fusaric acid has been researched along with Head and Neck Neoplasms in 3 studies
Fusaric Acid: A picolinic acid derivative isolated from various Fusarium species. It has been proposed for a variety of therapeutic applications but is primarily used as a research tool. Its mechanisms of action are poorly understood. It probably inhibits DOPAMINE BETA-HYDROXYLASE, the enzyme that converts dopamine to norepinephrine. It may also have other actions, including the inhibition of cell proliferation and DNA synthesis.
Head and Neck Neoplasms: Soft tissue tumors or cancer arising from the mucosal surfaces of the LIP; oral cavity; PHARYNX; LARYNX; and cervical esophagus. Other sites included are the NOSE and PARANASAL SINUSES; SALIVARY GLANDS; THYROID GLAND and PARATHYROID GLANDS; and MELANOMA and non-melanoma skin cancers of the head and neck. (from Holland et al., Cancer Medicine, 4th ed, p1651)
| Excerpt | Relevance | Reference |
|---|---|---|
| " Further nude mice studies are needed to optimize dosing and administration regimens for FA in anticipation of clinical trials." | 1.32 | Fusaric acid: a novel agent and mechanism to treat HNSCC. ( Hansen, JP; Hollenbeak, CS; Jaglowski, J; Ruda, JM; Shvidler, J; Stack, BC, 2004) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 3 (100.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Stack, BC | 3 |
| Hansen, JP | 1 |
| Ruda, JM | 2 |
| Jaglowski, J | 1 |
| Shvidler, J | 1 |
| Hollenbeak, CS | 2 |
| Jaglowski, JR | 1 |
| Beus, KS | 1 |
| Wilson, RP | 1 |
3 other studies available for fusaric acid and Head and Neck Neoplasms
| Article | Year |
|---|---|
Fusaric acid: a novel agent and mechanism to treat HNSCC.
Topics: Animals; Carcinoma, Squamous Cell; Cell Line, Tumor; Enzyme Inhibitors; Fusaric Acid; Head and Neck | 2004 |
Enhanced growth inhibition of squamous cell carcinoma of the head and neck by combination therapy of fusaric acid and paclitaxel or carboplatin.
Topics: Aged; Antineoplastic Agents; Carboplatin; Carcinoma, Squamous Cell; Cell Proliferation; Dose-Respons | 2006 |
The effect of single agent oral fusaric acid (FA) on the growth of subcutaneously xenografted SCC-1 cells in a nude mouse model.
Topics: Administration, Oral; Animals; Antineoplastic Agents; Carcinoma, Squamous Cell; Cell Line, Tumor; Fu | 2006 |