the use of intravenous immunoglobulin (Ig).

Topics: Autoantibodies; Demyelinating Diseases; Electromyography; G(M1) Ganglioside; Humans; Myelin Proteins; Neurologic Examination; Paraneoplastic Syndromes; Polyneuropathies; Polyradiculoneuropathy

1992

Other Studies

1 other study(ies) available for g(m1)-ganglioside and Paraneoplastic-Syndromes

Article	Year
Autoimmunity to beta IV spectrin in paraneoplastic lower motor neuron syndrome. Proceedings of the National Academy of Sciences of the United States of America, 2001, Jun-05, Volume: 98, Issue:12 Paraneoplastic neurological disorders may result from autoimmunity directed against antigens shared by the affected neurons and the associated cancer cells. We have recently reported the case of a woman with breast cancer and paraneoplastic lower motor neuron syndrome whose serum contained autoantibodies directed against axon initial segments and nodes of Ranvier of myelinated axons, including the axons of motoneurons. Here, we show that major targets of the autoantibodies of this patient are betaIVSigma1 spectrin and betaIV spectrin 140, two isoforms of the novel betaIV spectrin gene, as well as a neuronal surface epitope yet to be identified. Partial improvement of the neurological symptoms following cancer removal was associated with a drastic reduction in the titer of the autoantibodies against betaIV spectrin and nodal antigens in general, consistent with the autoimmune pathogenesis of the paraneoplastic lower motor neuron syndrome. The identification of betaIV spectrin isoforms and surface nodal antigens as novel autoimmune targets in lower motor neuron syndrome provide new insights into the pathogenesis of this severe neurological disease. Topics: Autoantibodies; Autoimmunity; Breast Neoplasms; Female; G(M1) Ganglioside; Humans; Molecular Weight; Motor Neuron Disease; Nerve Tissue Proteins; Paraneoplastic Syndromes; Spectrin	2001

Article

Year

Autoimmunity to beta IV spectrin in paraneoplastic lower motor neuron syndrome.

Proceedings of the National Academy of Sciences of the United States of America, 2001, Jun-05, Volume: 98, Issue:12

Paraneoplastic neurological disorders may result from autoimmunity directed against antigens shared by the affected neurons and the associated cancer cells. We have recently reported the case of a woman with breast cancer and paraneoplastic lower motor neuron syndrome whose serum contained autoantibodies directed against axon initial segments and nodes of Ranvier of myelinated axons, including the axons of motoneurons. Here, we show that major targets of the autoantibodies of this patient are betaIVSigma1 spectrin and betaIV spectrin 140, two isoforms of the novel betaIV spectrin gene, as well as a neuronal surface epitope yet to be identified. Partial improvement of the neurological symptoms following cancer removal was associated with a drastic reduction in the titer of the autoantibodies against betaIV spectrin and nodal antigens in general, consistent with the autoimmune pathogenesis of the paraneoplastic lower motor neuron syndrome. The identification of betaIV spectrin isoforms and surface nodal antigens as novel autoimmune targets in lower motor neuron syndrome provide new insights into the pathogenesis of this severe neurological disease.

Topics: Autoantibodies; Autoimmunity; Breast Neoplasms; Female; G(M1) Ganglioside; Humans; Molecular Weight; Motor Neuron Disease; Nerve Tissue Proteins; Paraneoplastic Syndromes; Spectrin

2001