furosemide and Brain Edema studies

Furosemide: A benzoic-sulfonamide-furan. It is a diuretic with fast onset and short duration that is used for EDEMA and chronic RENAL INSUFFICIENCY.
furosemide : A chlorobenzoic acid that is 4-chlorobenzoic acid substituted by a (furan-2-ylmethyl)amino and a sulfamoyl group at position 2 and 5 respectively. It is a diuretic used in the treatment of congestive heart failure.

Brain Edema: Increased intracellular or extracellular fluid in brain tissue. Cytotoxic brain edema (swelling due to increased intracellular fluid) is indicative of a disturbance in cell metabolism, and is commonly associated with hypoxic or ischemic injuries (see HYPOXIA, BRAIN). An increase in extracellular fluid may be caused by increased brain capillary permeability (vasogenic edema), an osmotic gradient, local blockages in interstitial fluid pathways, or by obstruction of CSF flow (e.g., obstructive HYDROCEPHALUS). (From Childs Nerv Syst 1992 Sep; 8(6):301-6)

Research Excerpts

Excerpt	Relevance	Reference
" The present study has been performed to establish, whether furosemide or bumetanide directly modify intracranial pressure in cytotoxic brain edema."	7.67	Effect of furosemide, bumetanide and mannitol on intracranial pressure in experimental brain edema of the rat. ( Plangger, C; Völkl, H, 1989)
"Altogether 102 patients with grave cerebral stroke were examined for the efficacy of the treatment of brain edema with lasix, mannitol+, glycerol and dexamethasone and for the influence of the drugs on the rheological blood properties."	5.06	[Comparative evaluation of drugs used in the treatment of brain edema in cerebral stroke and their effects on cerebral blood flow]. ( Gorbacheva, FE; Poniaev, MN, 1990)
"Changes in ischemic BW by fluid management correlated closely with changes in body weight except when high-dose mannitol was used."	3.70	Effects of fluid management on edema volume and midline shift in a rat model of ischemic stroke. ( Diringer, MN; He, YY; Hsu, CY; Lin, W; Paczynski, RP; Venkatesan, R, 2000)
" The present study has been performed to establish, whether furosemide or bumetanide directly modify intracranial pressure in cytotoxic brain edema."	3.67	Effect of furosemide, bumetanide and mannitol on intracranial pressure in experimental brain edema of the rat. ( Plangger, C; Völkl, H, 1989)
"Three independent methods were used to quantify the therapeutic effect on peritumoral brain edema with respect to different forms of treatment (dexamethasone, furosemide, and their combination with different dosages and different periods of treatment)."	3.66	Clinical, chemical, and CT evaluation of short-term and long-term antiedema therapy with dexamethasone and diuretics. ( Meinig, G; Reulen, HJ; Schürmann, K; Simon, RS, 1980)
"SIADH is underdiagnosed, and hospitalization often worsens the clinical situation, due to an iatrogenic excess in the use of oral and i."	2.46	[Current considerations in syndrome of inappropriate secretion of antidiuretic hormone/syndrome of inappropriate antidiuresis]. ( Runkle de la Vega, I; Velasco Cano, MV, 2010)
"The treatment of cerebral edema has changed during recent years."	2.37	[Current status of treatment of the cerebral edema]. ( Richling, B, 1987)
"Edema of the cerebellum with secondary obstructive hydrocephalus is a rare presentation of hypertensive encephalopathy."	1.33	Upward transtentorial herniation, hydrocephalus, and cerebellar edema in hypertensive encephalopathy. ( Adamson, DC; Bronec, PR; Dimitrov, DF, 2005)
"Brain edema is a serious consequence of hemispheric stroke and traumatic brain injury and contributes significantly to patient mortality."	1.33	Effects of chloride flux modulators in an in vitro model of brain edema formation. ( Hillert, M; Klein, J; Kumar, V; Naik, RS, 2006)
"Continuous HS infusion attenuated cerebral edema in the affected hemisphere as well as the contralateral noninjured hemisphere to a larger extent than was observed with furosemide or mannitol."	1.31	Hypertonic saline ameliorates cerebral edema associated with experimental brain tumor. ( Bhardwaj, A; Brem, H; Hurn, PD; Toung, TJ; Traystman, RJ; Tyler, B, 2002)
"By using a rat model of middle cerebral artery occlusion (MCAO), we tested the hypothesis that significant edema occurs in the contralateral uninjured hemisphere and that this postischemic complication can be manipulated by hypertonic saline therapy."	1.31	Global brain water increases after experimental focal cerebral ischemia: effect of hypertonic saline. ( Bhardwaj, A; Hurn, PD; Toung, TJ; Traystman, RJ, 2002)
"The animals were killed 48 hours after head trauma."	1.26	Effect of furosemide on experimental traumatic cerebral edema. ( McLaurin, RL; Sawaya, R; Tornheim, PA, 1979)
"Experimental vasogenic cerebral edema was created in rabbits with a cold-induced left occipital cortical lesions."	1.26	Acute therapeutic modalities for experimental vasogenic edema. ( Harbaugh, RD; James, HE; Laurin, R; Marshall, LF; Shapiro, HM, 1979)

Research

Studies (72)

Authors

Clinical Trials (2)

Trial Overview

Trial Outcomes

Acceptable vs. Unacceptable Brain Relaxation at Dural Opening

Timeframe	Studies, this research(%)	All Research%
pre-1990	57 (79.17)	18.7374
1990's	6 (8.33)	18.2507
2000's	8 (11.11)	29.6817
2010's	1 (1.39)	24.3611
2020's	0 (0.00)	2.80

Authors	Studies
Wyrick, SD	1
Smith, FT	1
Kemp, WE	1
Grippo, AA	1
Sripathirathan, K	1
Brown, J	1
Neafsey, EJ	2
Collins, MA	2
Velasco Cano, MV	1
Runkle de la Vega, I	1
Toung, TJ	2
Tyler, B	1
Brem, H	1
Traystman, RJ	2
Hurn, PD	2
Bhardwaj, A	2
KRAMER, G	1
Adamson, DC	1
Dimitrov, DF	1
Bronec, PR	1
Kumar, V	1
Naik, RS	1
Hillert, M	1
Klein, J	1
Todd, MM	1
Cutkomp, J	1
Brian, JE	1
Richter, S	1
Betz, C	1
Geiger, H	1
Schmidt, K	1
Millet, A	1
Albright, AL	2
Latchaw, RE	2
Robinson, AG	2
Cascino, T	1
Baglivo, J	1
Conti, J	1
Szewczykowski, J	1
Posner, JB	1
Rottenberg, DA	1
Pinegin, LE	1
Dolzhenko, DA	1
Natochin, IuV	1
James, HE	4
Herrmann, F	2
Gaab, M	2
Pflughaupt, KW	2
Gruss, P	1
Millson, C	1
Shapiro, HM	3
Laurin, R	3
Misiuk, NS	1
Kurgaev, VI	2
de los Reyes, RA	1
Ausman, JI	1
Diaz, FG	1
Millson, CH	1
McNamara, M	1
Quinn, C	1
Schütz, HJ	2
Hartmann, A	2
Alberti, E	2
Schreckenberger, F	2
Meinig, G	2
Reulen, HJ	3
Simon, RS	1
Schürmann, K	1
Tomita, H	2
Ito, U	2
Tone, O	2
Masaoka, H	2
Tominaga, B	2
Lauriat, SM	1
Berl, T	1
Thalacker, U	1
Liszka, G	1
Somogyi, A	1
Németh, G	1
Zou, JY	1
Paczynski, RP	1
Venkatesan, R	1
Diringer, MN	1
He, YY	1
Hsu, CY	1
Lin, W	1
Houston, CS	1
Dickinson, J	1
Knoblich, OE	1
Schupp, J	1
Fuhrmeister, U	1
Tornheim, PA	1
McLaurin, RL	1
Sawaya, R	1
Ignelzi, RJ	1
Sklar, F	1
Harbaugh, RD	1
Marshall, LF	1
Funk, C	1
Knoblauch, M	1
Gorbacheva, FE	1
Poniaev, MN	1
Plangger, C	1
Völkl, H	1
Schettini, A	1
Lippman, RH	1
Walsh, EK	1
Richling, B	1
Yang, JY	1
Li, QH	1
Tian, GZ	1
Clasen, RA	1
Pandolfi, S	1
Casey, D	1
Beteta, E	1
Wilson, R	1
Gottstein, U	2
Müchler, HC	1
Landolt, AM	1
Thilman, J	1
Zeumer, H	1
Baethmann, A	1
Lanksch, W	1
Schmiedek, P	1
Jahrmärker, H	1
Oelert, H	1
Ferrero, A	1
Marzullo, C	1
Salmoiraghi, ML	1
Eberle, H	1
Finnerty, FA	1
Schmidt, P	1
Berg, U	1
Gläsel, E	1
Pálossy, B	1
Fedor, I	1
Cabrini, GP	1
Giovanelli, M	1
Infuso, L	1
Nicola, GC	1
Paniagua, JL	1
Corral, C	1
Sacrez, R	1
Geisert, J	1
Willard, D	1
Sterkowicz, S	1
Tzonos, T	1

Trial	Enrollment	Study Type	Start Date	Status
Comparison of Mannitol Alone Versus Different Doses of Mannitol in Combination With Furosemide on Brain Relaxation in Supratentorial Mass Resection Surgery[NCT02712476]	47 participants (Actual)	Interventional	2013-07-31	Completed
The Effect of Furosemide Versus Placebo on Brain Relaxation and Incidence of Significant Intravascular Volume Depletion in Human Subjects Receiving Mannitol[NCT01054404]	23 participants (Actual)	Interventional	2010-02-28	Terminated (stopped due to Concern for volume depletion and electrolyte abnormalities in furosemide arm.)
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

"Rating of brain relaxation will be on a 4-point scale:~0 = brain very relaxed under dura, acceptable~= brain adequately relaxed under dura, acceptable~= brain slightly tense under dura, acceptable~= brain very tense under bulging dura, unacceptable" (NCT01054404)
Timeframe: just prior to dural opening for each subject

Article	Year
[Current considerations in syndrome of inappropriate secretion of antidiuretic hormone/syndrome of inappropriate antidiuresis]. Endocrinologia y nutricion : organo de la Sociedad Espanola de Endocrinologia y Nutricion, 2010, Volume: 57 Suppl 2 Topics: Aging; Aquaporin 2; Arginine Vasopressin; Blood Volume; Brain Edema; Combined Modality Therapy; Diag	2010
[Effect of osmotic diuretics, enzyme-inhibiting diuretics and neuroleptics on cerebral perfusion pressure]. Agressologie: revue internationale de physio-biologie et de pharmacologie appliquees aux effets de l'agression, 1983, Volume: 24, Issue:9 Topics: Acetazolamide; Adrenal Cortex Hormones; Animals; Antipsychotic Agents; Brain Edema; Brain Injuries;	1983
Agents for cerebral edema. Clinical neurosurgery, 1981, Volume: 28 Topics: Acetazolamide; Adult; Animals; Barbiturates; Brain Edema; Child; Dexamethasone; Ethacrynic Acid; Fur	1981
Epidural intracranial pressure monitoring: theory and clinical application. Journal of neurosurgical nursing, 1981, Volume: 13, Issue:5 Topics: Barbiturates; Brain; Brain Diseases; Brain Edema; Brain Injuries; Cerebrovascular Circulation; Epidu	1981
The hyponatremic patient: practical focus on therapy. Journal of the American Society of Nephrology : JASN, 1997, Volume: 8, Issue:10 Topics: Acute Disease; Blood Volume; Body Water; Brain Edema; Chronic Disease; Demyelinating Diseases; Diure	1997
Vasogenic brain oedema. New aspects in its formation, resolution and therapy. British journal of anaesthesia, 1976, Volume: 48, Issue:8 Topics: Brain Abscess; Brain Edema; Brain Neoplasms; Capillary Permeability; Cerebrovascular Circulation; Ce	1976
[Current status of treatment of the cerebral edema]. Der Anaesthesist, 1987, Volume: 36, Issue:5 Topics: Adrenal Cortex Hormones; Barbiturates; Bed Conversion; Brain Edema; Carbon Dioxide; Combined Modalit	1987
Acute high-altitude illness in mountaineers and problems of rescue. Annals of internal medicine, 1973, Volume: 78, Issue:3 Topics: Acclimatization; Acetazolamide; Acute Disease; Altitude; Brain Edema; Coma; Dexamethasone; Furosemid	1973
[What is assured in drug therapy of cerebrovascular circulation disorders?]. Medizinische Klinik, 1973, Jul-20, Volume: 68, Issue:29 Topics: Brain Edema; Carbon Dioxide; Cerebrovascular Circulation; Cerebrovascular Disorders; Dextrans; Digit	1973
[Current status of brain edema therapy]. Anasthesiologische und intensivmedizinische Praxis, 1974, Volume: 9, Issue:1 Topics: Acute Disease; Analgesics; Brain Edema; Carbon Dioxide; Ergot Alkaloids; Furosemide; Glucocorticoids	1974
[When and which diuretics? General and specific indications for diuretic therapy]. Der Internist, 1971, Volume: 12 Topics: Acid-Base Equilibrium; Brain Edema; Diuresis; Diuretics; Edema; Ethacrynic Acid; Furosemide; Humans;	1971
[Aldosterone and aldosterone antagonists in surgery]. Der Anaesthesist, 1971, Volume: 20, Issue:6 Topics: Adult; Aldosterone; Blood Volume; Brain Edema; Cardiac Surgical Procedures; Child; Digitalis Glycosi	1971

Article	Year
Quantitative CT assessment of furosemide- and mannitol-induced changes in brain water content. Neurology, 1983, Volume: 33, Issue:7 Topics: Brain Edema; Brain Neoplasms; Diuresis; Furosemide; Glioblastoma; Humans; Mannitol; Meningioma; Osmo	1983
[Effects of furosemide, spironolactone and 6-methylprednisolone on cerebrospinal fluid pressure. Contribution to the treatment of brain edema]. Die Medizinische Welt, 1982, Jul-30, Volume: 33, Issue:29-30 Topics: Brain Edema; Furosemide; Humans; Intracranial Pressure; Methylprednisolone; Spironolactone	1982
[Assessment of anti-oedematous therapy in brain tumour patients (author's transl)]. Neurochirurgia, 1980, Volume: 23, Issue:6 Topics: Brain Edema; Brain Neoplasms; Dexamethasone; Drug Therapy, Combination; Furosemide; Glioma; Humans;	1980
High colloid oncotic therapy for contusional brain edema. Acta neurochirurgica. Supplementum, 1994, Volume: 60 Topics: Adolescent; Adult; Aged; Aged, 80 and over; Albumins; Blood Proteins; Blood-Brain Barrier; Brain Con	1994
[Effect of furosemide and dexamethasone on cerebrospinal fluid pressure in brain tumors]. Die Medizinische Welt, 1976, Apr-30, Volume: 27, Issue:18 Topics: Brain Edema; Brain Neoplasms; Dexamethasone; Furosemide; Glioblastoma; Humans; Intracranial Pressure	1976
[Comparative evaluation of drugs used in the treatment of brain edema in cerebral stroke and their effects on cerebral blood flow]. Zhurnal nevropatologii i psikhiatrii imeni S.S. Korsakova (Moscow, Russia : 1952), 1990, Volume: 90, Issue:7 Topics: Adult; Aged; Brain Edema; Cerebral Infarction; Cerebrovascular Circulation; Dexamethasone; Diuretics	1990

Article	Year
Effects of [(N-alkyl-1,3-dioxo-1H,3H-isoindolin-5-yl)oxy]alkanoic acids, [(N-alkyl-1-oxo-1H,3H-isoindolin-5-yl)oxy]butanoic acids, and related derivatives on chloride influx in primary astroglial cultures. Journal of medicinal chemistry, 1987, Volume: 30, Issue:10 Topics: Animals; Brain Edema; Butyrates; Cats; Cells, Cultured; Cerebral Cortex; Chlorides; Craniocerebral T	1987
Linking binge alcohol-induced neurodamage to brain edema and potential aquaporin-4 upregulation: evidence in rat organotypic brain slice cultures and in vivo. Journal of neurotrauma, 2009, Feb-11, Volume: 26, Issue:2 Topics: Acetazolamide; Alcohol Drinking; Animals; Antioxidants; Aquaporin 4; Blotting, Western; Brain Edema;	2009
Hypertonic saline ameliorates cerebral edema associated with experimental brain tumor. Journal of neurosurgical anesthesiology, 2002, Volume: 14, Issue:3 Topics: Animals; Body Water; Brain Chemistry; Brain Edema; Brain Neoplasms; Diuretics; Diuretics, Osmotic; F	2002
[ON THE MEDICAL REGULATION OF WATER BALANCE IN CEREBRAL EDEMA]. Die Medizinische Welt, 1964, Oct-17, Volume: 42 Topics: Brain Edema; Diuretics; Drug Therapy; Furosemide; Humans; Water-Electrolyte Balance	1964
Upward transtentorial herniation, hydrocephalus, and cerebellar edema in hypertensive encephalopathy. The neurologist, 2005, Volume: 11, Issue:3 Topics: Adult; Blood Pressure; Brain Edema; Cerebellar Diseases; Cranial Fossa, Posterior; Diuretics; Enceph	2005
Effects of chloride flux modulators in an in vitro model of brain edema formation. Brain research, 2006, Nov-29, Volume: 1122, Issue:1 Topics: Animals; Bicuculline; Biological Transport; Brain Edema; Chlorides; Furosemide; GABA Antagonists; Hi	2006
Influence of mannitol and furosemide, alone and in combination, on brain water content after fluid percussion injury. Anesthesiology, 2006, Volume: 105, Issue:6 Topics: Animals; Blood Gas Analysis; Blood Pressure; Body Water; Brain Chemistry; Brain Edema; Brain Injurie	2006
Influence of mannitol and furosemide, alone and in combination, on brain water content after fluid percussion injury. Anesthesiology, 2006, Volume: 105, Issue:6 Topics: Animals; Blood Gas Analysis; Blood Pressure; Body Water; Brain Chemistry; Brain Edema; Brain Injurie	2006
Influence of mannitol and furosemide, alone and in combination, on brain water content after fluid percussion injury. Anesthesiology, 2006, Volume: 105, Issue:6 Topics: Animals; Blood Gas Analysis; Blood Pressure; Body Water; Brain Chemistry; Brain Edema; Brain Injurie	2006
Influence of mannitol and furosemide, alone and in combination, on brain water content after fluid percussion injury. Anesthesiology, 2006, Volume: 105, Issue:6 Topics: Animals; Blood Gas Analysis; Blood Pressure; Body Water; Brain Chemistry; Brain Edema; Brain Injurie	2006
[Severe hyponatremia with pulmonary and cerebral edema in an Ironman triathlete]. Deutsche medizinische Wochenschrift (1946), 2007, Volume: 132, Issue:36 Topics: Bicycling; Brain Edema; Catecholamines; Creatine Kinase; Diuretics; Female; Furosemide; Humans; Hypo	2007
[On the oncotherapy of brain edema with fursemid (Lasix) and with hypertonic human albumin solution]. Acta neurochirurgica, 1967, Volume: 17, Issue:1 Topics: Albumins; Brain Edema; Cerebrospinal Fluid; Diuresis; Furosemide; Hematocrit; Hemodynamics; Humans;	1967
Intracranial and systemic effects of hetastarch in experimental cerebral edema. Critical care medicine, 1984, Volume: 12, Issue:6 Topics: Animals; Blood Pressure; Brain Edema; Dogs; Drug Combinations; Furosemide; Hematocrit; Hydroxyethyl	1984
Intracranial and systemic effects of osmotic and oncotic therapy in experimental cerebral edema. Journal of neurosurgery, 1984, Volume: 60, Issue:3 Topics: Albumins; Animals; Blood Proteins; Blood Volume; Brain Edema; Crystalloid Solutions; Dogs; Furosemid	1984
[Mechanism of the decrease in intracranial pressure as affected by furosemide]. Biulleten' eksperimental'noi biologii i meditsiny, 1984, Volume: 98, Issue:12 Topics: Animals; Blood Pressure; Brain Edema; Diuresis; Dogs; Female; Furosemide; Intracranial Pressure; Rat	1984
Combination therapy in brain edema. Advances in neurology, 1980, Volume: 28 Topics: Acetazolamide; Animals; Brain Chemistry; Brain Edema; Dexamethasone; Diuretics; Drug Therapy, Combin	1980
[Medical treatment in experimental brain oedema (author's transl)]. Neurochirurgia, 1981, Volume: 24, Issue:2 Topics: Animals; Brain Chemistry; Brain Edema; Cold Temperature; Dexamethasone; Furosemide; Glycerol; Humans	1981
Intracranial hypertension and brain oedema in albino rabbits. Part 2: Effects of acute therapy with diuretics. Acta neurochirurgica, 1981, Volume: 56, Issue:3-4 Topics: Acetazolamide; Animals; Brain Chemistry; Brain Edema; Diuretics; Drug Therapy, Combination; Furosemi	1981
[Effect of glycerol, mannitol, and lasix on cerebrospinal fluid pressure in the acute period of a stroke]. Zhurnal nevropatologii i psikhiatrii imeni S.S. Korsakova (Moscow, Russia : 1952), 1981, Volume: 81, Issue:8 Topics: Acute Disease; Brain Edema; Brain Ischemia; Cerebral Hemorrhage; Female; Furosemide; Glycerol; Human	1981
Intracranial hypertension and brain oedema in albino rabbits. Part 3: Effect of acute simultaneous diuretic and barbiturate therapy. Acta neurochirurgica, 1982, Volume: 61, Issue:4 Topics: Animals; Body Water; Brain Chemistry; Brain Edema; Drug Combinations; Electroencephalography; Furose	1982
Clinical, chemical, and CT evaluation of short-term and long-term antiedema therapy with dexamethasone and diuretics. Advances in neurology, 1980, Volume: 28 Topics: Brain Chemistry; Brain Edema; Brain Neoplasms; Chlorides; Dexamethasone; Drug Therapy, Combination;	1980
High colloid oncotic therapy for brain edema with cerebral hemorrhage. Acta neurochirurgica. Supplementum, 1994, Volume: 60 Topics: Adult; Aged; Albumins; Blood Proteins; Blood-Brain Barrier; Brain Edema; Cerebral Hemorrhage; Combin	1994
[The observation of edema in the substantia alba during postoperative brain irradiation. The role of computed tomographic studies]. Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al], 1998, Volume: 174, Issue:1 Topics: Adult; Aged; Brain Edema; Brain Neoplasms; Diuretics; Drug Therapy, Combination; Furosemide; Glycero	1998
Brain damage due to episodic alcohol exposure in vivo and in vitro: furosemide neuroprotection implicates edema-based mechanism. FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 1998, Volume: 12, Issue:2 Topics: Alcoholic Intoxication; Animals; Brain; Brain Edema; Dentate Gyrus; Diuretics; Dizocilpine Maleate;	1998
Effects of fluid management on edema volume and midline shift in a rat model of ischemic stroke. Stroke, 2000, Volume: 31, Issue:7 Topics: Animals; Body Weight; Brain Edema; Brain Ischemia; Cerebral Cortex; Dehydration; Disease Models, Ani	2000
Global brain water increases after experimental focal cerebral ischemia: effect of hypertonic saline. Critical care medicine, 2002, Volume: 30, Issue:3 Topics: Analysis of Variance; Animals; Brain Edema; Brain Ischemia; Diuretics; Diuretics, Osmotic; Furosemid	2002
Cerebral form of high-altitude illness. Lancet (London, England), 1975, Oct-18, Volume: 2, Issue:7938 Topics: Adult; Altitude Sickness; Betamethasone; Brain Edema; Bronchopneumonia; Coronary Disease; Dexamethas	1975
Effect of furosemide (lasix) on acute severe experimental cerebral edema. Journal of neurology, 1979, May-02, Volume: 220, Issue:3 Topics: Albumins; Animals; Brain Chemistry; Brain Edema; Cats; Dexamethasone; Electroencephalography; Furose	1979
Effect of furosemide on experimental traumatic cerebral edema. Neurosurgery, 1979, Volume: 4, Issue:1 Topics: Animals; Blood Urea Nitrogen; Body Weight; Brain; Brain Edema; Cats; Contusions; Craniocerebral Trau	1979
Cerebral edema: present perspectives. Neurosurgery, 1979, Volume: 4, Issue:4 Topics: Acetazolamide; Barbiturates; Blood-Brain Barrier; Brain; Brain Edema; Dexamethasone; Energy Metaboli	1979
Decreased cerebral edema in cats treated with parenteral furosemide. Neurosurgery, 1979, Volume: 5, Issue:3 Topics: Animals; Brain Edema; Cats; Furosemide; Infusions, Parenteral	1979
Acute therapeutic modalities for experimental vasogenic edema. Neurosurgery, 1979, Volume: 5, Issue:6 Topics: Acetazolamide; Acute Disease; Animals; Brain Edema; Cerebrovascular Disorders; Cold Temperature; Dex	1979
[The effect of pyritinol on human brain circulation]. Fortschritte der Medizin, 1979, Dec-13, Volume: 97, Issue:47 Topics: Brain Edema; Brain Ischemia; Cerebrovascular Circulation; Dextrans; Female; Furosemide; Humans; Male	1979
[The dehydrating effect of glycerin, mannitol and lasix in the most acute period of a stroke]. Zhurnal nevropatologii i psikhiatrii imeni S.S. Korsakova (Moscow, Russia : 1952), 1978, Volume: 78, Issue:8 Topics: Blood Pressure; Brain Edema; Cerebrovascular Disorders; Electrocardiography; Electroencephalography;	1978
[Development and correction of water-electrolyte and acid base equilibrium disorders in brain edema (proceedings)]. Klinische Anasthesiologie und Intensivtherapie, 1977, Issue:15 Topics: Acid-Base Imbalance; Adult; Brain Edema; Child; Dexamethasone; Furosemide; Humans; Water-Electrolyte	1977
[Fulminant hepatitis]. Gastroenterologische Fortbildungskurse fur die Praxis, 1975, Volume: 5 Topics: Acute Disease; Adrenal Cortex Hormones; Alkalosis, Respiratory; Blood Transfusion; Brain Edema; Chem	1975
Effect of furosemide, bumetanide and mannitol on intracranial pressure in experimental brain edema of the rat. Zentralblatt fur Neurochirurgie, 1989, Volume: 50, Issue:3-4 Topics: Animals; Brain Edema; Bumetanide; Diuretics; Furosemide; Intracranial Pressure; Male; Mannitol; Neph	1989
Attenuation of decompressive hypoperfusion and cerebral edema by superoxide dismutase. Journal of neurosurgery, 1989, Volume: 71, Issue:4 Topics: Animals; Blood Pressure; Blood-Brain Barrier; Body Water; Brain; Brain Edema; Carbon Dioxide; Cerebr	1989
[Treatment of 40 cases of acute high altitude disease with complicating cerebral edema]. Zhonghua nei ke za zhi, 1987, Volume: 26, Issue:3 Topics: Acute Disease; Adult; Altitude Sickness; Brain Edema; Dexamethasone; Furosemide; Humans; Hypoxia; Ma	1987
Furosemide and pentobarbital in cryogenic cerebral injury and edema. Neurology, 1974, Volume: 24, Issue:7 Topics: Animals; Brain; Brain Edema; Cerebral Hemorrhage; Drug Synergism; Erythrocytes; Freezing; Furosemide	1974
[Medical treatment of brain edema]. Revista de neuro-psiquiatria, 1974, Volume: 37, Issue:1 Topics: Brain Edema; Dexamethasone; Furosemide; Glycerol; Humans; Hyperbaric Oxygenation; Hypothermia, Induc	1974
[The cerebral edema (author's transl)]. Therapeutische Umschau. Revue therapeutique, 1973, Volume: 30, Issue:8 Topics: Brain Edema; Furosemide; Humans; Mannitol	1973
[Treatment of cerebral oedema with high doses of furosemide (author's transl)]. Deutsche medizinische Wochenschrift (1946), 1974, Volume: 99, Issue:18 Topics: Brain Edema; Cerebrospinal Fluid; Diuresis; Electroencephalography; Female; Furosemide; Humans; Inje	1974
Formation and treatment of cerebral edema. Neurochirurgia, 1974, Volume: 17, Issue:2 Topics: Aldosterone; Animals; Blood-Brain Barrier; Brain Edema; Brain Injuries; Dexamethasone; Ethacrynic Ac	1974
[Intensive therapy of gestoses. Our experience in the years 1969-1971]. Annali di ostetricia, ginecologia, medicina perinatale, 1971, Volume: 92, Issue:12 Topics: Betamethasone; Brain Edema; Diazepam; Ergoloid Mesylates; Female; Furosemide; Humans; Mannitol; Papa	1971
[Decrease in mortality by emergency trepanation of covered skull-brain trauma with increasing intracranial pressure caused by hematoma]. Helvetica chirurgica acta, 1972, Volume: 39, Issue:1 Topics: Accidents, Traffic; Brain Edema; Craniocerebral Trauma; Craniotomy; Emergency Service, Hospital; Fur	1972
Hypertensive encephalopathy. The American journal of medicine, 1972, Volume: 52, Issue:5 Topics: Anxiety; Brain Diseases; Brain Edema; Coma; Diazoxide; Female; Furosemide; Glomerulonephritis; Heada	1972
[Diuresis and diuretics]. Wiener klinische Wochenschrift, 1971, Jun-25, Volume: 83, Issue:25 Topics: Acetazolamide; Acute Disease; Agranulocytosis; Anuria; Biological Transport; Blood Platelet Disorder	1971
[Encephalitic brain edema with special regard to therapy]. Zeitschrift fur arztliche Fortbildung, 1970, Volume: 64, Issue:7 Topics: Adrenal Cortex Hormones; Analgesics; Anticonvulsants; Brain Edema; Dextrans; Electroencephalography;	1970
[Clinical aspect and therapy of a severe acute dinitroorthocresol poisoning]. Zeitschrift fur die gesamte innere Medizin und ihre Grenzgebiete, 1970, Apr-15, Volume: 25, Issue:8 Topics: Acidosis; Adenosine Triphosphate; Adult; Bicarbonates; Bloodletting; Brain Edema; Carbohydrates; Cre	1970
[Our experience with fursemide in the management of edema]. Zeitschrift fur die gesamte innere Medizin und ihre Grenzgebiete, 1967, Nov-15, Volume: 22, Issue:22 Topics: Administration, Oral; Benzoates; Brain Edema; Edema; Furosemide; Humans; Hydrochlorothiazide; Inject	1967
[Changes in cerebrospinal fluid pressure in closed cranial injuries as related to drug therapy]. Minerva neurochirurgica, 1967, Volume: 11, Issue:3 Topics: Brain Edema; Brain Injuries; Caffeine; Contusions; Dexamethasone; Furosemide; Hematoma, Subdural; In	1967
[Therapy of cerebral circulatory disorders]. Deutsche medizinische Wochenschrift (1946), 1968, Sep-20, Volume: 93, Issue:38 Topics: Brain Edema; Cerebral Angiography; Cerebral Hemorrhage; Cerebrovascular Circulation; Cerebrovascular	1968
[Clinical study and treatment of neurologic manifestations that develope in medullary or cerebral edema]. Revista clinica espanola, 1968, Apr-30, Volume: 109, Issue:2 Topics: Adult; Brain Edema; Cerebral Angiography; Female; Furosemide; Humans; Hypotonic Solutions; Male; Neu	1968
[Place of new diuretics in the treatment of some neonatal diseases]. Annales de pediatrie, 1969, Jan-02, Volume: 16, Issue:1 Topics: Brain Edema; Diuresis; Edema; Ethacrynic Acid; Furosemide; Humans; Infant, Newborn; Infant, Newborn,	1969
[New diuretic--furosemide (lasix)--4-chloro-N-(2-furylmethylo)-5-sulfamoylo antranil acid]. Przeglad lekarski, 1966, Volume: 22, Issue:10 Topics: Brain Edema; Furosemide; Humans; Pulmonary Edema	1966
[Experimental studies on the modification of brain edema in model studies. I. Osmotherapy]. Deutsche Zeitschrift fur Nervenheilkunde, 1966, Jan-12, Volume: 188, Issue:1 Topics: Animals; Brain Edema; Cats; Furosemide; Intracranial Embolism and Thrombosis; Models, Theoretical; U	1966

furosemide and Brain Edema