furosemide and Respiratory Distress Syndrome studies

Furosemide: A benzoic-sulfonamide-furan. It is a diuretic with fast onset and short duration that is used for EDEMA and chronic RENAL INSUFFICIENCY.
furosemide : A chlorobenzoic acid that is 4-chlorobenzoic acid substituted by a (furan-2-ylmethyl)amino and a sulfamoyl group at position 2 and 5 respectively. It is a diuretic used in the treatment of congestive heart failure.

Respiratory Distress Syndrome: A syndrome characterized by progressive life-threatening RESPIRATORY INSUFFICIENCY in the absence of known LUNG DISEASES, usually following a systemic insult such as surgery or major TRAUMA.

Research Excerpts

Excerpt	Relevance	Reference
"To study the role of furosemide infusion in the management of Acute respiratory distress syndrome (ARDS) associated with dengue fever."	7.80	Furosemide infusion in children with dengue fever and hypoxemia. ( Basavaraja, GV; Reddy, KR, 2014)
"She was diagnosed with a large pulmonary embolism and was hemodynamically unstable therefore requiring endotracheal intubation and norepinephrine support."	5.56	Potential role for furosemide in the treatment of acute respiratory distress syndrome (ARDS) and an unusual presentation of pulmonary embolism in a complex patient. ( Bornstein, G; Zornitzki, L, 2020)
"Furosemide has been shown to improve pulmonary gas exchange and intrapulmonary shunt in animal models of ARDS by preferential perfusion of nonedematous lung units."	5.30	Continuous dose furosemide as a therapeutic approach to acute respiratory distress syndrome (ARDS). ( Chendrasekhar, A; Moorman, DW; Paradise, NF; Reising, CA; Timberlake, GA; Wall, PL, 1999)
"Furosemide (2 mg/kg) was then administered intravenously to eight dogs (treated group)."	5.27	Effect of furosemide on fully established low pressure pulmonary edema. ( Artman, L; Cheney, FW; Rusch, VW, 1986)
"The addition of albumin to furosemide therapy in hypoproteinemic patients with acute lung injury/acute respiratory distress syndrome significantly improves oxygenation, with greater net negative fluid balance and better maintenance of hemodynamic stability."	5.11	A randomized, controlled trial of furosemide with or without albumin in hypoproteinemic patients with acute lung injury. ( Bernard, GR; Martin, GS; Mealer, M; Morris, JA; Moss, M; Wheeler, AP, 2005)
"Five-day protocolized regimen of 25 g of human serum albumin every 8 hrs with continuous infusion furosemide, or dual placebo, targeted to diuresis, weight loss, and serum total protein."	5.10	Albumin and furosemide therapy in hypoproteinemic patients with acute lung injury. ( Bernard, GR; Dupont, WD; Mangialardi, RJ; Martin, GS; Morris, JA; Wheeler, AP, 2002)
"To study the role of furosemide infusion in the management of Acute respiratory distress syndrome (ARDS) associated with dengue fever."	3.80	Furosemide infusion in children with dengue fever and hypoxemia. ( Basavaraja, GV; Reddy, KR, 2014)
"Furosemide is often used to reduce edema in patients with acute respiratory distress syndrome (ARDS)."	3.69	High-dose furosemide alters gas exchange in a model of acute lung injury. ( Clanton, TL; Gadek, JE; Op't Holt, TB; Waugh, JB, 1996)
"Recently, the Acute Respiratory Distress Syndrome Network Fluid and Catheter Treatment Trial reported that a conservative fluid management strategy, compared with a fluid liberal strategy, increased the mean (+/- SE) number of ventilator-free days in patients with ALI (14."	2.44	Nonventilatory treatments for acute lung injury and ARDS. ( Calfee, CS; Matthay, MA, 2007)
" This patient's case highlights the need of further studies evaluating efficacy of repeated dosing of CCP."	1.62	Sequential dosing of convalescent COVID-19 plasma with significant temporal clinical improvements in a persistently SARS-COV-2 positive patient. ( Bloch, EM; Chua, F; Goel, R; Katz, LM; Mirihagalle, N; Parajuli, P; Prakash, V; Saha, D; Shah, A; Sundareshan, V; Tobian, AAR; Waqar, S, 2021)
"She was diagnosed with a large pulmonary embolism and was hemodynamically unstable therefore requiring endotracheal intubation and norepinephrine support."	1.56	Potential role for furosemide in the treatment of acute respiratory distress syndrome (ARDS) and an unusual presentation of pulmonary embolism in a complex patient. ( Bornstein, G; Zornitzki, L, 2020)
"Nine hundred thirty-four ventilated acute respiratory distress syndrome patients with a central venous pressure available at enrollment, 609 without baseline shock (for whom fluid balance was managed by the study protocol)."	1.43	Impact of Initial Central Venous Pressure on Outcomes of Conservative Versus Liberal Fluid Management in Acute Respiratory Distress Syndrome. ( Bernard, GR; Rice, TW; Semler, MW; Thompson, BT; Wheeler, AP; Wiedemann, HP, 2016)
"Subsequent Acute Respiratory Distress Syndrome Network studies used a simplified conservative fluid protocol (FACTT Lite)."	1.42	Fluid management with a simplified conservative protocol for the acute respiratory distress syndrome*. ( Brown, SM; Dickerson, JB; Grissom, CK; Hirshberg, EL; Hite, RD; Lanspa, MJ; Liu, KD; Miller, RR; Morris, AH; Rock, P; Schoenfeld, D; Tidswell, M, 2015)
"Acute lung injury was induced in Wistar rats by intravenous administration of 100 mg/kg of OA."	1.31	Effects of mannitol on the acute lung injury induced by oleic acid in rats. ( Arantes-Costa, FM; Hilkner-Silva, M; Leme, AS; Lichtenstein, A; Martins, MA; Saldiva, PH, 2001)
"Furosemide has been shown to improve pulmonary gas exchange and intrapulmonary shunt in animal models of ARDS by preferential perfusion of nonedematous lung units."	1.30	Continuous dose furosemide as a therapeutic approach to acute respiratory distress syndrome (ARDS). ( Chendrasekhar, A; Moorman, DW; Paradise, NF; Reising, CA; Timberlake, GA; Wall, PL, 1999)
"Two of them, which were both polytraumatized, suffered from adult respiratory distress syndrome (ARDS)."	1.27	Renin-angiotensin system in sepsis. ( Hilgenfeldt, U; Kellermann, W; Kienapfel, G; Schmidt, M; Schott, R, 1987)
"Furosemide (2 mg/kg) was then administered intravenously to eight dogs (treated group)."	1.27	Effect of furosemide on fully established low pressure pulmonary edema. ( Artman, L; Cheney, FW; Rusch, VW, 1986)

Research

Studies (35)

Authors

Clinical Trials (20)

Trial Overview

Trial Outcomes

Length of Hospital Stay

Timeframe	Studies, this research(%)	All Research%
pre-1990	9 (25.71)	18.7374
1990's	4 (11.43)	18.2507
2000's	14 (40.00)	29.6817
2010's	4 (11.43)	24.3611
2020's	4 (11.43)	2.80

Authors	Studies
Zornitzki, L	1
Bornstein, G	1
Kevorkian, JP	1
Riveline, JP	1
Vandiedonck, C	1
Girard, D	1
Galland, J	1
Féron, F	1
Gautier, JF	1
Mégarbane, B	1
Vignon, P	1
Evrard, B	1
Asfar, P	1
Busana, M	1
Calfee, CS	2
Coppola, S	1
Demiselle, J	1
Geri, G	1
Jozwiak, M	1
Martin, GS	4
Gattinoni, L	2
Chiumello, D	1
Mirihagalle, N	1
Parajuli, P	1
Sundareshan, V	1
Saha, D	1
Shah, A	1
Chua, F	1
Waqar, S	1
Prakash, V	1
Tobian, AAR	1
Bloch, EM	1
Katz, LM	1
Goel, R	1
Reddy, KR	1
Basavaraja, GV	1
Grissom, CK	1
Hirshberg, EL	1
Dickerson, JB	1
Brown, SM	1
Lanspa, MJ	1
Liu, KD	1
Schoenfeld, D	1
Tidswell, M	1
Hite, RD	2
Rock, P	1
Miller, RR	1
Morris, AH	1
Semler, MW	1
Wheeler, AP	4
Thompson, BT	2
Bernard, GR	4
Wiedemann, HP	2
Rice, TW	1
Abudiab, MM	1
Odunukan, OW	1
Freeman, WK	1
Mangialardi, RJ	1
Dupont, WD	1
Morris, JA	2
Caspani, ML	1
Hatherill, M	1
Dunkley, R	1
Reynolds, L	1
Argent, A	1
Messerschmitt, P	1
Stambough, JL	1
Moss, M	1
Mealer, M	1
Stapleton, RD	1
Steinberg, KP	1
Hayden, D	1
deBoisblanc, B	1
Connors, AF	1
Harabin, AL	1
Fung, YL	1
Williams, BA	1
Schuller, D	1
Schuster, DP	1
Kuper, M	1
Gunning, MP	1
Halder, S	1
Soni, N	1
Deady, B	1
Glezo, J	1
Blackie, S	1
Matthay, MA	1
Waugh, JB	1
Op't Holt, TB	1
Gadek, JE	1
Clanton, TL	1
Reising, CA	1
Chendrasekhar, A	1
Wall, PL	1
Paradise, NF	1
Timberlake, GA	1
Moorman, DW	1
Hilkner-Silva, M	1
Leme, AS	1
Arantes-Costa, FM	1
Saldiva, PH	1
Lichtenstein, A	1
Martins, MA	1
Powers, SR	1
Shah, D	1
Ryon, D	1
Newell, J	1
Ralph, C	1
Scovill, W	1
Dutton, R	1
Masson, RG	1
Ruggieri, J	1
Siddiqui, MM	1
Ferrara, A	1
Rizzi, AM	1
Clini, V	1
Fumagalli, G	1
Edoute, Y	1
Nagler, A	1
Zimer, E	1
Ben-Haim, S	1
Kraus, PA	1
Lipman, J	1
Becker, PJ	1
Murphy, JL	1
Hurt, TL	1
Griswold, WR	1
Peterson, BM	1
Rodarte, A	1
Krous, HF	1
Reznik, VM	1
Mendoza, SA	1
Hilgenfeldt, U	1
Kienapfel, G	1
Kellermann, W	1
Schott, R	1
Schmidt, M	1
Shi, YX	1
Rusch, VW	1
Artman, L	1
Cheney, FW	1
Schuster, HP	1
Lynn, AM	1
Redding, GJ	1
Morray, JP	1
Tyler, DC	1

Trial	Phase	Enrollment	Study Type	Start Date	Status
Platform Adaptive Embedded Trial for Acute Respiratory Distress Syndrome[NCT05658692]	Phase 4	1,000 participants (Anticipated)	Interventional	2022-10-01	Recruiting
Risk Factors and Prediction Score of ARDS After Cardiac Surgery[NCT02759770]		1,333 participants (Actual)	Observational	2017-07-01	Completed
Hemodynamics and Extravascular Lung Water in Acute Lung Injury: A Prospective Randomized Controlled Multicentered Trial of Goal Directed Treatment of EVLW Versus Standard Management for the Treatment of Acute Lung Injury[NCT00624650]	Phase 2	33 participants (Actual)	Interventional	2008-02-29	Completed
The Effect of Negatively Fluid Balancing Speed for ICU Patients With Acute Respiratory Distress Syndrome[NCT03552601]		70 participants (Anticipated)	Interventional	2018-08-01	Recruiting
Echocardiography Guided Fluid Resuscitation in Critically Ill Patients[NCT03296319]		120 participants (Actual)	Interventional	2018-01-01	Completed
Efficacy of Bevacizumab in Preventing Acute Respiratory Distress Syndrome (ARDS)[NCT01314066]	Phase 2	0 participants (Actual)	Interventional	2010-07-31	Withdrawn (stopped due to No funding)
Effect of High-Flow Nasal Cannula on IVC Measurements Using Point of Care Ultrasound[NCT05264454]		45 participants (Anticipated)	Interventional	2022-07-01	Not yet recruiting
Controlled Fluid Resuscitation Strategy in Sepsis Patient[NCT03214913]		550 participants (Anticipated)	Interventional	2018-01-01	Not yet recruiting
[NCT00281268]	Phase 3	0 participants	Interventional		Completed
Effect of Restricted Fluid Management Strategy on Outcomes in Critically Ill Pediatric Trauma Patients: A Multicenter Randomized Controlled Trial[NCT04201704]		250 participants (Anticipated)	Interventional	2018-08-27	Recruiting
Assessment of the Reliability of Changes in Plethysmography Variability Index During Tidal Volume Challenge for Predicting Fluid Responsiveness in Intensive Care Unit Patients[NCT05428423]		44 participants (Anticipated)	Observational	2022-06-06	Recruiting
Single Dose of Furosemide to Improve Respiratory Distress in Moderate to Severe Bronchiolitis[NCT02469597]	Phase 2	46 participants (Actual)	Interventional	2013-10-31	Completed
Aspiration in Acute Respiratory Failure Survivors[NCT02363686]		248 participants (Actual)	Interventional	2012-02-29	Completed
Bioelectrical Impedance Vector Analysis (BIVA) in Monitoring Hyperhydration and Polyneuromyopathy in Critically Ill Patients[NCT05991778]		61 participants (Actual)	Observational	2021-03-01	Completed
Fluid Balance in the ICU - Interventions to Minimize Fluids in Patients With Septic Shock[NCT02473718]		82 participants (Actual)	Interventional	2014-01-31	Completed
CRI and Continuous Assessment of Hemodynamic Compensation to Guide Fluid and Pressor Management in Severely Ill Patients With COVID-19[NCT04457817]		16 participants (Actual)	Observational	2020-12-01	Terminated (stopped due to Lack of feasibility)
REcruitment MAneuvers and Mechanical Ventilation Guided by EIT in Pediatric Acute Respiratory Distress Syndrome (pARDS)[NCT06067152]		13 participants (Anticipated)	Interventional	2022-01-01	Recruiting
Agreement Test of Intravascular Volume Assessment Between Inferior Vena Cava (IVC) Diameter and Vascular Pedicle Width (VPW)[NCT03535038]		35 participants (Actual)	Interventional	2018-05-31	Completed
Description of Fluid Balance in Patients With Acute Respiratory Failure[NCT02523872]		50 participants (Anticipated)	Observational	2015-08-31	Enrolling by invitation
A Pilot Study for the Efficacy and Safety of Mesenchymal Stem Cell in Acute Severe Respiratory Failure.[NCT02112500]	Phase 2	10 participants (Anticipated)	Interventional	2014-02-28	Recruiting
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

(NCT02469597)
Timeframe: Participants will be followed for the duration of hospital stay up to 1 week

Oxygen Saturation

Patient Needing Endotracheal Intubation

Respiratory Rate

Percentage of Participants Experiencing Aspiration

Intervention	Days (Least Squares Mean)
Single Dose of Furosemide	3.1
Placebo	3.0

Intervention	Percentage change in oxygen saturation (Least Squares Mean)
Single Dose of Furosemide	-0.14
Placebo	0.2

Intervention	Percentage change in oxygen saturation (Least Squares Mean)
Single Dose of Furosemide	-0.19
Placebo	0.29

Intervention	participants (Number)
Single Dose of Furosemide	0
Placebo	0

Intervention	Percentage change in respiratory rate (Least Squares Mean)
Single Dose of Furosemide	-3.7
Placebo	-1.7

Intervention	Percentage change in respiratory rate (Least Squares Mean)
Single Dose of Furosemide	-2.8
Placebo	-5.4

Aim: To develop a BSE-based non-invasive clinical prediction rule (CPR) that will accurately and efficiently diagnose aspiration in ARF survivors. Aspiration (PAS score of ≥6) on the FEES with any of the five feedings. This outcome measure will report the percentage of participants experiencing silent and non-silent aspiration, as visualized on the FEES. The FEES is a flexible fiberoptic camera that allows the investigators to visualize the patient swallowing each of the 5 different consistencies of food. (NCT02363686)
Timeframe: from extubation Day 1 through hospital discharge, expected to be within 28 days

Cumulative Fluid Administered

Intervention	percentage of participants (Number)
	Overall aspiration	Non-silent aspiration
FEES & Bedside Swallow Evaluation (BSE)	70	52

Cumulative volume of crystalloid boluses, continuous infusions, and colloid fluids administered in mL by day 3 (NCT02473718)
Timeframe: Day 3

Cumulative Fluid Administered

Intervention	mL of study fluid (Median)
Fluid Minimization Group	4417
Usual Care Group	4110

Cumulative volume of crystalloid boluses, continuous infusions, and colloid fluids administered in mL by day 5 (NCT02473718)
Timeframe: Day 5

Mortality

Intervention	mL of study fluid (Median)
Fluid Minimization Group	6244
Usual Care Group	8690

Percentage of patients who died during their hospitalization (NCT02473718)
Timeframe: Hospital stay, median of 16 days

Mortality

Intervention	Participants (Count of Participants)
Fluid Minimization Group	23
Usual Care Group	20

Percentage of patients who died during their ICU stay (NCT02473718)
Timeframe: ICU stay, median of 10 days

Net Fluid Balance

Intervention	Participants (Count of Participants)
Fluid Minimization Group	23
Usual Care Group	20

Difference between cumulative volume of all IV fluids administered and all outputs in mL by day 3 (NCT02473718)
Timeframe: Day 3

Net Fluid Balance

Intervention	mL (Median)
Fluid Minimization Group	1952
Usual Care Group	3124

Difference between cumulative volume of all IV fluids administered and all outputs in mL by day 5 (NCT02473718)
Timeframe: Day 5

Rate of Renal Replacement Therapy

Intervention	mL (Median)
Fluid Minimization Group	2641
Usual Care Group	3616

Percentage of patients requiring renal replacement therapy (NCT02473718)
Timeframe: ICU stay, median of 10 days

Ventilator Days

Intervention	Participants (Count of Participants)
Fluid Minimization Group	17
Usual Care Group	16

Number of days requiring mechanical ventilation support, including continuous noninvasive positive pressure ventilation (NCT02473718)
Timeframe: Hospital stay, median of 16 days

Article	Year
Fluid administration and monitoring in ARDS: which management? Intensive care medicine, 2020, Volume: 46, Issue:12 Topics: Extravascular Lung Water; Fluid Therapy; Furosemide; Humans; Respiration, Artificial; Respiratory Di	2020
Nonventilatory treatments for acute lung injury and ARDS. Chest, 2007, Volume: 131, Issue:3 Topics: Adrenal Cortex Hormones; Clinical Trials as Topic; Critical Care; Fluid Therapy; Furosemide; Humans;	2007
Fluid balance and colloid osmotic pressure in acute respiratory failure: emerging clinical evidence. Critical care (London, England), 2000, Volume: 4 Suppl 2 Topics: Diuretics; Furosemide; Humans; Osmotic Pressure; Respiratory Distress Syndrome; Serum Albumin; Water	2000

Article	Year
Potential role for furosemide in the treatment of acute respiratory distress syndrome (ARDS) and an unusual presentation of pulmonary embolism in a complex patient. BMJ case reports, 2020, Aug-24, Volume: 13, Issue:8 Topics: Aged, 80 and over; Anticoagulants; Ceftriaxone; Enoxaparin; Female; Furosemide; Humans; Pulmonary Em	2020
Early short-course corticosteroids and furosemide combination to treat non-critically ill COVID-19 patients: An observational cohort study. The Journal of infection, 2021, Volume: 82, Issue:1 Topics: Adrenal Cortex Hormones; Aged; Aged, 80 and over; Anti-Inflammatory Agents; Cohort Studies; Comorbid	2021
Sequential dosing of convalescent COVID-19 plasma with significant temporal clinical improvements in a persistently SARS-COV-2 positive patient. Transfusion and apheresis science : official journal of the World Apheresis Association : official journal of the European Society for Haemapheresis, 2021, Volume: 60, Issue:5 Topics: Anti-Bacterial Agents; Combined Modality Therapy; COVID-19; COVID-19 Serotherapy; Diabetes Mellitus,	2021
Furosemide infusion in children with dengue fever and hypoxemia. Indian pediatrics, 2014, Volume: 51, Issue:4 Topics: Adolescent; Child; Child, Preschool; Dengue; Diuretics; Furosemide; Humans; India; Infant; Infusions	2014
Fluid management with a simplified conservative protocol for the acute respiratory distress syndrome. Critical care medicine, 2015, Volume: 43, Issue:2* Topics: Central Venous Pressure; Clinical Protocols; Diuretics; Female; Fluid Therapy; Furosemide; Humans; I	2015
Impact of Initial Central Venous Pressure on Outcomes of Conservative Versus Liberal Fluid Management in Acute Respiratory Distress Syndrome. Critical care medicine, 2016, Volume: 44, Issue:4 Topics: Adult; Aged; Central Venous Pressure; Diuretics; Female; Fluid Therapy; Furosemide; Humans; Male; Mi	2016
95-year-old woman with sudden-onset dyspnea. Mayo Clinic proceedings, 2012, Volume: 87, Issue:6 Topics: Aged, 80 and over; Atrial Fibrillation; Diuretics; Dyspnea; Female; Furosemide; Humans; Pulmonary Ed	2012
Albumin and furosemide in acute lung injury: a little step forward? Critical care medicine, 2002, Volume: 30, Issue:10 Topics: Diuresis; Diuretics; Furosemide; Humans; Respiratory Distress Syndrome; Serum Albumin; Weight Loss	2002
Improved oxygenation in acute lung injury: albumin gain or fluid loss? Critical care medicine, 2003, Volume: 31, Issue:6 Topics: Diuretics; Furosemide; Hemodynamics; Humans; Oxygen; Respiratory Distress Syndrome; Serum Albumin	2003
Negative-pressure pulmonary edema in the arthroscopic patient. Orthopedics, 2005, Volume: 28, Issue:4 Topics: Airway Obstruction; Anesthesia, Inhalation; Arthroscopy; Cartilage, Articular; Critical Care; Diagno	2005
Fluid balance in acute lung injury: a model of clinical trial development. Critical care medicine, 2005, Volume: 33, Issue:8 Topics: Combined Modality Therapy; Diuretics; Furosemide; Humans; Hypoproteinemia; Respiratory Distress Synd	2005
TRALI in 2 cases of leukemia. Journal of pediatric hematology/oncology, 2006, Volume: 28, Issue:6 Topics: Adolescent; Anti-Inflammatory Agents; Blood Donors; Child, Preschool; Diuretics; False Positive Reac	2006
Fluid-management strategies in acute lung injury. The New England journal of medicine, 2006, Sep-14, Volume: 355, Issue:11 Topics: Algorithms; Diuretics; Fluid Therapy; Furosemide; Humans; Respiratory Distress Syndrome; Water-Elect	2006
A swimmer's wheeze. CJEM, 2006, Volume: 8, Issue:4 Topics: Adult; Diuretics; Dyspnea; Exercise Tolerance; Female; Furosemide; Hemoptysis; Humans; Hypoxia; Oxyg	2006
High-dose furosemide alters gas exchange in a model of acute lung injury. Journal of critical care, 1996, Volume: 11, Issue:3 Topics: Animals; Blood Gas Analysis; Disease Models, Animal; Dogs; Furosemide; Humans; Kidney; Pulmonary Ede	1996
Continuous dose furosemide as a therapeutic approach to acute respiratory distress syndrome (ARDS). The Journal of surgical research, 1999, Volume: 82, Issue:1 Topics: Animals; Disease Models, Animal; Diuretics; Dogs; Furosemide; Hemodynamics; Humans; Lung; Lung Injur	1999
Effects of mannitol on the acute lung injury induced by oleic acid in rats. Shock (Augusta, Ga.), 2001, Volume: 16, Issue:6 Topics: Animals; Diuretics; Diuretics, Osmotic; Furosemide; Humans; Hypertonic Solutions; Infusions, Intrave	2001
Amniotic fluid embolism: definitive diagnosis in a survivor. The American review of respiratory disease, 1979, Volume: 120, Issue:1 Topics: Adult; Embolism, Amniotic Fluid; Female; Forced Expiratory Volume; Functional Residual Capacity; Fur	1979
[Contribution to the study of "wet lung". Radiological and clinico-functional changes induced by depletion therapy in 5 patients with chronic bronchopulmonary disease]. Minerva medica, 1979, Jan-07, Volume: 70, Issue:1 Topics: Bloodletting; Chlorthalidone; Diuretics; Furosemide; Humans; Lung; Male; Middle Aged; Radiography; R	1979
[Adult respiratory distress syndrome complicating acute pyelonephritis in pregnancy]. Harefuah, 1991, Volume: 121, Issue:7-8 Topics: Adult; Anti-Bacterial Agents; Female; Furosemide; Humans; Klebsiella Infections; Pregnancy; Pregnanc	1991
Acute preload effects of furosemide. Chest, 1990, Volume: 98, Issue:1 Topics: Adult; Aged; Cardiovascular Diseases; Catheterization, Peripheral; Drug Administration Schedule; Fem	1990
Interference with creatinine concentration measurement by high dose furosemide infusion. Critical care medicine, 1989, Volume: 17, Issue:9 Topics: Blood Chemical Analysis; Child, Preschool; Colorimetry; Creatinine; Female; Furosemide; Humans; Infa	1989
Renin-angiotensin system in sepsis. Clinical and experimental hypertension. Part A, Theory and practice, 1987, Volume: 9, Issue:8-9 Topics: Acute Kidney Injury; Angiotensin I; Angiotensin II; Epinephrine; Furosemide; Humans; Multiple Trauma	1987
[Dehydration therapy in rabbit models of the respiratory distress syndrome induced by oleic acid]. Zhonghua jie he he hu xi za zhi = Zhonghua jiehe he huxi zazhi = Chinese journal of tuberculosis and respiratory diseases, 1988, Volume: 11, Issue:2 Topics: Animals; Dehydration; Female; Furosemide; Male; Oleic Acid; Oleic Acids; Rabbits; Respiratory Distre	1988
Effect of furosemide on fully established low pressure pulmonary edema. The Journal of surgical research, 1986, Volume: 41, Issue:2 Topics: Animals; Dogs; Furosemide; Oleic Acid; Oleic Acids; Pulmonary Edema; Respiratory Distress Syndrome	1986
[Acute pulmonary and renal failure in peritonitis]. Deutsche medizinische Wochenschrift (1946), 1985, Oct-18, Volume: 110, Issue:42 Topics: Acute Kidney Injury; Furosemide; Humans; Peritoneal Dialysis; Peritonitis; Positive-Pressure Respira	1985
Isolated deafness following recovery from neurologic injury and adult respiratory distress syndrome. A sequela of intercurrent aminoglycoside and diuretic use. American journal of diseases of children (1960), 1985, Volume: 139, Issue:5 Topics: Aminoglycosides; Anti-Bacterial Agents; Deafness; Diuresis; Furosemide; Hearing Tests; Humans; Infan	1985

furosemide and Respiratory Distress Syndrome

Research Excerpts

Research

Studies (35)

Authors

Clinical Trials (20)

Trial Overview

Trial Outcomes

Length of Hospital Stay

Oxygen Saturation

Oxygen Saturation

Patient Needing Endotracheal Intubation

Respiratory Rate

Respiratory Rate

Percentage of Participants Experiencing Aspiration

Cumulative Fluid Administered

Cumulative Fluid Administered

Mortality

Mortality

Net Fluid Balance

Net Fluid Balance

Rate of Renal Replacement Therapy

Ventilator Days

Reviews

Trials

Other Studies