furosemide has been researched along with Epilepsy in 19 studies
Furosemide: A benzoic-sulfonamide-furan. It is a diuretic with fast onset and short duration that is used for EDEMA and chronic RENAL INSUFFICIENCY.
furosemide : A chlorobenzoic acid that is 4-chlorobenzoic acid substituted by a (furan-2-ylmethyl)amino and a sulfamoyl group at position 2 and 5 respectively. It is a diuretic used in the treatment of congestive heart failure.
Epilepsy: A disorder characterized by recurrent episodes of paroxysmal brain dysfunction due to a sudden, disorderly, and excessive neuronal discharge. Epilepsy classification systems are generally based upon: (1) clinical features of the seizure episodes (e.g., motor seizure), (2) etiology (e.g., post-traumatic), (3) anatomic site of seizure origin (e.g., frontal lobe seizure), (4) tendency to spread to other structures in the brain, and (5) temporal patterns (e.g., nocturnal epilepsy). (From Adams et al., Principles of Neurology, 6th ed, p313)
| Excerpt | Relevance | Reference |
|---|---|---|
| "For bumetanide, it has been suggested that inhibition of the NKCC isoform NKCC1 in the membrane of brain neurons may be involved; however, NKCC1 is expressed by virtually all cell types in the brain, which makes any specific targeting of neuronal NKCC1 by bumetanide impossible." | 5.91 | The loop diuretic torasemide but not azosemide potentiates the anti-seizure and disease-modifying effects of midazolam in a rat model of birth asphyxia. ( Gramer, M; Kirchhoff, L; Löscher, W; Schmidt, R; Welzel, B, 2023) |
| "This study aimed to explore the effect of concomitant use of Furosemide (FRS) and Valproic acid (VPA), demonstrating anti-inflammation efficacy, on epilepsy, and its underlying mechanism." | 4.12 | The effect of valproic acid and furosemide on the regulation of the inflammasome complex (NLRP1 and NLRP3 mRNA) in the brain of epileptic animal model. ( Abdolmaleki, Z; Faedmaleki, F; Samadianzakaria, A, 2022) |
| " We also tested chlorthiazide and furosemide for seizure protection in animal models of epilepsy." | 3.71 | Are certain diuretics also anticonvulsants? ( Annegers, JF; Cascino, G; Hauser, WA; Hesdorffer, DC; Stables, JP, 2001) |
| "For bumetanide, it has been suggested that inhibition of the NKCC isoform NKCC1 in the membrane of brain neurons may be involved; however, NKCC1 is expressed by virtually all cell types in the brain, which makes any specific targeting of neuronal NKCC1 by bumetanide impossible." | 1.91 | The loop diuretic torasemide but not azosemide potentiates the anti-seizure and disease-modifying effects of midazolam in a rat model of birth asphyxia. ( Gramer, M; Kirchhoff, L; Löscher, W; Schmidt, R; Welzel, B, 2023) |
| "Furosemide was not found to alter synaptic field responses, excitatory postsynaptic currents or intrinsic membrane properties of principal hippocampal neurons." | 1.32 | A potential role for astrocytes in mediating the antiepileptic actions of furosemide in vitro. ( Baraban, SC; Barbaro, NM; Takahashi, DK, 2004) |
| " The anti-bursting activity of carbenoxolone showed dose-response dependence in the concentration range 50-400 microM." | 1.31 | Can gap-junction blockade preferentially inhibit neuronal hypersynchrony vs. excitability? ( Klitgaard, H; Margineanu, DG, 2001) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (15.79) | 18.7374 |
| 1990's | 2 (10.53) | 18.2507 |
| 2000's | 9 (47.37) | 29.6817 |
| 2010's | 3 (15.79) | 24.3611 |
| 2020's | 2 (10.53) | 2.80 |
| Authors | Studies |
|---|---|
| Samadianzakaria, A | 1 |
| Abdolmaleki, Z | 1 |
| Faedmaleki, F | 1 |
| Welzel, B | 1 |
| Schmidt, R | 1 |
| Kirchhoff, L | 1 |
| Gramer, M | 1 |
| Löscher, W | 1 |
| Viitanen, T | 1 |
| Ruusuvuori, E | 1 |
| Kaila, K | 2 |
| Voipio, J | 1 |
| Khirug, S | 1 |
| Ahmad, F | 1 |
| Puskarjov, M | 1 |
| Afzalov, R | 1 |
| Blaesse, P | 1 |
| Hochman, DW | 4 |
| Siniscalchi, A | 1 |
| Mancuso, F | 1 |
| Scornaienghi, D | 1 |
| Ferreri, G | 1 |
| De Sarro, G | 1 |
| Barbaro, NM | 1 |
| Takahashi, DK | 1 |
| Baraban, SC | 1 |
| Haglund, MM | 1 |
| Margineanu, DG | 2 |
| Klitgaard, H | 2 |
| Frey, HH | 1 |
| D'Ambrosio, R | 1 |
| Janigro, D | 1 |
| Schwartzkroin, PA | 2 |
| Gutschmidt, KU | 1 |
| Stenkamp, K | 1 |
| Buchheim, K | 1 |
| Heinemann, U | 2 |
| Meierkord, H | 1 |
| Hesdorffer, DC | 1 |
| Stables, JP | 1 |
| Hauser, WA | 1 |
| Annegers, JF | 1 |
| Cascino, G | 1 |
| Jauch, R | 1 |
| Windmüller, O | 1 |
| Lehmann, TN | 1 |
| Gabriel, S | 1 |
| Corcelle, P | 1 |
| Poirson, B | 1 |
| Dournovo, P | 1 |
| Duron, JJ | 1 |
| Garaix, JP | 1 |
| Delgado-Escueta, AV | 1 |
| Ahmad, S | 1 |
1 review available for furosemide and Epilepsy
| Article | Year |
|---|---|
The extracellular space and epileptic activity in the adult brain: explaining the antiepileptic effects of furosemide and bumetanide.
Topics: Animals; Anticonvulsants; Brain; Bumetanide; Diuretics; Epilepsy; Extracellular Space; Furosemide; H | 2012 |
2 trials available for furosemide and Epilepsy
| Article | Year |
|---|---|
Furosemide and mannitol suppression of epileptic activity in the human brain.
Topics: Adolescent; Adult; Child; Diagnostic Imaging; Diuretics; Dose-Response Relationship, Radiation; Elec | 2005 |
Renal insensitivity to frusemide caused by chronic anticonvulsant therapy.
Topics: Administration, Oral; Adult; Anticonvulsants; Clinical Trials as Topic; Diuresis; Drug Interactions; | 1974 |
16 other studies available for furosemide and Epilepsy
| Article | Year |
|---|---|
The effect of valproic acid and furosemide on the regulation of the inflammasome complex (NLRP1 and NLRP3 mRNA) in the brain of epileptic animal model.
Topics: Animals; Brain; Disease Models, Animal; DNA-Binding Proteins; Epilepsy; Furosemide; Inflammasomes; M | 2022 |
The loop diuretic torasemide but not azosemide potentiates the anti-seizure and disease-modifying effects of midazolam in a rat model of birth asphyxia.
Topics: Animals; Asphyxia; Bumetanide; Diuretics; Epilepsy; Furosemide; Rats; Sodium Potassium Chloride Symp | 2023 |
The K+-Cl cotransporter KCC2 promotes GABAergic excitation in the mature rat hippocampus.
Topics: Animals; Anticonvulsants; Barium; Bicarbonates; CA1 Region, Hippocampal; Carbonic Anhydrase Inhibito | 2010 |
A single seizure episode leads to rapid functional activation of KCC2 in the neonatal rat hippocampus.
Topics: Age Factors; Animals; Animals, Newborn; Biotinylation; Carbazoles; Enzyme Inhibitors; Epilepsy; Exci | 2010 |
Acute encephalopathy induced by oxcarbazepine and furosemide.
Topics: Anticonvulsants; Carbamazepine; Diuretics; Electroencephalography; Encephalitis; Epilepsy; Female; F | 2004 |
A potential role for astrocytes in mediating the antiepileptic actions of furosemide in vitro.
Topics: 4-Aminopyridine; Action Potentials; Animals; Anticonvulsants; Astrocytes; Barium; Cesium; Epilepsy; | 2004 |
Differential effects of cation-chloride co-transport-blocking diuretics in a rat hippocampal slice model of epilepsy.
Topics: Animals; Anticonvulsants; Bumetanide; Disease Models, Animal; Diuretics; Dose-Response Relationship, | 2006 |
Antiepileptic effect of loop diuretics? Comment to "Differential effects of cation-chloride co-transport-blocking diuretics in a rat hippocampal slice model of epilepsy" by Margineanu, Klitgaard, Epilepsy Res. 69 (2006) 93-99.
Topics: Animals; Bumetanide; Diuretics; Epilepsy; Ethacrynic Acid; Evoked Potentials; Furosemide; Rats | 2006 |
Extracellular chloride and the maintenance of spontaneous epileptiform activity in rat hippocampal slices.
Topics: 4-Aminopyridine; Animals; Bicuculline; Chlorides; Diuretics; Epilepsy; Furosemide; GABA Antagonists; | 1999 |
Anticonvulsant actions of furosemide in vitro.
Topics: 4-Aminopyridine; Action Potentials; Animals; Anticonvulsants; Calcium; Electric Stimulation; Entorhi | 1999 |
Chloride-cotransport blockade desynchronizes neuronal discharge in the "epileptic" hippocampal slice.
Topics: 4-Aminopyridine; Animals; Axons; Bicuculline; Carrier Proteins; Chlorides; Electric Stimulation; Epi | 2000 |
Can gap-junction blockade preferentially inhibit neuronal hypersynchrony vs. excitability?
Topics: 1-Octanol; Animals; Carbenoxolone; Diuretics; Dose-Response Relationship, Drug; Epilepsy; Evoked Pot | 2001 |
Are certain diuretics also anticonvulsants?
Topics: Aged; Animals; Case-Control Studies; Disease Models, Animal; Diuretics; Dose-Response Relationship, | 2001 |
Effects of barium, furosemide, ouabaine and 4,4'-diisothiocyanatostilbene-2,2'-disulfonic acid (DIDS) on ionophoretically-induced changes in extracellular potassium concentration in hippocampal slices from rats and from patients with epilepsy.
Topics: 2-Amino-5-phosphonovalerate; 4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid; Anesthetics, Local; A | 2002 |
[Fatal necrotizing pancreatitis following drowning in a swimming pool].
Topics: Acute Disease; Acute Kidney Injury; Adult; Drowning; Epilepsy; Furosemide; Hemolysis; Humans; Hydroc | 1976 |
Sodium outflux and influx within nerve terminals from chronic epileptogenic foci.
Topics: Acetylcholinesterase; Animals; Biological Transport, Active; Cats; Cerebral Cortex; Epilepsy; Ethacr | 1979 |