furosemide has been researched along with Hypertension, Pulmonary in 49 studies
Furosemide: A benzoic-sulfonamide-furan. It is a diuretic with fast onset and short duration that is used for EDEMA and chronic RENAL INSUFFICIENCY.
furosemide : A chlorobenzoic acid that is 4-chlorobenzoic acid substituted by a (furan-2-ylmethyl)amino and a sulfamoyl group at position 2 and 5 respectively. It is a diuretic used in the treatment of congestive heart failure.
Hypertension, Pulmonary: Increased VASCULAR RESISTANCE in the PULMONARY CIRCULATION, usually secondary to HEART DISEASES or LUNG DISEASES.
| Excerpt | Relevance | Reference |
|---|---|---|
| " The aim of this pilot study was to compare the effect of torasemide versus furosemide on systemic and pulmonary haemodynamics in patients with secondary pulmonary hypertension." | 9.13 | Secondary pulmonary hypertension: haemodynamic effects of torasemide versus furosemide. ( Schenk, H; Schlesinger, S; Spies, C; von Dossow, V; von Heymann, C, 2008) |
| "Thirteen patients with severe hypertension were treated with combined minoxidil, propranolol, and furosemide (mean daily doses 33 mg, 475 mg, and 578 mg, respectively) for nine to twenty-five months (mean 13." | 7.65 | Long-term treatment of severe hypertension with minoxidil, propranolol and furosemide. ( Bennet, CM; Blaufuss, A; Wilburn, RL, 1975) |
| " The aim of this pilot study was to compare the effect of torasemide versus furosemide on systemic and pulmonary haemodynamics in patients with secondary pulmonary hypertension." | 5.13 | Secondary pulmonary hypertension: haemodynamic effects of torasemide versus furosemide. ( Schenk, H; Schlesinger, S; Spies, C; von Dossow, V; von Heymann, C, 2008) |
| " Here we present a case of a 77-year old man initiated on a sildenfil regimen for the treatment of pulmonary hypertension, who developed sudden bilateral hearing loss after taking sildenafil, in the setting of high dose furosemide and diltiazem." | 3.79 | Sildenafil and furosemide associated ototoxicity: consideration of drug-drug interactions, synergy, and broader clinical relevance. ( Farquhar, D; Kim, RB; Mehta, S; Skeith, L; Yamashita, C, 2013) |
| "To determine whether dorsal displacement of the soft palate (DDSP) results in pulmonary artery hypertension and leads to increases in transmural pulmonary artery pressure (TPAP); to determine whether pulmonary hypertension can be prevented by prior administration of furosemide; and to determine whether tracheostomy reduces pulmonary hypertension." | 3.70 | Effects of extrathoracic airway obstruction on intrathoracic pressure and pulmonary artery pressure in exercising horses. ( Ainsworth, DM; Ducharme, NG; Erb, HN; Erickson, BK; Hackett, RP; Soderholm, LV; Thorson, LM, 1999) |
| "Thirteen patients with severe hypertension were treated with combined minoxidil, propranolol, and furosemide (mean daily doses 33 mg, 475 mg, and 578 mg, respectively) for nine to twenty-five months (mean 13." | 3.65 | Long-term treatment of severe hypertension with minoxidil, propranolol and furosemide. ( Bennet, CM; Blaufuss, A; Wilburn, RL, 1975) |
| "Babies with SS presenting with cardiac failure are prone to develop exaggerated pulmonary vascular disease." | 1.42 | Scimitar syndrome with absent right pulmonary artery and severe pulmonary hypertension treated with coil occlusion of aortopulmonary collaterals in a term neonate. ( Masud, F; Parappil, H; Salama, H; ur Rahman, S, 2015) |
| "Echocardiography detected left ventricular hypertrophy and diastolic dysfunction." | 1.39 | Pulmonary hypertension and refractory heart failure in a patient with Crow-Fukase (POEMS) syndrome. ( Hisa, S; Kanno, Y; Kobayashi, A; Mizukami, H; Nakazato, K; Noji, H; Ogawa, K; Ohkawara, H; Saitoh, S; Shichishima-Nakamura, A; Suzuki, H; Takahashi, H; Takeishi, Y; Yokokawa, T; Yoshihisa, A, 2013) |
| "A radiograph demonstrated pulmonary edema; echocardiography revealed an ostium secundum atrial septal defect with increased flow to the lung and severe pulmonary hypertension." | 1.37 | [Postoperative management of postpneumonectomy pulmonary edema in a patient with ostium secundum atrial septal defect]. ( Barberá, M; Marchante, M; Navarro, JL; Ramos, F; Vicente, R, 2011) |
| "We report a woman with myelofibrosis and myeloid metaplasia who presented with dyspnea and massive, painful splenomegaly." | 1.35 | [Dyspnea secondary to pulmonary hypertension in a patient with splenic myeloid metaplasia]. ( Anouti, S; Haddad, F; Jammal, M; Kettaneh, A; Maalouly, G; Nemnoum, R, 2009) |
| "The frusemide dose-response for attenuation of exercise-induced pulmonary capillary hypertension was studied in 7 healthy, exercise-conditioned Thoroughbred horses using previously described haemodynamic procedures." | 1.30 | Pulmonary vascular pressures of strenuously exercising Thoroughbreds after administration of varying doses of frusemide. ( Goetz, TE; Griffin, R; Manohar, M; Sullivan, E, 1997) |
| "Pregnancy was managed to term before she progressed to NYHA Class IV and cardiac failure at 37 wk gestation." | 1.30 | Cesarean section in a mother with uncorrected congenital coronary to pulmonary artery fistula. ( Ong, BC; Tan, SA; Tay, SM, 1999) |
| "Increased venous pressure caused by congestive heart failure and vomiting was implicated as the cause of bilateral uveal effusions." | 1.29 | Uveal effusion syndrome associated with primary pulmonary hypertension and vomiting. ( Akduman, L; Del Priore, LV; Kaplan, HJ; Meredith, T, 1996) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 15 (30.61) | 18.7374 |
| 1990's | 8 (16.33) | 18.2507 |
| 2000's | 15 (30.61) | 29.6817 |
| 2010's | 9 (18.37) | 24.3611 |
| 2020's | 2 (4.08) | 2.80 |
| Authors | Studies |
|---|---|
| Duvvuri, PD | 1 |
| Bhardwaj, C | 1 |
| Wattanakit, K | 1 |
| Wang, TS | 1 |
| Soni, K | 1 |
| De Marco, T | 1 |
| Yokokawa, T | 1 |
| Nakazato, K | 1 |
| Kanno, Y | 1 |
| Mizukami, H | 1 |
| Kobayashi, A | 1 |
| Yoshihisa, A | 1 |
| Takahashi, H | 1 |
| Shichishima-Nakamura, A | 1 |
| Ohkawara, H | 1 |
| Noji, H | 1 |
| Suzuki, H | 1 |
| Saitoh, S | 1 |
| Ogawa, K | 1 |
| Hisa, S | 1 |
| Takeishi, Y | 1 |
| Skeith, L | 1 |
| Yamashita, C | 1 |
| Mehta, S | 1 |
| Farquhar, D | 1 |
| Kim, RB | 1 |
| Pitsiou, G | 1 |
| Paspala, A | 1 |
| Bagalas, V | 1 |
| Boutou, AK | 1 |
| Stanopoulos, I | 1 |
| Parappil, H | 1 |
| Masud, F | 1 |
| Salama, H | 1 |
| ur Rahman, S | 1 |
| Tamura, Y | 1 |
| Kimura, M | 1 |
| Takei, M | 1 |
| Ono, T | 1 |
| Kuwana, M | 1 |
| Satoh, T | 1 |
| Fukuda, K | 1 |
| Humbert, M | 2 |
| Russell, NJ | 1 |
| Irwin, PJ | 1 |
| Hopper, BJ | 1 |
| Olivry, T | 1 |
| Nicholls, PK | 1 |
| Lammey, ML | 1 |
| Doane, CJ | 1 |
| Gigliotti, A | 1 |
| Lee, DR | 1 |
| Sleeper, MM | 1 |
| Khaldi, H | 1 |
| Marchand-Adam, S | 1 |
| Kannengiesser, C | 1 |
| Fabre, A | 1 |
| Debray, MP | 1 |
| Danel, C | 1 |
| Gougerot-Pocidalo, MA | 1 |
| El Benna, J | 1 |
| Aubier, M | 1 |
| Crestani, B | 1 |
| Haddad, F | 1 |
| Anouti, S | 1 |
| Maalouly, G | 1 |
| Jammal, M | 1 |
| Nemnoum, R | 1 |
| Kettaneh, A | 1 |
| Ebdrup, L | 1 |
| Pedersen, CM | 1 |
| Andersen, MH | 1 |
| Storgaard, M | 1 |
| Gueffet, JP | 1 |
| Piriou, N | 1 |
| Trochu, JN | 1 |
| Marchante, M | 1 |
| Ramos, F | 1 |
| Vicente, R | 1 |
| Navarro, JL | 1 |
| Barberá, M | 1 |
| Carrascosa, MF | 1 |
| Larroque, IC | 1 |
| Rivero, JL | 1 |
| García, JA | 1 |
| Hoz, MC | 1 |
| Ares, MA | 1 |
| López, XA | 1 |
| Caviedes, JR | 1 |
| Schneider, N | 1 |
| Harris, DK | 1 |
| Manohar, M | 5 |
| Goetz, TE | 5 |
| Sullivan, E | 1 |
| Griffin, R | 1 |
| Siva, A | 1 |
| Shah, AM | 1 |
| Bertoni, M | 1 |
| Niccoli, L | 1 |
| Porciello, G | 1 |
| Storri, L | 1 |
| Nannini, C | 1 |
| Manes, A | 1 |
| Palazzini, M | 1 |
| Galiè, N | 1 |
| Cantini, F | 1 |
| Schlag, K | 1 |
| Opitz, C | 1 |
| Wensel, R | 1 |
| Felix, S | 1 |
| Ewert, R | 1 |
| Nagashima, T | 1 |
| Masuyama, J | 1 |
| Okubo, H | 1 |
| Minota, S | 1 |
| Murcia Sánchez, E | 1 |
| Germán, MJ | 1 |
| Ibáñez, V | 1 |
| Pérez-Cerdá, F | 1 |
| Minotti, GC | 1 |
| Corsonello, A | 1 |
| Incalzi, RA | 1 |
| von Dossow, V | 1 |
| Spies, C | 1 |
| Schenk, H | 1 |
| Schlesinger, S | 1 |
| von Heymann, C | 1 |
| Pain, MC | 1 |
| Stannard, M | 1 |
| Sloman, G | 1 |
| Javier, R | 1 |
| Dumler, F | 1 |
| Park, JH | 1 |
| Bok, DV | 1 |
| Riley, RW | 1 |
| Levin, NW | 1 |
| Kassner, EG | 1 |
| Wideman, RF | 1 |
| Ismail, M | 1 |
| Kirby, YK | 1 |
| Bottje, WG | 1 |
| Moore, RW | 1 |
| Vardeman, RC | 1 |
| Akduman, L | 1 |
| Del Priore, LV | 1 |
| Kaplan, HJ | 1 |
| Meredith, T | 1 |
| Luciani, GB | 1 |
| Nichani, S | 1 |
| Chang, AC | 1 |
| Wells, WJ | 1 |
| Newth, CJ | 1 |
| Starnes, VA | 1 |
| Pfeifer, M | 1 |
| Bruckschlegel, G | 1 |
| Holmer, SR | 1 |
| Paul, M | 1 |
| Riegger, AJ | 1 |
| Schunkert, H | 1 |
| Hackett, RP | 1 |
| Ducharme, NG | 1 |
| Ainsworth, DM | 1 |
| Erickson, BK | 1 |
| Erb, HN | 1 |
| Soderholm, LV | 1 |
| Thorson, LM | 1 |
| Tay, SM | 1 |
| Ong, BC | 1 |
| Tan, SA | 1 |
| Magid, JH | 2 |
| Baker, GJ | 1 |
| Ulbricht, R | 1 |
| Bontkowski, S | 1 |
| Ghantous, S | 1 |
| Rothenbaum, P | 2 |
| Humphrey, S | 2 |
| Biddle, TL | 1 |
| Wilburn, RL | 1 |
| Blaufuss, A | 1 |
| Bennet, CM | 1 |
| Harari, A | 1 |
| Lemaire, F | 1 |
| Regnier, B | 1 |
| Rapin, M | 1 |
| Austin, SM | 1 |
| Schreiner, BF | 1 |
| Kramer, DH | 1 |
| Shah, PM | 1 |
| Yu, PN | 1 |
| Morrison, DA | 1 |
| Gay, RG | 1 |
| Feldshon, D | 1 |
| Sampliner, RE | 1 |
| Steeg, CN | 1 |
| Ellis, K | 1 |
| Gersony, WM | 1 |
| Hill, MG | 1 |
| Malmquist, J | 1 |
| Trell, E | 1 |
| Torp, A | 1 |
| Lindström, C | 1 |
| Singh, I | 1 |
| Schweizer, W | 1 |
| Levi, GF | 1 |
| Proto, C | 1 |
1 review available for furosemide and Hypertension, Pulmonary
| Article | Year |
|---|---|
Pulmonary hypertension in primary Sjögren's syndrome: report of a case and review of the literature.
Topics: Anticoagulants; Drug Therapy, Combination; Electrocardiography; Female; Follow-Up Studies; Furosemid | 2005 |
3 trials available for furosemide and Hypertension, Pulmonary
| Article | Year |
|---|---|
Sildenafil in older patients with secondary pulmonary hypertension.
Topics: Aged; Aged, 80 and over; Diuretics; Female; Furosemide; Humans; Hypertension, Pulmonary; Male; Piper | 2007 |
Secondary pulmonary hypertension: haemodynamic effects of torasemide versus furosemide.
Topics: Administration, Oral; Aged; Angiotensin II; Antihypertensive Agents; Cardiac Output; Diuretics; Dose | 2008 |
Continuous versus intermittent furosemide infusion in critically ill infants after open heart operations.
Topics: Cardiac Output, Low; Cardiac Surgical Procedures; Cardiopulmonary Bypass; Critical Illness; Diuretic | 1997 |
45 other studies available for furosemide and Hypertension, Pulmonary
| Article | Year |
|---|---|
A 50-Year-Old Woman With Shortness of Breath.
Topics: Azygos Vein; Diuretics; Dyspnea; Esophageal and Gastric Varices; Female; Furosemide; Hepatitis C; Hu | 2021 |
Pressures at an All-Time High.
Topics: Atenolol; Blood Pressure; Female; Furosemide; Histoplasmosis; Humans; Hypertension, Pulmonary; Middl | 2020 |
Pulmonary hypertension and refractory heart failure in a patient with Crow-Fukase (POEMS) syndrome.
Topics: Aged; Dexamethasone; Diuretics; Drug Resistance; Edema; Furosemide; Heart Failure; Humans; Hypertens | 2013 |
Sildenafil and furosemide associated ototoxicity: consideration of drug-drug interactions, synergy, and broader clinical relevance.
Topics: Aged; Canada; Cytochrome P-450 CYP3A; Cytochrome P-450 CYP3A Inhibitors; Diltiazem; Diuretics; Dose- | 2013 |
Inhaled iloprost plus levosimendan to decompensate right heart failure due to chronic thromboembolic pulmonary hypertension.
Topics: Administration, Inhalation; Critical Care; Diuretics; Furosemide; Heart Failure; Humans; Hydrazones; | 2013 |
Scimitar syndrome with absent right pulmonary artery and severe pulmonary hypertension treated with coil occlusion of aortopulmonary collaterals in a term neonate.
Topics: Cardiac Catheterization; Collateral Circulation; Coronary Angiography; Diuretics; Echocardiography; | 2015 |
Oral vasopressin receptor antagonist tolvaptan in right heart failure due to pulmonary hypertension.
Topics: Administration, Oral; Adult; Aged; Antidiuretic Hormone Receptor Antagonists; Benzazepines; Drug Adm | 2015 |
Acute necrotising pulmonary vasculitis and pulmonary hypertension in a juvenile dog.
Topics: Acute Disease; Animals; Anti-Anxiety Agents; Dog Diseases; Dogs; Fatal Outcome; Female; Furosemide; | 2008 |
Diagnosis and treatment of pulmonary arterial hypertension and atrial fibrillation in an adult chimpanzee (Pan troglodytes).
Topics: Animals; Antihypertensive Agents; Aspirin; Atrial Fibrillation; Cardiotonic Agents; Digoxin; Diureti | 2008 |
Diffuse interstitial pneumonia and pulmonary hypertension: a novel manifestation of chronic granulomatous disease.
Topics: Adult; Biopsy; Bronchoalveolar Lavage; Bronchoscopy; Diagnosis, Differential; Diuretics; Furosemide; | 2009 |
[Dyspnea secondary to pulmonary hypertension in a patient with splenic myeloid metaplasia].
Topics: Anticoagulants; Cardiac Catheterization; Diagnosis, Differential; Diuretics; Drug Therapy, Combinati | 2009 |
Prolonged hyperthermia from furosemide infusion--a case report.
Topics: Adolescent; Cryoglobulinemia; Diuretics; Drug Therapy, Combination; Female; Fever; Furosemide; Human | 2010 |
Valvular heart disease associated with benfluorex.
Topics: Appetite Depressants; Diuretics; Echocardiography, Doppler, Color; Female; Fenfluramine; Furosemide; | 2010 |
[Postoperative management of postpneumonectomy pulmonary edema in a patient with ostium secundum atrial septal defect].
Topics: Adenocarcinoma; Amiodarone; Bundle-Branch Block; Combined Modality Therapy; Diuretics; Electric Coun | 2011 |
Pulmonary arterial hypertension associated with neurofibromatosis type 1.
Topics: Aged; Anticoagulants; Combined Modality Therapy; Diuretics; Dyspnea; Fatal Outcome; Female; Follow-U | 2010 |
Telemedicine success story.
Topics: Adult; Diuretics; Edema; Female; Furosemide; Home Care Agencies; Humans; Hypertension, Pulmonary; Lo | 2003 |
Pulmonary vascular pressures of strenuously exercising Thoroughbreds after administration of varying doses of frusemide.
Topics: Animals; Blood Pressure; Cross-Over Studies; Diuretics; Dose-Response Relationship, Drug; Exercise T | 1997 |
Moderate mitral stenosis in pregnancy: the haemodynamic impact of diuresis.
Topics: Adult; Diuretics; Echocardiography; Female; Furosemide; Humans; Hypertension, Pulmonary; Mitral Valv | 2005 |
[Pulmonary hypertension in hereditary haemorrhagic teleangiectasia (Rendu-Osler-Weber disease). Progression over 10 years].
Topics: Anticoagulants; Antihypertensive Agents; Bosentan; Calcium Channel Blockers; Diuretics; Endothelin R | 2005 |
Marked dilatation of pulmonary arteries in mixed connective tissue disease.
Topics: Activities of Daily Living; Azathioprine; Blood Pressure; Digoxin; Dilatation, Pathologic; Drug Ther | 2005 |
[Anesthetic management for mediastinoscopy in a patient with severe pulmonary hypertension].
Topics: Anesthesia, General; Bundle-Branch Block; Dermatomyositis; Dyslipidemias; Epoprostenol; Female; Fent | 2007 |
Disturbances of pulmonary function after acute myocardial infarction.
Topics: Adult; Aged; Blood Gas Analysis; Cardiac Output; Furosemide; Hemodynamics; Humans; Hypertension, Pul | 1967 |
Long-term treatment with minoxidil in patients with severe renal failure.
Topics: Acute Kidney Injury; Adult; Body Weight; Female; Furosemide; Humans; Hypertension; Hypertension, Pul | 1980 |
New drugs, more complications--old drugs, new complications: drug-related sequelae of neonatal intensive care.
Topics: Bezoars; Critical Care; Drug-Related Side Effects and Adverse Reactions; Furosemide; Humans; Hyperte | 1984 |
Furosemide reduces the incidence of pulmonary hypertension syndrome (ascites) in broilers exposed to cool environmental temperatures.
Topics: Animals; Body Weight; Chickens; Cold Temperature; Furosemide; Hypertension, Pulmonary; Incidence; Ma | 1995 |
Uveal effusion syndrome associated with primary pulmonary hypertension and vomiting.
Topics: Aged; Diuretics; Echocardiography; Exudates and Transudates; Female; Fluorescein Angiography; Fundus | 1996 |
Reciprocal regulation of pulmonary and cardiac angiotensin-converting enzyme in rats with severe left ventricular hypertrophy.
Topics: Animals; Blotting, Northern; Body Weight; Diuretics; Furosemide; Hypertension, Pulmonary; Hypertroph | 1998 |
Effects of extrathoracic airway obstruction on intrathoracic pressure and pulmonary artery pressure in exercising horses.
Topics: Airway Obstruction; Animals; Diuretics; Exercise Test; Female; Furosemide; Hemorrhage; Horse Disease | 1999 |
Cesarean section in a mother with uncorrected congenital coronary to pulmonary artery fistula.
Topics: Adult; Analgesics, Opioid; Anesthesia, Inhalation; Anesthesia, Intravenous; Anesthesia, Obstetrical; | 1999 |
Repeated administration of frusemide does not offer an advantage over single dosing in attenuating exercise-induced pulmonary hypertension in thoroughbred horses.
Topics: Animals; Diuretics; Drug Administration Schedule; Exercise Test; Furosemide; Horse Diseases; Horses; | 1999 |
Pulmonary vascular pressures of thoroughbred horses exercised 1, 2, 3 and 4 h after furosemide administration.
Topics: Animals; Diuretics; Drug Administration Schedule; Female; Furosemide; Hemodynamics; Horses; Hyperten | 2000 |
Clenbuterol administration does not enhance the efficacy of furosemide in attenuating the exercise-induced pulmonary capillary hypertension in Thoroughbred horses.
Topics: Adrenergic beta-Agonists; Animals; Clenbuterol; Diuretics; Drug Synergism; Furosemide; Horses; Hyper | 2000 |
Intravenous pentoxifylline does not enhance the pulmonary haemodynamic efficacy of frusemide in strenuously exercising thoroughbred horses.
Topics: Animals; Breeding; Diuretics; Drug Administration Schedule; Drug Interactions; Female; Furosemide; H | 2001 |
Hemodynamic concepts in treating acute pulmonary edema.
Topics: Aminophylline; Blood Gas Analysis; Cardiac Output; Digitalis Glycosides; Furosemide; Hemodynamics; H | 1977 |
Complicated myocardial infarction with chronic pulmonary disease. Problems in management.
Topics: Aged; Blood Pressure; Catheterization; Digitalis Glycosides; Diuretics; Dopamine; Furosemide; Humans | 1979 |
Long-term treatment of severe hypertension with minoxidil, propranolol and furosemide.
Topics: Cardiac Catheterization; Drug Therapy, Combination; Echocardiography; Edema; Furosemide; Humans; Hyd | 1975 |
[Hemodynamic study of pulmonary edemas due to the increase of alveolo-capillary permeability].
Topics: Adult; Aged; Blood Pressure; Capillary Permeability; Cardiac Output; Furosemide; Hemodynamics; Human | 1975 |
The acute hemodynamic effects of ethacrynic acid and furosemide in patients with chronic postcapillary pulmonary hypertension.
Topics: Adult; Blood Pressure; Blood Volume; Body Fluids; Cardiac Output; Chronic Disease; Ethacrynic Acid; | 1976 |
Severe pulmonary hypertension in a patient with Whipple's disease.
Topics: Drug Combinations; Furosemide; Heart Failure; Heart Murmurs; Humans; Hypertension, Pulmonary; Male; | 1985 |
Total anomalous pulmonary venous drainage with ventricular septal defect.
Topics: Angiocardiography; Cardiac Catheterization; Cardiomegaly; Digoxin; Electrocardiography; Extracorpore | 1973 |
Pulmonary hypertension in pregnancy.
Topics: Adult; Cyanosis; Delivery, Obstetric; Eisenmenger Complex; Female; Furosemide; Humans; Hypertension, | 1972 |
A case of drug-induced (?) pulmonary hypertension.
Topics: Appetite Depressants; Dextroamphetamine; Female; Furosemide; Humans; Hypertension, Pulmonary; Middle | 1970 |
High-altitude pulmonary edema.
Topics: Adolescent; Adult; Altitude; Diuretics; Furosemide; Humans; Hypertension, Pulmonary; Middle Aged; Mo | 1965 |
[Therapy of pulmonary edema].
Topics: Bloodletting; Cyanosis; Furosemide; Humans; Hypertension, Pulmonary; Injections, Intravenous; Morphi | 1966 |
[Hypotensive effect of furosemide on the pulmonary circulation of mitral patients. (Preliminary note)].
Topics: Adult; Diuretics; Female; Furosemide; Humans; Hypertension, Pulmonary; Male; Middle Aged; Mitral Val | 1966 |