fusaric acid has been researched along with Hypertension in 22 studies
Fusaric Acid: A picolinic acid derivative isolated from various Fusarium species. It has been proposed for a variety of therapeutic applications but is primarily used as a research tool. Its mechanisms of action are poorly understood. It probably inhibits DOPAMINE BETA-HYDROXYLASE, the enzyme that converts dopamine to norepinephrine. It may also have other actions, including the inhibition of cell proliferation and DNA synthesis.
Hypertension: Persistently high systemic arterial BLOOD PRESSURE. Based on multiple readings (BLOOD PRESSURE DETERMINATION), hypertension is currently defined as when SYSTOLIC PRESSURE is consistently greater than 140 mm Hg or when DIASTOLIC PRESSURE is consistently 90 mm Hg or more.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The cardiovascular effects of a new antihypertensive drug, bupicomide, were compared with those of hydralazine in 6 patients with mild to moderate hypertension." | 5.04 | Antihypertensive effect of a dopamine beta hydroxylase inhibitor, bupicomide: a comparison with hydralazine. ( Gilbert, CA; McNay, JL; Rutledge, CO; Velasco, M, 1975) |
| " According to pharmacokinetic analysis based on the determination of blood drug concentration, the transfer rate of fusaric acid from the digestive tract to the blood was much higher than TFP by 1." | 1.27 | [Antihypertensive effect of trifluoropentoxypicolinic acid: a pharmacokinetic study]. ( Horisaka, K; Masuda, S, 1984) |
| "The hypotensive effect of fusaric acid calcium salt (Calcium salt of 5-butylpicolinic acid) was examined clinically in 10 elderly hypertensive patients by the long-term administration of this agent and the following results were obtained." | 1.26 | The hypotensive effect of fusaric acid: the results of long-term administration of fusaric acid in elderly hypertensive patients. ( Kameyama, M; Terasawa, F; Ying, LH, 1976) |
| "The hemodynamic effect of fusaric acid calcium salt (calcium salt of 5-butylpicolinic acid), an inhibitor of dopamine beta-hydroxylase, was studied in long-term administration of this agent in 10 elderly hypertensive patients." | 1.26 | The long-term hemodynamic effect of fusaric acid in elderly hypertensive patients. ( Suzuki, T; Terasawa, F; Ying, LH, 1976) |
| "Disulfiram was less active and the activity was one-tenth of FD-008." | 1.25 | Pharmacological action of FD-008, a new dopamine-beta-hydroxylase inhibitor. III. Effects on endogenous biogenic amine levels in rats. ( Homma, M; Ishii, Y; Umezawa, H; Yoshikawa, A, 1975) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 22 (100.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Finch, N | 2 |
| Campbell, TR | 2 |
| Gemenden, CW | 2 |
| Antonaccio, MJ | 1 |
| Povalski, HJ | 2 |
| Ochiai, T | 1 |
| Watanabe, K | 1 |
| Nishijima, H | 1 |
| Hayashi, R | 1 |
| Sato, H | 1 |
| Takagi, T | 2 |
| Mikami, K | 1 |
| Nishikawa, T | 2 |
| Tamura, Y | 2 |
| Kumagai, A | 2 |
| Watanabe, M | 1 |
| Kamiyama, Y | 1 |
| Horisaka, K | 1 |
| Masuda, S | 1 |
| Richter, R | 1 |
| Yoshimura, M | 1 |
| Hachiya, T | 1 |
| Ochi, Y | 1 |
| Nagasaka, A | 1 |
| Takeda, A | 1 |
| Chrysant, SG | 1 |
| Adamopoulos, P | 1 |
| Tsuchiya, M | 1 |
| Frohlich, ED | 1 |
| Kopin, IJ | 1 |
| Kaufman, S | 1 |
| Viveros, H | 1 |
| Jacobowitz, D | 1 |
| Lake, CR | 1 |
| Ziegler, MG | 1 |
| Lovenberg, W | 1 |
| Goodwin, FK | 1 |
| Velasco, M | 2 |
| McNay, JL | 2 |
| Ozawa, M | 1 |
| Nakajima, Y | 1 |
| Suzuki, K | 1 |
| Sato, T | 1 |
| Takahashi, E | 1 |
| Terasawa, F | 4 |
| Hidaka, H | 2 |
| Ying, LH | 3 |
| Kameyama, M | 1 |
| Suzuki, T | 2 |
| Gilbert, CA | 1 |
| Rutledge, CO | 1 |
| Ishi, Y | 1 |
| Homma, M | 2 |
| Yoshikawa, A | 2 |
| Ishii, Y | 2 |
| Fujii, Y | 1 |
| Mimura, Ch | 1 |
| Umezawa, H | 2 |
| Kiselev, GV | 1 |
| Minenko, AN | 1 |
| Oeme, P | 1 |
| Berkowitz, BA | 1 |
| Arleth, AJ | 1 |
| Sung, CP | 1 |
| Kruse, LI | 1 |
| DeWolf, WE | 1 |
| Ohlstein, EH | 1 |
| Racz, K | 1 |
| Kuchel, O | 1 |
| Buu, NT | 1 |
| Tenneson, S | 1 |
1 review available for fusaric acid and Hypertension
| Article | Year |
|---|---|
NIH conference. Dopamine- -hydroxylase. Basic and clinical studies.
Topics: Adolescent; Adrenal Medulla; Adult; Animals; Bipolar Disorder; Chemical Phenomena; Chemistry; Child; | 1976 |
4 trials available for fusaric acid and Hypertension
| Article | Year |
|---|---|
Systemic and renal hemodynamic effects of bupicomide: a new vasodilator.
Topics: Clinical Trials as Topic; Drug Evaluation; Fusaric Acid; Hemodynamics; Humans; Hypertension; Kidney; | 1976 |
Time-course changes in blood pressure, urinary excretion of norepinephrine and dopamine after administration of fusaric acid in a single dose in elderly hypertensive patients.
Topics: Aged; Antihypertensive Agents; Blood Pressure; Circadian Rhythm; Dopamine; Female; Fusaric Acid; Hum | 1976 |
Urinary norepinephrine excretion in elderly hypertensive patients during administration of fusaric acid.
Topics: Blood Pressure; Female; Fusaric Acid; Humans; Hypertension; Male; Norepinephrine; Picolinic Acids; P | 1976 |
Antihypertensive effect of a dopamine beta hydroxylase inhibitor, bupicomide: a comparison with hydralazine.
Topics: Adult; Antihypertensive Agents; Blood Pressure; Clinical Trials as Topic; Dopamine beta-Hydroxylase; | 1975 |
17 other studies available for fusaric acid and Hypertension
| Article | Year |
|---|---|
Synthesis and antihypertensive activity of 5-thio-2-pyridinecarboxylic acid derivatives.
Topics: Animals; Antihypertensive Agents; Blood Pressure; Dogs; Female; Haplorhini; Heart Rate; Hypertension | 1978 |
Synthesis and antihypertensive activity of 5-amino-2-pyridinecarboxylic acid derivatives.
Topics: Aminopyridines; Animals; Antihypertensive Agents; Chemical Phenomena; Chemistry; Dogs; Hypertension; | 1980 |
Results of treatment of hypertension after renal transplantation: effects of converting enzyme inhibitor, angiotensin II analog, beta-blockade, and dopamine beta-hydroxylase inhibitor.
Topics: Adolescent; Adult; Alprenolol; Angiotensin II; Angiotensin-Converting Enzyme Inhibitors; Blood Press | 1980 |
Mechanism of suppressed renin-angiotensin system in spontaneously hypertensive rat (SHR).
Topics: Angiotensin II; Animals; Body Weight; Catecholamines; Diet; Fusaric Acid; Hypertension; Kidney; Male | 1983 |
[Antihypertensive effect of trifluoropentoxypicolinic acid: a pharmacokinetic study].
Topics: Animals; Dopamine beta-Hydroxylase; Dose-Response Relationship, Drug; Fusaric Acid; Half-Life; Hyper | 1984 |
Effect of fusaric acid on the body temperature in spontaneously hypertensive and normotensive rats.
Topics: Animals; Body Temperature; Cold Temperature; Fusaric Acid; Hypertension; Male; Naloxone; Picolinic A | 1983 |
Suppression of elevated serum TSH levels in hypothyroidism by fusaric acid.
Topics: Adult; Female; Fusaric Acid; Humans; Hypertension; Hypothyroidism; Male; Middle Aged; Picolinic Acid | 1977 |
Physiologic mechanisms of bupicomide- and hydralazine-induced increase in plasma renin activity in hypertensive patients.
Topics: Adult; Antihypertensive Agents; Blood Pressure; Female; Fusaric Acid; Heart Rate; Humans; Hydralazin | 1977 |
[Effects of fusaric acid calcium on catecholamine metabolism and its clinical effects on essential hypertension].
Topics: Adult; Aged; Catecholamines; Dopamine beta-Hydroxylase; Drug Evaluation; Female; Fusaric Acid; Human | 1976 |
The hypotensive effect of fusaric acid: the results of long-term administration of fusaric acid in elderly hypertensive patients.
Topics: Aged; Blood Pressure; Female; Fusaric Acid; Humans; Hypertension; Male; Middle Aged; Picolinic Acids | 1976 |
The long-term hemodynamic effect of fusaric acid in elderly hypertensive patients.
Topics: Aged; Blood Pressure; Blood Volume; Cardiac Output; Female; Fusaric Acid; Heart Rate; Hematocrit; He | 1976 |
Effect of a dopamine beta-hydroxylase inhibitor on tissue catecholamine levels in spontaneously hypertensive rats subjected to immobilization-cold stress.
Topics: Animals; Brain Chemistry; Catecholamines; Cold Temperature; Dopamine; Dopamine beta-Hydroxylase; Fus | 1975 |
Pharmacological action of FD-008, a new dopamine beta-hydroxylase inhibitor. I. Effects on blood pressure in rats and dogs.
Topics: Administration, Oral; Animals; Blood Pressure; Depression, Chemical; Disulfiram; Dogs; Dose-Response | 1975 |
Pharmacological action of FD-008, a new dopamine-beta-hydroxylase inhibitor. III. Effects on endogenous biogenic amine levels in rats.
Topics: Adrenal Glands; Animals; Biogenic Amines; Brain Chemistry; Cerebellum; Disulfiram; Dopamine; Dopamin | 1975 |
[Effect of fusaric acid on phosphoinositide metabolism in the erythrocyte membranes of rats with spontaneous hypertension].
Topics: Animals; Erythrocyte Membrane; Fusaric Acid; Hypertension; Male; Phosphatidylinositols; Picolinic Ac | 1986 |
Effects of the novel dopamine beta-hydroxylase inhibitor SK&F 102698 on catecholamines and blood pressure in spontaneously hypertensive rats.
Topics: Animals; Antihypertensive Agents; Blood Pressure; Blood Vessels; Brain Chemistry; Catecholamines; Do | 1988 |
Peripheral dopamine synthesis and metabolism in spontaneously hypertensive rats.
Topics: Adrenal Glands; Animals; Blood Pressure; Catecholamines; Dopamine; Epinephrine; Fusaric Acid; Hypert | 1985 |