fusafungin and Pain--Postoperative

To investigate the effect of fusafungine spray on pain and healing process after pediatric tonsillectomy.. Sixty children with ages between 4 and 14 years underwent tonsillectomy or adenotonsillectomy. The patients were randomly divided into three groups and each group consisted of 20 patients. Group 1 was treated with antibiotic (amoxicillin-clavulanic acid) plus analgesic (acetaminophen), group 2 was treated with fusafungine plus analgesic (acetaminophen) and group 3 was treated with only fusafungine. The average ages were 7.8 + 3.4, 6.6 + 2.9, and 8.2 + 3.7 for groups 1, 2, and 3, respectively. Clinical evaluations were made after the operation on the 1st (T1), 3rd (T3), 7th (T7), 10th (T10), and 14th days (T14).. There was no significant difference in post-operative pain between study groups on the post-operative 1st, 3rd, and 7th days (P > 0.05), a statistically significant difference was present between groups 1 and 3, and groups 1 and 2 on the post-operative 10th and 14th day (P = 0.018 and 0.037, respectively). Pain was less in groups 2 and 3 than in group 1 on the 10th and 14th day. Also there was a significant difference in healing time of the tonsillary beds between groups 1 and 2, and groups 1 and 3 on the 10th and 14th post-operative day (P = 0.031 and 0.001, respectively). Healing was better in groups 2 and 3 than in group 1 on the 10th and 14th day.. Fusafungine administration after tonsillectomy was found to be beneficial on post-operative pain and wound healing of tonsillary beds in pediatric population.

Topics: Acetaminophen; Adolescent; Aerosols; Amoxicillin-Potassium Clavulanate Combination; Analgesics, Non-Narcotic; Anti-Bacterial Agents; Case-Control Studies; Child; Child, Preschool; Depsipeptides; Drug Therapy, Combination; Female; Fusarium; Humans; Male; Pain, Postoperative; Tonsillectomy; Treatment Outcome; Wound Healing

Postoperative period after tonsillectomy is characterized by inevitable discomfort for the patient. The aim of the study was to estimate whether fusafungine in spray has an effect on healing process after the operation, especially on pain and consumption of analgesics.. A prospective open, randomized study was performed on 68 patients (age 15 - 55) undergoing tonsillectomy for chronic tonsillitis. Except of standard postoperative therapy 34 patients received fusafungine in spray 4 times daily and 34 patients served as a control. Pain score in the morning and in the evening, consumption of analgesics and visual estimation of wound healing in the tonsillar fossa was evaluated.. Fusafungine in spray significantly reduces pain in the early days (2 - 4 day) after the operation and offers almost 16 % decrease in total consumption of analgesics (p < 0.04). Despite of that, total evaluation of pain score shows no significant differences in the both groups. The observation of wound healing suggests better cleanliness in 25 % of patients after fusafungine.. Fusafungine in spray improves quality of life after the tonsillectomy and so completes the spectrum of adjuvant postoperative local treatment possibilities.

Topics: Administration, Topical; Adolescent; Adult; Aerosols; Analgesics; Anti-Bacterial Agents; Depsipeptides; Female; Fusarium; Humans; Male; Middle Aged; Pain Measurement; Pain, Postoperative; Postoperative Care; Tonsillectomy; Treatment Outcome; Wound Healing