Page last updated: 2024-10-27

furosemide and Puerperal Disorders

furosemide has been researched along with Puerperal Disorders in 12 studies

Furosemide: A benzoic-sulfonamide-furan. It is a diuretic with fast onset and short duration that is used for EDEMA and chronic RENAL INSUFFICIENCY.
furosemide : A chlorobenzoic acid that is 4-chlorobenzoic acid substituted by a (furan-2-ylmethyl)amino and a sulfamoyl group at position 2 and 5 respectively. It is a diuretic used in the treatment of congestive heart failure.

Puerperal Disorders: Disorders or diseases associated with PUERPERIUM, the six-to-eight-week period immediately after PARTURITION in humans.

Research Excerpts

ExcerptRelevanceReference
"To evaluate the effectiveness of furosemide in accelerating blood pressure recovery among women with severe preeclampsia."5.20Diuretics vs. placebo for postpartum blood pressure control in preeclampsia (DIUPRE): a randomized clinical trial. ( Amorim, M; Coutinho, I; Cursino, T; Katz, L, 2015)
" She was treated because of low left ventricular ejection fraction and impression of postpartum cardiomyopathy, and her severe dyspnea improved by intravenous furosemide."4.02Severe acute respiratory syndrome coronavirus-2- or pregnancy-related cardiomyopathy, a differential to be considered in the current pandemic: a case report. ( Hajizadeh, R; Kavandi, H; Khademolhosseini, S; Nejadrahim, R, 2021)
"Echocardiography showed 73% dilated cardiomyopathy; 83% showed moderate to severe LV systolic dysfunction (mean EF 36."1.43Clinical and echocardiographic characteristics and outcomes in congestive heart failure at the Hospital of The State University of Haiti. ( Malebranche, R; Morisset, PH; Raphael, NA; Tabou Moyo, C; Wilentz, JR, 2016)
"Anemia, hypertension and rheumatic fever were the causes of heart failure in these 3 patients, but they were not apparent when the initial diagnosis was made."1.31[Peripartum heart failure: the underestimated role of frequent diseases in the Sudan-Sahelian area]. ( Ba, SA; Dia, AA; Diop, IB; Diouf, SM; Kane, A; Sarr, M, 2000)

Research

Studies (12)

TimeframeStudies, this research(%)All Research%
pre-19904 (33.33)18.7374
1990's1 (8.33)18.2507
2000's2 (16.67)29.6817
2010's4 (33.33)24.3611
2020's1 (8.33)2.80

Authors

AuthorsStudies
Nejadrahim, R1
Khademolhosseini, S1
Kavandi, H1
Hajizadeh, R1
Cursino, T1
Katz, L1
Coutinho, I1
Amorim, M1
Malebranche, R1
Tabou Moyo, C1
Morisset, PH1
Raphael, NA1
Wilentz, JR1
Veena, P1
Perivela, L1
Raghavan, SS1
Kim, DY1
Islam, S1
Mondal, NT1
Mussell, F1
Rauchholz, M1
Kane, A1
Dia, AA1
Diop, IB1
Sarr, M1
Ba, SA1
Diouf, SM1
Marcovici, I1
Gerhardt, S1
Turpin, S1
Lambert, R1
Querin, S1
Soulez, G1
Leveille, J1
Taillefer, R1
Sullivan, JM1
Palmer, ET1
Schoeneberger, AA1
Jennings, JC1
Morrison, JC1
Ratts, TE1
Neill, P1
Donadio, JV1
Holley, KE1

Clinical Trials (3)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Effectiveness of Postpartum Furosemide on Recovery Blood Pressure in Puerperal Women With Severe Preeclampsia: a Randomized Clinical Trial[NCT02163655]Phase 4120 participants (Actual)Interventional2014-03-31Completed
Lasix for the Prevention of De Novo Postpartum Hypertension: A Randomized Controlled Trial (LAPP Trial)[NCT04752475]Phase 382 participants (Actual)Interventional2021-10-20Completed
Postpartum Management of Gestational Hypertensive Disorders Using Furosemide: A Randomized Controlled Trial[NCT04343235]Phase 413 participants (Actual)Interventional2020-05-01Terminated (stopped due to Challenges with enrollment; primary investigator left the institution)
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

Mean Arterial Blood Pressure (MAP)

Difference in MAP averaged over the 24 hours prior to discharge or the 24 hours prior to antihypertensive therapy initiation (whichever occurs first) (NCT04752475)
Timeframe: 24 hours prior to discharge through discharge, up to 7 days

InterventionmmHg (Mean)
Lasix (Furosemide)88.9
Placebo86.8

Breastfeeding Status

breastfeeding continuation after discharge (NCT04343235)
Timeframe: at 1 week postpartum visit

InterventionParticipants (Count of Participants)
Labetalol + Furosemide1
Labetalol Only3

Change of Dose for Antihypertensive Therapy

number of patients who require a change in the dose of labetalol to control BP (NCT04343235)
Timeframe: Change in dose of hypertensive therapy from randomization until hospital discharge (up to 7 days)

InterventionParticipants (Count of Participants)
Labetalol + Furosemide3
Labetalol Only0

Hospital Length of Stay

days in hospital after delivery (NCT04343235)
Timeframe: Number of days of hospital stay from randomization to discharge

Interventiondays (Mean)
Labetalol + Furosemide3.5
Labetalol Only4.3

Hospital Readmission

readmission for hypertension management (NCT04343235)
Timeframe: up to 14 days after discharge

InterventionParticipants (Count of Participants)
Labetalol + Furosemide1
Labetalol Only2

Change of Gestational Hypertensive Disorder Symptoms (Diastolic BP)

average diastolic blood pressure reading on Day 0, Day 1, and Day 2 (NCT04343235)
Timeframe: Average diastolic blood pressure on Day 0, Day 1, and Day 2

,
Interventionmm of mercury (Mean)
Day 0Day 1Day 2
Labetalol + Furosemide84.181.878.8
Labetalol Only80.180.775.5

Change of Gestational Hypertensive Disorder Symptoms (Mean Arterial Pressure)

average mean arterial pressure reading on Day 0, Day 1, and Day 2 (NCT04343235)
Timeframe: Average mean arterial pressure on Day 0, Day 1, and Day 2

,
Interventionmm of mercury (Mean)
Day 0Day 1Day 2
Labetalol + Furosemide102.499.598.0
Labetalol Only100.0100.196.0

Change of Gestational Hypertensive Disorder Symptoms (Systolic BP)

average systolic blood pressure reading on Day 0, Day 1, and Day 2 (NCT04343235)
Timeframe: Average systolic blood pressure for Day 0, Day 1, and Day 2

,
Interventionmm of mercury (Mean)
Day 0Day 1Day 2
Labetalol + Furosemide138.4134.9135.2
Labetalol Only138.1138.2136.7

Trials

2 trials available for furosemide and Puerperal Disorders

ArticleYear
Diuretics vs. placebo for postpartum blood pressure control in preeclampsia (DIUPRE): a randomized clinical trial.
    Reproductive health, 2015, Aug-05, Volume: 12

    Topics: Blood Pressure; Diuretics; Eclampsia; Female; Furosemide; Humans; Hypertension; Length of Stay; Magn

2015
Furosemide in postpartum management of severe preeclampsia: A randomized controlled trial.
    Hypertension in pregnancy, 2017, Volume: 36, Issue:1

    Topics: Adult; Antihypertensive Agents; Diuretics; Drug Therapy, Combination; Female; Furosemide; Humans; Ni

2017
Furosemide in postpartum management of severe preeclampsia: A randomized controlled trial.
    Hypertension in pregnancy, 2017, Volume: 36, Issue:1

    Topics: Adult; Antihypertensive Agents; Diuretics; Drug Therapy, Combination; Female; Furosemide; Humans; Ni

2017
Furosemide in postpartum management of severe preeclampsia: A randomized controlled trial.
    Hypertension in pregnancy, 2017, Volume: 36, Issue:1

    Topics: Adult; Antihypertensive Agents; Diuretics; Drug Therapy, Combination; Female; Furosemide; Humans; Ni

2017
Furosemide in postpartum management of severe preeclampsia: A randomized controlled trial.
    Hypertension in pregnancy, 2017, Volume: 36, Issue:1

    Topics: Adult; Antihypertensive Agents; Diuretics; Drug Therapy, Combination; Female; Furosemide; Humans; Ni

2017

Other Studies

10 other studies available for furosemide and Puerperal Disorders

ArticleYear
Severe acute respiratory syndrome coronavirus-2- or pregnancy-related cardiomyopathy, a differential to be considered in the current pandemic: a case report.
    Journal of medical case reports, 2021, Mar-19, Volume: 15, Issue:1

    Topics: Adult; Anti-Bacterial Agents; Antiviral Agents; Azithromycin; Cardiomyopathies; Cesarean Section; Co

2021
Clinical and echocardiographic characteristics and outcomes in congestive heart failure at the Hospital of The State University of Haiti.
    American heart journal, 2016, Volume: 178

    Topics: Adolescent; Adrenergic beta-Antagonists; Adult; Age Distribution; Aged; Aged, 80 and over; Angiotens

2016
Biventricular thrombi associated with peripartum cardiomyopathy.
    Journal of health, population, and nutrition, 2011, Volume: 29, Issue:2

    Topics: Bangladesh; Cardiomyopathies; Drug Combinations; Echocardiography; Enalapril; Female; Furosemide; Hu

2011
[Peripartum heart failure: the underestimated role of frequent diseases in the Sudan-Sahelian area].
    Dakar medical, 2000, Volume: 45, Issue:2

    Topics: Adult; Africa, Northern; Anemia; Angiotensin-Converting Enzyme Inhibitors; Captopril; Cardiotonic Ag

2000
Postpartum preeclampsia management with furosemide: a randomized clinical trial.
    Obstetrics and gynecology, 2005, Volume: 105, Issue:4

    Topics: Diuretics; Female; Furosemide; Humans; Pancreatitis; Postpartum Period; Pre-Eclampsia; Pregnancy; Pu

2005
[Genesis and therapy of postpartum carpal tunnel syndrome].
    Psychiatrie, Neurologie, und medizinische Psychologie, 1984, Volume: 36, Issue:12

    Topics: Adult; Carpal Tunnel Syndrome; Edema; Female; Furosemide; Humans; Lactation; Pregnancy; Puerperal Di

1984
Radionuclide captopril renography in postpartum renal artery aneurysms.
    Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 1996, Volume: 37, Issue:8

    Topics: Adult; Aneurysm; Angiotensin-Converting Enzyme Inhibitors; Captopril; Diuretics; Female; Furosemide;

1996
SQ 20,881: effect on eclamptic--pre-eclamptic women with postpartum hypertension.
    American journal of obstetrics and gynecology, 1978, Aug-01, Volume: 131, Issue:7

    Topics: Adolescent; Adult; Angiotensin II; Eclampsia; Female; Furosemide; Hemodynamics; Humans; Hypertension

1978
Axillary vein thrombosis complicating peripartum congestive cardiomyopathy.
    The Central African journal of medicine, 1987, Volume: 33, Issue:12

    Topics: Adult; Axillary Vein; Cardiomyopathy, Dilated; Female; Follow-Up Studies; Furosemide; Heparin; Human

1987
Postpartum acute renal failure: recovery after heparin therapy.
    American journal of obstetrics and gynecology, 1974, Feb-15, Volume: 118, Issue:4

    Topics: Acute Kidney Injury; Adult; Anemia, Hemolytic; Biopsy; Cesarean Section; Creatinine; Disseminated In

1974