g(m1)-ganglioside and Brucellosis

g(m1)-ganglioside has been researched along with Brucellosis* in 2 studies

Other Studies

2 other study(ies) available for g(m1)-ganglioside and Brucellosis

Article	Year
Acute axonal poly-radiculoneuropathy associated with partially treated brucellosis: a case report. Journal of clinical neuromuscular disease, 2007, Volume: 9, Issue:1 We report a case of partially treated brucellosis that developed quadriparesis, sixth and seventh cranial nerve palsy, and apnea. Electrodiagnostic studies were in favor of acute axonal poly-radiculoneuropathy. Crossreactive immunological responses due to molecular mimicry between Brucella lipooligosaccharide and GM1 ganglioside may justify the development of acute axonal polyradiculoneuropathy after brucellosis. Topics: Acute Disease; Adult; Apnea; Brucellosis; Cranial Nerve Diseases; Electrodiagnosis; G(M1) Ganglioside; Humans; Male; Polyradiculoneuropathy	2007
Brucella melitensis infection associated with Guillain-Barré syndrome through molecular mimicry of host structures. FEMS immunology and medical microbiology, 2005, Aug-01, Volume: 45, Issue:2 Brucella melitensis is a facultative intracellular bacterium that can survive inside macrophages and the causative agent of brucellosis. In the present study, we found that a lipooligosaccharide of B. melitensis has a GM1 ganglioside-like structure and shows a strong antibody response in mice. The cholera toxin B subunit, which binds to GM1 ganglioside specifically, reacted with the surface of B. melitensis. Immunization with B. melitensis induced the production of anti-GM1 ganglioside antibodies in mice and serum from immunized mice showed a cross-reaction with Guillain-Barré syndrome (GBS)-associated Campylobacter jejuni, but not non-GBS-associated C. jejuni. When B. melitensis was treated with a neuraminidase, antibody responses disappeared. B. melitensis immunization induced the production of anti-GM1 ganglioside antibodies in BALB/c mice but not in C57BL/6 and ddY mice, and for BALB/c mice, immunization with B. melitensis induced much greater production of anti-GM1 ganglioside than GBS-associated C. jejuni. Flaccid limb weakness was observed in B. melitensis immunized mice. These results suggest that B. melitensis is a new etiological agent for GBS and that immunological responses between it and GBS-associated C. jejuni in the mouse model may be different. Topics: Animals; Antibodies, Bacterial; Brucella melitensis; Brucellosis; Campylobacter jejuni; Cholera Toxin; Cross Reactions; Disease Models, Animal; G(M1) Ganglioside; Guillain-Barre Syndrome; Humans; Immunization; In Vitro Techniques; Lipopolysaccharides; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Molecular Mimicry	2005

Article

Year

Acute axonal poly-radiculoneuropathy associated with partially treated brucellosis: a case report.

Journal of clinical neuromuscular disease, 2007, Volume: 9, Issue:1

We report a case of partially treated brucellosis that developed quadriparesis, sixth and seventh cranial nerve palsy, and apnea. Electrodiagnostic studies were in favor of acute axonal poly-radiculoneuropathy. Crossreactive immunological responses due to molecular mimicry between Brucella lipooligosaccharide and GM1 ganglioside may justify the development of acute axonal polyradiculoneuropathy after brucellosis.

Topics: Acute Disease; Adult; Apnea; Brucellosis; Cranial Nerve Diseases; Electrodiagnosis; G(M1) Ganglioside; Humans; Male; Polyradiculoneuropathy

2007

Brucella melitensis infection associated with Guillain-Barré syndrome through molecular mimicry of host structures.

FEMS immunology and medical microbiology, 2005, Aug-01, Volume: 45, Issue:2

Brucella melitensis is a facultative intracellular bacterium that can survive inside macrophages and the causative agent of brucellosis. In the present study, we found that a lipooligosaccharide of B. melitensis has a GM1 ganglioside-like structure and shows a strong antibody response in mice. The cholera toxin B subunit, which binds to GM1 ganglioside specifically, reacted with the surface of B. melitensis. Immunization with B. melitensis induced the production of anti-GM1 ganglioside antibodies in mice and serum from immunized mice showed a cross-reaction with Guillain-Barré syndrome (GBS)-associated Campylobacter jejuni, but not non-GBS-associated C. jejuni. When B. melitensis was treated with a neuraminidase, antibody responses disappeared. B. melitensis immunization induced the production of anti-GM1 ganglioside antibodies in BALB/c mice but not in C57BL/6 and ddY mice, and for BALB/c mice, immunization with B. melitensis induced much greater production of anti-GM1 ganglioside than GBS-associated C. jejuni. Flaccid limb weakness was observed in B. melitensis immunized mice. These results suggest that B. melitensis is a new etiological agent for GBS and that immunological responses between it and GBS-associated C. jejuni in the mouse model may be different.

Topics: Animals; Antibodies, Bacterial; Brucella melitensis; Brucellosis; Campylobacter jejuni; Cholera Toxin; Cross Reactions; Disease Models, Animal; G(M1) Ganglioside; Guillain-Barre Syndrome; Humans; Immunization; In Vitro Techniques; Lipopolysaccharides; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Molecular Mimicry

2005