furosemide has been researched along with Adverse Drug Event in 29 studies
Furosemide: A benzoic-sulfonamide-furan. It is a diuretic with fast onset and short duration that is used for EDEMA and chronic RENAL INSUFFICIENCY.
furosemide : A chlorobenzoic acid that is 4-chlorobenzoic acid substituted by a (furan-2-ylmethyl)amino and a sulfamoyl group at position 2 and 5 respectively. It is a diuretic used in the treatment of congestive heart failure.
| Excerpt | Relevance | Reference |
|---|---|---|
| " In two demonstrative investigations, it is concluded that nitrobenzenes for which the expected nitrosyl metabolite is likely to react with adjacent groups are less toxic than what is rationally expected, and that among aryl amine drugs allowing for the immediate quenching of the corresponding N-aryl hydroxylamine metabolite, the typical erythrocyte toxicity often seen with aryl amines is absent." | 2.53 | The role of intramolecular self-destruction of reactive metabolic intermediates in determining toxicity. ( Svennebring, A, 2016) |
| " The pathophysiology, clinical manifestations and risk factors and risk minimisation strategies regarding the ototoxicity associated with these drugs are presented in order to highlight this problem and reduce the incidence of adverse outcomes." | 2.43 | Systemic ototoxicity: a review. ( Coates, H; Shine, NP, 2005) |
| "Hydrocephalus is a neurological condition caused by an abnormal accumulation of cerebrospinal fluid; pharmacological intervention of the disease has been found to elicit a variety of adverse drug reactions (ADRs) in central nervous system (CNS) by unexpectedly targeting certain functional neuroproteins." | 1.51 | Systematic analysis and identification of unexpected interactions from the neuroprotein drug interactome in hydrocephalus pharmacological intervention. ( Chen, X; Lu, Y; Yuan, L; Zhang, A; Zhang, P; Zou, D, 2019) |
| " We proposed a systematic classification scheme using FDA-approved drug labeling to assess the DILI potential of drugs, which yielded a benchmark dataset with 287 drugs representing a wide range of therapeutic categories and daily dosage amounts." | 1.37 | FDA-approved drug labeling for the study of drug-induced liver injury. ( Chen, M; Fang, H; Liu, Z; Shi, Q; Tong, W; Vijay, V, 2011) |
| "Risk of breast cancer in women was assessed for eight pharmaceuticals that produce mammary tumors in experimental animals, using nested case-control analyses in two cohorts with prescription records in a comprehensive medical care program." | 1.35 | Pharmaceuticals that cause mammary gland tumors in animals: findings in women. ( Chan, J; Friedman, GD; Habel, LA; Jiang, SF; Quesenberry, CP; Udaltsova, N, 2009) |
| "5 million adverse drug reaction (ADR) reports for 8620 drugs/biologics that are listed for 1191 Coding Symbols for Thesaurus of Adverse Reaction (COSTAR) terms of adverse effects." | 1.32 | Assessment of the health effects of chemicals in humans: II. Construction of an adverse effects database for QSAR modeling. ( Benz, RD; Contrera, JF; Kruhlak, NL; Matthews, EJ; Weaver, JL, 2004) |
| "However, alcohol addiction was not considered in these studies." | 1.29 | Adverse drug reactions (ADRs) in patients with previous history of chronic alcohol consumption without signs of chronic hepatic damage. A prospective study. ( Díaz, M; Dominichinni, H; Gonzáles-Martín, G; Guevara, A, 1995) |
| "Drug-induced hepatic encephalopathy was more common in cirrhotics receiving diuretics (13." | 1.27 | An intensive drug monitoring study suggesting possible clinical irrelevance of impaired drug disposition in liver disease. ( Busto, U; Janecek, E; Kaplan, K; Naranjo, CA; Roach, CA; Ruiz, I, 1983) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 13 (44.83) | 18.7374 |
| 1990's | 1 (3.45) | 18.2507 |
| 2000's | 4 (13.79) | 29.6817 |
| 2010's | 9 (31.03) | 24.3611 |
| 2020's | 2 (6.90) | 2.80 |
| Authors | Studies |
|---|---|
| Matthews, EJ | 1 |
| Kruhlak, NL | 1 |
| Weaver, JL | 1 |
| Benz, RD | 1 |
| Contrera, JF | 1 |
| Pedersen, JM | 1 |
| Matsson, P | 1 |
| Bergström, CA | 1 |
| Norinder, U | 1 |
| Hoogstraate, J | 1 |
| Artursson, P | 1 |
| Chen, M | 1 |
| Vijay, V | 1 |
| Shi, Q | 2 |
| Liu, Z | 2 |
| Fang, H | 2 |
| Tong, W | 2 |
| Dawson, S | 1 |
| Stahl, S | 1 |
| Paul, N | 1 |
| Barber, J | 1 |
| Kenna, JG | 1 |
| Ding, D | 1 |
| Kelly, R | 1 |
| Sakatis, MZ | 1 |
| Reese, MJ | 1 |
| Harrell, AW | 1 |
| Taylor, MA | 1 |
| Baines, IA | 1 |
| Chen, L | 1 |
| Bloomer, JC | 1 |
| Yang, EY | 1 |
| Ellens, HM | 1 |
| Ambroso, JL | 1 |
| Lovatt, CA | 1 |
| Ayrton, AD | 1 |
| Clarke, SE | 1 |
| Morgan, RE | 1 |
| van Staden, CJ | 1 |
| Chen, Y | 1 |
| Kalyanaraman, N | 1 |
| Kalanzi, J | 1 |
| Dunn, RT | 1 |
| Afshari, CA | 1 |
| Hamadeh, HK | 1 |
| Anderssen-Nordahl, E | 1 |
| Riera-Arnau, J | 1 |
| Perelló Carrascosa, M | 1 |
| Gómez Muñoz, A | 1 |
| Nascimento, ARFD | 1 |
| Leopoldino, RWD | 1 |
| Santos, METD | 1 |
| Costa, TXD | 1 |
| Martins, RR | 1 |
| Lu, Y | 1 |
| Yuan, L | 1 |
| Chen, X | 1 |
| Zhang, A | 1 |
| Zhang, P | 1 |
| Zou, D | 1 |
| Preiss, AK | 1 |
| Roughead, EE | 1 |
| Pratt, NL | 1 |
| Svennebring, A | 1 |
| Slater, MB | 1 |
| Gruneir, A | 1 |
| Rochon, PA | 1 |
| Howard, AW | 1 |
| Koren, G | 1 |
| Parshuram, CS | 1 |
| Friedman, GD | 2 |
| Jiang, SF | 1 |
| Udaltsova, N | 1 |
| Chan, J | 1 |
| Quesenberry, CP | 1 |
| Habel, LA | 1 |
| Shine, NP | 1 |
| Coates, H | 1 |
| Kassner, EG | 1 |
| Gillette, JR | 1 |
| Naranjo, CA | 1 |
| Busto, U | 1 |
| Janecek, E | 1 |
| Ruiz, I | 1 |
| Roach, CA | 1 |
| Kaplan, K | 1 |
| Gonzáles-Martín, G | 1 |
| Dominichinni, H | 1 |
| Díaz, M | 1 |
| Guevara, A | 1 |
| Levine, L | 1 |
| Lawson, DH | 1 |
| Hutcheon, AW | 1 |
| Jick, H | 1 |
| Spino, M | 1 |
| Sellers, EM | 1 |
| Kaplan, HL | 1 |
| Mitchell, JR | 1 |
| Nelson, SD | 1 |
| Thorgeirsson, SS | 1 |
| McMurtry, RJ | 1 |
| Dybing, E | 2 |
| Cramarossa, L | 1 |
| D'Angelo, D | 1 |
| Galassi, A | 1 |
| Puletti, M | 1 |
| Dobrilla, G | 1 |
| Felder, M | 1 |
| Chilovi, F | 1 |
| Fabre, J | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Predicting Acute Kidney Injury in Infants Exposed to Nephrotoxic Drugs: A Big Data Approach to Predict NEOnatal Acute Kidney Injury in Newborns expoSed to nephroTOxic Drugs. (NeoAKI STOP)[NCT05851222] | 4,200 participants (Anticipated) | Observational | 2023-08-01 | Not yet recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
6 reviews available for furosemide and Adverse Drug Event
| Article | Year |
|---|---|
The role of intramolecular self-destruction of reactive metabolic intermediates in determining toxicity.
Topics: Animals; Drug Design; Drug Evaluation, Preclinical; Drug-Related Side Effects and Adverse Reactions; | 2016 |
Systemic ototoxicity: a review.
Topics: Africa South of the Sahara; Aminoglycosides; Antimalarials; Diuretics; Drug-Related Side Effects and | 2005 |
The problem of chemically reactive metabolites.
Topics: Acetaminophen; Animals; Biotransformation; Chemical Phenomena; Chemistry; Chloroform; Drug-Related S | 1982 |
Reported ocular side effects of the ten most frequently prescribed drugs.
Topics: Acetaminophen; Ampicillin; Brompheniramine; Codeine; Diazepam; Digoxin; Drug Prescriptions; Drug-Rel | 1979 |
Metabolic activation: biochemical basis for many drug-induced liver injuries.
Topics: Acetaminophen; Animals; Binding Sites; Carcinogens; Chemical and Drug Induced Liver Injury; Drug Hyp | 1976 |
[Drugs and the thyroid gland].
Topics: Adrenergic beta-Antagonists; Amiodarone; Carbamazepine; Danazol; Drug-Related Side Effects and Adver | 1987 |
23 other studies available for furosemide and Adverse Drug Event
| Article | Year |
|---|---|
Assessment of the health effects of chemicals in humans: II. Construction of an adverse effects database for QSAR modeling.
Topics: Adverse Drug Reaction Reporting Systems; Artificial Intelligence; Computers; Databases, Factual; Dru | 2004 |
Prediction and identification of drug interactions with the human ATP-binding cassette transporter multidrug-resistance associated protein 2 (MRP2; ABCC2).
Topics: Administration, Oral; Animals; Antineoplastic Agents; Antipsychotic Agents; Antiviral Agents; ATP Bi | 2008 |
FDA-approved drug labeling for the study of drug-induced liver injury.
Topics: Animals; Benchmarking; Biomarkers, Pharmacological; Chemical and Drug Induced Liver Injury; Drug Des | 2011 |
In vitro inhibition of the bile salt export pump correlates with risk of cholestatic drug-induced liver injury in humans.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters | 2012 |
Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps).
Topics: Animals; Anti-Infective Agents; Anti-Inflammatory Agents; Chemical and Drug Induced Liver Injury; Da | 2011 |
Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds.
Topics: Chemical and Drug Induced Liver Injury; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme | 2012 |
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily | 2013 |
Application of pharmacovigilance tools in a case of subacute anterior angle narrowing while under furosemide exposure.
Topics: Adverse Drug Reaction Reporting Systems; Aged; Drug-Related Side Effects and Adverse Reactions; Furo | 2022 |
DRUG-RELATED PROBLEMS IN CARDIAC NEONATES UNDER INTENSIVE CARE.
Topics: Anti-Bacterial Agents; Brazil; Cross-Sectional Studies; Diuretics; Drug-Related Side Effects and Adv | 2020 |
Systematic analysis and identification of unexpected interactions from the neuroprotein drug interactome in hydrocephalus pharmacological intervention.
Topics: Astrocytes; Cell Line; Computational Biology; Diuretics; Drug-Related Side Effects and Adverse React | 2019 |
Sequence symmetry analysis graphic adjustment for prescribing trends.
Topics: Adverse Drug Reaction Reporting Systems; Amlodipine; Databases, Factual; Drug Prescriptions; Drug-Re | 2019 |
Identifying High-Risk Medications Associated with Acute Kidney Injury in Critically Ill Patients: A Pharmacoepidemiologic Evaluation.
Topics: Acute Kidney Injury; Adolescent; Case-Control Studies; Child; Child, Preschool; Critical Illness; Dr | 2017 |
Pharmaceuticals that cause mammary gland tumors in animals: findings in women.
Topics: Adult; Aged; Antifungal Agents; Antiprotozoal Agents; Breast Neoplasms; Case-Control Studies; Diuret | 2009 |
New drugs, more complications--old drugs, new complications: drug-related sequelae of neonatal intensive care.
Topics: Bezoars; Critical Care; Drug-Related Side Effects and Adverse Reactions; Furosemide; Humans; Hyperte | 1984 |
An intensive drug monitoring study suggesting possible clinical irrelevance of impaired drug disposition in liver disease.
Topics: Brain Diseases; Diuretics; Drug Evaluation; Drug-Related Side Effects and Adverse Reactions; Furosem | 1983 |
Adverse drug reactions (ADRs) in patients with previous history of chronic alcohol consumption without signs of chronic hepatic damage. A prospective study.
Topics: Adult; Adverse Drug Reaction Reporting Systems; Aged; Aged, 80 and over; Alcohol Drinking; Alcoholis | 1995 |
Life threatening drug reactions amongst medical in-patients.
Topics: Aged; Arrhythmias, Cardiac; Bethanidine; Digoxin; Drug-Related Side Effects and Adverse Reactions; F | 1979 |
Effect of adverse drug reactions on the length of hospitalization.
Topics: Adult; Aged; Drug-Related Side Effects and Adverse Reactions; Female; Furosemide; Hospital Bed Capac | 1978 |
[Drug induced liver injury. Chemical liver necrosis caused by formation of reactive metabolites].
Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Cytochrome P-450 Enzyme System; Drug | 1976 |
[Acute drug-induced pancreatitis].
Topics: Acute Disease; Asparaginase; Azathioprine; Chlorothiazide; Drug-Related Side Effects and Adverse Rea | 1985 |
Psychiatric side effects of nonpsychiatric drugs.
Topics: Aminophylline; Analgesics; Anti-Anxiety Agents; Anti-Bacterial Agents; Anticonvulsants; Antiemetics; | 1971 |
[Management of drug therapy in presence of renal insufficiency].
Topics: Aged; Dehydration; Digoxin; Drug-Related Side Effects and Adverse Reactions; Furosemide; Guanethidin | 1972 |
Screening criteria for drug monitoring. The Kaiser-Permanente drug reaction monitoring system.
Topics: Aged; Drug-Related Side Effects and Adverse Reactions; Female; Furosemide; Humans; Registries; Stati | 1972 |