g(m1)-ganglioside and Adenoma--Pleomorphic

g(m1)-ganglioside has been researched along with Adenoma--Pleomorphic* in 1 studies

Reviews

1 review(s) available for g(m1)-ganglioside and Adenoma--Pleomorphic

Article	Year
High levels of GM(1)-ganglioside and GM(1)-ganglioside beta-galactosidase in the parotid gland: a new model for secretory mechanisms of the parotid gland. Otolaryngologic clinics of North America, 1999, Volume: 32, Issue:5 A new model for the subcellular basis of parotid secretion is presented in this article. GM(1)-ganglioside, typically found in neural tissues, is shown to be abundant in the parotid gland. This ganglioside may play a central role in membrane turnover mechanisms underlying exocytosis/endocytosis in its role as a promoter of membrane fusion or a fusogen. The lysosome and lysosomal hydrolases also play a central role in this model in catabolism of GM(1)-ganglioside. Consequently, high levels of the lysosomal hydrolase acidic beta-galactosidase are demonstrated in the salivary gland. GM(1)-gangliosidosis of the parotid glands, as described in mice, appears to be the first single-gene heritable disease found so far in the salivary glands. Topics: Adenoma, Pleomorphic; Animals; beta-Galactosidase; Biological Transport; Exocytosis; G(M1) Ganglioside; Humans; Mice; Parotid Gland; Parotid Neoplasms	1999

Article

Year

High levels of GM(1)-ganglioside and GM(1)-ganglioside beta-galactosidase in the parotid gland: a new model for secretory mechanisms of the parotid gland.

Otolaryngologic clinics of North America, 1999, Volume: 32, Issue:5

A new model for the subcellular basis of parotid secretion is presented in this article. GM(1)-ganglioside, typically found in neural tissues, is shown to be abundant in the parotid gland. This ganglioside may play a central role in membrane turnover mechanisms underlying exocytosis/endocytosis in its role as a promoter of membrane fusion or a fusogen. The lysosome and lysosomal hydrolases also play a central role in this model in catabolism of GM(1)-ganglioside. Consequently, high levels of the lysosomal hydrolase acidic beta-galactosidase are demonstrated in the salivary gland. GM(1)-gangliosidosis of the parotid glands, as described in mice, appears to be the first single-gene heritable disease found so far in the salivary glands.

Topics: Adenoma, Pleomorphic; Animals; beta-Galactosidase; Biological Transport; Exocytosis; G(M1) Ganglioside; Humans; Mice; Parotid Gland; Parotid Neoplasms

1999