furosemide has been researched along with Acute Liver Injury, Drug-Induced in 53 studies
Furosemide: A benzoic-sulfonamide-furan. It is a diuretic with fast onset and short duration that is used for EDEMA and chronic RENAL INSUFFICIENCY.
furosemide : A chlorobenzoic acid that is 4-chlorobenzoic acid substituted by a (furan-2-ylmethyl)amino and a sulfamoyl group at position 2 and 5 respectively. It is a diuretic used in the treatment of congestive heart failure.
| Excerpt | Relevance | Reference |
|---|---|---|
| " We present the case of a patient with hypoxic hepatitis in the setting of heart failure and dehydration from furosemide as a reminder of an important clinical lesson." | 7.88 | Hypoxic hepatitis and furosemide. ( Pizzarossa, AC; Rebella, M, 2018) |
| " We present the case of a patient with hypoxic hepatitis in the setting of heart failure and dehydration from furosemide as a reminder of an important clinical lesson." | 3.88 | Hypoxic hepatitis and furosemide. ( Pizzarossa, AC; Rebella, M, 2018) |
| "Furosemide-induced (400mg/kg ip) hepatotoxicity progressing to centrilobular necrosis was studied by light and electron microscopy in Swiss white mice." | 3.66 | Furosemide induced hepatotoxicity. ( McElligott, TF; Walker, RM, 1981) |
| "The possibility that furosemide-induced hepatic necrosis results from the formation of a chemically reactive hepatotoxic metabolite has been examined." | 3.65 | Metabolic activation of furosemide to a chemically reactive, hepatotoxic metabolite. ( Jollow, DJ; Mitchell, JR; Nelson, WL; Potter, WZ; Sasame, HA, 1976) |
| " These findings were confirmed with the histopathological observations, where SFEE was capable of reversing the toxic effects of CCl4 on liver cells compared to that observed in CCl4-intoxicated animals." | 1.43 | Hepatoprotective activity of ethanolic extract of Salix subserrata against CCl4-induced chronic hepatotoxicity in rats. ( Abouzied, MM; Eltahir, HM; Hamed, AN; Wahid, A, 2016) |
| "Furosemide is a diuretic drug, but its reactive intermediates lead to acute liver injury in mice." | 1.40 | Nrf2 protects against furosemide-induced hepatotoxicity. ( Klaassen, CD; Liu, J; Qu, Q; Zhou, HH, 2014) |
| " We proposed a systematic classification scheme using FDA-approved drug labeling to assess the DILI potential of drugs, which yielded a benchmark dataset with 287 drugs representing a wide range of therapeutic categories and daily dosage amounts." | 1.37 | FDA-approved drug labeling for the study of drug-induced liver injury. ( Chen, M; Fang, H; Liu, Z; Shi, Q; Tong, W; Vijay, V, 2011) |
| " An understanding of structure-activity relationships (SARs) of chemicals can make a significant contribution to the identification of potential toxic effects early in the drug development process and aid in avoiding such problems." | 1.36 | Developing structure-activity relationships for the prediction of hepatotoxicity. ( Fisk, L; Greene, N; Naven, RT; Note, RR; Patel, ML; Pelletier, DJ, 2010) |
| " Pharmacokinetic parameters of azosemide were not significantly different between the two groups of rats except t(1/2), MRT, and V(ss)." | 1.29 | Effect of a hepatoprotective agent, YH-439, on the pharmacokinetics of furosemide and azosemide in rats. ( Kim, ND; Kim, SH; Lee, JW; Lee, MG; Park, KJ; Yoon, WH, 1996) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 25 (47.17) | 18.7374 |
| 1990's | 2 (3.77) | 18.2507 |
| 2000's | 4 (7.55) | 29.6817 |
| 2010's | 21 (39.62) | 24.3611 |
| 2020's | 1 (1.89) | 2.80 |
| Authors | Studies |
|---|---|
| Fourches, D | 1 |
| Barnes, JC | 1 |
| Day, NC | 1 |
| Bradley, P | 1 |
| Reed, JZ | 1 |
| Tropsha, A | 1 |
| Greene, N | 1 |
| Fisk, L | 1 |
| Naven, RT | 1 |
| Note, RR | 1 |
| Patel, ML | 1 |
| Pelletier, DJ | 1 |
| Morgan, RE | 2 |
| Trauner, M | 1 |
| van Staden, CJ | 2 |
| Lee, PH | 1 |
| Ramachandran, B | 1 |
| Eschenberg, M | 1 |
| Afshari, CA | 2 |
| Qualls, CW | 1 |
| Lightfoot-Dunn, R | 1 |
| Hamadeh, HK | 2 |
| Ekins, S | 1 |
| Williams, AJ | 1 |
| Xu, JJ | 1 |
| Chen, M | 2 |
| Vijay, V | 1 |
| Shi, Q | 2 |
| Liu, Z | 2 |
| Fang, H | 2 |
| Tong, W | 3 |
| Dawson, S | 1 |
| Stahl, S | 2 |
| Paul, N | 1 |
| Barber, J | 1 |
| Kenna, JG | 2 |
| Ding, D | 1 |
| Kelly, R | 1 |
| Sakatis, MZ | 1 |
| Reese, MJ | 1 |
| Harrell, AW | 1 |
| Taylor, MA | 1 |
| Baines, IA | 1 |
| Chen, L | 1 |
| Bloomer, JC | 1 |
| Yang, EY | 1 |
| Ellens, HM | 1 |
| Ambroso, JL | 1 |
| Lovatt, CA | 1 |
| Ayrton, AD | 1 |
| Clarke, SE | 1 |
| Warner, DJ | 1 |
| Chen, H | 1 |
| Cantin, LD | 1 |
| Walker, CL | 1 |
| Noeske, T | 1 |
| Chen, Y | 2 |
| Kalyanaraman, N | 1 |
| Kalanzi, J | 1 |
| Dunn, RT | 1 |
| Aleo, MD | 1 |
| Luo, Y | 1 |
| Swiss, R | 1 |
| Bonin, PD | 1 |
| Potter, DM | 1 |
| Will, Y | 1 |
| Suzuki, A | 2 |
| Thakkar, S | 1 |
| Yu, K | 1 |
| Hu, C | 1 |
| Church, RJ | 1 |
| Schomaker, SJ | 1 |
| Eaddy, JS | 1 |
| Boucher, GG | 1 |
| Kreeger, JM | 1 |
| Aubrecht, J | 1 |
| Watkins, PB | 1 |
| Luo, L | 1 |
| Wang, H | 1 |
| Wang, S | 1 |
| Liu, K | 1 |
| Li, X | 1 |
| Wang, XJ | 1 |
| Tang, X | 1 |
| Pizzarossa, AC | 1 |
| Rebella, M | 1 |
| Qu, Q | 1 |
| Liu, J | 1 |
| Zhou, HH | 1 |
| Klaassen, CD | 1 |
| McGill, MR | 1 |
| Du, K | 1 |
| Xie, Y | 1 |
| Bajt, ML | 1 |
| Ding, WX | 1 |
| Jaeschke, H | 1 |
| Peyre, L | 1 |
| de Sousa, G | 1 |
| Barcellini-Couget, S | 1 |
| Luzy, AP | 1 |
| Zucchini-Pascal, N | 1 |
| Rahmani, R | 1 |
| Hernández, LM | 1 |
| Salinas, RM | 1 |
| Cabrera, MS | 1 |
| Acosta, GP | 1 |
| Henríquez, MS | 1 |
| Quintana, PP | 1 |
| Díaz, JG | 1 |
| Masubuchi, Y | 1 |
| Nakayama, J | 1 |
| Sadakata, Y | 1 |
| De Capadocia Rosell, J | 1 |
| Jiménez Vizuete, JM | 1 |
| Mateo Cerdá, CM | 1 |
| Lozano Serrano, B | 1 |
| Kobayashi, C | 1 |
| Sasaki, H | 1 |
| Kosuge, K | 1 |
| Miyakita, Y | 1 |
| Hayakawa, M | 1 |
| Abe, E | 1 |
| Suzuki, K | 1 |
| Aizawa, Y | 1 |
| Arai, A | 1 |
| Yan, W | 1 |
| Wakabayashi, S | 1 |
| Hayashi, S | 1 |
| Inazawa, J | 1 |
| Miura, O | 1 |
| Smith, CV | 2 |
| Hughes, H | 1 |
| Mitchell, JR | 10 |
| Krapf, R | 1 |
| Thalmann, H | 1 |
| Walker, RM | 1 |
| McElligott, TF | 1 |
| Grewal, KK | 1 |
| Rafeiro, E | 1 |
| Racz, WJ | 1 |
| Kim, SH | 1 |
| Park, KJ | 1 |
| Yoon, WH | 1 |
| Lee, JW | 1 |
| Kim, ND | 1 |
| Lee, MG | 1 |
| Rogers, LK | 1 |
| Valentine, CJ | 1 |
| Szczpyka, M | 1 |
| Robertson, DG | 1 |
| Reily, MD | 1 |
| Sigler, RE | 1 |
| Wells, DF | 1 |
| Paterson, DA | 1 |
| Braden, TK | 1 |
| Thorgeirsson, SS | 3 |
| Sasame, HA | 2 |
| Jollow, DJ | 3 |
| Potter, WZ | 4 |
| Dybing, E | 4 |
| D'Angelo, LJ | 1 |
| McMurtry, RJ | 2 |
| Nelson, SD | 1 |
| Spitznagle, LA | 1 |
| Wirth, PJ | 1 |
| Boobis, SW | 1 |
| Nelson, WL | 2 |
| Stillman, AS | 1 |
| Huxtable, R | 1 |
| Consroe, P | 1 |
| Kohnen, P | 1 |
| Smith, S | 1 |
| Snodgrass, WR | 1 |
| Gillette, JR | 2 |
| Jollows, DJ | 1 |
| Funk, C | 1 |
| Knoblauch, M | 1 |
| Klouchek, E | 1 |
| Popov, A | 1 |
| Huang, Y | 1 |
| Kamiya, A | 1 |
| Hayashi, Y | 1 |
| Inui, K | 1 |
| Hori, R | 1 |
| Mehrotra, R | 1 |
| Tandon, P | 1 |
| Nath, P | 1 |
| Mousson, C | 1 |
| Justrabo, E | 1 |
| Tanter, Y | 1 |
| Chalopin, JM | 1 |
| Rifle, G | 1 |
| Hinson, JA | 1 |
| Farber, HI | 1 |
| Wahid, A | 1 |
| Hamed, AN | 1 |
| Eltahir, HM | 1 |
| Abouzied, MM | 1 |
5 reviews available for furosemide and Acute Liver Injury, Drug-Induced
| Article | Year |
|---|---|
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Pr | 2016 |
Hypercalcemia worsened by the use of furosemide in a patient suffering from allopurinol-induced granulomatous hepatitis.
Topics: Allopurinol; Chemical and Drug Induced Liver Injury; Diabetes Mellitus, Type 2; Diuretics; Fever; Fu | 2010 |
Successful imatinib treatment of cardiac involvement of FIP1L1-PDGFRA-positive chronic eosinophilic leukemia followed by severe hepatotoxicity.
Topics: Adult; Antineoplastic Agents; Benzamides; Biopsy; Chemical and Drug Induced Liver Injury; Chromosome | 2007 |
Drug metabolism in the production of liver injury.
Topics: Acetaminophen; Acetanilides; Alkylating Agents; Bromobenzenes; Chemical and Drug Induced Liver Injur | 1975 |
Metabolic activation: biochemical basis for many drug-induced liver injuries.
Topics: Acetaminophen; Animals; Binding Sites; Carcinogens; Chemical and Drug Induced Liver Injury; Drug Hyp | 1976 |
48 other studies available for furosemide and Acute Liver Injury, Drug-Induced
| Article | Year |
|---|---|
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLI | 2010 |
Developing structure-activity relationships for the prediction of hepatotoxicity.
Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Humans; Structure-Activity Relationship; | 2010 |
Interference with bile salt export pump function is a susceptibility factor for human liver injury in drug development.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters | 2010 |
A predictive ligand-based Bayesian model for human drug-induced liver injury.
Topics: Bayes Theorem; Chemical and Drug Induced Liver Injury; Humans; Ligands | 2010 |
FDA-approved drug labeling for the study of drug-induced liver injury.
Topics: Animals; Benchmarking; Biomarkers, Pharmacological; Chemical and Drug Induced Liver Injury; Drug Des | 2011 |
In vitro inhibition of the bile salt export pump correlates with risk of cholestatic drug-induced liver injury in humans.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters | 2012 |
Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps).
Topics: Animals; Anti-Infective Agents; Anti-Inflammatory Agents; Chemical and Drug Induced Liver Injury; Da | 2011 |
Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds.
Topics: Chemical and Drug Induced Liver Injury; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme | 2012 |
Mitigating the inhibition of human bile salt export pump by drugs: opportunities provided by physicochemical property modulation, in silico modeling, and structural modification.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters | 2012 |
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily | 2013 |
Human drug-induced liver injury severity is highly associated with dual inhibition of liver mitochondrial function and bile salt export pump.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters | 2014 |
Glutamate dehydrogenase as a biomarker for mitotoxicity; insights from furosemide hepatotoxicity in the mouse.
Topics: Acetaminophen; Alanine Transaminase; Animals; Biomarkers; Chemical and Drug Induced Liver Injury; Fu | 2020 |
Mkp-1 protects mice against toxin-induced liver damage by promoting the Nrf2 cytoprotective response.
Topics: Animals; Butylated Hydroxyanisole; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Dua | 2018 |
Hypoxic hepatitis and furosemide.
Topics: Chemical and Drug Induced Liver Injury; Dehydration; Diagnosis, Differential; Diuretics; Echocardiog | 2018 |
Nrf2 protects against furosemide-induced hepatotoxicity.
Topics: Adaptor Proteins, Signal Transducing; Alanine Transaminase; Animals; Apoptosis; Biomarkers; Chemical | 2014 |
The role of the c-Jun N-terminal kinases 1/2 and receptor-interacting protein kinase 3 in furosemide-induced liver injury.
Topics: Animals; Anthracenes; Cell Line; Chemical and Drug Induced Liver Injury; DNA Damage; Enzyme Activati | 2015 |
High-content screening imaging and real-time cellular impedance monitoring for the assessment of chemical's bio-activation with regards hepatotoxicity.
Topics: Acetaminophen; Amodiaquine; Animals; Carbamazepine; Cell Line, Tumor; Cell Survival; Cells, Cultured | 2015 |
Protective effects of exogenous glutathione and related thiol compounds against drug-induced liver injury.
Topics: Acetaminophen; Acetylcysteine; Animals; Anti-Inflammatory Agents; Chemical and Drug Induced Liver In | 2011 |
[Presentation of a case of Paraquat poisoning].
Topics: Acetylcysteine; Acute Kidney Injury; Adult; Ascorbic Acid; Charcoal; Chemical and Drug Induced Liver | 2012 |
Severe starvation hypoglycemia and congestive heart failure induced by thyroid crisis, with accidentally induced severe liver dysfunction and disseminated intravascular coagulation.
Topics: Aged; Blood Glucose; Blood Pressure; Chemical and Drug Induced Liver Injury; Disseminated Intravascu | 2005 |
Free radicals in vivo. Covalent binding to lipids.
Topics: Acetaminophen; Animals; Bromobenzenes; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; | 1984 |
[Acute exposure to CS tear gas and clinical studies].
Topics: Adult; Chemical and Drug Induced Liver Injury; Digoxin; Furosemide; Heart Failure; Humans; Male; Nit | 1981 |
Furosemide induced hepatotoxicity.
Topics: Animals; Chemical and Drug Induced Liver Injury; Erythrocytes; Furosemide; Liver; Liver Diseases; Ma | 1981 |
Bromobenzene and furosemide hepatotoxicity: alterations in glutathione, protein thiols, and calcium.
Topics: Animals; Bromobenzenes; Calcium; Cell Membrane; Chemical and Drug Induced Liver Injury; Cytosol; Diu | 1996 |
Effect of a hepatoprotective agent, YH-439, on the pharmacokinetics of furosemide and azosemide in rats.
Topics: Animals; Area Under Curve; Chemical and Drug Induced Liver Injury; Diuretics; Drug Interactions; Fur | 1996 |
Effects of hepatotoxic doses of acetaminophen and furosemide on tissue concentrations of CoASH and CoASSG in vivo.
Topics: Acetaminophen; Alanine Transaminase; Animals; Chemical and Drug Induced Liver Injury; Chromatography | 2000 |
Metabonomics: evaluation of nuclear magnetic resonance (NMR) and pattern recognition technology for rapid in vivo screening of liver and kidney toxicants.
Topics: 1-Naphthylisothiocyanate; Aminophenols; Animals; Carbon Tetrachloride; Chemical and Drug Induced Liv | 2000 |
Biochemical changes after hepatic injury from toxic doses of acetaminophen or furosemide.
Topics: Acetaminophen; Aniline Hydroxylase; Animals; Chemical and Drug Induced Liver Injury; Cytochrome P-45 | 1976 |
The role of metabolic activation for drug-induced liver injuries.
Topics: Acetaminophen; Chemical and Drug Induced Liver Injury; Furosemide; Humans; Isoniazid; Liver; Methyld | 1977 |
Oxacillin and hepatotoxicity.
Topics: Acetaminophen; Chemical and Drug Induced Liver Injury; Furosemide; Humans; Meprobamate; Oxacillin; P | 1979 |
Activation of alpha-methyldopa, paracetamol and furosemide by human liver microsomes.
Topics: Acetaminophen; Biotransformation; Chemical and Drug Induced Liver Injury; Cytochrome P-450 Enzyme Sy | 1977 |
Renal and hepatic necrosis after metabolic activation of 2-substituted furans and thiophenes, including furosemide and cephaloridine.
Topics: Animals; Cephaloridine; Chemical and Drug Induced Liver Injury; Furans; Furosemide; In Vitro Techniq | 1977 |
The role of biliary excretion in the hepatotoxicity of furosemide in the mouse.
Topics: Animals; Autoradiography; Bile; Blood Proteins; Chemical and Drug Induced Liver Injury; Furosemide; | 1977 |
Hepatic veno-occlusive disease due to pyrrolizidine (Senecio) poisoning in Arizona.
Topics: Chemical and Drug Induced Liver Injury; Erythrocytes; Female; Furosemide; Hepatic Veins; Humans; Inf | 1977 |
Metabolic activation of furosemide to a chemically reactive, hepatotoxic metabolite.
Topics: Alanine Transaminase; Animals; Chemical and Drug Induced Liver Injury; Chemical Phenomena; Chemistry | 1976 |
The role of biotransformation in chemical-induced liver injury.
Topics: Acetaminophen; Animals; Biotransformation; Bromobenzenes; Chemical and Drug Induced Liver Injury; Cr | 1976 |
Progress in hepatology. Metabolic activation of drugs to toxic substances.
Topics: Acetaminophen; Animals; Bone Marrow Diseases; Chemical and Drug Induced Liver Injury; Chemical Pheno | 1975 |
[Furosemide--pancreas and liver].
Topics: Chemical and Drug Induced Liver Injury; Furosemide; Humans; Pancreatitis | 1975 |
[Fulminant hepatitis].
Topics: Acute Disease; Adrenal Cortex Hormones; Alkalosis, Respiratory; Blood Transfusion; Brain Edema; Chem | 1975 |
[Drug induced liver injury. Chemical liver necrosis caused by formation of reactive metabolites].
Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Cytochrome P-450 Enzyme System; Drug | 1976 |
[Experimental liver damage by furosemide for studying drugs with hepato-protective activity].
Topics: Animals; Chemical and Drug Induced Liver Injury; Furosemide; Male; Rats; Rats, Inbred Strains | 1989 |
Decreased diuretic response to furosemide in rats with acute hepatic failure.
Topics: Adrenalectomy; Aldosterone; Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; D | 1988 |
An experimental study of furosemide induced hepatotoxicity.
Topics: Animals; Chemical and Drug Induced Liver Injury; Female; Furosemide; Liver; Male; Mice; Microscopy, | 1986 |
[Acute granulomatous interstitial nephritis and hepatitis caused by drugs. Possible role of an allopurinol-furosemide combination].
Topics: Acute Disease; Allopurinol; Atenolol; Biopsy; Chemical and Drug Induced Liver Injury; Female; Furose | 1986 |
Hepatic necrosis caused by furosemide.
Topics: Animals; Chemical and Drug Induced Liver Injury; Dose-Response Relationship, Drug; Furosemide; Injec | 1974 |
Commentary. A perspective on the role of chemically reactive metabolites of foreign compounds in toxicity. I. Correlation of changes in covalent binding of reactivity metabolites with changes in the incidence and severity of toxicity.
Topics: Acetaminophen; Animals; Autoradiography; Benzene Derivatives; Carbon Tetrachloride Poisoning; Carcin | 1974 |
Fever, vomiting, and liver dysfunction with procainamide therapy.
Topics: Ampicillin; Blood; Chemical and Drug Induced Liver Injury; Digitalis; Drug Hypersensitivity; Female; | 1974 |
Hepatoprotective activity of ethanolic extract of Salix subserrata against CCl4-induced chronic hepatotoxicity in rats.
Topics: Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Female; Lipid Peroxidation; L | 2016 |