g(m1)-ganglioside and Craniocerebral-Trauma

g(m1)-ganglioside has been researched along with Craniocerebral-Trauma* in 1 studies

Other Studies

1 other study(ies) available for g(m1)-ganglioside and Craniocerebral-Trauma

Article	Year
An EEG analysis of drug effects after mild head injury in mice. Life sciences, 1992, Volume: 51, Issue:3 An electroencephalographic (EEG) and behavioral model of head injury in unanesthetized, free moving mice has been used to test the effects of TRH and GM1. In our experimental conditions a mechanical head injury capable of inducing loss of righting reflex for 2 to 60 sec, also induces a consistent decrease of the total power of the spectrum of EEG and a decrease of the power of fast beta band (20-40 Hz) for at least 120 min. TRH, injected after trauma in dose of 10 mg/kg, caused improvement of EEG total power of the spectrum. GM1 in high (30 mg/kg) but not in low dose (5 mg/kg) caused more rapid restoration of both the total power and fast as well as slow beta band power. These results suggest that GM1 has favorable effects on post-concussive neurophysiological symptoms in head injured animals. Topics: Animals; Craniocerebral Trauma; Disease Models, Animal; Electroencephalography; G(M1) Ganglioside; Male; Mice; Thyrotropin-Releasing Hormone	1992

Article

Year

An EEG analysis of drug effects after mild head injury in mice.

Life sciences, 1992, Volume: 51, Issue:3

An electroencephalographic (EEG) and behavioral model of head injury in unanesthetized, free moving mice has been used to test the effects of TRH and GM1. In our experimental conditions a mechanical head injury capable of inducing loss of righting reflex for 2 to 60 sec, also induces a consistent decrease of the total power of the spectrum of EEG and a decrease of the power of fast beta band (20-40 Hz) for at least 120 min. TRH, injected after trauma in dose of 10 mg/kg, caused improvement of EEG total power of the spectrum. GM1 in high (30 mg/kg) but not in low dose (5 mg/kg) caused more rapid restoration of both the total power and fast as well as slow beta band power. These results suggest that GM1 has favorable effects on post-concussive neurophysiological symptoms in head injured animals.

Topics: Animals; Craniocerebral Trauma; Disease Models, Animal; Electroencephalography; G(M1) Ganglioside; Male; Mice; Thyrotropin-Releasing Hormone

1992