furosemide has been researched along with Obesity in 36 studies
Furosemide: A benzoic-sulfonamide-furan. It is a diuretic with fast onset and short duration that is used for EDEMA and chronic RENAL INSUFFICIENCY.
furosemide : A chlorobenzoic acid that is 4-chlorobenzoic acid substituted by a (furan-2-ylmethyl)amino and a sulfamoyl group at position 2 and 5 respectively. It is a diuretic used in the treatment of congestive heart failure.
Obesity: A status with BODY WEIGHT that is grossly above the recommended standards, usually due to accumulation of excess FATS in the body. The standards may vary with age, sex, genetic or cultural background. In the BODY MASS INDEX, a BMI greater than 30.0 kg/m2 is considered obese, and a BMI greater than 40.0 kg/m2 is considered morbidly obese (MORBID OBESITY).
| Excerpt | Relevance | Reference |
|---|---|---|
| "Obesity is an important risk factor for the development of chronic kidney disease." | 6.80 | Effect of Acetazolamide on Obesity-Induced Glomerular Hyperfiltration: A Randomized Controlled Trial. ( Bar Sheshet Itach, S; Chagnac, A; Erman, A; Gafter, U; Herman-Edelstein, M; Ori, Y; Rozen-Zvi, B; Zingerman, B, 2015) |
| " The low solubility of furosemide in lipid makes it probable that aggravated drug toxicity in obese rats dosed to total body mass resulted in part from elevated furosemide concentrations in lean body mass." | 5.28 | Obesity as a risk factor in drug-induced organ injury. III. Increased liver and kidney injury by furosemide in the obese overfed rat. ( Chan, HH; Corcoran, GB; Salazar, DE, 1989) |
| "Experiments were carried out to investigate whether diuretics (hydrochlorothiazide + furosemide) impact on the effects of a sodium-dependent glucose cotransporter 2 (SGLT2) inhibitor on glucose metabolism and blood pressure (BP) in metabolic syndrome SHR/NDmcr-cp(+/+) rats (SHRcp)." | 3.83 | Effects of diuretics on sodium-dependent glucose cotransporter 2 inhibitor-induced changes in blood pressure in obese rats suffering from the metabolic syndrome. ( Fujisawa, Y; Hitomi, H; Kittikulsuth, W; Nakano, D; Nishiyama, A; Rafiq, K; Rahman, A; Sohara, E; Sufiun, A; Uchida, S, 2016) |
| "Diastolic heart failure patients (n = 183) were more likely to be older, female, hypertensive, obese, with shorter preexisting HF duration, atrial fibrillation, lower New York Heart Association (NYHA) class, lower maintenance furosemide dosages, and to receive calcium antagonists." | 3.75 | Clinical variables affecting survival in patients with decompensated diastolic versus systolic heart failure. ( Almoznino-Sarafian, D; Alon, I; Babakin, Z; Cohen, N; Efrati, S; Gorelik, O; Modai, D; Shteinshnaider, M; Sokolsky, I; Tzur, I, 2009) |
| "Measures of maximal rates of lithium-sodium countertransport and frusemide-sensitive sodium and potassium cotransport have been proposed as biochemical markers for human essential hypertension." | 3.67 | The antihypertensive effect of calorie restriction in obese adolescents: dissociation of effects on erythrocyte countertransport and cotransport. ( Katch, VL; Rocchini, AP; Torretti, BA; Weder, AB, 1984) |
| " Under these conditions ketoacidosis causes impaired renal uric acid excretion and hyperuricemia." | 3.65 | [Acute kidney failure as a complication of fasting therapy]. ( Binswanger, U; Huber, M; Lämmli, J; Meier, HR; Wick, A; Zürcher, HU, 1977) |
| "Obesity is an important risk factor for the development of chronic kidney disease." | 2.80 | Effect of Acetazolamide on Obesity-Induced Glomerular Hyperfiltration: A Randomized Controlled Trial. ( Bar Sheshet Itach, S; Chagnac, A; Erman, A; Gafter, U; Herman-Edelstein, M; Ori, Y; Rozen-Zvi, B; Zingerman, B, 2015) |
| "In patients with congestive heart failure (CHF), use of loop diuretic therapy may result in acute kidney insufficiency (AKI)." | 1.39 | Predisposing factors for acute kidney injury in Hispanic patients treated with diuretics for decompensated heart failure. ( Cangiano, JL; López, JE; Marmorato, R; Pagán, P; Ramírez, T; Ricci, F; Soto-Salgado, M; Vega, J, 2013) |
| "Obesity is reported to be associated with excessive growth of adipocyte mass tissue as a result of increases in the number and size of adipocytes differentiated from preadipocytes." | 1.39 | Salicortin-derivatives from Salix pseudo-lasiogyne twigs inhibit adipogenesis in 3T3-L1 cells via modulation of C/EBPα and SREBP1c dependent pathway. ( Jeong, EJ; Kang, J; Kim, HP; Kim, YC; Lee, M; Lee, SH; Sung, SH; Yang, H, 2013) |
| " Dosing of diuretics is difficult in these patients." | 1.37 | Management of diuretic treatment: a challenge in the obese patient. ( Jespersen, B; Lassen, CK, 2011) |
| "Only clonidine treatment totally prevented the development of insulin resistance, and high-dose aspirin, known to prevent insulin resistance by inhibition of the activity of IkappaB kinase-beta, decreased the degree of insulin resistance by almost 70%." | 1.32 | Hypertension and insulin resistance are not directly related in obese dogs. ( Gokee, A; Rocchini, AP; Yang, JQ, 2004) |
| "The biguanides were a therapeutic enrichment particularly in the treatment of adipose elderly diabetics with obligatory diet." | 1.26 | [Indications and results of an additional differentiated pharmacotherapy of obesity]. ( Kucher, E, 1978) |
| "Fenfluramine was a valuable adjuvant drug for refractory cases." | 1.25 | A review of obesity and its management in 263 cases. ( Mazansky, H, 1975) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 18 (50.00) | 18.7374 |
| 1990's | 2 (5.56) | 18.2507 |
| 2000's | 8 (22.22) | 29.6817 |
| 2010's | 8 (22.22) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Ricci, F | 1 |
| Ramírez, T | 1 |
| Marmorato, R | 1 |
| Vega, J | 1 |
| Pagán, P | 1 |
| López, JE | 1 |
| Soto-Salgado, M | 1 |
| Cangiano, JL | 1 |
| Babelova, A | 1 |
| Burckhardt, BC | 1 |
| Wegner, W | 1 |
| Burckhardt, G | 1 |
| Henjakovic, M | 1 |
| Zingerman, B | 1 |
| Herman-Edelstein, M | 1 |
| Erman, A | 1 |
| Bar Sheshet Itach, S | 1 |
| Ori, Y | 1 |
| Rozen-Zvi, B | 1 |
| Gafter, U | 1 |
| Chagnac, A | 1 |
| Rahman, A | 1 |
| Kittikulsuth, W | 1 |
| Fujisawa, Y | 1 |
| Sufiun, A | 1 |
| Rafiq, K | 1 |
| Hitomi, H | 1 |
| Nakano, D | 1 |
| Sohara, E | 1 |
| Uchida, S | 1 |
| Nishiyama, A | 1 |
| Gorelik, O | 1 |
| Almoznino-Sarafian, D | 1 |
| Shteinshnaider, M | 1 |
| Alon, I | 1 |
| Tzur, I | 1 |
| Sokolsky, I | 1 |
| Efrati, S | 1 |
| Babakin, Z | 1 |
| Modai, D | 1 |
| Cohen, N | 1 |
| Lassen, CK | 1 |
| Jespersen, B | 1 |
| Textor, SC | 1 |
| Gloviczki, ML | 1 |
| Flessner, MF | 1 |
| Calhoun, DA | 1 |
| Glockner, J | 1 |
| Grande, JP | 1 |
| McKusick, MA | 1 |
| Cha, SS | 1 |
| Lerman, LO | 1 |
| Rosario, M | 1 |
| Song, SX | 1 |
| McCullough, LD | 1 |
| Laffer, CL | 1 |
| Laniado-Schwartzman, M | 1 |
| Wang, MH | 1 |
| Nasjletti, A | 1 |
| Elijovich, F | 1 |
| LARIZZA, P | 1 |
| BRUNETTI, P | 1 |
| NENCI, G | 1 |
| COLI, L | 1 |
| Rocchini, AP | 2 |
| Yang, JQ | 1 |
| Gokee, A | 1 |
| Madala Halagappa, VK | 1 |
| Tiwari, S | 1 |
| Riazi, S | 1 |
| Hu, X | 1 |
| Ecelbarger, CM | 1 |
| Weder, AB | 1 |
| Torretti, BA | 1 |
| Katch, VL | 1 |
| Mathew, NT | 1 |
| Ravishankar, K | 1 |
| Sanin, LC | 1 |
| Truniger, B | 1 |
| Eberhardson, M | 1 |
| Patterson, S | 1 |
| Grapengiesser, E | 1 |
| Cugini, P | 2 |
| Scavo, D | 1 |
| Marugo, M | 1 |
| Giusti, M | 1 |
| Cocco, R | 1 |
| Bolognesi, F | 1 |
| Reitano, A | 1 |
| Kucher, E | 1 |
| Serdoz, R | 1 |
| Manconi, R | 1 |
| Mancini, A | 1 |
| Meucci, T | 1 |
| Zürcher, HU | 1 |
| Meier, HR | 1 |
| Huber, M | 1 |
| Lämmli, J | 1 |
| Wick, A | 1 |
| Binswanger, U | 1 |
| Mazansky, H | 1 |
| Corcoran, GB | 1 |
| Salazar, DE | 1 |
| Chan, HH | 1 |
| Niezgoda, JA | 1 |
| Walter, MC | 1 |
| Jarrard, MR | 1 |
| Cheba, L | 1 |
| Kowalska, K | 1 |
| Bricaire, H | 1 |
| Luton, JP | 1 |
| Szám, I | 1 |
| Sólyom, I | 1 |
| Fischer, J | 1 |
| Blaim, A | 1 |
| Sztymirski, L | 1 |
| Rymkiewicz-Kluczyńska, B | 1 |
| Kliachko, VR | 1 |
| Shaginova, EM | 1 |
| Tirkina, TN | 1 |
| Vague, J | 1 |
| Teitelbaum, M | 1 |
| Miller, G | 1 |
| Favro, C | 1 |
| Terrasse, J | 1 |
| Derycke, C | 1 |
| Marcheix, JC | 1 |
| Lee, M | 1 |
| Lee, SH | 1 |
| Kang, J | 1 |
| Yang, H | 1 |
| Jeong, EJ | 1 |
| Kim, HP | 1 |
| Kim, YC | 1 |
| Sung, SH | 1 |
| Han, LK | 2 |
| Sumiyoshi, M | 2 |
| Zhang, J | 1 |
| Liu, MX | 1 |
| Zhang, XF | 1 |
| Zheng, YN | 2 |
| Okuda, H | 2 |
| Kimura, Y | 2 |
| Coffey, CS | 1 |
| Steiner, D | 1 |
| Baker, BA | 1 |
| Allison, DB | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Effect of Acetazolamide and Furosemide on Obesity-induced Glomerular Hyperfiltration[NCT01146288] | 13 participants (Actual) | Interventional | 2010-07-31 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
(NCT01146288)
Timeframe: baseline and after diuretics administration
| Intervention | ml/min (Mean) | |
|---|---|---|
| GFR before acetazolamide/furosemide administration | GFR after acetazolamide/furosemide administration | |
| Acetazolamide | 151 | 120 |
| Furosemide | 152 | 150 |
(NCT01146288)
Timeframe: baseline and after diuretics administration
| Intervention | mm Hg/[ml/min] (Mean) | |
|---|---|---|
| before acetazolamide/furosemide administration | after acetazolamide/furosemide administration | |
| Acetazolamide | 0.078 | 0.088 |
| Furosemide | 0.073 | 0.080 |
4 trials available for furosemide and Obesity
| Article | Year |
|---|---|
Effect of Acetazolamide on Obesity-Induced Glomerular Hyperfiltration: A Randomized Controlled Trial.
Topics: Acetazolamide; Adult; Carbonic Anhydrase Inhibitors; Diuretics; Furosemide; Glomerular Filtration Ra | 2015 |
Differential regulation of natriuresis by 20-hydroxyeicosatetraenoic Acid in human salt-sensitive versus salt-resistant hypertension.
Topics: Adult; Blood Pressure; Creatinine; Diet, Sodium-Restricted; Female; Furosemide; Humans; Hydroxyeicos | 2003 |
[Biometric assay of the saluretic synergism of clopamide and furosemide].
Topics: Adult; Aged; Amides; Aortic Valve Insufficiency; Biometry; Clinical Trials as Topic; Clopamide; Diur | 1969 |
A randomized double-blind placebo-controlled clinical trial of a product containing ephedrine, caffeine, and other ingredients from herbal sources for treatment of overweight and obesity in the absence of lifestyle treatment.
Topics: Adult; Anti-Obesity Agents; Benzyl Alcohols; Body Mass Index; Caffeine; Cola; Double-Blind Method; D | 2004 |
32 other studies available for furosemide and Obesity
| Article | Year |
|---|---|
Predisposing factors for acute kidney injury in Hispanic patients treated with diuretics for decompensated heart failure.
Topics: Acute Kidney Injury; Adult; Aged; Blood Urea Nitrogen; Creatinine; Diabetes Mellitus; Drug Utilizati | 2013 |
Sex-differences in renal expression of selected transporters and transcription factors in lean and obese Zucker spontaneously hypertensive fatty rats.
Topics: Animals; Biological Transport; Blood Pressure; Cyclic GMP; Diabetes Mellitus; Diabetic Nephropathies | 2015 |
Effects of diuretics on sodium-dependent glucose cotransporter 2 inhibitor-induced changes in blood pressure in obese rats suffering from the metabolic syndrome.
Topics: Administration, Oral; Animals; Blood Pressure; Diuretics; Furosemide; Hydrochlorothiazide; Hypertens | 2016 |
Clinical variables affecting survival in patients with decompensated diastolic versus systolic heart failure.
Topics: Aged; Aged, 80 and over; Diuretics; Echocardiography; Electrocardiography; Female; Follow-Up Studies | 2009 |
Management of diuretic treatment: a challenge in the obese patient.
Topics: Acute Kidney Injury; Aged; Biomarkers; Comorbidity; Creatinine; Diuretics; Drug Overdose; Furosemide | 2011 |
Association of filtered sodium load with medullary volumes and medullary hypoxia in hypertensive African Americans as compared with whites.
Topics: Adult; Aged; Aged, 80 and over; Black or African American; Blood Pressure; Comorbidity; Dinoprost; D | 2012 |
An unusual case of stroke.
Topics: Antihypertensive Agents; Diabetes Mellitus, Type 2; Diagnosis, Differential; Diuretics; Female; Furo | 2012 |
[CLINICO-THERAPEUTIC OBSERVATIONS AND RENAL FUNCTION TESTS WITH THE NEW DIURETIC, FUROSEMIDE].
Topics: Diuretics; Edema; Furosemide; Heart Diseases; Heart Failure; Hepatitis; Hypertension; Kidney Functio | 1964 |
Hypertension and insulin resistance are not directly related in obese dogs.
Topics: Adrenergic beta-Antagonists; Animals; Aspirin; Atenolol; Blood Glucose; Clonidine; Diet, Sodium-Rest | 2004 |
Chronic candesartan alters expression and activity of NKCC2, NCC, and ENaC in the obese Zucker rat.
Topics: Amiloride; Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Benzimidazoles; Bipheny | 2008 |
The antihypertensive effect of calorie restriction in obese adolescents: dissociation of effects on erythrocyte countertransport and cotransport.
Topics: Adolescent; Biological Transport; Child; Diet, Reducing; Energy Intake; Erythrocytes; Female; Furose | 1984 |
Coexistence of migraine and idiopathic intracranial hypertension without papilledema.
Topics: Acetazolamide; Adolescent; Adult; Dihydroergotamine; Diuretics; Ergotamine; Female; Follow-Up Studie | 1996 |
[Therapy edema: secondary effect without effect!].
Topics: Adult; Anuria; Diuretics; Edema; Female; Furosemide; Humans; Lymphedema; Metolazone; Obesity | 1999 |
Microfluorometric analysis of Cl- permeability and its relation to oscillatory Ca2+ signalling in glucose-stimulated pancreatic beta-cells.
Topics: 4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid; Animals; Anions; Calcium; Calcium Channel Blockers | 2000 |
[Reliability and diagnostic use of the furosemide test in the study of the renin-angiotensin-aldosterone system].
Topics: Adolescent; Adult; Aldosterone; Cushing Syndrome; Electrolytes; Female; Furosemide; Humans; Hyperten | 1978 |
[Diazoxide in the treatment of obesity].
Topics: Diazoxide; Dietary Proteins; Fenfluramine; Furosemide; Glucagon; Humans; Obesity; Triiodothyronine | 1977 |
[Indications and results of an additional differentiated pharmacotherapy of obesity].
Topics: Adolescent; Adult; Aged; Biguanides; Diabetes Mellitus; Diet, Reducing; Female; Furosemide; Humans; | 1978 |
[New findings on the behavior of the renin-angiotensin-aldosterone system in obesity].
Topics: Adolescent; Adult; Aldosterone; Angiotensin II; Circadian Rhythm; Female; Furosemide; Humans; Male; | 1978 |
[Acute kidney failure as a complication of fasting therapy].
Topics: Acidosis; Acute Kidney Injury; Adult; Diuresis; Fasting; Female; Furosemide; Humans; Ketosis; Middle | 1977 |
A review of obesity and its management in 263 cases.
Topics: Adolescent; Adult; Aged; Child; Diet, Reducing; Family Practice; Female; Fenfluramine; Furosemide; H | 1975 |
Obesity as a risk factor in drug-induced organ injury. III. Increased liver and kidney injury by furosemide in the obese overfed rat.
Topics: Animals; Diet; Furosemide; Kidney; Liver; Male; Obesity; Rats; Rats, Inbred Strains; Risk Factors; S | 1989 |
Furosemide overdose and maximal allowable weight standards.
Topics: Adult; Female; Furosemide; Humans; Legislation as Topic; Male; Military Personnel; Obesity; Syncope; | 1989 |
[Plasma renin activity and aldosteronemia in patients with simple obesity and in persons with normal body weight at rest and after stimulation with furosemide and upright posture].
Topics: Adult; Aldosterone; Body Weight; Female; Furosemide; Humans; Male; Middle Aged; Obesity; Posture; Re | 1988 |
[Clinical and biological study of a new diuretic (furosemide) in simple obesity].
Topics: Adolescent; Adult; Aged; Female; Furosemide; Humans; Male; Middle Aged; Obesity | 1967 |
The lazy respiratory center--or how to recognize a tired horse. Clinical conference in pulmonary disease from Northwestern University-McGaw Medical Center, Chicago.
Topics: Brain Diseases; Chemoreceptor Cells; Chronic Disease; Diagnosis, Differential; Diazepam; Digoxin; Fu | 1974 |
[Effect of diuretics on water-electrolyte metabolism in obese children treated with a reducing diet].
Topics: Adolescent; Child; Diet, Reducing; Diuretics; Female; Furosemide; Humans; Male; Obesity; Potassium; | 1972 |
[Effect of saluretics on carbohydrate metabolism].
Topics: Adolescent; Adult; Carbohydrate Metabolism; Coronary Disease; Diabetes Mellitus; Diuretics; Furosemi | 1970 |
[Value of a new diuretic, furosemide or Lasilix, in the treatment of obesity].
Topics: Adolescent; Adult; Aged; Diuretics; Female; Furosemide; Humans; Male; Middle Aged; Obesity | 1965 |
[Study of a diuretic, furosemide, in hospital practice].
Topics: Edema; Furosemide; Heart Diseases; Humans; Liver Diseases; Obesity | 1966 |
Salicortin-derivatives from Salix pseudo-lasiogyne twigs inhibit adipogenesis in 3T3-L1 cells via modulation of C/EBPα and SREBP1c dependent pathway.
Topics: 3T3-L1 Cells; Adipocytes; Adipogenesis; Animals; CCAAT-Enhancer-Binding Proteins; Drug Evaluation, P | 2013 |
Anti-obesity action of Salix matsudana leaves (Part 1). Anti-obesity action by polyphenols of Salix matsudana in high fat-diet treated rodent animals.
Topics: Adipocytes; Adipose Tissue; Animals; Anti-Obesity Agents; Body Weight; Cholesterol; Diet; Dietary Fa | 2003 |
Anti-obesity action of Salix matsudana leaves (Part 2). Isolation of anti-obesity effectors from polyphenol fractions of Salix matsudana.
Topics: Adipocytes; Animals; Anti-Obesity Agents; Cholesterol; Diet; Dietary Fats; Dose-Response Relationshi | 2003 |