Page last updated: 2024-10-27

furosemide and Hypercapnia

furosemide has been researched along with Hypercapnia in 16 studies

Furosemide: A benzoic-sulfonamide-furan. It is a diuretic with fast onset and short duration that is used for EDEMA and chronic RENAL INSUFFICIENCY.
furosemide : A chlorobenzoic acid that is 4-chlorobenzoic acid substituted by a (furan-2-ylmethyl)amino and a sulfamoyl group at position 2 and 5 respectively. It is a diuretic used in the treatment of congestive heart failure.

Hypercapnia: A clinical manifestation of abnormal increase in the amount of carbon dioxide in arterial blood.

Research Excerpts

ExcerptRelevanceReference
"Aerosolized furosemide has been shown to relieve dyspnea; nevertheless, all published studies have shown great variability in response."9.27Aerosol furosemide for dyspnea: Controlled delivery does not improve effectiveness. ( Banzett, RB; Lansing, RW; Morélot-Panzini, C; O'Donnell, CR; Schwartzstein, RM, 2018)
"We herein report two cases in which add-on acetazolamide to furosemide was effective for diuretic-resistant volume overload and hypercapnia."8.12The Effect of Add-on Acetazolamide to Conventional Diuretics for Diuretic-resistant Edema Complicated with Hypercapnia: A Report of Two Cases. ( Hisamichi, M; Ichikawa, D; Inoue, T; Shibagaki, Y; Yazawa, M, 2022)
"Aerosolized furosemide has been shown to relieve dyspnea; nevertheless, all published studies have shown great variability in response."5.27Aerosol furosemide for dyspnea: Controlled delivery does not improve effectiveness. ( Banzett, RB; Lansing, RW; Morélot-Panzini, C; O'Donnell, CR; Schwartzstein, RM, 2018)
"We previously showed that inhaled furosemide improves experimentally induced dyspnea."5.10Effects of inhaled furosemide on CO(2) ventilatory responsiveness in humans. ( Ide, T; Minowa, Y; Nishino, T, 2002)
"We herein report two cases in which add-on acetazolamide to furosemide was effective for diuretic-resistant volume overload and hypercapnia."4.12The Effect of Add-on Acetazolamide to Conventional Diuretics for Diuretic-resistant Edema Complicated with Hypercapnia: A Report of Two Cases. ( Hisamichi, M; Ichikawa, D; Inoue, T; Shibagaki, Y; Yazawa, M, 2022)
" Hypovolemia was induced by administration of furosemide, the body temperature (Tb) was gradually elevated to 42 degrees C by body surface heating."3.74Effects of hypovolemia on hypercapnic ventilatory response in experimental hyperthermia. ( Brozmanova, A; Calkovska, A; Javorka, K; Javorka, M; Zila, I, 2007)
"Normocapnic and chronic hypercapnic COPD patients have the same ventilatory and cerebrovascular carbon dioxide responsiveness irrespective of induced metabolic state."1.31Effects of acetazolamide and furosemide on ventilation and cerebral blood volume in normocapnic and hypercapnic patients with COPD. ( Colier, WN; Folgering, H; Oeseburg, B; van de Ven, MJ; van der Sluijs, MC; Vis, P, 2002)
"We quantitatively analyzed the effect of long-term administration of oral furosemide on the PaCO2 - H+ relationship in patients with chronic hypercapnic respiratory failure."1.30Effect of chronic furosemide administration on acid-base balance in patients with chronic hypercapnic respiratory failure. ( Kondo, T; Kumagai, M; Miyairi, A; Oh-Hori, KI; Ohta, Y; Urano, T, 1998)
"In conclusion, only hypercapnia and respiratory acidosis combined with hypoxemia decreases the natriuretic and diuretic effect of furosemide."1.27Furosemide pharmacodynamics: effect of respiratory and acid-base disturbances. ( Babini, R; du Souich, P, 1986)

Research

Studies (16)

TimeframeStudies, this research(%)All Research%
pre-19907 (43.75)18.7374
1990's2 (12.50)18.2507
2000's4 (25.00)29.6817
2010's2 (12.50)24.3611
2020's1 (6.25)2.80

Authors

AuthorsStudies
Inoue, T1
Hisamichi, M1
Ichikawa, D1
Shibagaki, Y1
Yazawa, M1
Morélot-Panzini, C1
O'Donnell, CR1
Lansing, RW2
Schwartzstein, RM2
Banzett, RB2
Windsor, R1
Petchey, W1
Minowa, Y1
Ide, T1
Nishino, T1
Moosavi, SH1
Binks, AP1
Topulos, GP1
Zila, I1
Brozmanova, A1
Javorka, M1
Calkovska, A1
Javorka, K1
Gaida, A1
Mazza, R1
Tanigaki, T1
Kondo, T2
Hayashi, Y1
Katoh, H1
Kamio, K1
Urano, T2
Ohta, Y2
Oh-Hori, KI1
Kumagai, M1
Miyairi, A1
van de Ven, MJ1
Colier, WN1
van der Sluijs, MC1
Oeseburg, B1
Vis, P1
Folgering, H1
Ullrich, KJ1
Rumrich, G1
Baumann, K1
Heinemann, HO1
Babini, R1
du Souich, P1
Johnson, DC1
Singer, S1
Hoop, B1
Kazemi, H1
Penman, RW1
Luke, RG1
Jarboe, TM1

Clinical Trials (2)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Specificity of Dyspnoea Relief With Inhaled Furosemide[NCT02881866]Phase 116 participants (Actual)Interventional2015-10-31Completed
Brain During Effort : Effects of Hypoxia With Respiratory Patients[NCT02854280]33 participants (Actual)Interventional2013-06-30Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trials

3 trials available for furosemide and Hypercapnia

ArticleYear
Aerosol furosemide for dyspnea: Controlled delivery does not improve effectiveness.
    Respiratory physiology & neurobiology, 2018, Volume: 247

    Topics: Administration, Inhalation; Aerosols; Cross-Over Studies; Double-Blind Method; Dyspnea; Female; Furo

2018
Effects of inhaled furosemide on CO(2) ventilatory responsiveness in humans.
    Pulmonary pharmacology & therapeutics, 2002, Volume: 15, Issue:4

    Topics: Administration, Inhalation; Adult; Carbon Dioxide; Chemoreceptor Cells; Cross-Over Studies; Diuretic

2002
Effect of inhaled furosemide on air hunger induced in healthy humans.
    Respiratory physiology & neurobiology, 2007, Apr-16, Volume: 156, Issue:1

    Topics: Administration, Inhalation; Adolescent; Adult; Analysis of Variance; Cross-Over Studies; Double-Blin

2007

Other Studies

13 other studies available for furosemide and Hypercapnia

ArticleYear
The Effect of Add-on Acetazolamide to Conventional Diuretics for Diuretic-resistant Edema Complicated with Hypercapnia: A Report of Two Cases.
    Internal medicine (Tokyo, Japan), 2022, Feb-01, Volume: 61, Issue:3

    Topics: Acetazolamide; Diuretics; Edema; Female; Furosemide; Humans; Hypercapnia; Male

2022
Metabolic alkalosis in a patient with dyspnoea.
    BMJ (Clinical research ed.), 2013, May-02, Volume: 346

    Topics: Acidosis; Asthma; Diuretics; Dyspnea; Female; Furosemide; Humans; Hypercapnia; Middle Aged; Pneumoni

2013
Effects of hypovolemia on hypercapnic ventilatory response in experimental hyperthermia.
    Journal of physiology and pharmacology : an official journal of the Polish Physiological Society, 2007, Volume: 58 Suppl 5, Issue:Pt 2

    Topics: Animals; Blood Gas Analysis; Blood Pressure; Blood Volume; Body Temperature; Diuretics; Female; Feve

2007
[Influence of a sulfonamide diuretic on the pO2 and on the acid-base equilibrium of chronic hypercapnic lung disease patients].
    Minerva medica, 1967, Jan-31, Volume: 58, Issue:9

    Topics: Acid-Base Equilibrium; Acidosis, Respiratory; Aged; Furosemide; Humans; Hypercapnia; Middle Aged; Ox

1967
Rapid response to inhaled frusemide in severe acute asthma with hypercapnia.
    Respiration; international review of thoracic diseases, 1997, Volume: 64, Issue:1

    Topics: Acute Disease; Administration, Inhalation; Asthma; Blood Gas Analysis; Diuretics; Dose-Response Rela

1997
Effect of chronic furosemide administration on acid-base balance in patients with chronic hypercapnic respiratory failure.
    The Tokai journal of experimental and clinical medicine, 1998, Volume: 23, Issue:4

    Topics: Acid-Base Equilibrium; Aged; Blood Gas Analysis; Dose-Response Relationship, Drug; Drug Administrati

1998
Effects of acetazolamide and furosemide on ventilation and cerebral blood volume in normocapnic and hypercapnic patients with COPD.
    Chest, 2002, Volume: 121, Issue:2

    Topics: Acetazolamide; Administration, Oral; Alkalosis; Blood Volume; Carbon Dioxide; Cerebrovascular Circul

2002
Renal proximal tubular buffer-(glycodiazine) transport. Inhomogeneity of local transport rate, dependence on sodium, effect of inhibitors and chronic adaptation.
    Pflugers Archiv : European journal of physiology, 1975, Jun-26, Volume: 357, Issue:3-4

    Topics: Acid-Base Equilibrium; Animals; Biological Transport; Carbonic Anhydrase Inhibitors; Choline; Furose

1975
Right-sided heart failure and the use of diuretics.
    The American journal of medicine, 1978, Volume: 64, Issue:3

    Topics: Adaptation, Physiological; Cardiac Output; Diuretics; Ethacrynic Acid; Furosemide; Heart Failure; Hu

1978
Furosemide pharmacodynamics: effect of respiratory and acid-base disturbances.
    The Journal of pharmacology and experimental therapeutics, 1986, Volume: 237, Issue:2

    Topics: Acidosis, Respiratory; Animals; Carbon Dioxide; Furosemide; Hypercapnia; Hypoxia; Kidney; Kinetics;

1986
Chloride flux from blood to CSF: inhibition by furosemide and bumetanide.
    Journal of applied physiology (Bethesda, Md. : 1985), 1987, Volume: 63, Issue:4

    Topics: Animals; Bumetanide; Chlorides; Chlorine; Diuretics; Dogs; Furosemide; Hypercapnia; Models, Biologic

1987
The lazy respiratory center--or how to recognize a tired horse. Clinical conference in pulmonary disease from Northwestern University-McGaw Medical Center, Chicago.
    Chest, 1974, Volume: 66, Issue:1

    Topics: Brain Diseases; Chemoreceptor Cells; Chronic Disease; Diagnosis, Differential; Diazepam; Digoxin; Fu

1974
Respiratory effects of hypochloremic alkalosis and potassium depletion in the dog.
    Journal of applied physiology, 1972, Volume: 33, Issue:2

    Topics: Acid-Base Equilibrium; Alkalosis; Animals; Bicarbonates; Carbon Dioxide; Chlorides; Desoxycorticoste

1972