furosemide and Respiratory Distress Syndrome, Newborn studies

Furosemide: A benzoic-sulfonamide-furan. It is a diuretic with fast onset and short duration that is used for EDEMA and chronic RENAL INSUFFICIENCY.
furosemide : A chlorobenzoic acid that is 4-chlorobenzoic acid substituted by a (furan-2-ylmethyl)amino and a sulfamoyl group at position 2 and 5 respectively. It is a diuretic used in the treatment of congestive heart failure.

Respiratory Distress Syndrome, Newborn: A condition of the newborn marked by DYSPNEA with CYANOSIS, heralded by such prodromal signs as dilatation of the alae nasi, expiratory grunt, and retraction of the suprasternal notch or costal margins, mostly frequently occurring in premature infants, children of diabetic mothers, and infants delivered by cesarean section, and sometimes with no apparent predisposing cause.

Research Excerpts

Excerpt	Relevance	Reference
"To review the efficacy and safety of inhaled furosemide in the treatment of acute respiratory distress and possible bronchopulmonary dysplasia (BPD) in preterm neonates receiving ventilator and oxygen support."	8.80	Aerosolized furosemide in the treatment of acute respiratory distress and possible bronchopulmonary dysplasia in preterm neonates. ( Nahata, MC; Pai, VB, 2000)
"To review the efficacy and safety of inhaled furosemide in the treatment of acute respiratory distress and possible bronchopulmonary dysplasia (BPD) in preterm neonates receiving ventilator and oxygen support."	4.80	Aerosolized furosemide in the treatment of acute respiratory distress and possible bronchopulmonary dysplasia in preterm neonates. ( Nahata, MC; Pai, VB, 2000)
"Pulmonary edema has been demonstrated in the early stages of respiratory distress syndrome in premature infants."	2.65	Early furosemide therapy in premature infants (less than or equal to 2000 gm) with respiratory distress syndrome: a randomized controlled trial. ( Leu, ST; Pildes, RS; Raval, D; Shibli, A; Yeh, TF, 1984)
"During the study, the incidence of patent ductus arteriosus was significantly higher (P less than 0."	2.65	Furosemide promotes patent ductus arteriosus in premature infants with the respiratory-distress syndrome. ( Green, TP; Johnson, DE; Lock, JE; Thompson, TR, 1983)
"Babies with SS presenting with cardiac failure are prone to develop exaggerated pulmonary vascular disease."	1.42	Scimitar syndrome with absent right pulmonary artery and severe pulmonary hypertension treated with coil occlusion of aortopulmonary collaterals in a term neonate. ( Masud, F; Parappil, H; Salama, H; ur Rahman, S, 2015)
"All of the infants had hypoxemia with air-trapping in the chest at the time of admission to the hospital."	1.27	Antidiuretic hormone response in children with bronchopulmonary dysplasia during episodes of acute respiratory distress. ( Eid, N; Herrod, L; Parekh, A; Rao, M; Steiner, P, 1986)
" Similarities in their clinical courses included low birthweights, low calcium intakes, uncertain vitamin D intakes, and chronic administration of frusemide and sodium bicarbonate--all potential aetiological factors in the development of bone undermineralisation."	1.26	Nutritional rickets in 2 very low birthweight infants with chronic lung disease. ( Brown, DR; Chudley, AE; Holzman, IR; Oh, KS, 1980)
"Furosemide is a known stimulant of the renal release of prostaglandin E2, a potent dilator of the ductus arteriosus."	1.26	Furosemide use in premature infants and appearance of patent ductus arteriosus. ( Green, TP; Johnson, D; Lock, JE; Thompson, TR, 1981)
"Interstitial pulmonary edema in these patients can be related to both their lung disease and impaired water tolerance during ventilatory therapy."	1.25	Edema of the pulmonary interstitium in infants and children. ( Moylan, FM; O'Connell, K; Shannon, DC; Todres, ID, 1975)

Research

Studies (36)

Authors

Clinical Trials (1)

Trial Overview

Trial Outcomes

Length of Hospital Stay

Timeframe	Studies, this research(%)	All Research%
pre-1990	27 (75.00)	18.7374
1990's	4 (11.11)	18.2507
2000's	3 (8.33)	29.6817
2010's	2 (5.56)	24.3611
2020's	0 (0.00)	2.80

Authors	Studies
Parappil, H	1
Masud, F	1
Salama, H	1
ur Rahman, S	1
Stewart, A	1
Brion, LP	3
Soll, R	1
Soll, RF	2
Green, TP	5
Thompson, TR	4
Johnson, DE	3
Lock, JE	3
Yee, WF	1
Cataletto, M	1
Scarpelli, EM	1
Yeh, TF	2
Shibli, A	1
Leu, ST	1
Raval, D	2
Pildes, RS	2
Glasier, CM	1
Stoddard, RA	1
Ackerman, NB	1
McCurdy, FA	1
Null, DM	1
deLemos, RA	1
Venkataraman, PS	1
Han, BK	1
Tsang, RC	1
Daugherty, CC	1
Callahan, J	1
Haller, JO	1
Cacciarelli, AA	1
Slovis, TL	1
Friedman, AP	1
Wolf, P	1
Mannino, F	1
Hofmann, AF	1
Nickoloff, B	1
Edwards, DK	1
Najak, ZD	1
Harris, EM	1
Lazzara, A	1
Pruitt, AW	1
Tulassay, T	1
Kiszel, J	1
Machay, T	1
Csömör, S	1
Hufnagle, KG	1
Khan, SN	1
Penn, D	1
Cacciarelli, A	1
Williams, P	1
Jaso, E	1
Tejedor, JC	1
Quero, J	1
Pérez Rodríguez, J	1
Agustí, B	1
Castro, J	1
García Frías, E	1
Chudley, AE	1
Brown, DR	1
Holzman, IR	1
Oh, KS	1
Johnson, D	1
Oh, W	1
Guignard, JP	1
Dubourg, L	1
Gouyon, JB	1
Borradori, C	1
Fawer, CL	1
Buclin, T	1
Calame, A	1
Prabhu, VG	1
Keszler, M	1
Dhanireddy, R	1
Rama-Maceiras, P	1
Duro, J	1
Figueira-Moure, A	1
Rey-Rilo, T	1
Toral, A	1
Rodríguez-Rodríguez, A	1
Pai, VB	1
Nahata, MC	1
Moylan, FM	1
O'Connell, K	1
Todres, ID	1
Shannon, DC	1
Hall, GS	1
Helmsworth, JA	1
Schreiber, JT	1
Rosenkrantz, JG	1
Martin, LW	1
Baylen, BG	1
Kaplan, S	1
Savage, MO	2
Wilkinson, AR	1
Baum, JD	2
Roberton, NR	2
Bass, JL	1
Landrum, BG	1
Ferrara, TB	1
Aranda, JV	1
Chemtob, S	1
Laudignon, N	1
Sasyniuk, BI	1
Rao, M	1
Eid, N	1
Herrod, L	1
Parekh, A	1
Steiner, P	1
Vargas-Origel, A	1
Cruz-Anguiano, V	1
López-Montaño, E	1
Bolam, DL	1
Eggert, LD	1
Leuschen, MP	1
Nelson, RM	1
John, E	1
Llamas, R	1
Forthman, HJ	1

Trial	Phase	Enrollment	Study Type	Start Date	Status
Single Dose of Furosemide to Improve Respiratory Distress in Moderate to Severe Bronchiolitis[NCT02469597]	Phase 2	46 participants (Actual)	Interventional	2013-10-31	Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

(NCT02469597)
Timeframe: Participants will be followed for the duration of hospital stay up to 1 week

Oxygen Saturation

Patient Needing Endotracheal Intubation

Respiratory Rate

Reviews

Trials

Other Studies

21 other studies available for furosemide and Respiratory Distress Syndrome, Newborn

Intervention	Days (Least Squares Mean)
Single Dose of Furosemide	3.1
Placebo	3.0

Intervention	Percentage change in oxygen saturation (Least Squares Mean)
Single Dose of Furosemide	-0.14
Placebo	0.2

Intervention	Percentage change in oxygen saturation (Least Squares Mean)
Single Dose of Furosemide	-0.19
Placebo	0.29

Intervention	Percentage change in respiratory rate (Least Squares Mean)
Single Dose of Furosemide	-3.7
Placebo	-1.7

Intervention	Percentage change in respiratory rate (Least Squares Mean)
Single Dose of Furosemide	-2.8
Placebo	-5.4

Article	Year
Diuretics for respiratory distress syndrome in preterm infants. The Cochrane database of systematic reviews, 2011, Dec-07, Issue:12 Topics: Bronchodilator Agents; Chlorothiazide; Diuretics; Furosemide; Humans; Infant, Newborn; Infant, Prema	2011
Diuretics for respiratory distress syndrome in preterm infants. The Cochrane database of systematic reviews, 2008, Jan-23, Issue:1 Topics: Bronchodilator Agents; Chlorothiazide; Diuretics; Furosemide; Humans; Infant, Newborn; Infant, Prema	2008
[Diuretics in the neonatal period]. Revue medicale de la Suisse romande, 1995, Volume: 115, Issue:8 Topics: Benzothiadiazines; Bronchopulmonary Dysplasia; Diuretics; Furosemide; Heart Failure; Humans; Infant,	1995
Aerosolized furosemide in the treatment of acute respiratory distress and possible bronchopulmonary dysplasia in preterm neonates. The Annals of pharmacotherapy, 2000, Volume: 34, Issue:3 Topics: Administration, Inhalation; Aerosols; Bronchopulmonary Dysplasia; Diuretics; Furosemide; Humans; Inf	2000
Diuretics for respiratory distress syndrome in preterm infants. The Cochrane database of systematic reviews, 2001, Issue:2 Topics: Diuretics; Furosemide; Humans; Infant, Newborn; Infant, Premature; Randomized Controlled Trials as T	2001
The pharmacologic basis of diuretic therapy in the newborn. Clinics in perinatology, 1987, Volume: 14, Issue:4 Topics: Acute Kidney Injury; Diuretics; Furosemide; Humans; Infant, Newborn; Pulmonary Edema; Respiratory Di	1987
Furosemide and vitamin E. Two problem drugs in neonatology. Pediatric clinics of North America, 1986, Volume: 33, Issue:3 Topics: Acid-Base Imbalance; Anemia; Bronchopulmonary Dysplasia; Cerebral Hemorrhage; Diuresis; Ductus Arter	1986

Article	Year
Diuresis and pulmonary function in premature infants with respiratory distress syndrome. The Journal of pediatrics, 1983, Volume: 103, Issue:4 Topics: Chlorothiazide; Clinical Trials as Topic; Diuresis; Ductus Arteriosus, Patent; Furosemide; Humans; I	1983
Early furosemide therapy in premature infants (less than or equal to 2000 gm) with respiratory distress syndrome: a randomized controlled trial. The Journal of pediatrics, 1984, Volume: 105, Issue:4 Topics: Bronchopulmonary Dysplasia; Clinical Trials as Topic; Ductus Arteriosus, Patent; Furosemide; Humans;	1984
Furosemide promotes patent ductus arteriosus in premature infants with the respiratory-distress syndrome. The New England journal of medicine, 1983, Mar-31, Volume: 308, Issue:13 Topics: Chlorothiazide; Ductus Arteriosus, Patent; Furosemide; Humans; Infant, Newborn; Kidney; Prostaglandi	1983
Pulmonary effects of furosemide in preterm infants with lung disease. The Journal of pediatrics, 1983, Volume: 102, Issue:5 Topics: Furosemide; Humans; Infant, Newborn; Lung Compliance; Random Allocation; Respiration; Respiratory Di	1983
Pulmonary function changes after nebulised and intravenous frusemide in ventilated premature infants. Archives of disease in childhood. Fetal and neonatal edition, 1997, Volume: 77, Issue:1 Topics: Administration, Inhalation; Cross-Over Studies; Diuretics; Drug Administration Schedule; Female; Fur	1997
Frusemide in respiratory distress syndrome. Archives of disease in childhood, 1975, Volume: 50, Issue:9 Topics: Calcium; Carbon Dioxide; Clinical Trials as Topic; Drug Evaluation; Female; Furosemide; Humans; Infa	1975
Prophylactic furosemide in severe respiratory distress syndrome: blinded prospective study. The Journal of pediatrics, 1988, Volume: 112, Issue:4 Topics: Body Weight; Furosemide; Humans; Infant, Newborn; Plasma Volume; Pulse; Random Allocation; Respirati	1988
Renal response to frusemide in preterm infants with respiratory distress syndrome during the first three postnatal days. Archives of disease in childhood, 1985, Volume: 60, Issue:7 Topics: Apgar Score; Blood Urea Nitrogen; Body Weight; Calcium; Creatinine; Electrolytes; Furosemide; Glomer	1985

Article	Year
Scimitar syndrome with absent right pulmonary artery and severe pulmonary hypertension treated with coil occlusion of aortopulmonary collaterals in a term neonate. BMJ case reports, 2015, Feb-25, Volume: 2015 Topics: Cardiac Catheterization; Collateral Circulation; Coronary Angiography; Diuretics; Echocardiography;	2015
New concepts in neonatal respiratory distress syndrome. Comprehensive therapy, 1984, Volume: 10, Issue:5 Topics: Ductus Arteriosus, Patent; Female; Fetal Organ Maturity; Fluid Therapy; Furosemide; Humans; Infant,	1984
Nephrolithiasis in infants: association with chronic furosemide therapy. AJR. American journal of roentgenology, 1983, Volume: 140, Issue:1 Topics: Female; Furosemide; Humans; Infant; Infant, Newborn; Kidney Calculi; Male; Respiratory Distress Synd	1983
Secondary hyperparathyroidism and bone disease in infants receiving long-term furosemide therapy. American journal of diseases of children (1960), 1983, Volume: 137, Issue:12 Topics: Bone and Bones; Bone Diseases; Calcium; Furosemide; Humans; Hyperparathyroidism, Secondary; Infant,	1983
Cholelithiasis in infants: association with total parenteral nutrition and furosemide. Radiology, 1982, Volume: 143, Issue:2 Topics: Bronchopulmonary Dysplasia; Cholelithiasis; Female; Furosemide; Humans; Infant, Newborn; Male; Paren	1982
Calcium oxalate-phosphate gallstones, a unique chemical type of gallstone. Clinical chemistry, 1982, Volume: 28, Issue:8 Topics: Calcium Oxalate; Calcium Phosphates; Cholelithiasis; Chromatography, Ion Exchange; Female; Furosemid	1982
[Effects of furosemide on renal functions in prematures (author's transl)]. Monatsschrift Kinderheilkunde : Organ der Deutschen Gesellschaft fur Kinderheilkunde, 1982, Volume: 130, Issue:7 Topics: Acid-Base Equilibrium; Female; Furosemide; Glomerular Filtration Rate; Humans; Hyaline Membrane Dise	1982
Renal calcifications: a complication of long-term furosemide therapy in preterm infants. Pediatrics, 1982, Volume: 70, Issue:3 Topics: Ductus Arteriosus, Patent; Furosemide; Heart Failure; Humans; Infant; Infant, Newborn; Infant, Prema	1982
[Treatment of patent ductus arteriosus in preterm infants]. Anales espanoles de pediatria, 1982, Volume: 16, Issue:6 Topics: Digoxin; Ductus Arteriosus, Patent; Female; Furosemide; Humans; Indomethacin; Infant, Low Birth Weig	1982
Nutritional rickets in 2 very low birthweight infants with chronic lung disease. Archives of disease in childhood, 1980, Volume: 55, Issue:9 Topics: Bicarbonates; Bronchial Diseases; Calcium; Chronic Disease; Female; Furosemide; Humans; Infant; Infa	1980
Furosemide use in premature infants and appearance of patent ductus arteriosus. American journal of diseases of children (1960), 1981, Volume: 135, Issue:3 Topics: Ductus Arteriosus; Ductus Arteriosus, Patent; Fluid Therapy; Furosemide; Humans; Infant, Newborn; Re	1981
Renal functions and clinical disorders in the neonate. Clinics in perinatology, 1981, Volume: 8, Issue:2 Topics: Acute Kidney Injury; Anti-Bacterial Agents; Asphyxia Neonatorum; Furosemide; Humans; Indomethacin; I	1981
Risk factors of sensorineural hearing loss in preterm infants. Biology of the neonate, 1997, Volume: 71, Issue:1 Topics: Aminoglycosides; Evoked Potentials, Auditory, Brain Stem; Furosemide; Gestational Age; Hearing Loss,	1997
[Ventilation in prone decubitus in a patient with respiratory distress during heart surgery]. Revista espanola de anestesiologia y reanimacion, 1999, Volume: 46, Issue:2 Topics: Cardiotonic Agents; Combined Modality Therapy; Contraindications; Diuretics; Dopamine; Furosemide; H	1999
Edema of the pulmonary interstitium in infants and children. Pediatrics, 1975, Volume: 55, Issue:6 Topics: Adolescent; Auscultation; Bronchiolitis, Viral; Carbon Dioxide; Child, Preschool; Furosemide; Humans	1975
Premature infants with patent ductus arteriosus and respiratory distress: selection for ductal ligation. The Annals of thoracic surgery, 1976, Volume: 22, Issue:2 Topics: Digitalis Glycosides; Ductus Arteriosus, Patent; Echocardiography; Female; Furosemide; Heart Failure	1976
Antidiuretic hormone response in children with bronchopulmonary dysplasia during episodes of acute respiratory distress. American journal of diseases of children (1960), 1986, Volume: 140, Issue:8 Topics: Bronchopulmonary Dysplasia; Female; Furosemide; Humans; Hyponatremia; Hypoxia; Infant; Infant, Newbo	1986
[Indomethacin and furosemide in closure of ductus arteriosus]. Boletin medico del Hospital Infantil de Mexico, 1986, Volume: 43, Issue:8 Topics: Drug Evaluation; Ductus Arteriosus, Patent; Female; Furosemide; Humans; Indomethacin; Infant, Newbor	1986
Early furosemide therapy of RDS. The Journal of pediatrics, 1985, Volume: 106, Issue:2 Topics: Furosemide; Humans; Infant, Newborn; Respiration, Artificial; Respiratory Distress Syndrome, Newborn	1985
Respiratory distress syndrome in the adult after cardiopulmonary bypass. A successful therapeutic approach. JAMA, 1973, Sep-03, Volume: 225, Issue:10 Topics: Age Factors; Aged; Anti-Bacterial Agents; Dyspnea; Extracorporeal Circulation; Female; Furosemide; H	1973
Proceedings: Frusemide therapy in infants with respiratory distress syndrome. Archives of disease in childhood, 1974, Volume: 49, Issue:3 Topics: Calcium; Carbon Dioxide; Diuretics; Furosemide; Humans; Hydrogen-Ion Concentration; Infant, Newborn;	1974