furostanol-i and Kidney-Diseases

furostanol-i has been researched along with Kidney-Diseases* in 1 studies

Other Studies

1 other study(ies) available for furostanol-i and Kidney-Diseases

ArticleYear
Protodioscin ameliorates fructose-induced renal injury via inhibition of the mitogen activated protein kinase pathway.
    Phytomedicine : international journal of phytotherapy and phytopharmacology, 2016, Nov-15, Volume: 23, Issue:12

    High dietary fructose can cause metabolic syndrome and renal injury.. The effects of protodioscin on metabolic syndrome and renal injury were investigated in mice receiving high-dose fructose.. Mice received 30% (w/v) fructose in water and standard chow for 6 weeks to induce metabolic syndrome and were divided into four groups to receive carboxymethylcellulose sodium, allopurinol (5 mg/kg) and protodioscin (5 and 10 mg/kg) continuously for 6 weeks, respectively. The glucose intolerance, serum uric acid (UA), blood urea nitrogen (BUN), creatinine (Cr), total cholesterol (TC), triglyceride (TG), interleukin-1β (IL-1β), interleukin-6 (IL-6) and tumor necrosis factor-α (TNF-α) were determined.. Protodioscin significantly improved glucose intolerance and reduced the levels of serum UA, BUN, Cr, TC and TG. Histological examinations showed that protodioscin ameliorated glomerular and tubular pathological changes. Protodioscin significantly reduced renal concentrations of IL-1β, IL-6 and TNF-α by inhibiting the activation of nuclear factor-κB, c-Jun N-terminal kinase, p38 mitogen-activated protein kinase and extracellular signal-regulated kinase. In addition, the effect of protodioscin on the mitogen activated protein kinases (MAPK) pathway was examined.. Taken together, protodioscin is a potential drug candidate for high dietary fructose-induced metabolic syndrome and renal injury.

    Topics: Animals; Diet; Dietary Carbohydrates; Dioscorea; Diosgenin; Extracellular Signal-Regulated MAP Kinases; Fructose; Interleukin-1beta; Interleukin-6; JNK Mitogen-Activated Protein Kinases; Kidney; Kidney Diseases; Male; MAP Kinase Signaling System; Metabolic Syndrome; Mice, Inbred ICR; Mitogen-Activated Protein Kinases; NF-kappa B; p38 Mitogen-Activated Protein Kinases; Phytotherapy; Plant Extracts; Saponins; Tumor Necrosis Factor-alpha; Uric Acid

2016