furosemide has been researched along with Brain Injuries in 14 studies
Furosemide: A benzoic-sulfonamide-furan. It is a diuretic with fast onset and short duration that is used for EDEMA and chronic RENAL INSUFFICIENCY.
furosemide : A chlorobenzoic acid that is 4-chlorobenzoic acid substituted by a (furan-2-ylmethyl)amino and a sulfamoyl group at position 2 and 5 respectively. It is a diuretic used in the treatment of congestive heart failure.
Brain Injuries: Acute and chronic (see also BRAIN INJURIES, CHRONIC) injuries to the brain, including the cerebral hemispheres, CEREBELLUM, and BRAIN STEM. Clinical manifestations depend on the nature of injury. Diffuse trauma to the brain is frequently associated with DIFFUSE AXONAL INJURY or COMA, POST-TRAUMATIC. Localized injuries may be associated with NEUROBEHAVIORAL MANIFESTATIONS; HEMIPARESIS, or other focal neurologic deficits.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Continuous infusion of 3% hypertonic saline + furosemide is effective and safe for intracranial pressure control." | 1.42 | Efficacy and Safety of Continuous Micro-Pump Infusion of 3% Hypertonic Saline combined with Furosemide to Control Elevated Intracranial Pressure. ( Cheng, H; Fang, W; Gao, G; Gao, L; Li, L; Li, M; Li, Y; Li, Z; Wang, B; Yang, Y; Zhang, X; Zhao, B, 2015) |
| "Seventeen had Glasgow Coma Scales of 3 to 4 and 23 scales of 5 to 7." | 1.27 | Early prediction of outcome after severe head injury in children. ( Pfenninger, J, 1984) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 9 (64.29) | 18.7374 |
| 1990's | 1 (7.14) | 18.2507 |
| 2000's | 2 (14.29) | 29.6817 |
| 2010's | 2 (14.29) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Cragoe, EJ | 1 |
| Gould, NP | 1 |
| Woltersdorf, OW | 1 |
| Ziegler, C | 1 |
| Bourke, RS | 1 |
| Nelson, LR | 1 |
| Kimelberg, HK | 1 |
| Waldman, JB | 1 |
| Popp, AJ | 1 |
| Sedransk, N | 1 |
| Li, Y | 1 |
| Li, Z | 1 |
| Li, M | 1 |
| Yang, Y | 1 |
| Wang, B | 2 |
| Gao, L | 1 |
| Zhang, X | 1 |
| Cheng, H | 1 |
| Fang, W | 1 |
| Zhao, B | 1 |
| Gao, G | 1 |
| Li, L | 1 |
| Tang, ME | 1 |
| Lobel, DA | 1 |
| Mtchedlishvili, Z | 1 |
| Lepsveridze, E | 1 |
| Xu, H | 1 |
| Kharlamov, EA | 1 |
| Lu, B | 1 |
| Kelly, KM | 1 |
| Todd, MM | 1 |
| Cutkomp, J | 1 |
| Brian, JE | 1 |
| Millet, A | 1 |
| Pfenninger, J | 1 |
| McNamara, M | 1 |
| Quinn, C | 1 |
| Kirdan, KP | 1 |
| Kuberger, MB | 1 |
| Ivanov, LB | 1 |
| Dabrowska, E | 1 |
| Jagodziński, Z | 1 |
| Michalak, W | 1 |
| Baethmann, A | 1 |
| Lanksch, W | 1 |
| Schmiedek, P | 1 |
| Hayakawa, I | 1 |
| Cabrini, GP | 1 |
| Giovanelli, M | 1 |
| Infuso, L | 1 |
| Nicola, GC | 1 |
| Galle, P | 1 |
| Staudacher, M | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Comparison of Mannitol Alone Versus Different Doses of Mannitol in Combination With Furosemide on Brain Relaxation in Supratentorial Mass Resection Surgery[NCT02712476] | 47 participants (Actual) | Interventional | 2013-07-31 | Completed | |||
| The Effect of Furosemide Versus Placebo on Brain Relaxation and Incidence of Significant Intravascular Volume Depletion in Human Subjects Receiving Mannitol[NCT01054404] | 23 participants (Actual) | Interventional | 2010-02-28 | Terminated (stopped due to Concern for volume depletion and electrolyte abnormalities in furosemide arm.) | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
"Rating of brain relaxation will be on a 4-point scale:~0 = brain very relaxed under dura, acceptable~= brain adequately relaxed under dura, acceptable~= brain slightly tense under dura, acceptable~= brain very tense under bulging dura, unacceptable" (NCT01054404)
Timeframe: just prior to dural opening for each subject
| Intervention | units on a scale 0-3 (Mean) |
|---|---|
| Furosemide | 1.5 |
| Placebo | 1.3 |
3 reviews available for furosemide and Brain Injuries
| Article | Year |
|---|---|
Severe traumatic brain injury: maximizing outcomes.
Topics: Bacterial Infections; Brain Injuries; Cerebrovascular Circulation; Diuretics; Furosemide; Humans; Hy | 2009 |
[Effect of osmotic diuretics, enzyme-inhibiting diuretics and neuroleptics on cerebral perfusion pressure].
Topics: Acetazolamide; Adrenal Cortex Hormones; Animals; Antipsychotic Agents; Brain Edema; Brain Injuries; | 1983 |
Epidural intracranial pressure monitoring: theory and clinical application.
Topics: Barbiturates; Brain; Brain Diseases; Brain Edema; Brain Injuries; Cerebrovascular Circulation; Epidu | 1981 |
1 trial available for furosemide and Brain Injuries
| Article | Year |
|---|---|
[Effect of glucose and lasix on the functional state of the brain in craniocerebral injury in children].
Topics: Adolescent; Brain; Brain Injuries; Child; Clinical Trials as Topic; Drug Evaluation; Electroencephal | 1976 |
10 other studies available for furosemide and Brain Injuries
| Article | Year |
|---|---|
Agents for the treatment of brain injury. 1. (Aryloxy)alkanoic acids.
Topics: Animals; Astrocytes; Bicarbonates; Brain Injuries; Carboxylic Acids; Cats; Cerebral Cortex; Chemical | 1982 |
Efficacy and Safety of Continuous Micro-Pump Infusion of 3% Hypertonic Saline combined with Furosemide to Control Elevated Intracranial Pressure.
Topics: Aged; Brain Injuries; Female; Furosemide; Humans; Infusion Pumps; Intracranial Hypertension; Male; M | 2015 |
Increase of GABAA receptor-mediated tonic inhibition in dentate granule cells after traumatic brain injury.
Topics: Animals; Brain Injuries; Dentate Gyrus; Diazepam; Furosemide; GABA Agonists; GABA Modulators; GABA-A | 2010 |
Influence of mannitol and furosemide, alone and in combination, on brain water content after fluid percussion injury.
Topics: Animals; Blood Gas Analysis; Blood Pressure; Body Water; Brain Chemistry; Brain Edema; Brain Injurie | 2006 |
Influence of mannitol and furosemide, alone and in combination, on brain water content after fluid percussion injury.
Topics: Animals; Blood Gas Analysis; Blood Pressure; Body Water; Brain Chemistry; Brain Edema; Brain Injurie | 2006 |
Influence of mannitol and furosemide, alone and in combination, on brain water content after fluid percussion injury.
Topics: Animals; Blood Gas Analysis; Blood Pressure; Body Water; Brain Chemistry; Brain Edema; Brain Injurie | 2006 |
Influence of mannitol and furosemide, alone and in combination, on brain water content after fluid percussion injury.
Topics: Animals; Blood Gas Analysis; Blood Pressure; Body Water; Brain Chemistry; Brain Edema; Brain Injurie | 2006 |
Early prediction of outcome after severe head injury in children.
Topics: Adolescent; Blood Coagulation Tests; Brain Death; Brain Injuries; Child; Child, Preschool; Coma; Dex | 1984 |
[Remarks on conservative treatment of cerebral hematoma].
Topics: Accidental Falls; Accidents, Traffic; Adolescent; Adult; Aged; Brain Injuries; Cerebral Hemorrhage; | 1992 |
Formation and treatment of cerebral edema.
Topics: Aldosterone; Animals; Blood-Brain Barrier; Brain Edema; Brain Injuries; Dexamethasone; Ethacrynic Ac | 1974 |
[Clinical studies on a new intracranial pressure reducing agent].
Topics: Adolescent; Adult; Aged; Astrocytoma; Brain Diseases; Brain Injuries; Brain Neoplasms; Craniopharyng | 1967 |
[Changes in cerebrospinal fluid pressure in closed cranial injuries as related to drug therapy].
Topics: Brain Edema; Brain Injuries; Caffeine; Contusions; Dexamethasone; Furosemide; Hematoma, Subdural; In | 1967 |
[On the influence of dehydrated drug preparations on cerebrospinal fluid pressure in head-brain injuries].
Topics: Brain Injuries; Cerebrospinal Fluid; Furosemide; Humans; Phytotherapy; Plants, Medicinal; Pressure | 1967 |