furosemide and Hyponatremia studies

Furosemide: A benzoic-sulfonamide-furan. It is a diuretic with fast onset and short duration that is used for EDEMA and chronic RENAL INSUFFICIENCY.
furosemide : A chlorobenzoic acid that is 4-chlorobenzoic acid substituted by a (furan-2-ylmethyl)amino and a sulfamoyl group at position 2 and 5 respectively. It is a diuretic used in the treatment of congestive heart failure.

Hyponatremia: Deficiency of sodium in the blood; salt depletion. (Dorland, 27th ed)

Research Excerpts

Excerpt	Relevance	Reference
"Oral tolvaptan was associated with similar, but not superior, diuresis compared with intravenous furosemide for acute heart failure with concomitant hyponatremia."	9.34	Tolvaptan vs. furosemide-based diuretic regimens in patients hospitalized for heart failure with hyponatremia (AQUA-AHF). ( Elkayam, U; Fong, MW; Grazette, LP; Han, EE; Kuo, A; Lou, M; Mehra, A; Ng, TMH; Upadhyay, RY; Yoon, AJ, 2020)
"The change (Δ) in urine volume (ΔUV) and Δurine osmolality were greater in the tolvaptan group than in the furosemide group; however, ΔUV and Δurine osmolality did not show significant differences between the normonatremia subgroup and the hyponatremia subgroup in each group."	9.24	Effects of Tolvaptan Addition to Furosemide in Normo- and Hyponatremia Patients with Heart Failure and Chronic Kidney Disease Stages G3b-5: A Subanalysis of the K-STAR Study. ( Akashi, YJ; Inomata, T; Izumi, T; Kida, K; Sato, N; Shibagaki, Y; Tominaga, N, 2017)
"The Efficacy of Vasopressin Antagonism in Heart Failure Outcome Study With Tolvaptan database was examined to assess the short-term clinical course of patients hospitalized with heart failure and hyponatremia and the effect of tolvaptan on outcomes."	9.17	Clinical course of patients with hyponatremia and decompensated systolic heart failure and the effect of vasopressin receptor antagonism with tolvaptan. ( Burnett, J; Gheorghiade, M; Grinfeld, L; Hauptman, PJ; Konstam, MA; Kostic, D; Krasa, HB; Maggioni, A; Ouyang, J; Swedberg, K; Udelson, JE; Zannad, F; Zimmer, C, 2013)
"In this study, we evaluated the effects of tolvaptan (OPC-41061), a novel, oral, nonpeptide vasopressin V2-receptor antagonist in patients with chronic heart failure (CHF)."	9.10	Vasopressin V2-receptor blockade with tolvaptan in patients with chronic heart failure: results from a double-blind, randomized trial. ( Czerwiec, F; Gheorghiade, M; Kambayashi, J; Niazi, I; Orlandi, C; Ouyang, J; Zampino, M, 2003)
"To assess the effect of furosemide and captopril on renal function and hyponatremia in patients with severe heart failure, we studied two groups of patients with hyponatremia who were receiving digoxin therapy and whose sodium intake was 40 meq/d."	9.05	Renal response to captopril in severe heart failure: role of furosemide in natriuresis and reversal of hyponatremia. ( Dzau, VJ; Hollenberg, NK, 1984)
" We investigated the association of clinical variables and cardiovascular drugs, including furosemide, hydrochlorothiazide, spironolactone, and their doses, with the presence of hyponatremia at admission."	7.96	Furosemide and spironolactone doses and hyponatremia in patients with heart failure. ( Bušić, Ž; Čulić, V; Jurić Paić, M; Velat, I, 2020)
"Limited data exist comparing the efficacy and safety of bumetanide- or metolazone-based diuretic regimens to furosemide in acute heart failure (HF)."	7.79	Comparison of bumetanide- and metolazone-based diuretic regimens to furosemide in acute heart failure. ( Elkayam, U; Han, SY; Hshieh, S; Hyderi, AF; Jeng, AI; Kim, BJ; Konopka, E; Lou, M; Ng, TM; Phan, DH; Tsuji, Y, 2013)
"In order to determine how both diuretics affect water metabolism, we here compare the effects of a rechallenge with either amiloride-hydrochlorothiazide fixed association (AmHTZ; amiloride chlorhydrate 5 mg+hydrochlorothiazide 50 mg; Moduretic) or furosemide (F; 40 mg; Lasix) on water excretion in a 79 year old woman who was previously admitted for severe symptomatic hyponatremia secondary to a 5 days course of AmHTZ for systolic hypertension."	7.75	Safety of furosemide administration in an elderly woman recovered from thiazide-induced hyponatremia. ( Cogan, E; Fadel, S; Karmali, R, 2009)
" The experimental SIADH rat model was developed by means of continuous administration of arginine vasopressin (AVP) via a subcutaneously implanted osmotic mini pump, and hyponatremia was induced by additional water loading."	7.74	A novel vasopressin dual V1A/V2 receptor antagonist, conivaptan hydrochloride, improves hyponatremia in rats with syndrome of inappropriate secretion of antidiuretic hormone (SIADH). ( Arai, Y; Fujimori, A; Matsukawa, U; Miyata, K; Sasamata, M; Sudoh, K; Wada, K, 2007)
"We have studied the efficiency of urea in the treatment of hyponatremia and hydrosaline retention in a 76-year-old man with chronic ischemic congestive heart failure."	7.67	Urea treatment for water retention in hyponatremic congestive heart failure. ( Cauchie, P; Decaux, G; Vincken, W, 1987)
"We have studied the efficacy of urea in the treatment of hyponatremia and hydrosaline retention in cirrhotic patients with ascites resistant to diuretics."	7.67	Treatment of hyponatremic cirrhosis with ascites resistant to diuretics by urea. ( Cauchie, P; Decaux, G; Delwiche, F; Flamion, B; Mols, P, 1986)
"In patients with ACHF and dilutional hyponatremia, low natriuresis after furosemide is an early marker of poor diuretic response and correlates with higher NT-proBNP and higher incidence of worsening renal function at 72 h."	5.34	Spot urinary sodium in acute decompensation of advanced heart failure and dilutional hyponatremia: insights from DRAIN trial. ( Bergerone, S; Boretto, P; Canavosio, FG; De Ferrari, GM; Frea, S; Galluzzo, A; Golzio, PG; Pidello, S; Volpe, A, 2020)
"Oral tolvaptan was associated with similar, but not superior, diuresis compared with intravenous furosemide for acute heart failure with concomitant hyponatremia."	5.34	Tolvaptan vs. furosemide-based diuretic regimens in patients hospitalized for heart failure with hyponatremia (AQUA-AHF). ( Elkayam, U; Fong, MW; Grazette, LP; Han, EE; Kuo, A; Lou, M; Mehra, A; Ng, TMH; Upadhyay, RY; Yoon, AJ, 2020)
" We randomly assigned patients with cirrhosis and uncomplicated ascites who were treated with anti-aldosteronic drugs (≥200 mg/day) and furosemide (≥25 mg/day) to receive either standard medical treatment (SMT) or SMT plus HA (40 g twice weekly for 2 weeks, and then 40 g weekly) for up to 18 months."	5.27	Long-term albumin administration in decompensated cirrhosis (ANSWER): an open-label randomised trial. ( Airoldi, A; Alessandria, C; Andrealli, A; Angeli, P; Angelico, M; Baldassarre, M; Ballardini, G; Bernardi, M; Boccia, S; Cacciola, I; Cappa, FM; Caraceni, P; Cavallin, M; Cesarini, L; Cozzolongo, R; De Marco, R; Di Marco, V; Elia, C; Elia, G; Fagiuoli, S; Federico, A; Fidone, F; Foschi, FG; Galioto, A; Guarisco, R; Levantesi, F; Massironi, S; Morisco, F; Nardelli, S; Neri, S; Pasquale, C; Piano, S; Prestianni, L; Rendina, M; Riggio, O; Romanelli, RG; Roncadori, A; Ruggeri, M; Sangiovanni, V; Simone, L; Svegliati-Baroni, G; Toniutto, P; Tortora, A; Tufoni, M; Zaccherini, G, 2018)
"The change (Δ) in urine volume (ΔUV) and Δurine osmolality were greater in the tolvaptan group than in the furosemide group; however, ΔUV and Δurine osmolality did not show significant differences between the normonatremia subgroup and the hyponatremia subgroup in each group."	5.24	Effects of Tolvaptan Addition to Furosemide in Normo- and Hyponatremia Patients with Heart Failure and Chronic Kidney Disease Stages G3b-5: A Subanalysis of the K-STAR Study. ( Akashi, YJ; Inomata, T; Izumi, T; Kida, K; Sato, N; Shibagaki, Y; Tominaga, N, 2017)
"The Efficacy of Vasopressin Antagonism in Heart Failure Outcome Study With Tolvaptan database was examined to assess the short-term clinical course of patients hospitalized with heart failure and hyponatremia and the effect of tolvaptan on outcomes."	5.17	Clinical course of patients with hyponatremia and decompensated systolic heart failure and the effect of vasopressin receptor antagonism with tolvaptan. ( Burnett, J; Gheorghiade, M; Grinfeld, L; Hauptman, PJ; Konstam, MA; Kostic, D; Krasa, HB; Maggioni, A; Ouyang, J; Swedberg, K; Udelson, JE; Zannad, F; Zimmer, C, 2013)
"In this study, we evaluated the effects of tolvaptan (OPC-41061), a novel, oral, nonpeptide vasopressin V2-receptor antagonist in patients with chronic heart failure (CHF)."	5.10	Vasopressin V2-receptor blockade with tolvaptan in patients with chronic heart failure: results from a double-blind, randomized trial. ( Czerwiec, F; Gheorghiade, M; Kambayashi, J; Niazi, I; Orlandi, C; Ouyang, J; Zampino, M, 2003)
"Furosemide remains the drug of choice for patients with the transurethral resection syndrome."	5.06	Furosemide-induced disturbances of renal function in patients undergoing TURP. ( Deshon, GE; Donatucci, CF; Hunt, M; Wade, CE, 1990)
"To assess the effect of furosemide and captopril on renal function and hyponatremia in patients with severe heart failure, we studied two groups of patients with hyponatremia who were receiving digoxin therapy and whose sodium intake was 40 meq/d."	5.05	Renal response to captopril in severe heart failure: role of furosemide in natriuresis and reversal of hyponatremia. ( Dzau, VJ; Hollenberg, NK, 1984)
" Anorexia and the combination of thiazide together with furosemide, rather than thiazide use alone, were risk factors for hypovolemic hyponatremia without affecting FE-UA."	4.12	Thiazide-associated hyponatremia in internal medicine patients: analysis of epidemiological and biochemical profiles. ( Klhůfek, J; Šálek, T, 2022)
"Our objective was to characterize cases of hospitalized heart failure (HHF) focusing on in-hospital resource utilization (particularly furosemide doses) and worsening heart failure (WHF), and identify which factors are associated with the length of stay (LOS)."	3.96	In-hospital resource utilization, worsening heart failure, and factors associated with length of hospital stay in patients with hospitalized heart failure: A Japanese database cohort study. ( Funakubo, M; Ishii, T; Matsui, N; Mitani, H; Murayama, H; Oyama, N; Rached, RA; Sato, N; Yoshida, S, 2020)
" We investigated the association of clinical variables and cardiovascular drugs, including furosemide, hydrochlorothiazide, spironolactone, and their doses, with the presence of hyponatremia at admission."	3.96	Furosemide and spironolactone doses and hyponatremia in patients with heart failure. ( Bušić, Ž; Čulić, V; Jurić Paić, M; Velat, I, 2020)
"Limited data exist comparing the efficacy and safety of bumetanide- or metolazone-based diuretic regimens to furosemide in acute heart failure (HF)."	3.79	Comparison of bumetanide- and metolazone-based diuretic regimens to furosemide in acute heart failure. ( Elkayam, U; Han, SY; Hshieh, S; Hyderi, AF; Jeng, AI; Kim, BJ; Konopka, E; Lou, M; Ng, TM; Phan, DH; Tsuji, Y, 2013)
"In order to determine how both diuretics affect water metabolism, we here compare the effects of a rechallenge with either amiloride-hydrochlorothiazide fixed association (AmHTZ; amiloride chlorhydrate 5 mg+hydrochlorothiazide 50 mg; Moduretic) or furosemide (F; 40 mg; Lasix) on water excretion in a 79 year old woman who was previously admitted for severe symptomatic hyponatremia secondary to a 5 days course of AmHTZ for systolic hypertension."	3.75	Safety of furosemide administration in an elderly woman recovered from thiazide-induced hyponatremia. ( Cogan, E; Fadel, S; Karmali, R, 2009)
" The experimental SIADH rat model was developed by means of continuous administration of arginine vasopressin (AVP) via a subcutaneously implanted osmotic mini pump, and hyponatremia was induced by additional water loading."	3.74	A novel vasopressin dual V1A/V2 receptor antagonist, conivaptan hydrochloride, improves hyponatremia in rats with syndrome of inappropriate secretion of antidiuretic hormone (SIADH). ( Arai, Y; Fujimori, A; Matsukawa, U; Miyata, K; Sasamata, M; Sudoh, K; Wada, K, 2007)
"Colchicine poisoning is an uncommon, but potentially life-threatening, toxicologic emergency."	3.74	Acute colchicine intoxication in a child: a case report. ( Biçer, S; Ctak, A; Karaböcüoğlu, M; Soysal, DD; Uçsel, R; Uzel, N, 2007)
"We have studied the efficiency of urea in the treatment of hyponatremia and hydrosaline retention in a 76-year-old man with chronic ischemic congestive heart failure."	3.67	Urea treatment for water retention in hyponatremic congestive heart failure. ( Cauchie, P; Decaux, G; Vincken, W, 1987)
"We have studied the efficacy of urea in the treatment of hyponatremia and hydrosaline retention in cirrhotic patients with ascites resistant to diuretics."	3.67	Treatment of hyponatremic cirrhosis with ascites resistant to diuretics by urea. ( Cauchie, P; Decaux, G; Delwiche, F; Flamion, B; Mols, P, 1986)
" In contradistinction, clonidine caused a dose-related hypotension in conscious unrestrained rats subjected to sodium depletion via furosemide."	3.65	Hypotensive effect of clonidine during sodium depletion in the rat. ( Pals, DT, 1975)
" The lower Na and SBP in this instance should not lead to withholding or minimising diuretic dosage which should rather be dictated by volume status."	2.94	Higher Diuretic Requirements in Acute Heart Failure With Admission Hyponatraemia Versus Normonatraemia. ( Guglin, M; Omar, HR, 2020)
"The occurrence of renal failure is associated to an increased death risk."	2.73	Hypertonic saline solution for renal failure prevention in patients with decompensated heart failure. ( Azevedo, CH; Bacal, F; Bocchi, EA; Carneiro, RM; Chizzola, PR; Ferreira, SM; Issa, VS; Mangini, S, 2007)
"He was diagnosed with lateral medullary syndrome based on the neurological examination and brain magnetic resonance imaging."	2.53	Syndrome of inappropriate secretion of antidiuretic hormone (SIADH) associated with lateral medullary syndrome: case report and literature review. ( Nakano, H; Yamada, M; Yanase, D, 2016)
"SIADH is underdiagnosed, and hospitalization often worsens the clinical situation, due to an iatrogenic excess in the use of oral and i."	2.46	[Current considerations in syndrome of inappropriate secretion of antidiuretic hormone/syndrome of inappropriate antidiuresis]. ( Runkle de la Vega, I; Velasco Cano, MV, 2010)
"The diagnosis of SIADH is based on the exclusion of other hyponatremic conditions; low plasma osmolality (<275 mosmol/kg) and inappropriate urine concentration (urine osmolality >100 mosmol/kg) are of pathognomic value."	2.44	[Etiology, diagnostics and therapy of hyponatremias]. ( Laczi, F, 2008)
"Hyponatremia is common and associated with adverse outcomes in patients with congestive heart failure (CHF)."	2.43	Treating hyponatremia in heart failure. ( Goldsmith, SR, 2006)
"In most instances, hyponatremia is caused by inappropriate concentration of urine because of either appropriate or inappropriate antidiuretic hormone secretion."	2.38	Disorders of sodium metabolism: hypernatremia and hyponatremia. ( Carroll, HJ; Oh, MS, 1992)
"Hyponatremia was present in 68/233 patients with 27 cases classified as dilutional hyponatremia versus 41 as depletional."	1.48	Hyponatremia in Acute Heart Failure in Relation to Hematocrit Levels: Clinical Relevance and Prognostic Implication. ( Nuti, R; Palazzuoli, A; Ruocco, G; Verbrugge, FH, 2018)
"Acute hyponatremia is defined as a reduction in the plasma sodium level in less than 48 h."	1.39	How quickly can acute symptomatic hyponatremia be corrected? ( Aşçı, G; Çırpan, T; Demirci, MS; Peker, N; Tamer, AF; Turan, MN; Yaprak, M, 2013)
"Although, pharmacological intervention with a selective arginine vasopressin (AVP) V(2) receptor antagonist has been demonstrated to be effective for syndrome of inappropriate secretion of antidiuretic hormone (SIADH), its long-term administration has some therapeutic limitations."	1.34	Lithium effectively complements vasopressin V2 receptor antagonist in the treatment of hyponatraemia of SIADH rats. ( Arata, T; Ejima, Y; Hatano, R; Kazama, I; Matsubara, M; Michimata, M; Miyama, N; Sanada, S; Sasaki, S; Sato, A; Satomi, S; Suzuki, M, 2007)
"Severe hyponatremia is most frequently caused by the syndrome of inappropriate secretion of antidiuretic hormone (SIADH)."	1.33	BSC1 inhibition complements effects of vasopressin V2 receptor antagonist on hyponatremia in SIADH rats. ( Arata, T; Ejima, Y; Hatano, R; Kazama, I; Matsubara, M; Michimata, M; Miyama, N; Sasaki, S; Sato, A; Satomi, S; Suzuki, K; Suzuki, M, 2005)
"We report a case of hyponatremic seizures in a 7-year old boy with spina bifida following cystoscopy and suprapubic catheter placement."	1.33	Hyponatremic seizures after suprapubic catheter placement in 7-year-old child. ( Camporesi, EM; Puskas, F; Sweeney, DM; Szolnoki, JM; Upadhyay, J, 2006)
"Xipamide is a sulfonamide-like diuretic whose action does not depend on transtubular secretion."	1.31	Severe electrolyte disturbances and renal failure in elderly patients with combined diuretic therapy including xipamid. ( Bellmann, R; Heininger, D; Joannidis, M; Kähler, C; Sandhofer, A; Wiedermann, CJ, 2002)
"A patient presented to our unit with seizures and profound hyponatraemia after ingestion of a single tablet of ecstasy."	1.30	Hyponatraemia and seizures after ecstasy use. ( Alexander, WD; Banerjee, AK; Holmes, SB, 1999)
"She progressed to develop a spastic quadriparesis, speech and swallowing difficulties."	1.28	Diuretic abuse and central pontine myelinolysis. ( Copeland, PM, 1989)
"Hyponatremia should be considered when seizures or mental changes occur in patients treated with DDP."	1.27	Cis-dichlorodiammineplatinum II-induced syndrome of inappropriate secretion of antidiuretic hormone. ( Ritch, PS, 1988)
"Hyponatremia is a common complication of chronic advanced CHF unresponsive to the usual therapeutic measures."	1.27	A correctable complication of advanced congestive heart failure. ( Lemberg, L; Valle, GA, 1987)
"All of the infants had hypoxemia with air-trapping in the chest at the time of admission to the hospital."	1.27	Antidiuretic hormone response in children with bronchopulmonary dysplasia during episodes of acute respiratory distress. ( Eid, N; Herrod, L; Parekh, A; Rao, M; Steiner, P, 1986)
"Because hyponatremia is frequently associated with preceding diuretic treatment and unrestricted fluid intake--conditions which have not been addressed sufficiently in published literature--we studied the pathophysiology and the clinical setting of such hyponatremia in a large group of internal medicine patients."	1.27	Role of diuretics, hormonal derangements, and clinical setting of hyponatremia in medical patients. ( Gross, P; Hackenthal, E; Hausmann, C; Ketteler, M; Rascher, W; Reinhard, C; Ritz, E; Schömig, A, 1988)

Research

Studies (146)

Authors

Clinical Trials (7)

Trial Overview

Trial Outcomes

Change in Brain Natriuretic Peptide (BNP) Levels From Admission to the Discharge

Timeframe	Studies, this research(%)	All Research%
pre-1990	75 (51.37)	18.7374
1990's	12 (8.22)	18.2507
2000's	26 (17.81)	29.6817
2010's	22 (15.07)	24.3611
2020's	11 (7.53)	2.80

Authors	Studies
Heinz, AT	1
Eichholz, T	1
Queudeville, M	1
Hartmann, U	1
Ott, A	1
Heinzel, O	1
Handgretinger, R	1
Ebinger, M	1
Klhůfek, J	2
Šálek, T	1
Vodička, M	1
Lopes-Menezes, VC	1
Dos-Santos, RC	1
Felintro, V	1
Monteiro, LRN	1
Paes-Leme, B	1
Lustrino, D	1
Casartelli, EA	1
Vivas, L	1
Mecawi, AS	2
Reis, LC	2
Galluzzo, A	1
Frea, S	1
Boretto, P	1
Pidello, S	1
Volpe, A	1
Canavosio, FG	1
Golzio, PG	1
Bergerone, S	1
De Ferrari, GM	1
Ng, TMH	1
Grazette, LP	1
Fong, MW	1
Yoon, AJ	1
Lou, M	2
Kuo, A	1
Upadhyay, RY	1
Han, EE	1
Mehra, A	1
Elkayam, U	2
Garrahy, A	1
Sherlock, M	1
Thompson, CJ	1
Noppakun, K	1
Pin-On, P	1
Ruengorn, C	1
Mitani, H	1
Funakubo, M	1
Sato, N	2
Murayama, H	1
Rached, RA	1
Matsui, N	1
Yoshida, S	1
Ishii, T	1
Oyama, N	1
Velat, I	1
Bušić, Ž	1
Jurić Paić, M	1
Čulić, V	1
Mannheimer, B	1
Falhammar, H	1
Calissendorff, J	1
Lindh, JD	1
Skov, J	1
Tominaga, N	1
Kida, K	1
Inomata, T	1
Izumi, T	1
Akashi, YJ	1
Shibagaki, Y	1
Omar, HR	2
Guglin, M	2
Caraceni, P	1
Riggio, O	1
Angeli, P	1
Alessandria, C	1
Neri, S	1
Foschi, FG	1
Levantesi, F	1
Airoldi, A	1
Boccia, S	1
Svegliati-Baroni, G	1
Fagiuoli, S	1
Romanelli, RG	1
Cozzolongo, R	1
Di Marco, V	1
Sangiovanni, V	1
Morisco, F	1
Toniutto, P	1
Tortora, A	1
De Marco, R	1
Angelico, M	1
Cacciola, I	1
Elia, G	1
Federico, A	1
Massironi, S	1
Guarisco, R	1
Galioto, A	1
Ballardini, G	1
Rendina, M	1
Nardelli, S	1
Piano, S	1
Elia, C	1
Prestianni, L	1
Cappa, FM	1
Cesarini, L	1
Simone, L	1
Pasquale, C	1
Cavallin, M	1
Andrealli, A	1
Fidone, F	1
Ruggeri, M	1
Roncadori, A	1
Baldassarre, M	1
Tufoni, M	1
Zaccherini, G	1
Bernardi, M	1
Ruocco, G	2
Verbrugge, FH	1
Nuti, R	2
Palazzuoli, A	2
Ng, TM	1
Konopka, E	1
Hyderi, AF	1
Hshieh, S	1
Tsuji, Y	1
Kim, BJ	1
Han, SY	1
Phan, DH	1
Jeng, AI	1
Hauptman, PJ	1
Burnett, J	1
Gheorghiade, M	2
Grinfeld, L	1
Konstam, MA	1
Kostic, D	1
Krasa, HB	1
Maggioni, A	1
Ouyang, J	2
Swedberg, K	1
Zannad, F	1
Zimmer, C	1
Udelson, JE	1
Llorens, P	1
Miró, Ò	1
Herrero, P	1
Martín-Sánchez, FJ	1
Jacob, J	1
Valero, A	1
Alonso, H	1
Pérez-Durá, MJ	1
Noval, A	1
Gil-Román, JJ	1
Zapater, P	1
Llanos, L	1
Gil, V	1
Perelló, R	1
Runkle, I	1
Villabona, C	1
Navarro, A	1
Pose, A	1
Formiga, F	1
Tejedor, A	1
Poch, E	1
Pellegrini, M	1
Martini, G	1
Franci, B	1
Campagna, MS	1
Gilleman, M	1
McCullough, PA	1
Ronco, C	1
Cil, O	1
Esteva-Font, C	1
Tas, ST	1
Su, T	1
Lee, S	1
Anderson, MO	1
Ertunc, M	1
Verkman, AS	1
Sansoè, G	1
Aragno, M	1
Mastrocola, R	1
Parola, M	1
Filippatos, TD	1
Liamis, G	1
Elisaf, MS	1
Genoni, T	1
Tenconi, R	1
Bertolozzi, G	1
Laicini, EA	1
Tardini, G	1
Vianello, F	1
Leva, E	1
Milani, GP	1
Fossali, EF	1
Nakano, H	1
Yanase, D	1
Yamada, M	1
Laczi, F	1
Alilou, M	1
Awab, A	1
Zarouf, M	1
Moussaoui, RE	1
Hijri, AE	1
Azzouzi, A	1
Slaoui, A	1
Fadel, S	1
Karmali, R	1
Cogan, E	2
Haass, M	1
Ellis, C	1
Cuthill, J	1
Hew-Butler, T	1
George, SM	1
Rosner, MH	1
Morris, MJ	2
Na, ES	2
Johnson, AK	2
Velasco Cano, MV	1
Runkle de la Vega, I	1
Varsavsky, M	1
Quesada Charneco, M	1
Rozas Moreno, P	1
Vandergheynst, F	1
Brachet, C	1
Heinrichs, C	1
Decaux, G	3
Yaprak, M	1
Turan, MN	1
Tamer, AF	1
Peker, N	1
Demirci, MS	1
Çırpan, T	1
Aşçı, G	1
Minami, Y	1
Ito, N	1
Watabe, R	1
Yamane, M	1
Prasad, NK	1
Balkiran, V	1
Kumar, BS	1
Agrawal, R	1
Babu, BK	1
Kumar, VS	1
Sandhofer, A	1
Kähler, C	1
Heininger, D	1
Bellmann, R	1
Wiedermann, CJ	1
Joannidis, M	1
Shimizu, K	1
Niazi, I	1
Czerwiec, F	1
Kambayashi, J	1
Zampino, M	1
Orlandi, C	1
Liu, J	1
Callahan, SM	1
Brunner, LJ	1
Siniscalchi, A	1
Mancuso, F	1
Scornaienghi, D	1
Ferreri, G	1
De Sarro, G	1
Kazama, I	2
Hatano, R	2
Michimata, M	2
Suzuki, K	1
Arata, T	2
Suzuki, M	2
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Hsu, YJ	1
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Trial	Phase	Enrollment	Study Type	Start Date	Status
The Use of Human Albumin for the Treatment of Ascites in Patients With Hepatic Cirrhosis: a Multicenter, Open-label Randomized Clinical Trial[NCT01288794]	Phase 4	431 participants (Actual)	Interventional	2011-03-31	Completed
Protocol 156-03-236: Multicenter, Randomized, Double-blind, Placebo-controlled Study to Evaluate the Long Term Efficacy and Safety of Oral Tolvaptan Tablets in Subjects Hospitalized With Worsening Congestive Heart Failure[NCT00071331]	Phase 3	3,600 participants	Interventional	2003-09-30	Completed
Continuous Versus Intermittent Loop Diuretics Infusion Dosing in Acute Heart Failure: Effects on Renal Function, Outcome and BNP Levels[NCT01441245]	Phase 4	57 participants (Actual)	Interventional	2010-04-30	Completed
Continuous Versus Bolus Intermittent Loop Diuretic Infusion in Acutely Decompensated Heart Failure: Evaluation of Renal Function, Congestion Signs, BNP and Outcome[NCT02638142]		116 participants (Actual)	Observational	2015-12-31	Active, not recruiting
The Role of Vasopressin Antagonism on Renal Sodium Handling[NCT03910231]	Phase 1	30 participants (Actual)	Interventional	2012-02-01	Completed
Hypertonic Saline Solution in Decompensated Heart Failure[NCT00555685]	Phase 2	34 participants (Actual)	Interventional	2008-02-29	Completed
The Effects of Clonidine on the Diuretic Response in Cirrhotic Patients With Ascites and Activation of Sympathetic Nervous System: a Randomized Double-Blind Placebo Controlled Study.[NCT00356226]		64 participants	Interventional	2000-10-31	Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

(NCT01441245)
Timeframe: participants were followed for the duration of hospital stay, an average of 13 days

Dopamine Infusion During Hospitalization

Evaluation of B-type Natriuretic Peptide (BNP) Levels From Admission to the End of Treatment

Evaluation of Mean Urine Output Volume During the Infusion Period

Intervention	pg/mL (Mean)
BNP Change in cIV	-525
BNP Change in iIV	-148

Intervention	percentage of partecipants (Number)
Dopamine Infusion in cIV	50
Dopamine Infusion in iIV	26

Intervention	pg/ml (Mean)
BNP Levels at Discharge in cIV Group	679
BNP Levels at Discharge in iIV Group	949

this study aimed to evaluate the effects of continuous infusion of furosemide in comparison to twice daily regimens at similar doses with respect to changes in renal function in terms of creatinine levels and GFR, urine output and BNP levels from admission to discharge (NCT01441245)
Timeframe: time period ranging from 72 h to 120 h.

Evaluation of Renal Function in Terms of Changes in Creatinine Levels

Intervention	mL (Mean)
Urine Output in cIV	2505
Urine Output in iIV	2140

evaluation of renal function in terms of changes in creatinine levels during hospitalization in the two arms. (NCT01441245)
Timeframe: participants were followed for the duration of hospital stay, an average of 13 days

Evaluation of Renal Function in Terms of Changes in GFR

Evaluation of Renal Function in Terms of Creatinine Levels at Discharge

Evaluation of Renal Function in Terms of GFR Values at Discharge

Length of Hospitalization in the Two Groups

Intervention	mg/dL (Mean)
Changes in Creatinine in cIV Group	-0.10
Changes in Creatinine in iIV Group	-0.50

Intervention	(ml/min·1.73 m2) (Mean)
GFR Change in cIV	-3.18
GFR Change in iIV	-1.93

Intervention	mg/dL (Mean)
Creatinine at Discharge in cIV	1.78
Creatinine at Discharge in iIV	1.51

Intervention	(ml/min·1.73 m2) (Mean)
GFR at Discharge in cIV	44.8
GFR at Discharge in iIV	46.7

percentage of participants with hospital stay > 10 days (NCT01441245)
Timeframe: in-hospital

Article	Year
Ten pitfalls in the proper management of patients with hyponatremia. Postgraduate medicine, 2016, Volume: 128, Issue:5 Topics: Acute Disease; Antidiuretic Hormone Receptor Antagonists; Chronic Disease; Diuretics; Drug Dosage Ca	2016
Syndrome of inappropriate secretion of antidiuretic hormone (SIADH) associated with lateral medullary syndrome: case report and literature review. BMC neurology, 2016, Jul-27, Volume: 16 Topics: Aged; Antipyrine; Arginine; Clopidogrel; Diffusion Magnetic Resonance Imaging; Diuretics; Edaravone;	2016
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Long-term treatment of hyponatremic patients with nephrogenic syndrome of inappropriate antidiuresis: personal experience and review of published case reports. Nephron. Clinical practice, 2012, Volume: 120, Issue:3 Topics: Adult; Aged; Diuretics; Furosemide; Genetic Diseases, X-Linked; Humans; Hyponatremia; Inappropriate	2012
Treating hyponatremia in heart failure. Current cardiology reports, 2006, Volume: 8, Issue:3 Topics: Antidiuretic Hormone Receptor Antagonists; Arginine Vasopressin; Diuretics; Furosemide; Heart Failur	2006
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Diuretic drug therapy of edema. The Medical clinics of North America, 1971, Volume: 55, Issue:2 Topics: Ambulatory Care; Ascites; Body Weight; Chlorides; Diuresis; Diuretics; Edema; Ethacrynic Acid; Furos	1971
Diuretics. II. Clinical considerations. Drugs, 1971, Volume: 1, Issue:2 Topics: Administration, Oral; Aminophylline; Ascites; Calcium; Carbohydrate Metabolism; Carbonic Anhydrase I	1971
Combination diuretic drug therapy. Cardiovascular clinics, 1971, Volume: 2, Issue:3 Topics: Amiloride; Benzothiadiazines; Diet; Diuretics; Drug Therapy, Combination; Ethacrynic Acid; Furosemid	1971

Article	Year
Spot urinary sodium in acute decompensation of advanced heart failure and dilutional hyponatremia: insights from DRAIN trial. Clinical research in cardiology : official journal of the German Cardiac Society, 2020, Volume: 109, Issue:10 Topics: Administration, Intravenous; Aged; Biomarkers; Diuretics; Double-Blind Method; Drug Resistance; Fema	2020
Tolvaptan vs. furosemide-based diuretic regimens in patients hospitalized for heart failure with hyponatremia (AQUA-AHF). ESC heart failure, 2020, Volume: 7, Issue:4 Topics: Antidiuretic Hormone Receptor Antagonists; Benzazepines; Diuretics; Furosemide; Heart Failure; Human	2020
Effects of Tolvaptan Addition to Furosemide in Normo- and Hyponatremia Patients with Heart Failure and Chronic Kidney Disease Stages G3b-5: A Subanalysis of the K-STAR Study. American journal of nephrology, 2017, Volume: 46, Issue:5 Topics: Administration, Oral; Aged; Aged, 80 and over; Antidiuretic Hormone Receptor Antagonists; Benzazepin	2017
Long-term albumin administration in decompensated cirrhosis (ANSWER): an open-label randomised trial. Lancet (London, England), 2018, 06-16, Volume: 391, Issue:10138 Topics: Aged; Albumins; Ascites; Diuretics; Drug Therapy, Combination; Female; Furosemide; Humans; Hyperkale	2018
Higher Diuretic Requirements in Acute Heart Failure With Admission Hyponatraemia Versus Normonatraemia. Heart, lung & circulation, 2020, Volume: 29, Issue:2 Topics: Acute Disease; Adult; Aged; Diuretics; Female; Furosemide; Heart Failure; Humans; Hyponatremia; Male	2020
Clinical course of patients with hyponatremia and decompensated systolic heart failure and the effect of vasopressin receptor antagonism with tolvaptan. Journal of cardiac failure, 2013, Volume: 19, Issue:6 Topics: Aged; Analysis of Variance; Antidiuretic Hormone Receptor Antagonists; Arginine Vasopressin; Benzaze	2013
Clinical effects and safety of different strategies for administering intravenous diuretics in acutely decompensated heart failure: a randomised clinical trial. Emergency medicine journal : EMJ, 2014, Volume: 31, Issue:9 Topics: Acute Disease; Aged; Aged, 80 and over; Biomarkers; Creatinine; Diuretics; Female; Furosemide; Heart	2014
Continuous versus bolus intermittent loop diuretic infusion in acutely decompensated heart failure: a prospective randomized trial. Critical care (London, England), 2014, Jun-28, Volume: 18, Issue:3 Topics: Acute Kidney Injury; Aged; Aged, 80 and over; Creatinine; Diuretics; Double-Blind Method; Female; Fu	2014
Continuous versus bolus intermittent loop diuretic infusion in acutely decompensated heart failure: a prospective randomized trial. Critical care (London, England), 2014, Jun-28, Volume: 18, Issue:3 Topics: Acute Kidney Injury; Aged; Aged, 80 and over; Creatinine; Diuretics; Double-Blind Method; Female; Fu	2014
Continuous versus bolus intermittent loop diuretic infusion in acutely decompensated heart failure: a prospective randomized trial. Critical care (London, England), 2014, Jun-28, Volume: 18, Issue:3 Topics: Acute Kidney Injury; Aged; Aged, 80 and over; Creatinine; Diuretics; Double-Blind Method; Female; Fu	2014
Continuous versus bolus intermittent loop diuretic infusion in acutely decompensated heart failure: a prospective randomized trial. Critical care (London, England), 2014, Jun-28, Volume: 18, Issue:3 Topics: Acute Kidney Injury; Aged; Aged, 80 and over; Creatinine; Diuretics; Double-Blind Method; Female; Fu	2014
Combined effects of vasopressin V2 receptor antagonist and loop diuretic in humans. Clinical nephrology, 2003, Volume: 59, Issue:3 Topics: Adult; Benzazepines; Cross-Over Studies; Diuretics; Drug Therapy, Combination; Edema; Electrolytes;	2003
Vasopressin V2-receptor blockade with tolvaptan in patients with chronic heart failure: results from a double-blind, randomized trial. Circulation, 2003, Jun-03, Volume: 107, Issue:21 Topics: Administration, Oral; Adult; Aged; Aged, 80 and over; Antidiuretic Hormone Receptor Antagonists; Arg	2003
Hypertonic saline solution for renal failure prevention in patients with decompensated heart failure. Arquivos brasileiros de cardiologia, 2007, Volume: 89, Issue:4 Topics: Biomarkers; Cardiotonic Agents; Creatinine; Diuretics; Dobutamine; Female; Furosemide; Heart Failure	2007
Renal response to captopril in severe heart failure: role of furosemide in natriuresis and reversal of hyponatremia. Annals of internal medicine, 1984, Volume: 100, Issue:6 Topics: Adult; Aged; Blood Pressure; Captopril; Drug Therapy, Combination; Female; Furosemide; Glomerular Fi	1984
Comparative effect of diuretics on renal water excretion in hyponatraemic oedematous disorders. Clinical science (London, England : 1979), 1982, Volume: 62, Issue:2 Topics: Adult; Chlorothiazide; Edema; Furosemide; Humans; Hyponatremia; Middle Aged; Osmolar Concentration;	1982
[Letter: Ascrtogenicliver cirrhosis. Effect of amiloride on water-electrolytemetabolsim]. La Nouvelle presse medicale, 1975, Apr-05, Volume: 4, Issue:14 Topics: Amiloride; Ascites; Chlorides; Clinical Trials as Topic; Furosemide; Humans; Hydrochlorothiazide; Hy	1975
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Furosemide-induced disturbances of renal function in patients undergoing TURP. Urology, 1990, Volume: 35, Issue:4 Topics: Aged; Aldosterone; Chlorides; Creatinine; Diuresis; Dyspnea; Furosemide; Humans; Hyponatremia; Male;	1990
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Article	Year
Introducing isotonic fluids into pediatric oncology. Pediatric hematology and oncology, 2022, Volume: 39, Issue:4 Topics: Child; Fluid Therapy; Furosemide; Humans; Hypernatremia; Hyponatremia; Hypotonic Solutions; Infusion	2022
Thiazide-associated hyponatremia in internal medicine patients: analysis of epidemiological and biochemical profiles. Postgraduate medicine, 2022, Volume: 134, Issue:5 Topics: Anorexia; Creatinine; Female; Furosemide; Humans; Hyponatremia; Hypovolemia; Internal Medicine; Male	2022
Furosemide-associated hyponatremia in internal medicine patients: Analysis of epidemiological and biochemical profiles. European journal of internal medicine, 2023, Volume: 114 Topics: Diuretics; Furosemide; Humans; Hyponatremia; Sodium	2023
Acute body sodium depletion induces skin sodium mobilization in female Wistar rats. Experimental physiology, 2019, Volume: 104, Issue:12 Topics: Animals; Estradiol; Female; Furosemide; Hyponatremia; Ovariectomy; Rats; Rats, Wistar; Skin; Sodium;	2019
Treatment Outcomes in Syndrome of Inappropriate Antidiuresis: Improvements in Hyponatremia May Reflect Successful Treatment or Resolution of the Underlying Cause. American journal of kidney diseases : the official journal of the National Kidney Foundation, 2020, Volume: 76, Issue:4 Topics: Furosemide; Humans; Hyponatremia; Inappropriate ADH Syndrome; Sodium Chloride; Treatment Outcome	2020
In Reply to 'Treatment Outcomes in Syndrome of Inappropriate Antidiuresis: Improvements in Hyponatremia May Reflect Successful Treatment or Resolution of the Underlying Cause'. American journal of kidney diseases : the official journal of the National Kidney Foundation, 2020, Volume: 76, Issue:4 Topics: Furosemide; Humans; Hyponatremia; Inappropriate ADH Syndrome; Sodium Chloride; Treatment Outcome	2020
In-hospital resource utilization, worsening heart failure, and factors associated with length of hospital stay in patients with hospitalized heart failure: A Japanese database cohort study. Journal of cardiology, 2020, Volume: 76, Issue:4 Topics: Aged; Aged, 80 and over; Cohort Studies; Databases, Factual; Disease Progression; Female; Furosemide	2020
Furosemide and spironolactone doses and hyponatremia in patients with heart failure. BMC pharmacology & toxicology, 2020, 08-03, Volume: 21, Issue:1 Topics: Aged; Aged, 80 and over; Diuretics; Female; Furosemide; Heart Failure; Hospitalization; Humans; Hydr	2020
Non-thiazide diuretics and hospitalization due to hyponatraemia: A population-based case-control study. Clinical endocrinology, 2021, Volume: 95, Issue:3 Topics: Adult; Case-Control Studies; Diuretics; Furosemide; Hospitalization; Humans; Hyponatremia	2021
Etiology of discharge hyponatremia in decompensated heart failure and normal admission Na European journal of internal medicine, 2018, Volume: 48 Topics: Diuretics; Female; Furosemide; Heart Failure; Hemodynamics; Humans; Hyponatremia; Male; Middle Aged;	2018
Hyponatremia in Acute Heart Failure in Relation to Hematocrit Levels: Clinical Relevance and Prognostic Implication. Cardiorenal medicine, 2018, Volume: 8, Issue:4 Topics: Acute Disease; Administration, Intravenous; Aged; Aged, 80 and over; Diuretics; Female; Furosemide;	2018
Comparison of bumetanide- and metolazone-based diuretic regimens to furosemide in acute heart failure. Journal of cardiovascular pharmacology and therapeutics, 2013, Volume: 18, Issue:4 Topics: Acute Disease; Adult; Aged; Blood Urea Nitrogen; Bumetanide; Cohort Studies; Diuretics; Drug Therapy	2013
[The treament of hyponatremia secundary to the syndrome of inappropriate antidiuretic hormone secretion]. Medicina clinica, 2013, Dec-07, Volume: 141, Issue:11 Topics: Acute Disease; Algorithms; Benzazepines; Combined Modality Therapy; Decision Support Techniques; Flu	2013
Salt-sparing diuretic action of a water-soluble urea analog inhibitor of urea transporters UT-A and UT-B in rats. Kidney international, 2015, Volume: 88, Issue:2 Topics: Animals; Binding Sites; Disease Models, Animal; Diuresis; Diuretics; Dogs; Drug Evaluation, Preclini	2015
Pathogenesis of solute-free water retention in experimental ascitic cirrhosis: is vasopressin the only culprit? Clinical science (London, England : 1979), 2016, Volume: 130, Issue:2 Topics: Animals; Ascites; Canrenoic Acid; Diuretics; Furosemide; Guanfacine; Hyponatremia; Liver Cirrhosis,	2016
Treatment of Severe Hypervolemic Hyponatremia in a Child With Pneumonia. Pediatric emergency care, 2016, Volume: 32, Issue:6 Topics: Diagnosis, Differential; Diuretics; Fluid Therapy; Furosemide; Humans; Hyponatremia; Inappropriate A	2016
[Severe hyponatraemia secondary to cure of cyclophosphamide (about three cases)]. Annales francaises d'anesthesie et de reanimation, 2009, Volume: 28, Issue:1 Topics: Adult; Antineoplastic Agents, Alkylating; Behcet Syndrome; Cyclophosphamide; Diuretics; Female; Furo	2009
Safety of furosemide administration in an elderly woman recovered from thiazide-induced hyponatremia. European journal of internal medicine, 2009, Volume: 20, Issue:1 Topics: Aged; Diuretics; Drinking; Female; Furosemide; Humans; Hydrochlorothiazide; Hypertension; Hyponatrem	2009
Case report: exercise-associated hyponatremia with rhabdomyolysis during endurance exercise. The Physician and sportsmedicine, 2009, Volume: 37, Issue:1 Topics: Adult; Diuretics; Female; Fluid Therapy; Furosemide; Humans; Hyponatremia; Male; Middle Aged; Physic	2009
Mineralocorticoid receptor antagonism prevents hedonic deficits induced by a chronic sodium appetite. Behavioral neuroscience, 2010, Volume: 124, Issue:2 Topics: Aldosterone; Animals; Appetite; Captopril; Desoxycorticosterone; Drug Interactions; Furosemide; Hypo	2010
[Urea as therapeutic option for the treatment of the syndrome of inappropriate antidiuretic hormone secretion]. Medicina clinica, 2011, Jul-23, Volume: 137, Issue:5 Topics: Amitriptyline; Carbamazepine; Comorbidity; Demeclocycline; Diabetic Neuropathies; Diuretics; Furosem	2011
Opioid mechanisms that mediate the palatability of and appetite for salt in sodium replete and deficient states. Physiology & behavior, 2012, May-15, Volume: 106, Issue:2 Topics: Animals; Appetite Regulation; Drinking; Food Preferences; Furosemide; Hyponatremia; Male; Morphine;	2012
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[Patient with pseudomyxoma peritonei in whom, hyperglycemia and hyponatremia were induced by massive intraperitoneal lavage with 5% glucose]. Masui. The Japanese journal of anesthesiology, 2012, Volume: 61, Issue:10 Topics: Aged; Anesthesia, General; Cecum; Digestive System Surgical Procedures; Female; Furosemide; Glucose;	2012
"Euvolemic hyponatremia"--3 case reports and approach to management. Indian journal of medical sciences, 2002, Volume: 56, Issue:3 Topics: Aged; Aged, 80 and over; Diuretics; Female; Furosemide; Humans; Hyponatremia; Inappropriate ADH Synd	2002
Severe electrolyte disturbances and renal failure in elderly patients with combined diuretic therapy including xipamid. Wiener klinische Wochenschrift, 2002, Nov-30, Volume: 114, Issue:21-22 Topics: Age Factors; Aged; Aged, 80 and over; Diuretics; Drug Therapy, Combination; Emergencies; Female; Fur	2002
Effect of sodium alterations on hepatic cytochrome P450 3A2 and 2C11 and renal function in rats. Drug development and industrial pharmacy, 2003, Volume: 29, Issue:7 Topics: Animals; Aryl Hydrocarbon Hydroxylases; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Cyto	2003
Acute encephalopathy induced by oxcarbazepine and furosemide. The Annals of pharmacotherapy, 2004, Volume: 38, Issue:3 Topics: Anticonvulsants; Carbamazepine; Diuretics; Electroencephalography; Encephalitis; Epilepsy; Female; F	2004
BSC1 inhibition complements effects of vasopressin V2 receptor antagonist on hyponatremia in SIADH rats. Kidney international, 2005, Volume: 67, Issue:5 Topics: Animals; Antidiuretic Hormone Receptor Antagonists; Aquaporin 2; Aquaporins; Benzazepines; Deamino A	2005
Biochemical and etiological characteristics of acute hyponatremia in the emergency department. The Journal of emergency medicine, 2005, Volume: 29, Issue:4 Topics: Acute Disease; Adolescent; Adult; Aged; Aged, 80 and over; Diagnosis, Differential; Drinking; Emerge	2005
Aldosterone target neurons in the nucleus tractus solitarius drive sodium appetite. The Journal of neuroscience : the official journal of the Society for Neuroscience, 2006, Jan-11, Volume: 26, Issue:2 Topics: 11-beta-Hydroxysteroid Dehydrogenase Type 2; Adrenalectomy; Aldosterone; Animals; Appetite; Corticos	2006
Hyponatremic seizures after suprapubic catheter placement in 7-year-old child. Paediatric anaesthesia, 2006, Volume: 16, Issue:2 Topics: Abdominal Wall; Anticonvulsants; Catheterization; Child; Cystoscopy; Diuretics; Furosemide; Glucose;	2006
Lithium effectively complements vasopressin V2 receptor antagonist in the treatment of hyponatraemia of SIADH rats. Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, 2007, Volume: 22, Issue:1 Topics: Animals; Antidiuretic Hormone Receptor Antagonists; Aquaporin 2; Benzazepines; Diabetes Insipidus, N	2007
A novel vasopressin dual V1A/V2 receptor antagonist, conivaptan hydrochloride, improves hyponatremia in rats with syndrome of inappropriate secretion of antidiuretic hormone (SIADH). Biological & pharmaceutical bulletin, 2007, Volume: 30, Issue:1 Topics: Animals; Antidiuretic Hormone Receptor Antagonists; Arginine Vasopressin; Benzazepines; Disease Mode	2007
Acute colchicine intoxication in a child: a case report. Pediatric emergency care, 2007, Volume: 23, Issue:5 Topics: Acute Disease; Alopecia; Ataxia; Blood Transfusion; Case Management; Child, Preschool; Colchicine; C	2007
[Severe hyponatremia with pulmonary and cerebral edema in an Ironman triathlete]. Deutsche medizinische Wochenschrift (1946), 2007, Volume: 132, Issue:36 Topics: Bicycling; Brain Edema; Catecholamines; Creatine Kinase; Diuretics; Female; Furosemide; Humans; Hypo	2007
Oestrogenic influence on brain AT1 receptor signalling on the thirst and sodium appetite in osmotically stimulated and sodium-depleted female rats. Experimental physiology, 2008, Volume: 93, Issue:8 Topics: Angiotensin II Type 1 Receptor Blockers; Angiotensin-Converting Enzyme Inhibitors; Animals; Brain; C	2008
Refractory heart failure. Geriatrics, 1967, Volume: 22, Issue:5 Topics: Adult; Aged; Alkalosis; Digitalis Glycosides; Diuretics; Ethacrynic Acid; Furosemide; Heart Failure;	1967
[Marked effect of furosemide and hypertonic saline in the treatment of SIAD after head injury]. No shinkei geka. Neurological surgery, 1984, Volume: 12, Issue:5 Topics: Adult; Brain Neoplasms; Combined Modality Therapy; Furosemide; Humans; Hyponatremia; Inappropriate A	1984
Diuretic-induced azotemia: unmasking the role of increased peripheral catabolism through evisceration-hepatectomy. Kidney international. Supplement, 1983, Volume: 16 Topics: Amino Acids; Animals; Furosemide; Hepatectomy; Hyponatremia; Intestines; Metabolic Clearance Rate; M	1983
Effects of indomethacin on plasma renin activity in the conscious rat. The American journal of physiology, 1981, Volume: 240, Issue:3 Topics: Animals; Arachidonic Acids; Furosemide; Hyponatremia; Indomethacin; Isoproterenol; Male; Prostagland	1981
Rapid correction of severe hyponatremia with intravenous hypertonic saline solution. The American journal of medicine, 1982, Volume: 72, Issue:1 Topics: Adult; Aged; Brain Diseases; Female; Furosemide; Humans; Hyponatremia; Infusions, Parenteral; Male;	1982
Combined treatment of severe hyponatremia due to inappropriate antidiuretic hormone secretion. Pediatrics, 1982, Volume: 69, Issue:5 Topics: Child; Desoxycorticosterone; Drug Therapy, Combination; Female; Furosemide; Humans; Hyponatremia; In	1982
Combating sodium and potassium imbalance in older patients. Geriatrics, 1981, Volume: 36, Issue:8 Topics: Acute Disease; Aged; Furosemide; Humans; Hyperkalemia; Hypernatremia; Hypokalemia; Hyponatremia; Pot	1981
Treatment of dilutional hyponatremia in congestive heart failure. Acta medica Scandinavica, 1980, Volume: 207, Issue:4 Topics: Adult; Aged; Body Weight; Diuretics; Female; Furosemide; Heart Failure; Humans; Hyponatremia; Infusi	1980
Diagnosis and treatment of hyponatraemia in SIAD. Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, 1997, Volume: 12, Issue:5 Topics: Diuretics; Furosemide; Humans; Hyponatremia; Inappropriate ADH Syndrome; Saline Solution, Hypertonic	1997
Iatrogenic acute hyponatraemia in a college athlete. British journal of sports medicine, 1998, Volume: 32, Issue:3 Topics: Acute Disease; Adult; Confusion; Dehydration; Diagnosis, Differential; Diuretics; Dyspnea; Fluid The	1998
Hyponatraemia and seizures after ecstasy use. Postgraduate medical journal, 1999, Volume: 75, Issue:879 Topics: Adult; Furosemide; Hallucinogens; Humans; Hyponatremia; Male; N-Methyl-3,4-methylenedioxyamphetamine	1999
Falciparum malaria: a case report of severe hyponatraemia. Annals of tropical medicine and parasitology, 2000, Volume: 94, Issue:2 Topics: Adult; Animals; Antiemetics; Antimalarials; Diuretics; Fatal Outcome; Furosemide; Humans; Hyponatrem	2000
Hyponatremia. The New England journal of medicine, 2000, Sep-21, Volume: 343, Issue:12 Topics: Diuretics; Electrolytes; Furosemide; Humans; Hyponatremia; Saline Solution, Hypertonic; Sodium	2000
[Biological factors influencing response to diuretics in patients with cirrhosis and ascites]. Gastroenterologie clinique et biologique, 2001, Volume: 25, Issue:3 Topics: Aldosterone; Ascites; Diuretics; Female; Furosemide; Glomerular Filtration Rate; Humans; Hyperkalemi	2001
[Acute symptomatic hyponatremia in a 70-year-old patient. Insufficient ADH secretion syndrome]. Medizinische Klinik (Munich, Germany : 1983), 2002, May-15, Volume: 97, Issue:5 Topics: Aged; Diagnosis, Differential; Furosemide; Hematoma, Subdural; Humans; Hyponatremia; Inappropriate A	2002
Antidiuretic hormone excess. The Journal of pediatrics, 1979, Volume: 94, Issue:4 Topics: Blood; Demeclocycline; Furosemide; Humans; Hyponatremia; Inappropriate ADH Syndrome; Lithium; Osmola	1979
[Temporal aspects of the function of the renin-angiotensin-aldosterone system. Contribution to the methodological standardization of explorative test (author's transl)]. Annali dell'Istituto superiore di sanita, 1979, Volume: 15, Issue:2 Topics: Adolescent; Adult; Aldosterone; Circadian Rhythm; Diet, Sodium-Restricted; Female; Furosemide; Human	1979
Hyponatraemia and severity and outcome of myocardial infarction. British medical journal, 1979, May-12, Volume: 1, Issue:6173 Topics: Acute Disease; Chlorides; Female; Furosemide; Humans; Hypokalemia; Hyponatremia; Male; Middle Aged;	1979
[Basis and clinical aspects of diuretic drug therapy]. Therapeutische Umschau. Revue therapeutique, 1979, Volume: 36, Issue:7 Topics: Acetazolamide; Benzothiadiazines; Diuretics; Edema; Edema, Cardiac; Furosemide; Glaucoma; Humans; Hy	1979
The use of diuretics in nonedematous conditions. Medical times, 1979, Volume: 107, Issue:12 Topics: Acute Kidney Injury; Benzothiadiazines; Calcium; Diuretics; Ethacrynic Acid; Furosemide; Humans; Hyp	1979
Hyponatremia in myxedema: a suggested therapeutic approach. Israel journal of medical sciences, 1979, Volume: 15, Issue:11 Topics: Aged; Female; Furosemide; Humans; Hyponatremia; Inappropriate ADH Syndrome; Myxedema; Saline Solutio	1979
[Hyponatremia as a complication of high-dose furosemide therapy in chronic kidney failure]. Die Medizinische Welt, 1979, Dec-07, Volume: 30, Issue:49 Topics: Adult; Aged; Dose-Response Relationship, Drug; Female; Furosemide; Humans; Hyponatremia; Kidney Fail	1979
Management of intractable heart failure with hyponatremia. The Indian journal of chest diseases & allied sciences, 1978, Volume: 20, Issue:1 Topics: Adult; Aged; Dexamethasone; Drug Therapy, Combination; Female; Furosemide; Heart Failure; Humans; Hy	1978
A guide to the practical use of diuretics. JAMA, 1976, Apr-26, Volume: 235, Issue:17 Topics: Administration, Oral; Diuretics; Edema; Furosemide; Humans; Hypercalcemia; Hyperglycemia; Hypertensi	1976
Non-ketotic, hyponatraemic normosmolar diabetic coma and moderate furosemide therapy. South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde, 1976, Dec-18, Volume: 50, Issue:54 Topics: Aged; Diabetic Coma; Female; Furosemide; Humans; Hyponatremia; Osmolar Concentration	1976
Rapid correction of water intoxication by hypertonic saline and frusemide. Australian and New Zealand journal of medicine, 1975, Volume: 5, Issue:6 Topics: Aged; Female; Furosemide; Humans; Hyponatremia; Saline Solution, Hypertonic; Smoking; Sodium Chlorid	1975
Hypotensive effect of clonidine during sodium depletion in the rat. Circulation research, 1975, Volume: 37, Issue:6 Topics: Animals; Blood Pressure; Clonidine; Disease Models, Animal; Dose-Response Relationship, Drug; Drug S	1975
Radioimmunoassay of plasma vasopressin in physiological and pathological states in man. The Journal of endocrinology, 1975, Volume: 67, Issue:2 Topics: Arginine Vasopressin; Blood Preservation; Bronchial Neoplasms; Dehydration; Furosemide; Growth Hormo	1975
[Effect of beta-adrenergic block on the response of plasma renin activity to acute sodium depletion in the rabbit]. Bollettino della Societa italiana di biologia sperimentale, 1975, Sep-30, Volume: 51, Issue:18 Topics: Animals; Furosemide; Hyponatremia; Kidney; Natriuresis; Oxprenolol; Rabbits; Receptors, Adrenergic;	1975
Diuretic induced hyponatraemia in the elderly. The Journal of the Association of Physicians of India, 1992, Volume: 40, Issue:9 Topics: Aged; Diagnosis, Differential; Furosemide; Humans; Hydrochlorothiazide; Hypertension; Hypokalemia; H	1992
Inappropriate secretion of antidiuretic hormone in Sheehan's syndrome: a rare cause of postpartum hyponatremia. American journal of obstetrics and gynecology, 1991, Volume: 165, Issue:5 Pt 1 Topics: Adult; Estrogens; Female; Follicle Stimulating Hormone; Furosemide; Growth Hormone; Humans; Hydrocor	1991
Adverse effects of dietary and furosemide-induced sodium depletion on thermoregulation. Aviation, space, and environmental medicine, 1990, Volume: 61, Issue:11 Topics: Animals; Body Temperature Regulation; Diet, Sodium-Restricted; Disease Models, Animal; Furosemide; H	1990
Management of severe hyponatremia. The American journal of medicine, 1990, Volume: 88, Issue:6 Topics: Furosemide; Humans; Hyponatremia; Osmolar Concentration; Saline Solution, Hypertonic; Sodium	1990
Diuretic abuse and central pontine myelinolysis. Psychotherapy and psychosomatics, 1989, Volume: 52, Issue:1-3 Topics: Adult; Anorexia Nervosa; Deglutition Disorders; Demyelinating Diseases; Dose-Response Relationship,	1989
Cis-dichlorodiammineplatinum II-induced syndrome of inappropriate secretion of antidiuretic hormone. Cancer, 1988, Feb-01, Volume: 61, Issue:3 Topics: Cisplatin; Furosemide; Glioblastoma; Humans; Hyponatremia; Inappropriate ADH Syndrome; Male; Mental	1988
Role of diuretics, hormonal derangements, and clinical setting of hyponatremia in medical patients. Klinische Wochenschrift, 1988, Aug-01, Volume: 66, Issue:15 Topics: Aldosterone; Arginine Vasopressin; Diuretics; Electrolytes; Epinephrine; Furosemide; Heart Failure;	1988
Chronic hyponatremia associated with diabetic amyotrophy. Archives of internal medicine, 1986, Volume: 146, Issue:3 Topics: Atrophy; Body Weight; Demeclocycline; Diabetes Mellitus, Type 2; Electrolytes; Furosemide; Humans; H	1986
A correctable complication of advanced congestive heart failure. Heart & lung : the journal of critical care, 1987, Volume: 16, Issue:2 Topics: Captopril; Female; Furosemide; Heart Failure; Humans; Hyponatremia; Middle Aged; Sodium	1987
Refractory ascites: definition and mechanism. Minerva medica, 1987, May-31, Volume: 78, Issue:10 Topics: Anti-Inflammatory Agents, Non-Steroidal; Ascites; Diet, Sodium-Restricted; Diuretics; Drainage; Drug	1987
Urea treatment for water retention in hyponatremic congestive heart failure. International journal of cardiology, 1987, Volume: 17, Issue:1 Topics: Aged; Drug Therapy, Combination; Furosemide; Heart Failure; Humans; Hyponatremia; Male; Urea	1987
What's new in diuretic therapy. American family physician, 1986, Volume: 33, Issue:5 Topics: Acetazolamide; Acid-Base Imbalance; Biological Transport; Diuretics; Drug Resistance; Ethacrynic Aci	1986
Antidiuretic hormone response in children with bronchopulmonary dysplasia during episodes of acute respiratory distress. American journal of diseases of children (1960), 1986, Volume: 140, Issue:8 Topics: Bronchopulmonary Dysplasia; Female; Furosemide; Humans; Hyponatremia; Hypoxia; Infant; Infant, Newbo	1986
Significance of the measurement of uric acid fractional clearance in diuretic induced hyponatraemia. Postgraduate medical journal, 1986, Volume: 62, Issue:728 Topics: Aged; Benzothiadiazines; Diuretics; Furosemide; Humans; Hyponatremia; Sodium Chloride Symporter Inhi	1986
Treatment of hyponatremic cirrhosis with ascites resistant to diuretics by urea. Nephron, 1986, Volume: 44, Issue:4 Topics: Adult; Ascites; Body Weight; Creatinine; Drug Therapy, Combination; Edema; Furosemide; Humans; Hypon	1986
Water intoxication and hyponatremic encephalopathy from the use of an oxytocin nasal spray. A case report. The Journal of reproductive medicine, 1985, Volume: 30, Issue:3 Topics: Adult; Aerosols; Brain Diseases; Epilepsy, Tonic-Clonic; Female; Furosemide; Humans; Hyponatremia; L	1985
Complications of diuretic therapy in hepatic cirrhosis. Lancet (London, England), 1966, May-14, Volume: 1, Issue:7446 Topics: Chlorothiazide; Diuretics; Ethacrynic Acid; Furosemide; Hepatic Encephalopathy; Humans; Hypokalemia;	1966
Amiloride ('MK 870') in patients with ascites due to cirrhosis of the liver. Lancet (London, England), 1968, Jan-20, Volume: 1, Issue:7534 Topics: Adult; Ascites; Bicarbonates; Creatinine; Diuretics; Ethacrynic Acid; Furosemide; Guanidines; Humans	1968
Rapid correction of hyponatremia in the syndrome of inappropriate secretion of antidiuretic hormone. An alternative treatment to hypertonic saline. Annals of internal medicine, 1973, Volume: 78, Issue:6 Topics: Adult; Body Water; Body Weight; Diuresis; Epilepsy, Tonic-Clonic; Female; Furosemide; Humans; Hypert	1973
[Side effects and complication possibilities following high-dosage furosemide treatment]. Medizinische Klinik, 1972, Oct-27, Volume: 67, Issue:43 Topics: Adult; Aged; Alkalosis; Blood Coagulation Disorders; Blood Glucose; Dehydration; Drug Eruptions; Ear	1972
Double isotope assay of aldosterone, corticosterone and cortisol in human peripheral plasma. The Journal of endocrinology, 1968, Volume: 40, Issue:1 Topics: Adrenocorticotropic Hormone; Aldosterone; Carbon Isotopes; Chromatography, Paper; Corticosterone; Fu	1968
Renin and angiotensin in relation to aldosterone. American journal of clinical pathology, 1970, Volume: 54, Issue:3 Topics: Adrenal Glands; Aldosterone; Angiotensin II; Animals; Dogs; Furosemide; Heparin; Humans; Hydrocortis	1970
[Hyponatremic hypertensive crisis (author's transl)]. Klinische Wochenschrift, 1974, Aug-15, Volume: 52, Issue:16 Topics: Adult; Blood Pressure; Creatinine; Diet, Sodium-Restricted; Female; Furosemide; Humans; Hypertension	1974
Hypertension and renin in human renal transplantation. Annals of surgery, 1974, Volume: 179, Issue:5 Topics: Blood Pressure; Creatinine; Furosemide; Graft Rejection; Humans; Hypertension; Hyponatremia; Kidney	1974
Sodium conservation in chronic renal failure: studies using oral diazoxide. Clinical science, 1972, Volume: 43, Issue:6 Topics: Administration, Oral; Creatinine; Diazoxide; Fludrocortisone; Furosemide; Humans; Hyponatremia; Kidn	1972
Self-induced secondary hyperaldosteronism simulating Bartter's syndrome. Israel journal of medical sciences, 1972, Volume: 8, Issue:11 Topics: Adult; Alkalosis; Diagnosis, Differential; Female; Furosemide; Humans; Hyperaldosteronism; Hypertrop	1972
Effect of furosemide on free water excretion in edematous patients with hyponatremia. Kidney international, 1973, Volume: 3, Issue:1 Topics: Edema; Furosemide; Hemodynamics; Humans; Hyponatremia; Kidney; Osmolar Concentration; Sodium; Vasopr	1973
Electrolyte disturbances resulting from diuretic therapy. Texas medicine, 1973, Volume: 69, Issue:7 Topics: Acetazolamide; Diuretics; Ethacrynic Acid; Furosemide; Humans; Hypercalcemia; Hypokalemia; Hyponatre	1973
Management of acute renal failure in infants and children. Nephron, 1973, Volume: 11, Issue:2 Topics: Acidosis; Acute Kidney Injury; Anemia; Bicarbonates; Calcium; Child, Preschool; Dehydration; Furosem	1973
[Hyponatremia syndrome in congestive heart failure]. Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke, 1973, May-10, Volume: 93, Issue:13 Topics: Female; Furosemide; Heart Failure; Humans; Hyponatremia; Middle Aged; Sodium; Spironolactone; Syndro	1973
Letter: Correction of hyponatremia. Annals of internal medicine, 1973, Volume: 79, Issue:5 Topics: Desoxycorticosterone; Drug Combinations; Furosemide; Humans; Hyponatremia	1973
[Pathogenesis and therapy of ascites in liver cirrhosis]. Der Internist, 1966, Volume: 7, Issue:1 Topics: Acid-Base Equilibrium; Alkalosis; Ascites; Deficiency Diseases; Diet; Diuresis; Diuretics; Furosemid	1966
Diuretic-induced hyponatremia. Annals of internal medicine, 1971, Volume: 75, Issue:6 Topics: Adult; Aged; Alkalosis; Bendroflumethiazide; Biological Assay; Blood Urea Nitrogen; Bromine; Carbon	1971
[Water-sodium depletion and clonidine in severe arterial hypertension]. Maroc medical, 1972, Volume: 52, Issue:556 Topics: Adult; Antihypertensive Agents; Body Weight; Clonidine; Creatinine; Drug Synergism; Electrocardiogra	1972
Complications from diuretic therapy with ethacrynic acid and furosemide. Southern medical journal, 1971, Volume: 64, Issue:7 Topics: Adult; Alkalosis; Blood Volume; Ethacrynic Acid; Female; Furosemide; Humans; Hypokalemia; Hyponatrem	1971
[Diuresis and diuretics]. Wiener klinische Wochenschrift, 1971, Jun-25, Volume: 83, Issue:25 Topics: Acetazolamide; Acute Disease; Agranulocytosis; Anuria; Biological Transport; Blood Platelet Disorder	1971
Indications and contraindications for diuretic therapy. Annals of the New York Academy of Sciences, 1966, Nov-22, Volume: 139, Issue:2 Topics: Diuretics; Ethacrynic Acid; Female; Furosemide; Glomerular Filtration Rate; Hemodynamics; Humans; Hy	1966
The complications of diuretic therapy in patients with cirrhosis. Annals of the New York Academy of Sciences, 1966, Nov-22, Volume: 139, Issue:2 Topics: Alkalosis; Ascites; Blood Urea Nitrogen; Chlorothiazide; Ethacrynic Acid; Furosemide; Hepatic Enceph	1966
Complications of diuretic therapy: severe alkalosis and syndrome resembling inappropriate secretion of antidiuretic hormone. Metabolism: clinical and experimental, 1970, Volume: 19, Issue:9 Topics: Alkalosis; Bicarbonates; Blood Pressure; Blood Urea Nitrogen; Diet, Sodium-Restricted; Diuresis; Ede	1970
[Mechanims of the acute antihypertensive effect of pharmacologic sodium deprivation]. Klinische Wochenschrift, 1970, Feb-01, Volume: 48, Issue:3 Topics: Blood Pressure; Depression, Chemical; Female; Furosemide; Humans; Hypertension; Hyponatremia; Male;	1970
[Apropos of certain secondary effects of diuretics]. Acta clinica Belgica, 1968, Volume: 23, Issue:1 Topics: Blood Volume; Diabetes Mellitus; Diuretics; Ethacrynic Acid; Furosemide; Humans; Hyperkalemia; Hypon	1968
[Diuretics in cirrhosis. Accidents. Indications]. La Presse medicale, 1969, Mar-29, Volume: 77, Issue:16 Topics: Adrenal Cortex Hormones; Alkalosis; Blood Urea Nitrogen; Blood Volume; Diuretics; Edema; Ethacrynic	1969
[Saluretic therapy and insulin resistance in diabetes mellitus]. Medizinische Klinik, 1966, Dec-23, Volume: 61, Issue:51 Topics: Aged; Diabetes Complications; Diabetes Mellitus; Diabetic Coma; Female; Furosemide; Humans; Hyponatr	1966

furosemide and Hyponatremia