furosemide and Aura
furosemide has been researched along with Aura in 19 studies
Furosemide: A benzoic-sulfonamide-furan. It is a diuretic with fast onset and short duration that is used for EDEMA and chronic RENAL INSUFFICIENCY.
furosemide : A chlorobenzoic acid that is 4-chlorobenzoic acid substituted by a (furan-2-ylmethyl)amino and a sulfamoyl group at position 2 and 5 respectively. It is a diuretic used in the treatment of congestive heart failure.
Research Excerpts
| Excerpt | Relevance | Reference |
|---|---|---|
| "For bumetanide, it has been suggested that inhibition of the NKCC isoform NKCC1 in the membrane of brain neurons may be involved; however, NKCC1 is expressed by virtually all cell types in the brain, which makes any specific targeting of neuronal NKCC1 by bumetanide impossible." | 5.91 | The loop diuretic torasemide but not azosemide potentiates the anti-seizure and disease-modifying effects of midazolam in a rat model of birth asphyxia. ( Gramer, M; Kirchhoff, L; Löscher, W; Schmidt, R; Welzel, B, 2023) |
| "This study aimed to explore the effect of concomitant use of Furosemide (FRS) and Valproic acid (VPA), demonstrating anti-inflammation efficacy, on epilepsy, and its underlying mechanism." | 4.12 | The effect of valproic acid and furosemide on the regulation of the inflammasome complex (NLRP1 and NLRP3 mRNA) in the brain of epileptic animal model. ( Abdolmaleki, Z; Faedmaleki, F; Samadianzakaria, A, 2022) |
| " We also tested chlorthiazide and furosemide for seizure protection in animal models of epilepsy." | 3.71 | Are certain diuretics also anticonvulsants? ( Annegers, JF; Cascino, G; Hauser, WA; Hesdorffer, DC; Stables, JP, 2001) |
| "For bumetanide, it has been suggested that inhibition of the NKCC isoform NKCC1 in the membrane of brain neurons may be involved; however, NKCC1 is expressed by virtually all cell types in the brain, which makes any specific targeting of neuronal NKCC1 by bumetanide impossible." | 1.91 | The loop diuretic torasemide but not azosemide potentiates the anti-seizure and disease-modifying effects of midazolam in a rat model of birth asphyxia. ( Gramer, M; Kirchhoff, L; Löscher, W; Schmidt, R; Welzel, B, 2023) |
| "Furosemide was not found to alter synaptic field responses, excitatory postsynaptic currents or intrinsic membrane properties of principal hippocampal neurons." | 1.32 | A potential role for astrocytes in mediating the antiepileptic actions of furosemide in vitro. ( Baraban, SC; Barbaro, NM; Takahashi, DK, 2004) |
| " The anti-bursting activity of carbenoxolone showed dose-response dependence in the concentration range 50-400 microM." | 1.31 | Can gap-junction blockade preferentially inhibit neuronal hypersynchrony vs. excitability? ( Klitgaard, H; Margineanu, DG, 2001) |
Research
Studies (19)
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (15.79) | 18.7374 |
| 1990's | 2 (10.53) | 18.2507 |
| 2000's | 9 (47.37) | 29.6817 |
| 2010's | 3 (15.79) | 24.3611 |
| 2020's | 2 (10.53) | 2.80 |
Authors
| Authors | Studies |
|---|---|
| Samadianzakaria, A | 1 |
| Abdolmaleki, Z | 1 |
| Faedmaleki, F | 1 |
| Welzel, B | 1 |
| Schmidt, R | 1 |
| Kirchhoff, L | 1 |
| Gramer, M | 1 |
| Löscher, W | 1 |
| Viitanen, T | 1 |
| Ruusuvuori, E | 1 |
| Kaila, K | 2 |
| Voipio, J | 1 |
| Khirug, S | 1 |
| Ahmad, F | 1 |
| Puskarjov, M | 1 |
| Afzalov, R | 1 |
| Blaesse, P | 1 |
| Hochman, DW | 4 |
| Siniscalchi, A | 1 |
| Mancuso, F | 1 |
| Scornaienghi, D | 1 |
| Ferreri, G | 1 |
| De Sarro, G | 1 |
| Barbaro, NM | 1 |
| Takahashi, DK | 1 |
| Baraban, SC | 1 |
| Haglund, MM | 1 |
| Margineanu, DG | 2 |
| Klitgaard, H | 2 |
| Frey, HH | 1 |
| D'Ambrosio, R | 1 |
| Janigro, D | 1 |
| Schwartzkroin, PA | 2 |
| Gutschmidt, KU | 1 |
| Stenkamp, K | 1 |
| Buchheim, K | 1 |
| Heinemann, U | 2 |
| Meierkord, H | 1 |
| Hesdorffer, DC | 1 |
| Stables, JP | 1 |
| Hauser, WA | 1 |
| Annegers, JF | 1 |
| Cascino, G | 1 |
| Jauch, R | 1 |
| Windmüller, O | 1 |
| Lehmann, TN | 1 |
| Gabriel, S | 1 |
| Corcelle, P | 1 |
| Poirson, B | 1 |
| Dournovo, P | 1 |
| Duron, JJ | 1 |
| Garaix, JP | 1 |
| Delgado-Escueta, AV | 1 |
| Ahmad, S | 1 |
Reviews
1 review available for furosemide and Aura
| Article | Year |
|---|---|
The extracellular space and epileptic activity in the adult brain: explaining the antiepileptic effects of furosemide and bumetanide.
Topics: Animals; Anticonvulsants; Brain; Bumetanide; Diuretics; Epilepsy; Extracellular Space; Furosemide; H | 2012 |
Trials
2 trials available for furosemide and Aura
| Article | Year |
|---|---|
Furosemide and mannitol suppression of epileptic activity in the human brain.
Topics: Adolescent; Adult; Child; Diagnostic Imaging; Diuretics; Dose-Response Relationship, Radiation; Elec | 2005 |
Renal insensitivity to frusemide caused by chronic anticonvulsant therapy.
Topics: Administration, Oral; Adult; Anticonvulsants; Clinical Trials as Topic; Diuresis; Drug Interactions; | 1974 |
Other Studies
16 other studies available for furosemide and Aura
| Article | Year |
|---|---|
The effect of valproic acid and furosemide on the regulation of the inflammasome complex (NLRP1 and NLRP3 mRNA) in the brain of epileptic animal model.
Topics: Animals; Brain; Disease Models, Animal; DNA-Binding Proteins; Epilepsy; Furosemide; Inflammasomes; M | 2022 |
The loop diuretic torasemide but not azosemide potentiates the anti-seizure and disease-modifying effects of midazolam in a rat model of birth asphyxia.
Topics: Animals; Asphyxia; Bumetanide; Diuretics; Epilepsy; Furosemide; Rats; Sodium Potassium Chloride Symp | 2023 |
The K+-Cl cotransporter KCC2 promotes GABAergic excitation in the mature rat hippocampus.
Topics: Animals; Anticonvulsants; Barium; Bicarbonates; CA1 Region, Hippocampal; Carbonic Anhydrase Inhibito | 2010 |
A single seizure episode leads to rapid functional activation of KCC2 in the neonatal rat hippocampus.
Topics: Age Factors; Animals; Animals, Newborn; Biotinylation; Carbazoles; Enzyme Inhibitors; Epilepsy; Exci | 2010 |
Acute encephalopathy induced by oxcarbazepine and furosemide.
Topics: Anticonvulsants; Carbamazepine; Diuretics; Electroencephalography; Encephalitis; Epilepsy; Female; F | 2004 |
A potential role for astrocytes in mediating the antiepileptic actions of furosemide in vitro.
Topics: 4-Aminopyridine; Action Potentials; Animals; Anticonvulsants; Astrocytes; Barium; Cesium; Epilepsy; | 2004 |
Differential effects of cation-chloride co-transport-blocking diuretics in a rat hippocampal slice model of epilepsy.
Topics: Animals; Anticonvulsants; Bumetanide; Disease Models, Animal; Diuretics; Dose-Response Relationship, | 2006 |
Antiepileptic effect of loop diuretics? Comment to "Differential effects of cation-chloride co-transport-blocking diuretics in a rat hippocampal slice model of epilepsy" by Margineanu, Klitgaard, Epilepsy Res. 69 (2006) 93-99.
Topics: Animals; Bumetanide; Diuretics; Epilepsy; Ethacrynic Acid; Evoked Potentials; Furosemide; Rats | 2006 |
Extracellular chloride and the maintenance of spontaneous epileptiform activity in rat hippocampal slices.
Topics: 4-Aminopyridine; Animals; Bicuculline; Chlorides; Diuretics; Epilepsy; Furosemide; GABA Antagonists; | 1999 |
Anticonvulsant actions of furosemide in vitro.
Topics: 4-Aminopyridine; Action Potentials; Animals; Anticonvulsants; Calcium; Electric Stimulation; Entorhi | 1999 |
Chloride-cotransport blockade desynchronizes neuronal discharge in the "epileptic" hippocampal slice.
Topics: 4-Aminopyridine; Animals; Axons; Bicuculline; Carrier Proteins; Chlorides; Electric Stimulation; Epi | 2000 |
Can gap-junction blockade preferentially inhibit neuronal hypersynchrony vs. excitability?
Topics: 1-Octanol; Animals; Carbenoxolone; Diuretics; Dose-Response Relationship, Drug; Epilepsy; Evoked Pot | 2001 |
Are certain diuretics also anticonvulsants?
Topics: Aged; Animals; Case-Control Studies; Disease Models, Animal; Diuretics; Dose-Response Relationship, | 2001 |
Effects of barium, furosemide, ouabaine and 4,4'-diisothiocyanatostilbene-2,2'-disulfonic acid (DIDS) on ionophoretically-induced changes in extracellular potassium concentration in hippocampal slices from rats and from patients with epilepsy.
Topics: 2-Amino-5-phosphonovalerate; 4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid; Anesthetics, Local; A | 2002 |
[Fatal necrotizing pancreatitis following drowning in a swimming pool].
Topics: Acute Disease; Acute Kidney Injury; Adult; Drowning; Epilepsy; Furosemide; Hemolysis; Humans; Hydroc | 1976 |
Sodium outflux and influx within nerve terminals from chronic epileptogenic foci.
Topics: Acetylcholinesterase; Animals; Biological Transport, Active; Cats; Cerebral Cortex; Epilepsy; Ethacr | 1979 |