furosemide has been researched along with Disease Models, Animal in 182 studies
Furosemide: A benzoic-sulfonamide-furan. It is a diuretic with fast onset and short duration that is used for EDEMA and chronic RENAL INSUFFICIENCY.
furosemide : A chlorobenzoic acid that is 4-chlorobenzoic acid substituted by a (furan-2-ylmethyl)amino and a sulfamoyl group at position 2 and 5 respectively. It is a diuretic used in the treatment of congestive heart failure.
Disease Models, Animal: Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Furosemide, either alone or in combination with captopril, is capable to prevent myocardial calcification, cardiac hypertrophy and hypertension, maintaining blood Ca(2+) and phosphate levels by slowing CRF." | 9.14 | Myocardial calcification and hypertension following chronic renal failure and ameliorative effects of furosemide and captopril. ( Kang, HS; Kim, JS; Kim, SJ; Kim, SZ; Lee, YU; Rahman, M, 2010) |
| "Our previous study indicates that hydrochlorothiazide inhibits transforming growth factor (TGF)-β/Smad signaling pathway, improves cardiac function and reduces fibrosis." | 7.85 | Hydrochlorothiazide modulates ischemic heart failure-induced cardiac remodeling via inhibiting angiotensin II type 1 receptor pathway in rats. ( Chen, X; Gao, X; Lu, G; Luo, C; Luo, J; Peng, L; Zuo, Z, 2017) |
| "In an experimental heart failure model, we tested the hypothesis that furosemide causes excess mortality." | 7.78 | Furosemide induces mortality in a rat model of chronic heart failure. ( Anker, SD; Bauersachs, J; Bockmeyer, B; Doehner, W; Hocher, B; Rokutan, H; Springer, J; Strassburg, S; Suckow, C; von Haehling, S; von Websky, K; Waller, C, 2012) |
| " Here, we compared the effects of tolvaptan, a newly developed nonpeptide V(2) receptor antagonist, with those of furosemide, a loop diuretic, and a combination of these 2 agents in rats with left ventricular dysfunction after myocardial infarction (MI)." | 7.78 | Tolvaptan improves left ventricular dysfunction after myocardial infarction in rats. ( Fujiki, H; Hanatani, A; Iwao, H; Izumi, Y; Nakamura, Y; Osada-Oka, M; Shimada, K; Shiota, M; Yamashita, N; Yamazaki, T; Yoshiyama, M, 2012) |
| " We hypothesized that TRV120027 would elicit beneficial cardiorenal actions when added to furosemide in experimental heart failure." | 7.78 | TRV120027, a novel β-arrestin biased ligand at the angiotensin II type I receptor, unloads the heart and maintains renal function when added to furosemide in experimental heart failure. ( Boerrigter, G; Burnett, JC; Lark, MW; Soergel, DG; Violin, JD, 2012) |
| "Intraamniotic furosemide injection caused a substantial decrease in ID encountered in gastroschisis." | 7.77 | Induction of fetal diuresis with intraamniotic furosemide injection reduces intestinal damage in a rat model of gastroschisis. ( Akgür, FM; Flake, AW; Gürel, D; Hakguder, G; Olguner, M, 2011) |
| "We investigated the effects of tolvaptan, a vasopressin V(2)-receptor antagonist, on diuretic response and systemic and renal hemodynamic characteristics in conscious dogs with congestive heart failure (CHF)." | 7.77 | Effects of tolvaptan on systemic and renal hemodynamic function in dogs with congestive heart failure. ( Fujiki, H; Nakamura, S; Nakayama, S; Onogawa, T; Sakamoto, Y; Yamamura, Y, 2011) |
| "This study sought to investigate the cellular profile of NKCC1 expression in the lung and examine the effects of furosemide on several outcome measurements in a mouse model of allergic asthma." | 7.77 | Effects of furosemide on allergic asthmatic responses in mice. ( Ellis, R; Feng, M; Inman, MD; Lu, WY; Wang, S; Wattie, J; Xiang, YY, 2011) |
| "Nebulised furosemide treatment following phosgene induced acute lung injury does not improve survival and worsens PaO2: FiO2 ratio." | 7.76 | Furosemide in the treatment of phosgene induced acute lung injury. ( Fairhall, SJ; Grainge, C; Jenner, J; Jugg, BJ; Mann, T; Millar, T; Perrott, R; Rice, P; Smith, AJ, 2010) |
| "Ucn2 cotreatment with furosemide enhanced hemodynamic and renal function and diuretic responsiveness (without additional potassium depletion) in experimental heart failure." | 7.75 | Urocortin 2 inhibits furosemide-induced activation of renin and enhances renal function and diuretic responsiveness in experimental heart failure. ( Charles, CJ; Nicholls, MG; Rademaker, MT; Richards, AM, 2009) |
| " The experimental SIADH rat model was developed by means of continuous administration of arginine vasopressin (AVP) via a subcutaneously implanted osmotic mini pump, and hyponatremia was induced by additional water loading." | 7.74 | A novel vasopressin dual V1A/V2 receptor antagonist, conivaptan hydrochloride, improves hyponatremia in rats with syndrome of inappropriate secretion of antidiuretic hormone (SIADH). ( Arai, Y; Fujimori, A; Matsukawa, U; Miyata, K; Sasamata, M; Sudoh, K; Wada, K, 2007) |
| "Furosemide shortened the time to left ventricular dysfunction (35." | 7.72 | Furosemide and the progression of left ventricular dysfunction in experimental heart failure. ( Haigney, MC; Hanlon, SU; McCurley, JM; Michalski, M; Wedam, EF; Wei, SK, 2004) |
| "Auditory characteristics of metabolic or strial presbycusis were investigated using an animal model in which young adult Mongolian gerbils ( Meriones unguiculates) were implanted with an osmotic pump supplying furosemide continuously to the round window." | 7.72 | Metabolic presbycusis: differential changes in auditory brainstem and otoacoustic emission responses with chronic furosemide application in the gerbil. ( Mills, DM; Schmiedt, RA, 2004) |
| " Recombinant human serum albumin (rHSA) (1 g/kg) significantly decreased the weight of ascites in rats with puromycin aminonucleoside-induced nephropathy." | 7.70 | Effects of recombinant human serum albumin on ascites in rats with puromycin aminonucleoside-induced nephropathy. ( Hanada, S; Maruyama, T; Matsui, T; Nakamura, N; Shintome, M; Tsuchiyama, H; Tsukada, M; Yuki, T, 1998) |
| "We have examined the expression of insulin-like growth factor 1 (IGF-1), IGF binding protein-1 (IGFBP-1), and IGF binding protein-3 (IGFBP-3) in the rat distal nephron during increased cell work load and hypertrophy, induced by the diuretic, furosemide." | 7.69 | Tubular hypertrophy due to work load induced by furosemide is associated with increases of IGF-1 and IGFBP-1. ( Clemmons, DR; Kobayashi, S; Nogami, H; Roy, AK; Venkatachalam, MA, 1995) |
| " This study suggests that chronic administration of captopril, but not furosemide, could be beneficial in patients with HFpEF, particularly in those with comorbidities such as obesity, diabetes, and dyslipidemias." | 5.48 | Captopril Attenuates Cardiovascular and Renal Disease in a Rat Model of Heart Failure With Preserved Ejection Fraction. ( Bastacky, SI; Jackson, EK; Salah, EM; Tofovic, SP, 2018) |
| "Hypertension is a major risk factor for atherogenesis and heart hypertrophy, both of which are associated with specific morphological and functional changes of the myocardium." | 5.43 | Furosemide modifies heart hypertrophy and glycosaminoglycan myocardium content in a rat model of neurogenic hypertension. ( Karakiulakis, G; Kouvelas, D; Manthou, ME; Papakonstantinou, E; Pourzitaki, C; Tsaousi, G, 2016) |
| "Aminoglycoside antibiotics are highly effective agents against gram-negative bacterial infections, but they cause adverse effects on hearing and balance dysfunction as a result of toxicity to hair cells of the cochlea and vestibular organs." | 5.40 | Systemic lipopolysaccharide induces cochlear inflammation and exacerbates the synergistic ototoxicity of kanamycin and furosemide. ( Hirose, K; Li, SZ; Ohlemiller, KK; Ransohoff, RM, 2014) |
| "Furosemide has been shown to improve pulmonary gas exchange and intrapulmonary shunt in animal models of ARDS by preferential perfusion of nonedematous lung units." | 5.30 | Continuous dose furosemide as a therapeutic approach to acute respiratory distress syndrome (ARDS). ( Chendrasekhar, A; Moorman, DW; Paradise, NF; Reising, CA; Timberlake, GA; Wall, PL, 1999) |
| "Then furosemide treatment was stopped and the rat food was changed to 1% NaCl diet." | 5.30 | Effects of renal papillary-medullary lesion on the antihypertensive effect of furosemide and development of salt-sensitive hypertension in Dahl-S rats. ( Christensen, S; Haugan, K; Marcussen, N; Petersen, JS; Shalmi, M; Spannow, J, 1997) |
| "Furosemide, either alone or in combination with captopril, is capable to prevent myocardial calcification, cardiac hypertrophy and hypertension, maintaining blood Ca(2+) and phosphate levels by slowing CRF." | 5.14 | Myocardial calcification and hypertension following chronic renal failure and ameliorative effects of furosemide and captopril. ( Kang, HS; Kim, JS; Kim, SJ; Kim, SZ; Lee, YU; Rahman, M, 2010) |
| " There is no benefit for the use of mannitol as an osmotic diuretic over hydration in rhabdomyolysis." | 4.85 | Diuretics in acute kidney injury. ( Karajala, V; Kellum, JA; Mansour, W, 2009) |
| "The efficacy of willow bark extract in the treatment of painful mobility disorders, such as back pain and arthritis, has been attributed to the content of salicin and its derivatives as pro-drugs of salicylates." | 4.84 | Willow bark extract: the contribution of polyphenols to the overall effect. ( Jäggi, R; Khayyal, MT; Metz, J; Nahrstedt, A; Schmidt, M, 2007) |
| "This study aimed to explore the effect of concomitant use of Furosemide (FRS) and Valproic acid (VPA), demonstrating anti-inflammation efficacy, on epilepsy, and its underlying mechanism." | 4.12 | The effect of valproic acid and furosemide on the regulation of the inflammasome complex (NLRP1 and NLRP3 mRNA) in the brain of epileptic animal model. ( Abdolmaleki, Z; Faedmaleki, F; Samadianzakaria, A, 2022) |
| " In our study, dehydration duration and the iohexol dosage were found to be the two most important factors to develop a rat CIN model." | 3.91 | A novel rat model of contrast-induced nephropathy based on dehydration. ( Chen, LH; Cheng, WJ; Hu, C; Li, DY; Liu, K; Wang, JL; Xie, YL; Yin, WJ; Zhou, G; Zhou, LY; Zuo, SR; Zuo, XC, 2019) |
| "Our previous study indicates that hydrochlorothiazide inhibits transforming growth factor (TGF)-β/Smad signaling pathway, improves cardiac function and reduces fibrosis." | 3.85 | Hydrochlorothiazide modulates ischemic heart failure-induced cardiac remodeling via inhibiting angiotensin II type 1 receptor pathway in rats. ( Chen, X; Gao, X; Lu, G; Luo, C; Luo, J; Peng, L; Zuo, Z, 2017) |
| "Rats received nitric oxide synthase inhibitor L-NAME (10 mg/kg) and cyclooxygenase inhibitor indomethacin (10 mg/kg) to induce the risk for developing iodinated contrast-induced acute kidney injury before receiving one of the interventions: NAC, furosemide, or placebo." | 3.80 | Efficacy of preventive interventions for iodinated contrast-induced acute kidney injury evaluated by intrarenal oxygenation as an early marker. ( Franklin, T; Li, LP; Lu, J; Papadopoulou, MV; Prasad, PV; Solomon, R; Thacker, J; Zhou, Y, 2014) |
| " We hypothesized that TRV120027 would elicit beneficial cardiorenal actions when added to furosemide in experimental heart failure." | 3.78 | TRV120027, a novel β-arrestin biased ligand at the angiotensin II type I receptor, unloads the heart and maintains renal function when added to furosemide in experimental heart failure. ( Boerrigter, G; Burnett, JC; Lark, MW; Soergel, DG; Violin, JD, 2012) |
| " Here, we compared the effects of tolvaptan, a newly developed nonpeptide V(2) receptor antagonist, with those of furosemide, a loop diuretic, and a combination of these 2 agents in rats with left ventricular dysfunction after myocardial infarction (MI)." | 3.78 | Tolvaptan improves left ventricular dysfunction after myocardial infarction in rats. ( Fujiki, H; Hanatani, A; Iwao, H; Izumi, Y; Nakamura, Y; Osada-Oka, M; Shimada, K; Shiota, M; Yamashita, N; Yamazaki, T; Yoshiyama, M, 2012) |
| "In an experimental heart failure model, we tested the hypothesis that furosemide causes excess mortality." | 3.78 | Furosemide induces mortality in a rat model of chronic heart failure. ( Anker, SD; Bauersachs, J; Bockmeyer, B; Doehner, W; Hocher, B; Rokutan, H; Springer, J; Strassburg, S; Suckow, C; von Haehling, S; von Websky, K; Waller, C, 2012) |
| "This study sought to investigate the cellular profile of NKCC1 expression in the lung and examine the effects of furosemide on several outcome measurements in a mouse model of allergic asthma." | 3.77 | Effects of furosemide on allergic asthmatic responses in mice. ( Ellis, R; Feng, M; Inman, MD; Lu, WY; Wang, S; Wattie, J; Xiang, YY, 2011) |
| "We investigated the effects of tolvaptan, a vasopressin V(2)-receptor antagonist, on diuretic response and systemic and renal hemodynamic characteristics in conscious dogs with congestive heart failure (CHF)." | 3.77 | Effects of tolvaptan on systemic and renal hemodynamic function in dogs with congestive heart failure. ( Fujiki, H; Nakamura, S; Nakayama, S; Onogawa, T; Sakamoto, Y; Yamamura, Y, 2011) |
| "Intraamniotic furosemide injection caused a substantial decrease in ID encountered in gastroschisis." | 3.77 | Induction of fetal diuresis with intraamniotic furosemide injection reduces intestinal damage in a rat model of gastroschisis. ( Akgür, FM; Flake, AW; Gürel, D; Hakguder, G; Olguner, M, 2011) |
| "Nebulised furosemide treatment following phosgene induced acute lung injury does not improve survival and worsens PaO2: FiO2 ratio." | 3.76 | Furosemide in the treatment of phosgene induced acute lung injury. ( Fairhall, SJ; Grainge, C; Jenner, J; Jugg, BJ; Mann, T; Millar, T; Perrott, R; Rice, P; Smith, AJ, 2010) |
| ", Conium maculatum) and salicylic acid (Filipendula ulmaria, Salix viminalis, Fragaria vesca, Rubus idaeus) inhibited the development of main symptoms of inflammation, viz." | 3.75 | [Evaluation of anti-inflammatory activity of extracts from Siberian plants]. ( Aksinenko, SG; Andreeva, TI; Gaĭdamovich, NN; Kravtsova, SS; Nagorniak, IuG; Nesterova, IuV; Popova, EV; Povet'eva, TN; Suslov, NI, 2009) |
| "Ucn2 cotreatment with furosemide enhanced hemodynamic and renal function and diuretic responsiveness (without additional potassium depletion) in experimental heart failure." | 3.75 | Urocortin 2 inhibits furosemide-induced activation of renin and enhances renal function and diuretic responsiveness in experimental heart failure. ( Charles, CJ; Nicholls, MG; Rademaker, MT; Richards, AM, 2009) |
| " The experimental SIADH rat model was developed by means of continuous administration of arginine vasopressin (AVP) via a subcutaneously implanted osmotic mini pump, and hyponatremia was induced by additional water loading." | 3.74 | A novel vasopressin dual V1A/V2 receptor antagonist, conivaptan hydrochloride, improves hyponatremia in rats with syndrome of inappropriate secretion of antidiuretic hormone (SIADH). ( Arai, Y; Fujimori, A; Matsukawa, U; Miyata, K; Sasamata, M; Sudoh, K; Wada, K, 2007) |
| "We hypothesized that the increased urinary Ca2+ and Mg2+ excretion and bone loss that accompanies aldosteronism is aggravated with furosemide and is attenuated by spironolactone." | 3.73 | Diuretics and bone loss in rats with aldosteronism. ( Bhattacharya, SK; Chhokar, VS; Law, PH; Sun, Y; Weber, KT, 2005) |
| " The present work reports the consequences on high- vs low-level DPOAEs of three types of cochlear impairments involving OHCs: progressive OHC degeneration of genetic origin in CD1 mice, complete cochlear ischemia in gerbils, and furosemide injection vs ischemia-reperfusion in gerbils." | 3.72 | Physiopathological significance of distortion-product otoacoustic emissions at 2f1-f2 produced by high- versus low-level stimuli. ( Avan, P; Bonfils, P; Gilain, L; Mom, T, 2003) |
| "Auditory characteristics of metabolic or strial presbycusis were investigated using an animal model in which young adult Mongolian gerbils ( Meriones unguiculates) were implanted with an osmotic pump supplying furosemide continuously to the round window." | 3.72 | Metabolic presbycusis: differential changes in auditory brainstem and otoacoustic emission responses with chronic furosemide application in the gerbil. ( Mills, DM; Schmiedt, RA, 2004) |
| "Furosemide shortened the time to left ventricular dysfunction (35." | 3.72 | Furosemide and the progression of left ventricular dysfunction in experimental heart failure. ( Haigney, MC; Hanlon, SU; McCurley, JM; Michalski, M; Wedam, EF; Wei, SK, 2004) |
| " We also tested chlorthiazide and furosemide for seizure protection in animal models of epilepsy." | 3.71 | Are certain diuretics also anticonvulsants? ( Annegers, JF; Cascino, G; Hauser, WA; Hesdorffer, DC; Stables, JP, 2001) |
| "Changes in ischemic BW by fluid management correlated closely with changes in body weight except when high-dose mannitol was used." | 3.70 | Effects of fluid management on edema volume and midline shift in a rat model of ischemic stroke. ( Diringer, MN; He, YY; Hsu, CY; Lin, W; Paczynski, RP; Venkatesan, R, 2000) |
| "We previously demonstrated improved myocardial preservation with polarized (tetrodotoxin-induced), compared with depolarized (hyperkalemia-induced), arrest and hypothermic storage." | 3.70 | Long-term myocardial preservation: effects of hyperkalemia, sodium channel, and Na/K/2Cl cotransport inhibition on extracellular potassium accumulation during hypothermic storage. ( Chambers, DJ; Shattock, MJ; Snabaitis, AK, 1999) |
| " Recombinant human serum albumin (rHSA) (1 g/kg) significantly decreased the weight of ascites in rats with puromycin aminonucleoside-induced nephropathy." | 3.70 | Effects of recombinant human serum albumin on ascites in rats with puromycin aminonucleoside-induced nephropathy. ( Hanada, S; Maruyama, T; Matsui, T; Nakamura, N; Shintome, M; Tsuchiyama, H; Tsukada, M; Yuki, T, 1998) |
| "Furosemide is often used to reduce edema in patients with acute respiratory distress syndrome (ARDS)." | 3.69 | High-dose furosemide alters gas exchange in a model of acute lung injury. ( Clanton, TL; Gadek, JE; Op't Holt, TB; Waugh, JB, 1996) |
| " The ratio of heart weight to body weight and left ventricular cavity dimension were significantly smaller in both amiloride groups than those in furosemide and control (untreated DCM) groups (p < 0." | 3.69 | Beneficial effect of amiloride, A Na(+)-H+ exchange blocker, in a murine model of dilated cardiomyopathy. ( Hasegawa, S; Imai, S; Kanda, T; Kobayashi, I; Nagai, R; Nakano, M; Suzuki, T; Taniguchi, Y, 1996) |
| "Furosemide attenuates hyperpnea-induced airway obstruction (HIAO) in asthmatic subjects via unknown mechanism(s)." | 3.69 | Effect of furosemide on hyperpnea-induced airway obstruction, injury, and microvascular leakage. ( Freed, AN; Omori, C; Schofield, B; Taskar, V, 1996) |
| "We have examined the expression of insulin-like growth factor 1 (IGF-1), IGF binding protein-1 (IGFBP-1), and IGF binding protein-3 (IGFBP-3) in the rat distal nephron during increased cell work load and hypertrophy, induced by the diuretic, furosemide." | 3.69 | Tubular hypertrophy due to work load induced by furosemide is associated with increases of IGF-1 and IGFBP-1. ( Clemmons, DR; Kobayashi, S; Nogami, H; Roy, AK; Venkatachalam, MA, 1995) |
| "Nephrocalcinosis has been observed in premature infants treated with furosemide." | 3.68 | Furosemide increases total calcium in kidney and cytoplasmic free calcium in blood mononuclear cells of guinea pigs. ( Klip, A; Radde, IC; Tsao, PW, 1990) |
| "In an attempt to produce an animal model for the disease cystic fibrosis (CF), mice were treated chronically with the diuretics amiloride and furosemide, in order to cause chronic inhibition of transepithelial ion transport." | 3.68 | Effect of chronic treatment with diuretics on mouse liver: a morphological and microanalytical investigation. ( Mörk, AC; Roomans, GM; von Euler, A, 1992) |
| " min-1 furosemide in 5% body wt normal saline for the 60 min preceding 60 min of total renal ischemia." | 3.66 | Prior mannitol and furosemide infusion in a model of ischemic acute renal failure. ( Davidson, K; Hanley, MJ, 1981) |
| " In contradistinction, clonidine caused a dose-related hypotension in conscious unrestrained rats subjected to sodium depletion via furosemide." | 3.65 | Hypotensive effect of clonidine during sodium depletion in the rat. ( Pals, DT, 1975) |
| "The effects of each drug on hemodynamics were also compared." | 1.56 | Effects of Sodium-Glucose Cotransporter 2 Inhibition on Glucose Metabolism, Liver Function, Ascites, and Hemodynamics in a Mouse Model of Nonalcoholic Steatohepatitis and Type 2 Diabetes. ( Nakamoto, K; Tsubakimoto, M; Yabiku, K, 2020) |
| "Furosemide was infused for 60 min at 1." | 1.56 | Renal Nerve Deafferentation Attenuates the Fall in GFR during Intravenous Infusion of Furosemide in Anesthetized Rats. ( Araujo, M; Solis, G; Welch, WJ; Wilcox, CS, 2020) |
| " This study suggests that chronic administration of captopril, but not furosemide, could be beneficial in patients with HFpEF, particularly in those with comorbidities such as obesity, diabetes, and dyslipidemias." | 1.48 | Captopril Attenuates Cardiovascular and Renal Disease in a Rat Model of Heart Failure With Preserved Ejection Fraction. ( Bastacky, SI; Jackson, EK; Salah, EM; Tofovic, SP, 2018) |
| "Pharmacological treatment for heart failure involves different drugs as: angiotensin-converting enzyme inhibitors, B-adrenergic blockers, digitalis glycosides and diuretics." | 1.46 | [Analysis of the mitochondrial function and ultrastructure in healthy albino mice treated with heart failure medications] ( Baez, A; Bazán, C; Camino Willhuber, GO; Fretes, R; Guzman Mentesana, G; Lo Presti, S; Paglini-Oliva, PA; Rivarola, HW; Strauss, M, 2017) |
| "Hypertension is a major risk factor for atherogenesis and heart hypertrophy, both of which are associated with specific morphological and functional changes of the myocardium." | 1.43 | Furosemide modifies heart hypertrophy and glycosaminoglycan myocardium content in a rat model of neurogenic hypertension. ( Karakiulakis, G; Kouvelas, D; Manthou, ME; Papakonstantinou, E; Pourzitaki, C; Tsaousi, G, 2016) |
| "Nephrotic syndrome is a renal disease accompanied by abnormal body fluid balance." | 1.42 | Thirst and sodium appetite in rats with experimental nephrotic syndrome. ( Johnson, AK; Thunhorst, RL; Xu, J, 2015) |
| "Furosemide treatment significantly increased the urinary protein excretion when compared with the normal rats." | 1.40 | Comparative evaluation of torasemide and furosemide on rats with streptozotocin-induced diabetic nephropathy. ( Afrin, R; Arumugam, S; Giridharan, VV; Harima, M; Karuppagounder, V; Miyashita, S; Pitchaimani, V; Sreedhar, R; Suzuki, K; Thandavarayan, RA; Watanabe, K, 2014) |
| "Aminoglycoside antibiotics are highly effective agents against gram-negative bacterial infections, but they cause adverse effects on hearing and balance dysfunction as a result of toxicity to hair cells of the cochlea and vestibular organs." | 1.40 | Systemic lipopolysaccharide induces cochlear inflammation and exacerbates the synergistic ototoxicity of kanamycin and furosemide. ( Hirose, K; Li, SZ; Ohlemiller, KK; Ransohoff, RM, 2014) |
| " Dosing with dexamethasone following ototoxic insult shows promising yet variable response in hair cell survival." | 1.40 | Development of an ototoxicity model in the adult CBA/CaJ mouse and determination of a golden window of corticosteroid intervention for otoprotection. ( Fernandes, VT; Lin, VY, 2014) |
| "We conclude that severe sensorineural hearing loss can be induced in mice." | 1.39 | Deafness induction in mice. ( Bremer, HG; Grolman, W; Hendriksen, FG; Jansen, TT; Klis, SF; Topsakal, V, 2013) |
| "We used a murine model of arrhythmogenic right ventricular cardiomyopathy (ARVC) to test whether reducing ventricular load prevents or slows development of this cardiomyopathy." | 1.37 | Load-reducing therapy prevents development of arrhythmogenic right ventricular cardiomyopathy in plakoglobin-deficient mice. ( Breithardt, G; Coronel, R; de Bakker, JM; Ebnet, K; Fabritz, L; Fortmueller, L; Franke, WW; Hoogendijk, MG; Kirchhof, P; Kreienkamp, N; Laakmann, S; Levkau, B; Noppinger, PR; Piccini, I; Pieperhoff, S; Scicluna, BP; van Amersfoorth, SC; Wichter, T; Witt, H; Wolf, S, 2011) |
| " A dose-response study identified 200 mg/kg of furosemide as the optimal dose for disrupting the stria vascularis and opening the blood-ear barrier." | 1.37 | Co-administration of cisplatin and furosemide causes rapid and massive loss of cochlear hair cells in mice. ( Ding, D; Fu, Y; Jiang, H; Li, Y; Salvi, R, 2011) |
| "Furosemide did not cause an additional elevation of the threshold of the auditory nerve brainstem evoked response (ABR) over that induced by the salicylic acid injection." | 1.36 | How are the inner hair cells and auditory nerve fibers activated without the mediation of the outer hair cells and the cochlear amplifier? ( Adelman, C; Sohmer, H; Weinberger, JM, 2010) |
| "Furosemide was also s." | 1.36 | In vivo dilatation of the ductus arteriosus induced by furosemide in the rat. ( Momma, K; Nakanishi, T; Toyoshima, K, 2010) |
| " This treatment has to be continued for at least several months and decreasing the dosage must be progressive." | 1.35 | [Benign intracranial hypertension: the role of medical treatment]. ( Defoort, S; Dhellemmes, P; Vinchon, M, 2008) |
| "Acute renal failure was caused by D." | 1.35 | The effects of the nonsteroidal anti-inflammatory drug diclofenac sodium on the rat kidney, and alteration by furosemide. ( Balal, M; Besen, A; Dogan, A; Gonlusen, G; Inal, T; Kibar, M; Kose, F; Paydas, S, 2009) |
| "Treatment with furosemide significantly (p < 0." | 1.34 | Furosemide prevents apoptosis and associated gene expression in a rat model of surgical ischemic acute renal failure. ( Aravindan, N; Aravindan, S; Riedel, BJ; Shaw, AD; Weng, HR, 2007) |
| "The furosemide-induced increase in plasma renin concentration was significantly decreased in EP4-/- mice and to a lesser degree also in IP-/- mice." | 1.33 | Dominant role of prostaglandin E2 EP4 receptor in furosemide-induced salt-losing tubulopathy: a model for hyperprostaglandin E syndrome/antenatal Bartter syndrome. ( Bek, M; Jensen, B; Narumiya, S; Nüsing, RM; Seyberth, HW; Treude, A; Wagner, C; Weissenberger, C, 2005) |
| "Heart failure is often treated with ACE inhibitors and diuretics although diuretic treatment could activate the renin-angiotensin system (RAS)." | 1.32 | Effects of diuretic treatment on cardiac and circulating RAS in chronic heart failure post-myocardial infarction in rats. ( Böhm, M; Itter, G; Jockenhövel, F; Kouchi, I; Linz, W; Seeland, U; Zolk, O, 2003) |
| "Then furosemide treatment was stopped and the rat food was changed to 1% NaCl diet." | 1.30 | Effects of renal papillary-medullary lesion on the antihypertensive effect of furosemide and development of salt-sensitive hypertension in Dahl-S rats. ( Christensen, S; Haugan, K; Marcussen, N; Petersen, JS; Shalmi, M; Spannow, J, 1997) |
| "Furosemide has been shown to improve pulmonary gas exchange and intrapulmonary shunt in animal models of ARDS by preferential perfusion of nonedematous lung units." | 1.30 | Continuous dose furosemide as a therapeutic approach to acute respiratory distress syndrome (ARDS). ( Chendrasekhar, A; Moorman, DW; Paradise, NF; Reising, CA; Timberlake, GA; Wall, PL, 1999) |
| "Using various models of acute renal failure (ARF) in rats, the diuretic effects of 8-(noradamantan-3-yl)-1,3-dipropylxanthine (KW-3902), a novel adenosine A1-receptor antagonist (0." | 1.29 | Diuretic effects of KW-3902, a novel adenosine A1-receptor antagonist, in various models of acute renal failure in rats. ( Karasawa, A; Kusaka, H; Sano, J; Sato, K; Yao, K, 1994) |
| "Treatment with amiloride or furosemide in utero caused a decrease in cellular sodium and chloride levels, indicative of inhibition of transepithelial ion and fluid transport." | 1.28 | Effects of chronic and in utero treatment with diuretics on mouse exocrine cells studied by X-ray microanalysis. ( Mörk, AC; Roomans, GM; Von Euler, A, 1992) |
| "Hypokalemia resulted in ventricular arrhythmias in only 6 dogs, 2 of them exhibiting runs of ventricular tachycardia and even "torsade de pointes" as their potassium levels fell below 2 mmol/L." | 1.28 | Methods and limitations of an experimental model of long QT syndrome. ( Cheymol, G; Chezalviel, F; Cynober, L; Davy, JM; Engel, F; Guhennec, C; Lainée, P; Motté, G; Penin, E; Weissenburger, J, 1991) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 28 (15.38) | 18.7374 |
| 1990's | 31 (17.03) | 18.2507 |
| 2000's | 39 (21.43) | 29.6817 |
| 2010's | 72 (39.56) | 24.3611 |
| 2020's | 12 (6.59) | 2.80 |
| Authors | Studies |
|---|---|
| Avdeef, A | 1 |
| Tam, KY | 1 |
| Abrams, RPM | 1 |
| Yasgar, A | 1 |
| Teramoto, T | 1 |
| Lee, MH | 1 |
| Dorjsuren, D | 1 |
| Eastman, RT | 1 |
| Malik, N | 1 |
| Zakharov, AV | 1 |
| Li, W | 1 |
| Bachani, M | 1 |
| Brimacombe, K | 1 |
| Steiner, JP | 1 |
| Hall, MD | 1 |
| Balasubramanian, A | 1 |
| Jadhav, A | 1 |
| Padmanabhan, R | 1 |
| Simeonov, A | 1 |
| Nath, A | 1 |
| Wu, J | 1 |
| Shen, J | 1 |
| Wang, W | 1 |
| Jiang, N | 1 |
| Jin, H | 1 |
| Che, X | 1 |
| Ni, Z | 1 |
| Fang, Y | 1 |
| Mou, S | 1 |
| Samadianzakaria, A | 1 |
| Abdolmaleki, Z | 1 |
| Faedmaleki, F | 1 |
| Behrends, W | 1 |
| Ahrens, D | 1 |
| Bankstahl, JP | 1 |
| Esser, KH | 1 |
| Paasche, G | 1 |
| Lenarz, T | 1 |
| Scheper, V | 1 |
| Okamura, K | 1 |
| Lu, S | 1 |
| He, Z | 1 |
| Altmann, C | 1 |
| Montford, JR | 1 |
| Li, AS | 1 |
| Lucia, MS | 1 |
| Orlicky, DJ | 1 |
| Weiser-Evans, M | 1 |
| Faubel, S | 1 |
| Liu, K | 1 |
| Zhou, LY | 1 |
| Li, DY | 1 |
| Cheng, WJ | 1 |
| Yin, WJ | 1 |
| Hu, C | 1 |
| Xie, YL | 1 |
| Wang, JL | 1 |
| Zuo, SR | 1 |
| Chen, LH | 1 |
| Zhou, G | 1 |
| Zuo, XC | 1 |
| Araujo, M | 1 |
| Solis, G | 1 |
| Welch, WJ | 1 |
| Wilcox, CS | 2 |
| Ramekers, D | 3 |
| Klis, SFL | 1 |
| Versnel, H | 7 |
| Prieto-García, L | 1 |
| Vicente-Vicente, L | 1 |
| Blanco-Gozalo, V | 1 |
| Hidalgo-Thomas, O | 1 |
| García-Macías, MC | 1 |
| Kurtz, A | 2 |
| Layton, AT | 1 |
| Sanz, AB | 1 |
| Morales, AI | 1 |
| Martínez-Salgado, C | 1 |
| Pericacho, M | 1 |
| Sancho-Martínez, SM | 1 |
| López-Hernández, FJ | 1 |
| Andrade-Franzé, GMF | 1 |
| Pereira, ED | 1 |
| Yosten, GLC | 1 |
| Samson, WK | 1 |
| Menani, JV | 2 |
| De Luca, LA | 2 |
| Andrade, CAF | 1 |
| Yabiku, K | 1 |
| Nakamoto, K | 1 |
| Tsubakimoto, M | 1 |
| Rao, VS | 1 |
| Maulion, C | 1 |
| Asher, JL | 1 |
| Ivey-Miranda, JB | 1 |
| Cox, ZL | 1 |
| Moreno-Villagomez, J | 1 |
| Mahoney, D | 1 |
| Turner, JM | 1 |
| Wilson, FP | 1 |
| Testani, JM | 1 |
| Mandai, S | 1 |
| Furukawa, S | 1 |
| Kodaka, M | 1 |
| Hata, Y | 1 |
| Mori, T | 1 |
| Nomura, N | 2 |
| Ando, F | 1 |
| Mori, Y | 2 |
| Takahashi, D | 1 |
| Yoshizaki, Y | 1 |
| Kasagi, Y | 1 |
| Arai, Y | 2 |
| Sasaki, E | 1 |
| Yoshida, S | 2 |
| Furuichi, Y | 1 |
| Fujii, NL | 1 |
| Sohara, E | 2 |
| Rai, T | 2 |
| Uchida, S | 3 |
| Trojan, BP | 1 |
| Trojan, SJ | 1 |
| Navetta, A | 1 |
| Staches, B | 1 |
| Sutton, B | 1 |
| Filleur, S | 1 |
| Nelius, T | 1 |
| Kaur, T | 1 |
| Ohlemiller, KK | 2 |
| Warchol, ME | 1 |
| García-Alcántara, F | 1 |
| Murillo-Cuesta, S | 1 |
| Pulido, S | 1 |
| Bermúdez-Muñoz, JM | 1 |
| Martínez-Vega, R | 1 |
| Milo, M | 1 |
| Varela-Nieto, I | 1 |
| Rivera, T | 1 |
| Ma, YR | 1 |
| Luo, X | 1 |
| Wu, YF | 1 |
| Zhang, T | 1 |
| Zhang, F | 1 |
| Zhang, GQ | 1 |
| Wu, XA | 1 |
| Salah, EM | 1 |
| Bastacky, SI | 1 |
| Jackson, EK | 1 |
| Tofovic, SP | 1 |
| Camino Willhuber, GO | 1 |
| Guzman Mentesana, G | 1 |
| Baez, A | 1 |
| Lo Presti, S | 1 |
| Bazán, C | 1 |
| Strauss, M | 1 |
| Fretes, R | 1 |
| Paglini-Oliva, PA | 1 |
| Rivarola, HW | 1 |
| Deng, X | 1 |
| Liu, Z | 1 |
| Li, X | 1 |
| Zhou, Y | 2 |
| Hu, Z | 1 |
| Henry, KS | 1 |
| Sayles, M | 1 |
| Hickox, AE | 1 |
| Heinz, MG | 1 |
| Karmakar, S | 1 |
| Padman, A | 1 |
| Swamy Mane, N | 1 |
| Sen, T | 1 |
| Mesbahzadeh, B | 1 |
| Ajalloueyan, M | 1 |
| Kaka, GR | 1 |
| Askari, A | 1 |
| Hasanalifard, M | 1 |
| Jansen, TT | 1 |
| Bremer, HG | 1 |
| Topsakal, V | 1 |
| Hendriksen, FG | 2 |
| Klis, SF | 8 |
| Grolman, W | 8 |
| Ogawa, Y | 1 |
| Mochizuki, A | 1 |
| Nakamura, Y | 3 |
| Fujimoto, T | 1 |
| Sugita, C | 1 |
| Miyazaki, S | 1 |
| Tamaki, K | 1 |
| Nagayama, T | 1 |
| Nagai, Y | 1 |
| Inoue, S | 1 |
| Chiba, K | 1 |
| Nishi, T | 1 |
| Havenith, S | 3 |
| Yamazaki, T | 2 |
| Shiota, M | 2 |
| Osada-Oka, M | 2 |
| Fujiki, H | 3 |
| Hanatani, A | 2 |
| Shimada, K | 2 |
| Miura, K | 1 |
| Yoshiyama, M | 2 |
| Iwao, H | 2 |
| Izumi, Y | 2 |
| Wu, F | 1 |
| Mi, W | 1 |
| Cannon, SC | 1 |
| Schmitz, HM | 1 |
| Johnson, SB | 1 |
| Santi, PA | 1 |
| Fernandes, VT | 1 |
| Lin, VY | 1 |
| Hirose, K | 2 |
| Li, SZ | 1 |
| Ransohoff, RM | 1 |
| Li, LP | 1 |
| Thacker, J | 1 |
| Lu, J | 1 |
| Franklin, T | 1 |
| Papadopoulou, MV | 1 |
| Solomon, R | 1 |
| Prasad, PV | 1 |
| Wu, ZL | 1 |
| Ren, H | 1 |
| Lai, WY | 1 |
| Lin, S | 1 |
| Jiang, RY | 1 |
| Ye, TC | 1 |
| Shen, QB | 1 |
| Zeng, QC | 1 |
| Xu, DL | 1 |
| Arumugam, S | 2 |
| Sreedhar, R | 2 |
| Miyashita, S | 1 |
| Karuppagounder, V | 2 |
| Thandavarayan, RA | 2 |
| Giridharan, VV | 2 |
| Pitchaimani, V | 1 |
| Afrin, R | 1 |
| Harima, M | 3 |
| Suzuki, K | 2 |
| Watanabe, K | 3 |
| Hurley, SW | 1 |
| Zhang, Z | 1 |
| Beltz, TG | 1 |
| Xue, B | 1 |
| Johnson, AK | 2 |
| Grigson, PS | 1 |
| Colechio, EM | 1 |
| Power, ML | 1 |
| Schulkin, J | 1 |
| Norgren, R | 1 |
| Strahl, SB | 1 |
| Kaur, A | 1 |
| Bali, A | 1 |
| Singh, N | 1 |
| Jaggi, AS | 1 |
| Cil, O | 1 |
| Esteva-Font, C | 1 |
| Tas, ST | 1 |
| Su, T | 1 |
| Lee, S | 1 |
| Anderson, MO | 1 |
| Ertunc, M | 1 |
| Verkman, AS | 1 |
| Xu, J | 1 |
| Thunhorst, RL | 1 |
| Wang, Y | 3 |
| Qiao, L | 1 |
| Chen, Y | 1 |
| Wen, L | 1 |
| Yue, B | 1 |
| Qiu, J | 1 |
| Wu, S | 1 |
| Pourzitaki, C | 1 |
| Tsaousi, G | 1 |
| Manthou, ME | 1 |
| Karakiulakis, G | 1 |
| Kouvelas, D | 1 |
| Papakonstantinou, E | 1 |
| Żak, M | 1 |
| van der Linden, CA | 1 |
| Bezdjian, A | 1 |
| Jokinen, V | 1 |
| Lilius, T | 1 |
| Laitila, J | 1 |
| Niemi, M | 1 |
| Kambur, O | 1 |
| Kalso, E | 1 |
| Rauhala, P | 1 |
| Saporito, MS | 1 |
| Zuvich, E | 1 |
| DiCamillo, A | 1 |
| Antony, S | 1 |
| Nakamura, M | 1 |
| Suzuki, H | 1 |
| Sone, H | 1 |
| Fujimoto, E | 1 |
| Yamanaka, S | 1 |
| Kurihara, S | 1 |
| Tajiri, S | 1 |
| Izuhara, L | 1 |
| Katsuoka, Y | 1 |
| Yokote, S | 1 |
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| Kobayashi, E | 1 |
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| Chikaraishi, T | 1 |
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| Peng, L | 1 |
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| Karajala, V | 1 |
| Mansour, W | 1 |
| Kellum, JA | 1 |
| Gottlieb, SS | 1 |
| Dhellemmes, P | 1 |
| Defoort, S | 1 |
| Vinchon, M | 1 |
| Besen, A | 1 |
| Kose, F | 1 |
| Paydas, S | 1 |
| Gonlusen, G | 1 |
| Inal, T | 1 |
| Dogan, A | 1 |
| Kibar, M | 1 |
| Balal, M | 1 |
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| Dalhoff, E | 1 |
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| Zenner, HP | 1 |
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| Tanaka, H | 1 |
| Thanikachalam, PV | 1 |
| Yamaguchi, K | 1 |
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| Toyoshima, K | 1 |
| Momma, K | 1 |
| Nakanishi, T | 1 |
| Rademaker, MT | 1 |
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| Nicholls, MG | 1 |
| Richards, AM | 1 |
| Lang, H | 2 |
| Jyothi, V | 1 |
| Smythe, NM | 1 |
| Dubno, JR | 1 |
| Schulte, BA | 2 |
| Schmiedt, RA | 3 |
| Xiong, H | 2 |
| Chu, HQ | 1 |
| Huang, XW | 1 |
| Cui, YH | 1 |
| Zhou, LQ | 1 |
| Chen, J | 2 |
| Li, JL | 1 |
| Chen, QG | 1 |
| Li, ZY | 1 |
| Morimoto, Y | 1 |
| Shibata, Y | 1 |
| Rahman, M | 1 |
| Kim, SJ | 1 |
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| Kim, SZ | 1 |
| Lee, YU | 1 |
| Kang, HS | 1 |
| Yang, SS | 1 |
| Lo, YF | 1 |
| Wu, CC | 1 |
| Lin, SW | 1 |
| Yeh, CJ | 1 |
| Chu, P | 1 |
| Sytwu, HK | 1 |
| Sasaki, S | 3 |
| Lin, SH | 1 |
| Warner, L | 1 |
| Glockner, JF | 1 |
| Woollard, J | 1 |
| Textor, SC | 2 |
| Romero, JC | 1 |
| Lerman, LO | 2 |
| Agterberg, MJ | 2 |
| de Groot, JC | 2 |
| Sedee, RJ | 1 |
| de Almeida, RL | 1 |
| Constancio, J | 1 |
| Vendramini, RC | 1 |
| Fracasso, JF | 1 |
| Stronks, HC | 1 |
| Prijs, VF | 1 |
| Sato, E | 1 |
| Adelman, C | 1 |
| Weinberger, JM | 1 |
| Sohmer, H | 1 |
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| Zhou, X | 1 |
| Huang, X | 1 |
| Cui, Y | 2 |
| Zhou, L | 1 |
| Li, J | 1 |
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| Freece, JA | 1 |
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| Seyberth, HW | 1 |
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| Aravindan, N | 1 |
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| Riedel, BJ | 1 |
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| Hurley, PA | 1 |
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| Kobayashi, I | 1 |
| Nagai, R | 1 |
| Waugh, JB | 1 |
| Op't Holt, TB | 1 |
| Gadek, JE | 1 |
| Clanton, TL | 1 |
| Freed, AN | 1 |
| Taskar, V | 1 |
| Schofield, B | 1 |
| Omori, C | 1 |
| Haugan, K | 1 |
| Petersen, JS | 1 |
| Spannow, J | 1 |
| Ordóñez, FA | 1 |
| Fernández, P | 1 |
| Rodríguez, J | 1 |
| Martínez, V | 1 |
| Muñoz, R | 1 |
| Coto, T | 1 |
| Santos, F | 1 |
| Okazaki, T | 1 |
| Watanabe, T | 1 |
| Kikuchi, K | 1 |
| Suga, A | 1 |
| Shibasaki, M | 1 |
| Inagaki, O | 1 |
| Yanagisawa, I | 1 |
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| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A Randomised, Double-blind, Placebo-controlled, Phase II Clinical Trial With a Cross-over Design Assessing Efficacy of a Single Dose of Bumetanide in Reducing Focal Attack Severity in Hypokalaemic Periodic Paralysis Assessed Using the McManis Protocol[NCT02582476] | Phase 2 | 12 participants (Anticipated) | Interventional | 2015-01-31 | Terminated (stopped due to Slow enrolment and end of funding) | ||
| The Biological Characteristics of Adipose Tissue-derived Mesenchymal Stem Cells and Its Role in the Treatment of Chronic Renal Failure[NCT03321942] | 100 participants (Anticipated) | Interventional | 2017-01-01 | Recruiting | |||
| Hemodynamics and Extravascular Lung Water in Acute Lung Injury: A Prospective Randomized Controlled Multicentered Trial of Goal Directed Treatment of EVLW Versus Standard Management for the Treatment of Acute Lung Injury[NCT00624650] | Phase 2 | 33 participants (Actual) | Interventional | 2008-02-29 | Completed | ||
| Evaluation of the Impact of the HL Natural, Inc. Tension Relief Product on the Reduction of Symptoms in Adults Who Suffer From Mild to Moderate Tension Headaches[NCT04091555] | 117 participants (Actual) | Interventional | 2019-10-16 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
4 reviews available for furosemide and Disease Models, Animal
| Article | Year |
|---|---|
Diuretics in acute kidney injury.
Topics: Acute Kidney Injury; Animals; Cohort Studies; Combined Modality Therapy; Contraindications; Critical | 2009 |
Adenosine A1 antagonists and the cardiorenal syndrome.
Topics: Adenosine A1 Receptor Antagonists; Animals; Disease Models, Animal; Dose-Response Relationship, Drug | 2008 |
Studies on acute disease models.
Topics: Acute Kidney Injury; Animals; Disease Models, Animal; Female; Furosemide; In Vitro Techniques; Ische | 1982 |
Willow bark extract: the contribution of polyphenols to the overall effect.
Topics: Animals; Arthritis; Back Pain; Benzyl Alcohols; Cells, Cultured; Disease Models, Animal; Drug Compou | 2007 |
1 trial available for furosemide and Disease Models, Animal
| Article | Year |
|---|---|
Myocardial calcification and hypertension following chronic renal failure and ameliorative effects of furosemide and captopril.
Topics: Analysis of Variance; Animals; Antihypertensive Agents; Calcinosis; Captopril; Cardiomyopathies; Dis | 2010 |
177 other studies available for furosemide and Disease Models, Animal
| Article | Year |
|---|---|
How well can the Caco-2/Madin-Darby canine kidney models predict effective human jejunal permeability?
Topics: Animals; Disease Models, Animal; Dogs; Humans; Jejunal Diseases; Kidney Diseases; Models, Biological | 2010 |
Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors.
Topics: Animals; Antiviral Agents; Artificial Intelligence; Chlorocebus aethiops; Disease Models, Animal; Dr | 2020 |
A novel contrast-induced acute kidney injury mouse model based on low-osmolar contrast medium.
Topics: Acute Kidney Injury; Animals; Contrast Media; Disease Models, Animal; Furosemide; Iohexol; Kidney; M | 2022 |
The effect of valproic acid and furosemide on the regulation of the inflammasome complex (NLRP1 and NLRP3 mRNA) in the brain of epileptic animal model.
Topics: Animals; Brain; Disease Models, Animal; DNA-Binding Proteins; Epilepsy; Furosemide; Inflammasomes; M | 2022 |
Refinement of systemic guinea pig deafening in hearing research: Sensorineural hearing loss induced by co-administration of kanamycin and furosemide via the leg veins.
Topics: Animals; Disease Models, Animal; Furosemide; Guinea Pigs; Hair Cells, Auditory; Hearing; Hearing Los | 2023 |
IL-6 mediates the hepatic acute phase response after prerenal azotemia in a clinically defined murine model.
Topics: Acute Kidney Injury; Acute-Phase Reaction; Animals; Azotemia; Biomarkers; Disease Models, Animal; Fu | 2023 |
A novel rat model of contrast-induced nephropathy based on dehydration.
Topics: Acute Kidney Injury; Animals; Biomarkers; Contrast Media; Creatinine; Dehydration; Disease Models, A | 2019 |
Renal Nerve Deafferentation Attenuates the Fall in GFR during Intravenous Infusion of Furosemide in Anesthetized Rats.
Topics: Animals; Disease Models, Animal; Furosemide; Glomerular Filtration Rate; Humans; Infusions, Intraven | 2020 |
Simultaneous rather than retrograde spiral ganglion cell degeneration following ototoxically induced hair cell loss in the guinea pig cochlea.
Topics: Animals; Auditory Threshold; Deafness; Disease Models, Animal; Evoked Potentials, Auditory, Brain St | 2020 |
Pathophysiological mechanisms underlying a rat model of triple whammy acute kidney injury.
Topics: Acute Kidney Injury; Angiotensin-Converting Enzyme Inhibitors; Animals; Anti-Inflammatory Agents, No | 2020 |
Blockade of ERK1/2 activation with U0126 or PEP7 reduces sodium appetite and angiotensin II-induced pressor responses in spontaneously hypertensive rats.
Topics: Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Appetite; Butadienes; Captopril; D | 2021 |
Effects of Sodium-Glucose Cotransporter 2 Inhibition on Glucose Metabolism, Liver Function, Ascites, and Hemodynamics in a Mouse Model of Nonalcoholic Steatohepatitis and Type 2 Diabetes.
Topics: Animals; Ascites; Benzhydryl Compounds; Biomarkers; Blood Glucose; Diabetes Mellitus, Type 2; Diseas | 2020 |
Renal negative pressure treatment as a novel therapy for heart failure-induced renal dysfunction.
Topics: Animals; Cardio-Renal Syndrome; Disease Models, Animal; Diuresis; Female; Fluid Therapy; Furosemide; | 2021 |
Loop diuretics affect skeletal myoblast differentiation and exercise-induced muscle hypertrophy.
Topics: Animals; Bumetanide; Cell Differentiation; Cell Line; Disease Models, Animal; Diuretics; Furosemide; | 2017 |
Novel porcine model for calcium oxalate stone formation.
Topics: Ammonium Chloride; Animals; Blood Urea Nitrogen; Calcium Oxalate; Citric Acid; Creatinine; Disease M | 2017 |
Genetic disruption of fractalkine signaling leads to enhanced loss of cochlear afferents following ototoxic or acoustic injury.
Topics: Acoustic Stimulation; Animals; Cell Survival; CX3C Chemokine Receptor 1; Disease Models, Animal; Evo | 2018 |
The expression of oxidative stress response genes is modulated by a combination of resveratrol and N-acetylcysteine to ameliorate ototoxicity in the rat cochlea.
Topics: Acetylcysteine; Animals; Antioxidants; Apoptosis; Auditory Fatigue; Brain Stem; Cochlea; Cytoprotect | 2018 |
Alteration of renal excretion pathways in gentamicin-induced renal injury in rats.
Topics: Acute Kidney Injury; Animals; Antiporters; ATP Binding Cassette Transporter, Subfamily G, Member 2; | 2018 |
Captopril Attenuates Cardiovascular and Renal Disease in a Rat Model of Heart Failure With Preserved Ejection Fraction.
Topics: Angiotensin-Converting Enzyme Inhibitors; Animals; Blood Pressure; Captopril; Comorbidity; Disease M | 2018 |
[Analysis of the mitochondrial function and ultrastructure in healthy albino mice treated with heart failure medications]
Topics: Animals; Antihypertensive Agents; Atenolol; Cardiotonic Agents; Digoxin; Disease Models, Animal; Diu | 2017 |
Generation of new hair cells by DNA methyltransferase (Dnmt) inhibitor 5-azacytidine in a chemically-deafened mouse model.
Topics: Animals; Azacitidine; Cochlea; Disease Models, Animal; DNA (Cytosine-5-)-Methyltransferase 1; Ear, I | 2019 |
Divergent Auditory Nerve Encoding Deficits Between Two Common Etiologies of Sensorineural Hearing Loss.
Topics: Animals; Auditory Perception; Auditory Threshold; Chinchilla; Cochlear Nerve; Disease Models, Animal | 2019 |
Hypokalemia: a potent risk for QTc prolongation in clarithromycin treated rats.
Topics: Animals; Anti-Bacterial Agents; Arrhythmias, Cardiac; Clarithromycin; Dietary Supplements; Disease M | 2013 |
A model portraying experimental loss of hair cell: the use of distortion product otoacoustic emission in the assessment of rat's ear.
Topics: Amikacin; Animals; Deafness; Disease Models, Animal; Furosemide; Hair Cells, Auditory; Male; Otoacou | 2013 |
Deafness induction in mice.
Topics: Animals; Disease Models, Animal; Diuretics; Furosemide; Hair Cells, Auditory; Hearing Loss, Sensorin | 2013 |
Synthesis and optimization of novel (3S,5R)-5-(2,2-dimethyl-5-oxo-4-phenylpiperazin-1-yl)piperidine-3-carboxamides as orally active renin inhibitors.
Topics: Administration, Oral; Amides; Animals; Blood Pressure; Disease Models, Animal; Furosemide; Half-Life | 2013 |
A guinea pig model of selective severe high-frequency hearing loss.
Topics: Action Potentials; Animals; Cochlea; Disease Models, Animal; Furosemide; Guinea Pigs; Hair Cells, Au | 2013 |
Tolvaptan attenuates left ventricular fibrosis after acute myocardial infarction in rats.
Topics: Acute-Phase Reaction; Animals; Benzazepines; Disease Models, Animal; Drug Therapy, Combination; Fibr | 2013 |
Beneficial effects of bumetanide in a CaV1.1-R528H mouse model of hypokalaemic periodic paralysis.
Topics: Acetazolamide; Animals; Arginine; Bumetanide; Calcium Channels, L-Type; Carbonic Anhydrase Inhibitor | 2013 |
Kanamycin-furosemide ototoxicity in the mouse cochlea: a 3-dimensional analysis.
Topics: Animals; Cochlea; Cochlear Diseases; Disease Models, Animal; Female; Furosemide; Hair Cells, Auditor | 2014 |
Development of an ototoxicity model in the adult CBA/CaJ mouse and determination of a golden window of corticosteroid intervention for otoprotection.
Topics: Animals; Cell Survival; Dexamethasone; Disease Models, Animal; Furosemide; Hair Cells, Auditory; Kan | 2014 |
Systemic lipopolysaccharide induces cochlear inflammation and exacerbates the synergistic ototoxicity of kanamycin and furosemide.
Topics: Animals; Anti-Bacterial Agents; Cochlea; Cochlear Diseases; CX3C Chemokine Receptor 1; Disease Model | 2014 |
Efficacy of preventive interventions for iodinated contrast-induced acute kidney injury evaluated by intrarenal oxygenation as an early marker.
Topics: Acetylcysteine; Acute Kidney Injury; Acute-Phase Proteins; Animals; Biomarkers; Contrast Media; Dise | 2014 |
Sclederma of Poria cocos exerts its diuretic effect via suppression of renal aquaporin-2 expression in rats with chronic heart failure.
Topics: Administration, Oral; Animals; Aquaporin 2; Arginine Vasopressin; Chronic Disease; Disease Models, A | 2014 |
Comparative evaluation of torasemide and furosemide on rats with streptozotocin-induced diabetic nephropathy.
Topics: Animals; Blood Glucose; Body Weight; Diabetic Nephropathies; Disease Models, Animal; Diuretics; Echo | 2014 |
Sensitization of sodium appetite: evidence for sustained molecular changes in the lamina terminalis.
Topics: Animals; Appetite Regulation; Behavior, Animal; Captopril; Dehydration; Disease Models, Animal; Dizo | 2014 |
Local delivery of brain-derived neurotrophic factor on the perforated round window membrane in Guinea pigs: a possible clinical application.
Topics: Animals; Brain-Derived Neurotrophic Factor; Deafness; Disease Models, Animal; Drug Administration Ro | 2015 |
Parabrachial lesions in rats disrupt sodium appetite induced by furosemide but not by calcium deprivation.
Topics: Analysis of Variance; Animals; Appetite; Calcium; Calcium Chloride; Conditioning, Psychological; Des | 2015 |
Recovery characteristics of the electrically stimulated auditory nerve in deafened guinea pigs: relation to neuronal status.
Topics: Animals; Auditory Perception; Cochlear Implantation; Cochlear Nerve; Disease Models, Animal; Electri | 2015 |
Investigating the stress attenuating potential of furosemide in immobilization and electric foot-shock stress models in mice.
Topics: Animals; Behavior, Animal; Corticosterone; Disease Models, Animal; Dose-Response Relationship, Drug; | 2015 |
Salt-sparing diuretic action of a water-soluble urea analog inhibitor of urea transporters UT-A and UT-B in rats.
Topics: Animals; Binding Sites; Disease Models, Animal; Diuresis; Diuretics; Dogs; Drug Evaluation, Preclini | 2015 |
Thirst and sodium appetite in rats with experimental nephrotic syndrome.
Topics: Angiotensin II; Animals; Antibiotics, Antineoplastic; Appetite; Blood Pressure; Bronchodilator Agent | 2015 |
Establishment of a model of cochlear lesions in rats to study potential gene therapy for sensorineural hearing loss.
Topics: Adenoviridae; Animals; Axons; Cell Death; Disease Models, Animal; Furosemide; Gene Transfer Techniqu | 2015 |
Furosemide modifies heart hypertrophy and glycosaminoglycan myocardium content in a rat model of neurogenic hypertension.
Topics: Animals; Aorta; Cardiomegaly; Denervation; Disease Models, Animal; Epinephrine; Furosemide; Glycosam | 2016 |
Scar formation in mice deafened with kanamycin and furosemide.
Topics: Animals; Disease Models, Animal; Furosemide; Hair Cells, Auditory; Hearing Loss, Sensorineural; Kana | 2016 |
Do Diuretics have Antinociceptive Actions: Studies of Spironolactone, Eplerenone, Furosemide and Chlorothiazide, Individually and with Oxycodone and Morphine.
Topics: Analgesics; Analgesics, Opioid; Animals; Behavior, Animal; Brain; Chlorothiazide; Disease Models, An | 2017 |
A Mouse Model of Furosemide-Induced Overactive Bladder.
Topics: Animals; Disease Models, Animal; Furosemide; Male; Mice; Muscarinic Antagonists; Urinary Bladder; Ur | 2016 |
Comparative effects of torasemide and furosemide on gap junction proteins and cardiac fibrosis in a rat model of dilated cardiomyopathy.
Topics: Animals; Cadherins; Cardiac Myosins; Cardiomyopathy, Dilated; Connexin 43; Connexins; Disease Models | 2017 |
Embryonic kidney function in a chronic renal failure model in rodents.
Topics: Animals; Disease Models, Animal; Diuretics; Female; Furosemide; Gestational Age; Graft Survival; Kid | 2017 |
Hydrochlorothiazide modulates ischemic heart failure-induced cardiac remodeling via inhibiting angiotensin II type 1 receptor pathway in rats.
Topics: Aldosterone; Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Animals, Newborn; Cel | 2017 |
[Benign intracranial hypertension: the role of medical treatment].
Topics: Acetazolamide; Animals; Carbonic Anhydrase Inhibitors; Cerebrospinal Fluid Pressure; Child; Disease | 2008 |
The effects of the nonsteroidal anti-inflammatory drug diclofenac sodium on the rat kidney, and alteration by furosemide.
Topics: Acute Kidney Injury; Analysis of Variance; Animals; Anti-Inflammatory Agents, Non-Steroidal; Biopsy, | 2009 |
Accuracy of velocity distortion product otoacoustic emissions for estimating mechanically based hearing loss.
Topics: Acoustic Stimulation; Action Potentials; Anesthesia; Animals; Audiometry; Auditory Threshold; Diseas | 2009 |
[Effects of various diuretics on cardiac function in rats with heart failure].
Topics: Animals; Cytochrome P-450 CYP11B2; Disease Models, Animal; Diuretics; Furosemide; Heart Failure; Hem | 2009 |
In vivo dilatation of the ductus arteriosus induced by furosemide in the rat.
Topics: Animals; Animals, Newborn; Cesarean Section; Cyclooxygenase Inhibitors; Dilatation, Pathologic; Dise | 2010 |
Urocortin 2 inhibits furosemide-induced activation of renin and enhances renal function and diuretic responsiveness in experimental heart failure.
Topics: Aldosterone; Animals; Biomarkers; Cardiac Pacing, Artificial; Cardiovascular Agents; Corticotropin-R | 2009 |
Chronic reduction of endocochlear potential reduces auditory nerve activity: further confirmation of an animal model of metabolic presbyacusis.
Topics: Action Potentials; Adaptation, Physiological; Aging; Animals; Cochlear Nerve; Disease Models, Animal | 2010 |
[Rapid cochlea lesion induced by co-administration of kanamycin and furosemide in mouse].
Topics: Animals; Cell Death; Cochlea; Disease Models, Animal; Drug Synergism; Evoked Potentials, Auditory, B | 2010 |
Effects of various fragrant ingredients on desmopressin-induced fluid retention in mice.
Topics: Animals; Aromatherapy; Cyclohexenes; Deamino Arginine Vasopressin; Disease Models, Animal; Diuretics | 2010 |
SPAK-knockout mice manifest Gitelman syndrome and impaired vasoconstriction.
Topics: Animals; Aorta; Blood Pressure; Disease Models, Animal; Diuretics; Female; Furosemide; Gitelman Synd | 2010 |
Determinations of renal cortical and medullary oxygenation using blood oxygen level-dependent magnetic resonance imaging and selective diuretics.
Topics: Analysis of Variance; Animals; Disease Models, Animal; Diuretics; Furosemide; Glomerular Filtration | 2011 |
Spiral ganglion cell survival after round window membrane application of brain-derived neurotrophic factor using gelfoam as carrier.
Topics: Acoustic Stimulation; Animals; Auditory Threshold; Brain-Derived Neurotrophic Factor; Cell Shape; Ce | 2011 |
Lipopolysaccharide reduces sodium intake and sodium excretion in dehydrated rats.
Topics: Analysis of Variance; Angiotensin-Converting Enzyme Inhibitors; Animals; Antidiuretic Agents; Appeti | 2011 |
Effects of electrical stimulation on the acoustically evoked auditory-nerve response in guinea pigs with a high-frequency hearing loss.
Topics: Acoustic Stimulation; Animals; Auditory Threshold; Cochlea; Cochlear Implantation; Cochlear Micropho | 2011 |
Comparative analysis of combination kanamycin-furosemide versus kanamycin alone in the mouse cochlea.
Topics: Acoustic Stimulation; Animals; Atrophy; Auditory Threshold; Cell Death; Cell Movement; Cochlea; Dise | 2011 |
How are the inner hair cells and auditory nerve fibers activated without the mediation of the outer hair cells and the cochlear amplifier?
Topics: Animals; Anion Transport Proteins; Cochlear Nerve; Disease Models, Animal; Evoked Potentials, Audito | 2010 |
Conservation of endocochlear potential in mice with profound hearing loss induced by co-administration of kanamycin and furosemide.
Topics: Animals; Anti-Bacterial Agents; Auditory Threshold; Cell Death; Cell Survival; Cochlea; Cochlear Mic | 2011 |
Furosemide in the treatment of phosgene induced acute lung injury.
Topics: Acute Lung Injury; Administration, Inhalation; Animals; Disease Models, Animal; Female; Furosemide; | 2010 |
Load-reducing therapy prevents development of arrhythmogenic right ventricular cardiomyopathy in plakoglobin-deficient mice.
Topics: Animals; Arrhythmogenic Right Ventricular Dysplasia; Cardiac Volume; Connexin 43; Disease Models, An | 2011 |
High salt differentially regulates surface NKCC2 expression in thick ascending limbs of Dahl salt-sensitive and salt-resistant rats.
Topics: Absorption; Animals; Blood Pressure; Cell Membrane; Disease Models, Animal; Furosemide; Hypertension | 2011 |
Induction of fetal diuresis with intraamniotic furosemide injection reduces intestinal damage in a rat model of gastroschisis.
Topics: Amnion; Animals; Disease Models, Animal; Diuresis; Diuretics; Fetal Therapies; Furosemide; Gastrosch | 2011 |
Furosemide induces mortality in a rat model of chronic heart failure.
Topics: Angiotensin-Converting Enzyme Inhibitors; Animals; Chronic Disease; Disease Models, Animal; Diuretic | 2012 |
Co-administration of cisplatin and furosemide causes rapid and massive loss of cochlear hair cells in mice.
Topics: Animals; Antineoplastic Agents; Auditory Threshold; Cell Death; Cisplatin; Disease Models, Animal; D | 2011 |
Differential effects of salicylate, quinine, and furosemide on Guinea pig inner and outer hair cell function revealed by the input-output relation of the auditory brainstem response.
Topics: Analgesics, Non-Narcotic; Animals; Anti-Inflammatory Agents, Non-Steroidal; Disease Models, Animal; | 2011 |
Generation and analyses of R8L barttin knockin mouse.
Topics: Animals; Bartter Syndrome; Chloride Channels; Disease Models, Animal; Furosemide; Gene Knock-In Tech | 2011 |
Effects of furosemide on allergic asthmatic responses in mice.
Topics: Allergens; Animals; Anti-Asthmatic Agents; Asthma; Bronchial Hyperreactivity; Bronchoalveolar Lavage | 2011 |
Effect of the cation-chloride cotransporter inhibitor furosemide in a rat model of postoperative pain.
Topics: Amino Acid Transport Systems, Basic; Animals; Disease Models, Animal; Furosemide; Injections, Spinal | 2011 |
Positive shifts of the GABAA receptor reversal potential due to altered chloride homeostasis is widespread after status epilepticus.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Analysis of Variance; Animals; Bi | 2011 |
Effects of tolvaptan on systemic and renal hemodynamic function in dogs with congestive heart failure.
Topics: Animals; Antidiuretic Hormone Receptor Antagonists; Arginine Vasopressin; Atrial Natriuretic Factor; | 2011 |
NADPH oxidase and PKC contribute to increased Na transport by the thick ascending limb during type 1 diabetes.
Topics: Animals; Biological Transport; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 1; Disease M | 2012 |
Loop diuretics have anxiolytic effects in rat models of conditioned anxiety.
Topics: Animals; Anti-Anxiety Agents; Anxiety; Bumetanide; Disease Models, Animal; Furosemide; Male; Rats; R | 2012 |
TRV120027, a novel β-arrestin biased ligand at the angiotensin II type I receptor, unloads the heart and maintains renal function when added to furosemide in experimental heart failure.
Topics: Angiotensin II Type 1 Receptor Blockers; Animals; Arrestins; Arterial Pressure; Atrial Natriuretic F | 2012 |
Tolvaptan improves left ventricular dysfunction after myocardial infarction in rats.
Topics: Animals; Antidiuretic Hormone Receptor Antagonists; Benzazepines; Disease Models, Animal; Dose-Respo | 2012 |
Changes in glomerular filtration rate after renal revascularization correlate with microvascular hemodynamics and inflammation in Swine renal artery stenosis.
Topics: Acetylcholine; Angioplasty, Balloon; Animals; Biomarkers; Disease Models, Animal; Female; Furosemide | 2012 |
Development of an animal model of nephrocalcinosis via selective dietary sodium and chloride depletion.
Topics: Animals; Blood Pressure; Calcium; Chlorides; Disease Models, Animal; Furosemide; Kidney; Male; Nephr | 2013 |
Spiral ganglion cell morphology in guinea pigs after deafening and neurotrophic treatment.
Topics: Animals; Auditory Threshold; Brain-Derived Neurotrophic Factor; Cell Shape; Cell Size; Cell Survival | 2013 |
Effects of furosemide applied chronically to the round window: a model of metabolic presbyacusis.
Topics: Action Potentials; Aging; Animals; Auditory Threshold; Cochlea; Disease Models, Animal; Female; Furo | 2002 |
Effects of renal denervation on tubular sodium handling in rats with CBL-induced liver cirrhosis.
Topics: Aldosterone; Animals; Common Bile Duct; Denervation; Disease Models, Animal; Diuretics; Female; Furo | 2003 |
Physiopathological significance of distortion-product otoacoustic emissions at 2f1-f2 produced by high- versus low-level stimuli.
Topics: Acoustic Stimulation; Animals; Auditory Threshold; Brain Stem; Cochlea; Deafness; Disease Models, An | 2003 |
Effects of diuretic treatment on cardiac and circulating RAS in chronic heart failure post-myocardial infarction in rats.
Topics: Angiotensin-Converting Enzyme Inhibitors; Animals; Chronic Disease; Disease Models, Animal; Diuretic | 2003 |
Metabolic presbycusis: differential changes in auditory brainstem and otoacoustic emission responses with chronic furosemide application in the gerbil.
Topics: Animals; Auditory Threshold; Disease Models, Animal; Diuretics; Evoked Potentials, Auditory, Brain S | 2004 |
Ensemble spontaneous activity in the guinea-pig cochlear nerve.
Topics: Acoustic Stimulation; Adenosine Triphosphate; Animals; Cochlear Nerve; Disease Models, Animal; Elect | 2004 |
Effects of forebrain circumventricular organ ablation on drinking or salt appetite after sodium depletion or hypernatremia.
Topics: Analysis of Variance; Animals; Appetite; Diet, Sodium-Restricted; Disease Models, Animal; Diuresis; | 2004 |
Furosemide and the progression of left ventricular dysfunction in experimental heart failure.
Topics: Adrenergic beta-Agonists; Aldosterone; Animals; Biomarkers; Disease Models, Animal; Disease Progress | 2004 |
Resprouting and survival of guinea pig cochlear neurons in response to the administration of the neurotrophins brain-derived neurotrophic factor and neurotrophin-3.
Topics: Animals; Brain-Derived Neurotrophic Factor; Cell Count; Cell Survival; Cochlea; Cochlear Implantatio | 2005 |
Dominant role of prostaglandin E2 EP4 receptor in furosemide-induced salt-losing tubulopathy: a model for hyperprostaglandin E syndrome/antenatal Bartter syndrome.
Topics: Actins; Animals; Bartter Syndrome; Cyclooxygenase Inhibitors; Dinoprostone; Disease Models, Animal; | 2005 |
Diuretics and bone loss in rats with aldosteronism.
Topics: Animals; Bone Density; Calcium; Disease Models, Animal; Diuretics; Furosemide; Hyperaldosteronism; M | 2005 |
Automated drug delivery system to control systemic arterial pressure, cardiac output, and left heart filling pressure in acute decompensated heart failure.
Topics: Animals; Antihypertensive Agents; Atrial Function, Left; Automation; Blood Pressure; Cardiac Output; | 2006 |
Differential effects of cation-chloride co-transport-blocking diuretics in a rat hippocampal slice model of epilepsy.
Topics: Animals; Anticonvulsants; Bumetanide; Disease Models, Animal; Diuretics; Dose-Response Relationship, | 2006 |
Lithium effectively complements vasopressin V2 receptor antagonist in the treatment of hyponatraemia of SIADH rats.
Topics: Animals; Antidiuretic Hormone Receptor Antagonists; Aquaporin 2; Benzazepines; Diabetes Insipidus, N | 2007 |
A novel vasopressin dual V1A/V2 receptor antagonist, conivaptan hydrochloride, improves hyponatremia in rats with syndrome of inappropriate secretion of antidiuretic hormone (SIADH).
Topics: Animals; Antidiuretic Hormone Receptor Antagonists; Arginine Vasopressin; Benzazepines; Disease Mode | 2007 |
Furosemide prevents apoptosis and associated gene expression in a rat model of surgical ischemic acute renal failure.
Topics: Acute Kidney Injury; Animals; Apoptosis; Disease Models, Animal; Diuretics; DNA Fragmentation; Furos | 2007 |
Furosemide potentiates the anticonvulsant action of valproate in the mouse maximal electroshock seizure model.
Topics: Analysis of Variance; Animals; Anticonvulsants; Brain; Disease Models, Animal; Dose-Response Relatio | 2007 |
Acoustic-electric interactions in the guinea pig auditory nerve: simultaneous and forward masking of the electrically evoked compound action potential.
Topics: Acoustic Stimulation; Adaptation, Physiological; Animals; Auditory Perception; Cochlear Nerve; Deafn | 2007 |
Schwann cells revert to non-myelinating phenotypes in the deafened rat cochlea.
Topics: Animals; Animals, Newborn; Cochlea; Deafness; Disease Models, Animal; Evoked Potentials, Auditory, B | 2007 |
Sox2 and JAGGED1 expression in normal and drug-damaged adult mouse inner ear.
Topics: Animals; Animals, Newborn; Anti-Bacterial Agents; Biomarkers; Calcium-Binding Proteins; Chickens; Co | 2008 |
Mice lacking the transient receptor vanilloid potential 1 channel display normal thirst responses and central Fos activation to hypernatremia.
Topics: Adrenergic beta-Agonists; Animals; Blood Proteins; Disease Models, Animal; Diuretics; Drinking; Furo | 2008 |
Taurine attenuates aminoglycoside ototoxicity by inhibiting inducible nitric oxide synthase expression in the cochlea.
Topics: Aminoglycosides; Animals; Cochlea; Disease Models, Animal; Down-Regulation; Drug Interactions; Evoke | 2008 |
Mouse model of type II Bartter's syndrome. I. Upregulation of thiazide-sensitive Na-Cl cotransport activity.
Topics: Adaptation, Physiological; Amiloride; Animals; Bartter Syndrome; Cation Transport Proteins; Chloride | 2008 |
[Experimental research about the effect of Rehmannia glutinosa on the drug effect fingerprints of the rabbit's blood serum of Yin deficiency and heat flourishing syndrome].
Topics: Animals; Chromatography, High Pressure Liquid; Disease Models, Animal; Drugs, Chinese Herbal; Endoto | 2007 |
Oestrogenic influence on brain AT1 receptor signalling on the thirst and sodium appetite in osmotically stimulated and sodium-depleted female rats.
Topics: Angiotensin II Type 1 Receptor Blockers; Angiotensin-Converting Enzyme Inhibitors; Animals; Brain; C | 2008 |
Drug safety in porphyria.
Topics: Animals; Disease Models, Animal; Furosemide; Humans; Porphyrias; Rats; Rifampin; Risk; Valproic Acid | 1980 |
[Evaluation of the efficacy of various hypotensive drugs in broad-breasted white turkeys as an experimental model of arterial hypertension with high catecholamine levels].
Topics: Animals; Antihypertensive Agents; Captopril; Catecholamines; Disease Models, Animal; Furosemide; Hyp | 1983 |
Effects of acute metabolic acid-base changes and furosemide on magnesium excretion in rats.
Topics: Acid-Base Imbalance; Acidosis; Alkalosis; Animals; Binding Sites; Biological Transport; Disease Mode | 1983 |
Prior mannitol and furosemide infusion in a model of ischemic acute renal failure.
Topics: Acute Kidney Injury; Animals; Disease Models, Animal; Female; Furosemide; Ischemia; Kidney; Kidney T | 1981 |
Comparative antihypertensive effects of a diuretic, reserpine, and hydralazine in the spontaneously hypertensive rat.
Topics: Animals; Body Weight; Disease Models, Animal; Female; Furosemide; Hydralazine; Hypertension; Intesti | 1981 |
Relative allergenicity of cow's milk and cow's milk-based formulas in an animal model.
Topics: Allergens; Anaphylaxis; Animals; Bronchial Spasm; Calcium Channel Blockers; Cattle; Chloride Channel | 1995 |
Tubular hypertrophy due to work load induced by furosemide is associated with increases of IGF-1 and IGFBP-1.
Topics: Animals; Carrier Proteins; Disease Models, Animal; Furosemide; Hypertrophy; Immunohistochemistry; In | 1995 |
Protective effects of KW-3902, an adenosine A1-receptor antagonist, against cisplatin-induced acute renal failure in rats.
Topics: Absorption; Acute Kidney Injury; Administration, Oral; Animals; Blood Urea Nitrogen; Cisplatin; Crea | 1995 |
Control of renin gene expression in 2 kidney-1 clip rats.
Topics: Animals; Arginine; Denervation; Disease Models, Animal; Furosemide; Gene Expression Regulation; Hype | 1994 |
Lithiuretic and natriuretic dose-response curves following constant intravenous administration of furosemide to euvolaemic rats.
Topics: Animals; Disease Models, Animal; Dose-Response Relationship, Drug; Female; Furosemide; Glomerular Fi | 1994 |
Protective effects of KW-3902, a novel adenosine A1-receptor antagonist, against gentamicin-induced acute renal failure in rats.
Topics: Acute Kidney Injury; Administration, Oral; Animals; Disease Models, Animal; Furosemide; Gentamicins; | 1994 |
Diuretic effects of KW-3902, a novel adenosine A1-receptor antagonist, in various models of acute renal failure in rats.
Topics: Acute Kidney Injury; Animals; Disease Models, Animal; Diuresis; Furosemide; Male; Purinergic P1 Rece | 1994 |
Reduction of urine volume ameliorates adriamycin-induced nephropathy.
Topics: Animals; Disease Models, Animal; Doxorubicin; Furosemide; Glomerulonephritis; Glomerulosclerosis, Fo | 1993 |
Comparison of the effects of EXP3174, an angiotensin II antagonist and enalaprilat on myocardial infarct size in anaesthetized dogs.
Topics: Anesthesia; Angiotensin I; Angiotensin II; Animals; Antihypertensive Agents; Blood Pressure; Coronar | 1993 |
[Effects of carperitide (alpha-human atrial natriuretic peptide) on acute congestive heart failure in dogs].
Topics: Animals; Atrial Natriuretic Factor; Disease Models, Animal; Dogs; Dose-Response Relationship, Drug; | 1993 |
Beneficial effect of amiloride, A Na(+)-H+ exchange blocker, in a murine model of dilated cardiomyopathy.
Topics: Amiloride; Angiotensin II; Animals; Body Weight; Cardiomyopathy, Dilated; Disease Models, Animal; Di | 1996 |
High-dose furosemide alters gas exchange in a model of acute lung injury.
Topics: Animals; Blood Gas Analysis; Disease Models, Animal; Dogs; Furosemide; Humans; Kidney; Pulmonary Ede | 1996 |
Effect of furosemide on hyperpnea-induced airway obstruction, injury, and microvascular leakage.
Topics: Airway Resistance; Animals; Asthma; Bronchoconstriction; Disease Models, Animal; Dogs; Furosemide; M | 1996 |
Effects of renal papillary-medullary lesion on the antihypertensive effect of furosemide and development of salt-sensitive hypertension in Dahl-S rats.
Topics: Animals; Antihypertensive Agents; Body Weight; Disease Models, Animal; Drinking Behavior; Furosemide | 1997 |
Rat models of normocalcemic hypercalciuria of different pathogenic mechanisms.
Topics: Animals; Calcitriol; Calcium; Creatinine; Disease Models, Animal; Female; Furosemide; Parathyroid Ho | 1998 |
Studies on nonpeptide angiotensin II receptor antagonists. IV. Synthesis and biological evaluation of 4-acrylamide-1H-imidazole derivatives.
Topics: Acrylamides; Angiotensin Receptor Antagonists; Animals; Antihypertensive Agents; Aorta, Thoracic; Bl | 1998 |
NaCl appetite in two strains of rat reported to be resistant to mineralocorticoid-induced hypertension.
Topics: Analysis of Variance; Animals; Appetite Regulation; Captopril; Desoxycorticosterone; Disease Models, | 1998 |
Effects of recombinant human serum albumin on ascites in rats with puromycin aminonucleoside-induced nephropathy.
Topics: Animals; Ascites; Disease Models, Animal; Diuretics; Drug Evaluation, Preclinical; Furosemide; Human | 1998 |
Continuous dose furosemide as a therapeutic approach to acute respiratory distress syndrome (ARDS).
Topics: Animals; Disease Models, Animal; Diuretics; Dogs; Furosemide; Hemodynamics; Humans; Lung; Lung Injur | 1999 |
Long-term myocardial preservation: effects of hyperkalemia, sodium channel, and Na/K/2Cl cotransport inhibition on extracellular potassium accumulation during hypothermic storage.
Topics: Animals; Chloride Channels; Disease Models, Animal; Diuretics; Dose-Response Relationship, Drug; Dru | 1999 |
Effects of fluid management on edema volume and midline shift in a rat model of ischemic stroke.
Topics: Animals; Body Weight; Brain Edema; Brain Ischemia; Cerebral Cortex; Dehydration; Disease Models, Ani | 2000 |
Effects of hepatotoxic doses of acetaminophen and furosemide on tissue concentrations of CoASH and CoASSG in vivo.
Topics: Acetaminophen; Alanine Transaminase; Animals; Chemical and Drug Induced Liver Injury; Chromatography | 2000 |
Minipig model for the study of voiding parameters in the conscious state and natural posture: normal urodynamic profiles.
Topics: Animals; Catheters, Indwelling; Disease Models, Animal; Diuretics; Female; Furosemide; Posture; Refe | 1998 |
Are certain diuretics also anticonvulsants?
Topics: Aged; Animals; Case-Control Studies; Disease Models, Animal; Diuretics; Dose-Response Relationship, | 2001 |
Synergism of dopamine plus furosemide in preventing acute renal failure in the dog.
Topics: Acute Kidney Injury; Animals; Disease Models, Animal; Dogs; Dopamine; Drug Synergism; Female; Furose | 1979 |
Effect of furosemide on acut ischaemic renal failure in the dog.
Topics: Acute Kidney Injury; Animals; Disease Models, Animal; Dogs; Furosemide; Kidney; Kidney Function Test | 1978 |
Molecular basis for several drug-induced nephropathies.
Topics: Acetaminophen; Analgesics; Animals; Carbon Tetrachloride Poisoning; Cephaloridine; Chloroform; Cytoc | 1977 |
[Protection against acute renal insufficiency by means of forced diuresis in an ischemic rat model].
Topics: Acute Kidney Injury; Animals; Creatinine; Desoxycorticosterone; Disease Models, Animal; Diuresis; Fu | 1977 |
Reduction of folic acid-induced acute tubular injury by diuresis: an experimental model.
Topics: Acute Kidney Injury; Animals; Blood Urea Nitrogen; Body Weight; Disease Models, Animal; Diuresis; DN | 1976 |
Hypotensive effect of clonidine during sodium depletion in the rat.
Topics: Animals; Blood Pressure; Clonidine; Disease Models, Animal; Dose-Response Relationship, Drug; Drug S | 1975 |
Effect of chronic treatment with diuretics on mouse liver: a morphological and microanalytical investigation.
Topics: Amiloride; Animals; Cystic Fibrosis; Disease Models, Animal; Electron Probe Microanalysis; Female; F | 1992 |
Effects of renin-angiotensin system blockade in guinea pigs.
Topics: Angiotensin-Converting Enzyme Inhibitors; Animals; Biphenyl Compounds; Blood Pressure; Bradykinin; C | 1992 |
Effects of chronic and in utero treatment with diuretics on mouse exocrine cells studied by X-ray microanalysis.
Topics: Amiloride; Animals; Animals, Newborn; Anions; Cystic Fibrosis; Disease Models, Animal; Diuretics; El | 1992 |
Methods and limitations of an experimental model of long QT syndrome.
Topics: Animals; Arrhythmias, Cardiac; Atrioventricular Node; Benzothiadiazines; Creatinine; Databases, Bibl | 1991 |
Ototoxicity of furosemide during development.
Topics: Animals; Animals, Newborn; Cochlea; Disease Models, Animal; Electrophysiology; Furosemide; Humans; I | 1991 |
Contrast medium-induced acute renal failure. Can it be prevented?
Topics: Acute Kidney Injury; Animals; Contrast Media; Disease Models, Animal; Furosemide; Humans; Mannitol; | 1990 |
Characterization of a primate model of hypertension. The response of hypertensive and normotensive male vervets (Cercopithecus aethiops) to cold pressor stress, captopril administration, and acute bolus of atrial natriuretic factor.
Topics: Analysis of Variance; Animals; Atrial Natriuretic Factor; Blood Pressure; Blood Pressure Determinati | 1990 |
Adverse effects of dietary and furosemide-induced sodium depletion on thermoregulation.
Topics: Animals; Body Temperature Regulation; Diet, Sodium-Restricted; Disease Models, Animal; Furosemide; H | 1990 |
Furosemide increases total calcium in kidney and cytoplasmic free calcium in blood mononuclear cells of guinea pigs.
Topics: Analysis of Variance; Animals; Animals, Newborn; Calcium; Disease Models, Animal; Female; Furosemide | 1990 |
Changes in rat and mouse salivary glands and pancreas after chronic treatment with diuretics: a potential animal model for cystic fibrosis.
Topics: Acetazolamide; Amiloride; Animals; Biological Transport; Chlorides; Cystic Fibrosis; Disease Models, | 1990 |
Renin-angiotensin II response to the hemodynamic pathology of ovines with ventricular septal defect.
Topics: Angiotensin II; Animals; Captopril; Disease Models, Animal; Furosemide; Heart Septal Defects, Ventri | 1989 |
Prevention of the normal expansion of maternal plasma volume: a model for chronic fetal hypoxaemia.
Topics: Angiotensin II; Animals; Blood Pressure; Bloodletting; Catecholamines; Disease Models, Animal; Femal | 1989 |
Volume-dependent K+ transport in rabbit red blood cells comparison with oxygenated human SS cells.
Topics: Anemia, Sickle Cell; Animals; Anions; Biological Transport; Chlorides; Disease Models, Animal; Eryth | 1989 |
Augmented bicarbonate reabsorption by both the proximal and distal nephron maintains chloride-deplete metabolic alkalosis in rats.
Topics: Absorption; Acid-Base Equilibrium; Alkalosis; Animals; Arteries; Bicarbonates; Blood Pressure; Chlor | 1989 |
The chronically furosemide-treated mouse as a possible ultrastructural model for cystic fibrosis.
Topics: Animals; Chlorides; Cystic Fibrosis; Cytoplasmic Granules; Disease Models, Animal; Enzyme Precursors | 1987 |
The reserpine-treated rat as an experimental animal model for cystic fibrosis: abnormal Cl transport in pancreatic acinar cells.
Topics: 4-Acetamido-4'-isothiocyanatostilbene-2,2'-disulfonic Acid; 4,4'-Diisothiocyanostilbene-2,2'-Disulfo | 1988 |
Effects of chronic furosemide treatment on rat exocrine glands.
Topics: Animals; Biological Transport; Cations; Chlorides; Cystic Fibrosis; Disease Models, Animal; Exocrine | 1988 |
Different cation transport inhibitor in benign and malignant experimental renal hypertension.
Topics: Animals; Biological Transport; Cations; Depression, Chemical; Disease Models, Animal; Furosemide; Hy | 1986 |
Diuretics and carbohydrate metabolism: the effects of furosemide and amiloride on blood glucose, plasma insulin and cations in the rat.
Topics: Adrenalectomy; Amiloride; Animals; Blood Glucose; Chemical Phenomena; Chemistry; Diabetes Mellitus; | 1973 |
[Acute renal failure after scalding of the rat (author's transl)].
Topics: Acute Kidney Injury; Aldosterone; Animals; Anuria; Burns; Diabetes Insipidus; Disease Models, Animal | 1974 |
Influence of sodium withdrawal by a diuretic agent or peritoneal dialysis on arterial pressure in one-kidney Goldblatt hypertension in the rat.
Topics: Animals; Blood Pressure; Desoxycorticosterone; Disease Models, Animal; Furosemide; Hypertension, Ren | 1973 |
Disturbances of the control of renin secretion in chronic one-kidney-Goldblatt hypertension in the rat.
Topics: Animals; Blood Pressure; Constriction; Disease Models, Animal; Furosemide; Hypertension, Renal; Kidn | 1974 |
Relative nephrotoxicity of cephalosporin antibiotics in an animal model.
Topics: Acute Kidney Injury; Animals; Blood Urea Nitrogen; Cephalexin; Cephaloridine; Cephalosporins; Cephal | 1972 |
Effect of metyrapone on plasma renin activity in dogs.
Topics: Animals; Blood Pressure; Desoxycorticosterone; Dexamethasone; Diet, Sodium-Restricted; Disease Model | 1971 |
[Ligated rat tail as a new edema model].
Topics: Animals; Disease Models, Animal; Edema; Furosemide; Hydrochlorothiazide; Rats; Tail | 1970 |
Effects of water and furosemide-induced diuresis on the acquisition and course of experimental pyelonephritis.
Topics: Animals; Antibodies; Disease Models, Animal; Diuretics; Enterobacteriaceae Infections; Female; Furos | 1971 |
Effects of hot‑water extracts from 26 herbs on α‑glucosidase activity.
Topics: alpha-Glucosidases; Animals; Arctostaphylos; Aspalathus; Diabetes Mellitus, Type 2; Disease Models, | 2020 |
[Evaluation of anti-inflammatory activity of extracts from Siberian plants].
Topics: Aconitum; Alkaloids; Animals; Conium; Delphinium; Disease Models, Animal; Female; Fragaria; Inflamma | 2009 |
Amelioration of collagen-induced arthritis by Salix nigra bark extract via suppression of pro-inflammatory cytokines and oxidative stress.
Topics: Animals; Anti-Inflammatory Agents; Antioxidants; Arthritis, Experimental; Body Weight; Collagen Type | 2011 |
Anti-obesity action of Salix matsudana leaves (Part 1). Anti-obesity action by polyphenols of Salix matsudana in high fat-diet treated rodent animals.
Topics: Adipocytes; Adipose Tissue; Animals; Anti-Obesity Agents; Body Weight; Cholesterol; Diet; Dietary Fa | 2003 |
[From willow bark to the coxibs. Development of antiphlogistic analgesics].
Topics: Acetanilides; Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Antipyrine; Aspirin; Cyc | 2007 |