g(m1)-ganglioside and Bone-Diseases--Metabolic

g(m1)-ganglioside has been researched along with Bone-Diseases--Metabolic* in 1 studies

Other Studies

1 other study(ies) available for g(m1)-ganglioside and Bone-Diseases--Metabolic

Article	Year
Neurovisceral and skeletal GM1-gangliosidosis in dogs with beta-galactosidase deficiency. Science (New York, N.Y.), 1985, Aug-02, Volume: 229, Issue:4712 Beta-galactosidase-deficient siblings in two litters of English springer spaniel puppies showed a progressive neurological impairment, dwarfism, orbital hypertelorism, and dysostosis multiplex. An excess of GM1-ganglioside was found in the brain. Three abnormal oligosaccharides were present in samples of urine, brain, liver, and cartilage. Light microscopy of selected tissue specimens revealed cytoplasmic vacuoles in neurons, circulating blood cells, macrophages, and chondrocytes. Ultrastructural studies demonstrated that these membrane-bound vacuoles were of two types--one containing lamellated membranes and the other, finely granular material. These clinical and pathological findings are similar to those observed in human patients affected by the infantile form of GM1-gangliosidosis. Topics: Animals; Bone Diseases, Metabolic; Dog Diseases; Dogs; Female; G(M1) Ganglioside; Gangliosidoses; Humans; Lactose Intolerance; Male; Neurons; Oligosaccharides; Pedigree; Vacuoles	1985

Article

Year

Neurovisceral and skeletal GM1-gangliosidosis in dogs with beta-galactosidase deficiency.

Science (New York, N.Y.), 1985, Aug-02, Volume: 229, Issue:4712

Beta-galactosidase-deficient siblings in two litters of English springer spaniel puppies showed a progressive neurological impairment, dwarfism, orbital hypertelorism, and dysostosis multiplex. An excess of GM1-ganglioside was found in the brain. Three abnormal oligosaccharides were present in samples of urine, brain, liver, and cartilage. Light microscopy of selected tissue specimens revealed cytoplasmic vacuoles in neurons, circulating blood cells, macrophages, and chondrocytes. Ultrastructural studies demonstrated that these membrane-bound vacuoles were of two types--one containing lamellated membranes and the other, finely granular material. These clinical and pathological findings are similar to those observed in human patients affected by the infantile form of GM1-gangliosidosis.

Topics: Animals; Bone Diseases, Metabolic; Dog Diseases; Dogs; Female; G(M1) Ganglioside; Gangliosidoses; Humans; Lactose Intolerance; Male; Neurons; Oligosaccharides; Pedigree; Vacuoles

1985