furosemide and Acute Kidney Failure studies

Furosemide: A benzoic-sulfonamide-furan. It is a diuretic with fast onset and short duration that is used for EDEMA and chronic RENAL INSUFFICIENCY.
furosemide : A chlorobenzoic acid that is 4-chlorobenzoic acid substituted by a (furan-2-ylmethyl)amino and a sulfamoyl group at position 2 and 5 respectively. It is a diuretic used in the treatment of congestive heart failure.

Research Excerpts

Excerpt	Relevance	Reference
"This study investigated the effect and mechanism of rosiglitazone on a rat model with contrast-induced acute kidney injury (CI-AKI)."	9.51	Rosiglitazone Alleviates Contrast-Induced Acute Kidney Injury in Rats via the PPAR ( Chen, E; Huang, J; Wu, J; Zheng, X, 2022)
"To study whether furosemide infusion in early-onset acute kidney injury (AKI) in critically ill children would be associated with a reduced proportion of patients progressing to the higher stage (Injury or Failure) as compared to placebo."	9.41	Trial of Furosemide to Prevent Acute Kidney Injury in Critically Ill Children: A Double-Blind, Randomized, Controlled Trial. ( Abraham, S; Bhowmick, R; Chidambaram, M; Mahadevan, S; Maulik, K; Rameshkumar, R; Sheriff, A; Soundravally, R; Subramani, S, 2021)
"Furosemide is commonly prescribed in acute kidney injury (AKI)."	9.24	The effect of low-dose furosemide in critically ill patients with early acute kidney injury: A pilot randomized blinded controlled trial (the SPARK study). ( Bagshaw, SM; Bellomo, R; Gibney, RTN; Hassan, I; Kruger, P; McAlister, FA, 2017)
"This study assessed the determinants of urinary output response to furosemide in acute kidney injury; specifically, whether the response is related to altered pharmacokinetics or pharmacodynamics."	9.22	Determinants of Urinary Output Response to IV Furosemide in Acute Kidney Injury: A Pharmacokinetic/Pharmacodynamic Study. ( Barden, AE; Corcoran, TB; Ho, KM; Lipman, J; Mas, E; Morgan, DJ; Mori, TA; Pavey, W; Roberts, JA; Silbert, BI, 2016)
"A meta-analysis was performed to evaluate the effect of furosemide combined with hydration therapy on the incidence and prognosis of contrast-induced acute kidney injury (CI-AKI) in patients after coronary intervention."	9.12	Meta-analysis of the effects of furosemide combined with hydration therapy on contrast-induced acute kidney injury after coronary intervention. ( Gong, JB; Hu, MJ; Luo, EF; Tang, CC; Wang, L; Zhang, QG, 2021)
"To evaluate the safety and efficacy of low-dose dopamine, high-dose furosemide, and their combination in the treatment of refractory congestive heart failure."	9.08	Increased toxicity of high-dose furosemide versus low-dose dopamine in the treatment of refractory congestive heart failure. ( Cotter, G; Golik, A; Litinski, I; Metzkor, E; Moshkovitz, Y; Perry, C; Tavori, U; Weissgarten, J; Zaidenstein, R, 1997)
"The effects of furosemide and furosemide with dopamine on renal function were studied in 23 patients with acute renal failure due to falciparum malaria whose serum creatinine ranged from 230 to 947 mumol/l."	9.06	Furosemide and dopamine in malarial acute renal failure. ( Keoplung, M; Lumlertgul, D; Moollaor, P; Sitprija, V; Suwangool, P, 1989)
"The use of the furosemide stress test (FST) as an acute kidney injury (AKI) severity marker has been described in several trials."	9.05	Furosemide stress test as a predictive marker of acute kidney injury progression or renal replacement therapy: a systemic review and meta-analysis. ( Chang, CH; Chen, JJ; Huang, YT; Kuo, G, 2020)
"The objective of this meta-analysis of randomized trials was to evaluate if the administration of furosemide with matched hydration using the RenalGuard System reduces contrast-induced acute kidney injury (CI-AKI) in patients undergoing interventional procedures."	8.95	Prevention of Contrast-Induced Acute Kidney Injury by Furosemide With Matched Hydration in Patients Undergoing Interventional Procedures: A Systematic Review and Meta-Analysis of Randomized Trials. ( Belletti, A; Boscolo Berto, M; Cassina, T; Moccetti, T; Pasotti, E; Pedrazzini, G; Putzu, A, 2017)
"Furosemide, a potent loop diuretic, is frequently used in different stages of acute kidney injury, but its clinical roles remain uncertain."	8.86	Benefits and risks of furosemide in acute kidney injury. ( Ho, KM; Power, BM, 2010)
"Although current guidelines didn't support the routine use of furosemide in oliguric acute kidney injury (AKI) management, some patients may benefit from furosemide administration at an early stage."	8.31	Explainable machine learning model for predicting furosemide responsiveness in patients with oliguric acute kidney injury. ( Jiang, M; Li, CL; Li, J; Pan, CQ; Xu, LG, 2023)
"Furosemide, a loop diuretic, is often empirically used to treat acute decompensated heart failure (ADHF) initially."	8.31	Tolvaptan's Association with Low Risk of Acute Kidney Injury in Patients with Advanced Chronic Kidney Disease and Acute Decompensated Heart Failure. ( Hasegawa, M; Hayashi, H; Inaguma, D; Koide, S; Ogata, S; Tagaya, T; Takahashi, K; Tsuboi, N; Yuzawa, Y, 2023)
"To investigate the association between furosemide administration and clinical outcomes in patients with sepsis-associated acute kidney injury (SAKI) receiving renal replacement therapy (RRT)."	8.31	Association between furosemide administration and clinical outcomes in patients with sepsis-associated acute kidney injury receiving renal replacement therapy: a retrospective observational cohort study based on MIMIC-IV database. ( Han, H; Li, C; Li, X; Ren, Q; Wang, G; Xie, K, 2023)
"Furosemide, a frequently prescribed diuretic for managing congestive heart failure and edema, remains a topic of debate regarding its potential risk of inducing acute kidney injury (AKI) in patients."	8.31	Hospitalized patients received furosemide undergoing acute kidney injury: the risk and prediction tool. ( Che, L; Guan, C; Li, C; Liu, Z; Luan, H; Man, X; Wang, Y; Xu, L; Xu, Y; Yang, C; Zhang, N; Zhao, L; Zhou, B, 2023)
"Kidney injury (KI) has been documented in dogs treated with furosemide for left-sided congestive heart failure (CHF)."	8.12	Retrospective evaluation of risk factors for development of kidney injury after parenteral furosemide treatment of left-sided congestive heart failure in dogs. ( Adin, DB; Giorgi, ME; Mochel, JP; Ward, JL; Yuan, L, 2022)
"A standardized assessment of response to furosemide is predictive of acute kidney injury progression in adults, but a paucity of data exists in pediatric patients."	7.91	Furosemide response predicts acute kidney injury in children after cardiac surgery. ( Basu, RK; Cooper, DS; Gist, KM; Goldstein, SL; Kitzmiller, L; Li, Y; Penk, J; Wald, EL; Webb, TN, 2019)
"To examine the effect of furosemide administered under hyperchloremic acidosis on intraoperative oliguria and acute kidney injury in patients with preoperatively normal renal function."	7.91	Effect of Furosemide under Hyperchloremic Acidosis on Intraoperative Oliguria and Acute Kidney Injury in Patients with Normal Renal Function. ( Kikura, M; Nishino, J; Suzuki, Y; Uraoka, M, 2019)
"To validate the furosemide stress test (FST) for predicting the progression of acute kidney injury (AKI)."	7.91	The furosemide stress test for prediction of worsening acute kidney injury in critically ill patients: A multicenter, prospective, observational study. ( Bagshaw, SM; Chawla, LS; Koyner, JL; Liu, KD; McMahon, B; Rewa, OG; Shapiro, J; Smith, O; Trevino, SA; Wald, R; Wang, X, 2019)
"Urine output response to furosemide within 24 hours of cardiopulmonary bypass predicts cardiac surgery-induced acute kidney injury development and other important morbidity in children younger than 90 days old; prospective validation is warranted."	7.88	Furosemide Response Predicts Acute Kidney Injury After Cardiac Surgery in Infants and Neonates. ( Alten, JA; Borasino, S; Cleveland, DC; Crawford, JH; Hock, KM; Martin, KD; Rahman, F; Wall, KM, 2018)
"Furosemide, a loop diuretic, is used to increase urine output in patients with acute kidney injury (AKI)."	7.85	Does Furosemide Increase Oxidative Stress in Acute Kidney Injury? ( Barden, AE; Corcoran, TB; Ho, KM; Lipman, J; Mas, E; Morgan, DJ; Mori, TA; Pavey, W; Roberts, JA; Silbert, BI, 2017)
" An infant affected by initial congestive cardiac failure, after starting the treatment with enalapril in association with furosemide, developed acute kidney injury (AKI)."	7.83	Enalapril Associated with Furosemide Induced Acute Kidney Injury in an Infant with Heart Failure. A Case Report, a Revision of the Literature and a Pharmacovigilance Database Analysis. ( Carnovale, C; Clementi, E; Fabiano, V; Gentili, M; Mameli, C; Perrotta, C; Radice, S; Zuccotti, GV, 2016)
"Children with congenital heart disease in PICU who received furosemide or aminophylline to treat intraoperative oliguria."	7.83	Comparison of Intraoperative Aminophylline Versus Furosemide in Treatment of Oliguria During Pediatric Cardiac Surgery. ( Cottrell, L; Grossman, OK; Gustafson, K; Gustafson, R; Iqbal, HI; Kanosky, S; Mullett, C; Onder, AM; Rhodes, L; Rosen, D; Samsell, L; Seachrist, E, 2016)
"Clinical data are scarce for furosemide administered as a low-dose (<160 mg/24 hours) continuous intravenous infusion in acute heart failure (HF)."	7.78	Clinical experience with low-dose continuous infusion of furosemide in acute heart failure: assessment of efficacy and safety. ( Chan, CY; Elkayam, U; Hshieh, S; Ng, TM, 2012)
"Nephrolithiasis and nephrocalcinosis in low-birth-weight, preterm neonates are well-documented complications of furosemide administration."	7.72	Furosemide nephrolithiasis causing ureteral obstruction and urinoma in a preterm neonate. ( Alpert, SA; Noe, HN, 2004)
"To report a patient with lung cancer and idiopathic myelofibrosis with myeloid metaplasia who developed purpura and acute renal failure while receiving levofloxacin, and review the existing literature on quinolone nephrotoxicity."	7.71	Nephrotoxicity and purpura associated with levofloxacin. ( De Simone, C; Famularo, G, 2002)
"Acute interstitial nephritis with severe acute renal failure is reported following tetracycline treatment in a 22-year-old male medical student."	7.70	Tetracycline-induced acute interstitial nephritis as a cause of acute renal failure. ( Akoglu, E; Bihorac, A; Kullu, S; Ozener, C, 1999)
"An analysis was made in 22 patients with glomerulonephritis taking furosemide as to occurrence of acute renal failure."	7.69	[Acute kidney failure in patients with glomerulonephritis related to the use of furosemide]. ( Dzgoeva, FU; Milovanov, IuS; Nikolaev, AIu; Trofimova, EI, 1995)
"A case of rhabdomyolysis with acute renal failure associated with bezafibrate and furosemide treatment is reported."	7.68	[A case of acute rhabdomyolysis and acute renal insufficiency caused by the simultaneous use of furosemide and bezafibrate]. ( Cordi, GC; Corsi, L; Dapelo, M; De Micheli, A; Grimaldi, GP; Venzano, C, 1990)
"A patient with congestive heart failure and moderate renal insufficiency developed severe reversible non-oliguric renal failure while on frusemide and enalapril."	7.67	Reversible renal failure after combined treatment with enalapril and frusemide in a patient with congestive heart failure. ( Alexandre, JM; Chatellier, G; Funck-Brentano, C, 1986)
" Two patients with acute pulmonary edema and oliguric renal failure were treated with a combined therapy of sorbitol and furosemide."	7.66	The treatment of pulmonary edema in the absence of renal function. A role for sorbitol and furosemide. ( Anderson, CC; Shahvari, MB; Zimmerman, JE, 1979)
"31% of patients had type 2 diabetes mellitus (DM2)."	7.30	The use of Dapagliflozin in Acute Decompensated Heart Failure: Results of the Randomized Study. ( Andreev, DA; Charaya, KV; Dimchishina, AS; Kusova, ZR; Mesitskaya, DF; Nikiforova, TV; Novikova, NA; Schekochikhin, DIY; Shkliarov, AM; Soboleva, TV, 2023)
"31% of patients had type 2 diabetes mellitus (DM2)."	7.30	The use of Dapagliflozin in Acute Decompensated Heart Failure: Results of the Randomized Study. ( Andreev, DA; Charaya, KV; Dimchishina, AS; Kusova, ZR; Mesitskaya, DF; Nikiforova, TV; Novikova, NA; Schekochikhin, DY; Shkliarov, AM; Soboleva, TV, 2023)
"A pharmacokinetic study with high doses of frusemide has been performed in nine patients with acute tubulopathy, treated by hemodialysis."	6.64	[Pharmacokinetic characteristics of a massive dose of furosemide in acute kidney failure]. ( Le Gall, JR; Lucas, A; Meignan, M; Rapin, M; Tillement, JP, 1976)
" Even if the diuretic response to furosemide is expressed by a steep dose-response curve positively correlated with renal function, pharmacodynamic limitations occur when creatinine clearance is < 20 ml/min or urine output is < 500 ml/12 h."	6.61	Furosemide as a functional marker of acute kidney injury in ICU patients: a new role for an old drug. ( Biancone, L; Mariano, F; Mella, A; Vincenti, M, 2019)
"Furosemide is a commonly used loop diuretic in neonatal intensive care."	6.44	Furosemide and acute kidney injury in neonates. ( Moghal, NE; Shenoy, M, 2008)
"The combined prophylactic strategy of sodium bicarbonate plus N-acetylsyteine (NAC) seems to be effective in preventing contrast induced acute kidney injury (CI-AKI) in patients at low-to-medium risk."	6.25	Renal insufficiency following contrast media administration trial II (REMEDIAL II): RenalGuard system in high-risk patients for contrast-induced acute kidney injury: rationale and design. ( Briguori, C; Condorelli, G; Ricciardelli, B; Visconti, G, 2011)
"Methyl bromide is a pre-plant soil fumigant that is widely used to control nematodes, insects, and fungi in farmlands."	5.72	Severe methyl bromide poisoning causing early acute renal failure and anuria: a case report. ( Jian, X; Kan, B; Li, Y; Shi, L; Wang, W; Wen, Z; Yu, G; Zhao, L, 2022)
" The incidence of AKI increased significantly when the cumulative dosage of furosemide exceeded 110 mg (odds ratio [OR] 6."	5.62	Preoperative use of furosemide may increase the incidence of acute kidney injury after coronary artery bypass grafting: a propensity score-matched study. ( Chang, B; Fan, G; Liu, L; Liu, Z; Wang, Z; Zheng, H, 2021)
"Furosemide was associated with reduced in-hospital mortality [hazard ratio (HR) 0."	5.56	Association between furosemide administration and outcomes in critically ill patients with acute kidney injury. ( Hong, GL; Li, MF; Lü, WB; Lu, ZQ; Wu, B; Xu, C; Yao, YM; Ying, JC; Zhao, GJ, 2020)
"This study investigated the effect and mechanism of rosiglitazone on a rat model with contrast-induced acute kidney injury (CI-AKI)."	5.51	Rosiglitazone Alleviates Contrast-Induced Acute Kidney Injury in Rats via the PPAR ( Chen, E; Huang, J; Wu, J; Zheng, X, 2022)
"To study whether furosemide infusion in early-onset acute kidney injury (AKI) in critically ill children would be associated with a reduced proportion of patients progressing to the higher stage (Injury or Failure) as compared to placebo."	5.41	Trial of Furosemide to Prevent Acute Kidney Injury in Critically Ill Children: A Double-Blind, Randomized, Controlled Trial. ( Abraham, S; Bhowmick, R; Chidambaram, M; Mahadevan, S; Maulik, K; Rameshkumar, R; Sheriff, A; Soundravally, R; Subramani, S, 2021)
"Age, use of furosemide, and septic shock were predictors of AKI in critically ill patients."	5.38	Furosemide is associated with acute kidney injury in critically ill patients. ( Almeida, DN; Cruz, CM; Levi, TM; Martins, RT; Rocha, MS; Sanjuan, IT; Santana, NC; Silva, MG, 2012)
"The case of vasomotor parenchymal acute renal failure is reported in a patient a few days after the initiation of treatment by Enalapril which is a new converting enzyme inhibitor."	5.27	[Acute renal insufficiency caused by observed a combination of enalapril, furosemide and flurbiprofen in a patient with retroperitoneal fibrosis]. ( Coevoet, B; Demontis, R; Fournier, A; Guellal, A, 1987)
"Acute renal failure was induced in rats by subcutaneous injection of 200 mg/kg body weight gentamicin on 3 consecutive days."	5.26	Gentamicin-induced acute renal failure in the rat. Effect of dehydration, DOCA-saline and furosemide. ( Brunner, FP; de Rougemont, D; Konrad, L; Oeschger, A; Thiel, G; Torhorst, J; Wenk, M; Wunderlich, P, 1981)
"Post-transplant acute renal failure was reduced from 58 to 21 per cent in those kidneys protected with furosemide and methylprednisolone."	5.25	Reduction of acute tubular necrosis (ATN) by furosemide and steroids in cadaveric kidney recovery. ( Hashim, GM; Lattes, C; McCabe, R; Stevens, LE; Subramamian, A, 1975)
"Furosemide is commonly prescribed in acute kidney injury (AKI)."	5.24	The effect of low-dose furosemide in critically ill patients with early acute kidney injury: A pilot randomized blinded controlled trial (the SPARK study). ( Bagshaw, SM; Bellomo, R; Gibney, RTN; Hassan, I; Kruger, P; McAlister, FA, 2017)
"This study assessed the determinants of urinary output response to furosemide in acute kidney injury; specifically, whether the response is related to altered pharmacokinetics or pharmacodynamics."	5.22	Determinants of Urinary Output Response to IV Furosemide in Acute Kidney Injury: A Pharmacokinetic/Pharmacodynamic Study. ( Barden, AE; Corcoran, TB; Ho, KM; Lipman, J; Mas, E; Morgan, DJ; Mori, TA; Pavey, W; Roberts, JA; Silbert, BI, 2016)
"RenalGuard therapy is superior to sodium bicarbonate and N-acetylcysteine in preventing contrast-induced acute kidney injury in high-risk patients."	5.15	Renal Insufficiency After Contrast Media Administration Trial II (REMEDIAL II): RenalGuard System in high-risk patients for contrast-induced acute kidney injury. ( Airoldi, F; Briguori, C; Condorelli, G; Focaccio, A; Golia, B; Ricciardelli, B; Sangiorgi, GM; Valgimigli, M; Visconti, G, 2011)
"Furosemide by continuous infusion in the recovery phase of hemofiltration-dependent acute kidney failure did increase urinary volume and sodium excretion but did not lead to a shorter duration of renal failure or more frequent renal recovery."	5.14	Furosemide does not improve renal recovery after hemofiltration for acute renal failure in critically ill patients: a double blind randomized controlled trial. ( Boerma, EC; de Ruiter, J; Egbers, PH; Gerritsen, RT; Kingma, WP; Koopmans, M; Kuiper, MA; van der Voort, PH; Zandberg, M, 2009)
"A meta-analysis was performed to evaluate the effect of furosemide combined with hydration therapy on the incidence and prognosis of contrast-induced acute kidney injury (CI-AKI) in patients after coronary intervention."	5.12	Meta-analysis of the effects of furosemide combined with hydration therapy on contrast-induced acute kidney injury after coronary intervention. ( Gong, JB; Hu, MJ; Luo, EF; Tang, CC; Wang, L; Zhang, QG, 2021)
"To evaluate the safety and efficacy of low-dose dopamine, high-dose furosemide, and their combination in the treatment of refractory congestive heart failure."	5.08	Increased toxicity of high-dose furosemide versus low-dose dopamine in the treatment of refractory congestive heart failure. ( Cotter, G; Golik, A; Litinski, I; Metzkor, E; Moshkovitz, Y; Perry, C; Tavori, U; Weissgarten, J; Zaidenstein, R, 1997)
"The effects of furosemide and furosemide with dopamine on renal function were studied in 23 patients with acute renal failure due to falciparum malaria whose serum creatinine ranged from 230 to 947 mumol/l."	5.06	Furosemide and dopamine in malarial acute renal failure. ( Keoplung, M; Lumlertgul, D; Moollaor, P; Sitprija, V; Suwangool, P, 1989)
"The use of the furosemide stress test (FST) as an acute kidney injury (AKI) severity marker has been described in several trials."	5.05	Furosemide stress test as a predictive marker of acute kidney injury progression or renal replacement therapy: a systemic review and meta-analysis. ( Chang, CH; Chen, JJ; Huang, YT; Kuo, G, 2020)
"The objective of this meta-analysis of randomized trials was to evaluate if the administration of furosemide with matched hydration using the RenalGuard System reduces contrast-induced acute kidney injury (CI-AKI) in patients undergoing interventional procedures."	4.95	Prevention of Contrast-Induced Acute Kidney Injury by Furosemide With Matched Hydration in Patients Undergoing Interventional Procedures: A Systematic Review and Meta-Analysis of Randomized Trials. ( Belletti, A; Boscolo Berto, M; Cassina, T; Moccetti, T; Pasotti, E; Pedrazzini, G; Putzu, A, 2017)
"Furosemide, a potent loop diuretic, is frequently used in different stages of acute kidney injury, but its clinical roles remain uncertain."	4.86	Benefits and risks of furosemide in acute kidney injury. ( Ho, KM; Power, BM, 2010)
" There is no benefit for the use of mannitol as an osmotic diuretic over hydration in rhabdomyolysis."	4.85	Diuretics in acute kidney injury. ( Karajala, V; Kellum, JA; Mansour, W, 2009)
"Furosemide (frusemide) is a potent loop diuretic used in the treatment of oedematous states associated with cardiac, renal and hepatic failure, and for the treatment of hypertension."	4.78	Furosemide (frusemide). A pharmacokinetic/pharmacodynamic review (Part I). ( Ponto, LL; Schoenwald, RD, 1990)
" Some examples such as the modification of furosemide pharmacokinetics in acute renal failure, the impaired metabolism of opiate analgesics in hepatic insufficiency, the alterations of the usual disposition process in salicylic acid intoxication, and the influence of cardiac failure upon some drugs pharmacokinetics, have been chosen to illustrate some of the aspects discussed."	4.76	Disease-induced modifications of drug pharmacokinetics. ( Barre, J; Bree, F; Brunner, F; Houin, G; Tillement, JP, 1983)
"Although current guidelines didn't support the routine use of furosemide in oliguric acute kidney injury (AKI) management, some patients may benefit from furosemide administration at an early stage."	4.31	Explainable machine learning model for predicting furosemide responsiveness in patients with oliguric acute kidney injury. ( Jiang, M; Li, CL; Li, J; Pan, CQ; Xu, LG, 2023)
"Furosemide, a loop diuretic, is often empirically used to treat acute decompensated heart failure (ADHF) initially."	4.31	Tolvaptan's Association with Low Risk of Acute Kidney Injury in Patients with Advanced Chronic Kidney Disease and Acute Decompensated Heart Failure. ( Hasegawa, M; Hayashi, H; Inaguma, D; Koide, S; Ogata, S; Tagaya, T; Takahashi, K; Tsuboi, N; Yuzawa, Y, 2023)
"To investigate the association between furosemide administration and clinical outcomes in patients with sepsis-associated acute kidney injury (SAKI) receiving renal replacement therapy (RRT)."	4.31	Association between furosemide administration and clinical outcomes in patients with sepsis-associated acute kidney injury receiving renal replacement therapy: a retrospective observational cohort study based on MIMIC-IV database. ( Han, H; Li, C; Li, X; Ren, Q; Wang, G; Xie, K, 2023)
"Furosemide, a frequently prescribed diuretic for managing congestive heart failure and edema, remains a topic of debate regarding its potential risk of inducing acute kidney injury (AKI) in patients."	4.31	Hospitalized patients received furosemide undergoing acute kidney injury: the risk and prediction tool. ( Che, L; Guan, C; Li, C; Liu, Z; Luan, H; Man, X; Wang, Y; Xu, L; Xu, Y; Yang, C; Zhang, N; Zhao, L; Zhou, B, 2023)
" Spironolactone, furosemide, and trimethoprim with sulfamethoxazole are medicines that, in particular, need to be used carefully and monitored closely in patients in the community at risk of acute kidney injury."	4.12	Medicine-Induced Acute Kidney Injury Findings from Spontaneous Reporting Systems, Sequence Symmetry Analysis and a Case-Control Study with a Focus on Medicines Used in Primary Care. ( Kassie, GM; Kerr, M; Moffat, A; Pratt, N; Roughead, EE, 2022)
"Kidney injury (KI) has been documented in dogs treated with furosemide for left-sided congestive heart failure (CHF)."	4.12	Retrospective evaluation of risk factors for development of kidney injury after parenteral furosemide treatment of left-sided congestive heart failure in dogs. ( Adin, DB; Giorgi, ME; Mochel, JP; Ward, JL; Yuan, L, 2022)
" In our study, dehydration duration and the iohexol dosage were found to be the two most important factors to develop a rat CIN model."	3.91	A novel rat model of contrast-induced nephropathy based on dehydration. ( Chen, LH; Cheng, WJ; Hu, C; Li, DY; Liu, K; Wang, JL; Xie, YL; Yin, WJ; Zhou, G; Zhou, LY; Zuo, SR; Zuo, XC, 2019)
"A standardized assessment of response to furosemide is predictive of acute kidney injury progression in adults, but a paucity of data exists in pediatric patients."	3.91	Furosemide response predicts acute kidney injury in children after cardiac surgery. ( Basu, RK; Cooper, DS; Gist, KM; Goldstein, SL; Kitzmiller, L; Li, Y; Penk, J; Wald, EL; Webb, TN, 2019)
" On multivariate logistic regression analysis, furosemide infusion was observed as an independent risk factor for acute kidney injury (OR 23; 95% CI, 3-141; P<0."	3.91	Profile of Acute Kidney Injury in Hospitalized Children with Idiopathic Nephrotic Syndrome. ( Dabas, A; Kumar, M; Mishra, K; Prasad, BS, 2019)
"To examine the effect of furosemide administered under hyperchloremic acidosis on intraoperative oliguria and acute kidney injury in patients with preoperatively normal renal function."	3.91	Effect of Furosemide under Hyperchloremic Acidosis on Intraoperative Oliguria and Acute Kidney Injury in Patients with Normal Renal Function. ( Kikura, M; Nishino, J; Suzuki, Y; Uraoka, M, 2019)
"To validate the furosemide stress test (FST) for predicting the progression of acute kidney injury (AKI)."	3.91	The furosemide stress test for prediction of worsening acute kidney injury in critically ill patients: A multicenter, prospective, observational study. ( Bagshaw, SM; Chawla, LS; Koyner, JL; Liu, KD; McMahon, B; Rewa, OG; Shapiro, J; Smith, O; Trevino, SA; Wald, R; Wang, X, 2019)
"We aimed to test if PuO2 measurements in patients with septic shock would be similar to those shown in experimental sepsis and would detect changes induced by the administration of furosemide."	3.91	Effect of Furosemide on Urinary Oxygenation in Patients with Septic Shock. ( Bellomo, R; Bitker, L; Canet, E; Cioccari, L; Cutuli, SL; Eastwood, GM; Evans, RG; Iguchi, N; Lankadeva, YR; May, CN; Osawa, EA, 2019)
"Urine output response to furosemide within 24 hours of cardiopulmonary bypass predicts cardiac surgery-induced acute kidney injury development and other important morbidity in children younger than 90 days old; prospective validation is warranted."	3.88	Furosemide Response Predicts Acute Kidney Injury After Cardiac Surgery in Infants and Neonates. ( Alten, JA; Borasino, S; Cleveland, DC; Crawford, JH; Hock, KM; Martin, KD; Rahman, F; Wall, KM, 2018)
"Prospective cohort observational study of 15 patients with septic AKI undergoing continuous veno-venous hemodiafiltration (CVVHDF) divided according to urine volume (< 500 ml/12 h, Oliguria group, n = 5; > 500 ml/12 h, Diuresis group, n = 10) during continuous infusion of furosemide (120 mg/12 h) at steady-state condition."	3.88	Urine volume as a predicting factor for furosemide clearance during continuous infusion in AKI septic shock patients on hemodiafiltration. ( Biancone, L; Carignano, P; Leporati, M; Mariano, F; Stella, M; Vincenti, M, 2018)
"Furosemide, a loop diuretic, is used to increase urine output in patients with acute kidney injury (AKI)."	3.85	Does Furosemide Increase Oxidative Stress in Acute Kidney Injury? ( Barden, AE; Corcoran, TB; Ho, KM; Lipman, J; Mas, E; Morgan, DJ; Mori, TA; Pavey, W; Roberts, JA; Silbert, BI, 2017)
" An infant affected by initial congestive cardiac failure, after starting the treatment with enalapril in association with furosemide, developed acute kidney injury (AKI)."	3.83	Enalapril Associated with Furosemide Induced Acute Kidney Injury in an Infant with Heart Failure. A Case Report, a Revision of the Literature and a Pharmacovigilance Database Analysis. ( Carnovale, C; Clementi, E; Fabiano, V; Gentili, M; Mameli, C; Perrotta, C; Radice, S; Zuccotti, GV, 2016)
"Children with congenital heart disease in PICU who received furosemide or aminophylline to treat intraoperative oliguria."	3.83	Comparison of Intraoperative Aminophylline Versus Furosemide in Treatment of Oliguria During Pediatric Cardiac Surgery. ( Cottrell, L; Grossman, OK; Gustafson, K; Gustafson, R; Iqbal, HI; Kanosky, S; Mullett, C; Onder, AM; Rhodes, L; Rosen, D; Samsell, L; Seachrist, E, 2016)
"To determine if aminophylline administration is associated with improved creatinine clearance and greater urine output in children with acute kidney injury in the cardiovascular ICU."	3.80	Initial experience using aminophylline to improve renal dysfunction in the pediatric cardiovascular ICU. ( Anglemyer, AT; Axelrod, DM; Grimm, PC; Roth, SJ; Sherman-Levine, SF; Sutherland, SM; Zhu, A, 2014)
"Rats received nitric oxide synthase inhibitor L-NAME (10 mg/kg) and cyclooxygenase inhibitor indomethacin (10 mg/kg) to induce the risk for developing iodinated contrast-induced acute kidney injury before receiving one of the interventions: NAC, furosemide, or placebo."	3.80	Efficacy of preventive interventions for iodinated contrast-induced acute kidney injury evaluated by intrarenal oxygenation as an early marker. ( Franklin, T; Li, LP; Lu, J; Papadopoulou, MV; Prasad, PV; Solomon, R; Thacker, J; Zhou, Y, 2014)
"Clinical data are scarce for furosemide administered as a low-dose (<160 mg/24 hours) continuous intravenous infusion in acute heart failure (HF)."	3.78	Clinical experience with low-dose continuous infusion of furosemide in acute heart failure: assessment of efficacy and safety. ( Chan, CY; Elkayam, U; Hshieh, S; Ng, TM, 2012)
"Nephrolithiasis and nephrocalcinosis in low-birth-weight, preterm neonates are well-documented complications of furosemide administration."	3.72	Furosemide nephrolithiasis causing ureteral obstruction and urinoma in a preterm neonate. ( Alpert, SA; Noe, HN, 2004)
"The aim of this study was to evaluate the efficacy of noradrenaline and furosemide in combination for the treatment of impending acute renal failure in early stage of severe sepsis."	3.72	Renal rescue therapy in early stage of severe sepsis: a case study approach. ( Belovicova, C; Blaskova, A; Cintula, D; Setvak, D; Zahorec, R, 2004)
"To report a patient with lung cancer and idiopathic myelofibrosis with myeloid metaplasia who developed purpura and acute renal failure while receiving levofloxacin, and review the existing literature on quinolone nephrotoxicity."	3.71	Nephrotoxicity and purpura associated with levofloxacin. ( De Simone, C; Famularo, G, 2002)
"The effects of furosemide administered at the onset of postischaemic renal failure were investigated in Sprague-Dawley rats one month after exposing the left kidney to 45 min of renal ischemia."	3.71	Failure of loop diuretics to improve the long term outcome of ischaemic damage in rat kidneys. ( Källskog, O; Nygren, K; Wolgast, M, 2001)
"Acute interstitial nephritis with severe acute renal failure is reported following tetracycline treatment in a 22-year-old male medical student."	3.70	Tetracycline-induced acute interstitial nephritis as a cause of acute renal failure. ( Akoglu, E; Bihorac, A; Kullu, S; Ozener, C, 1999)
" FA produced necrosis of the epithelial cells of the convoluted tubules as the detection of the beta-aminoisobutyric acid end product of DNA and thymine catabolism indicated."	3.70	DNA degradation in the kidney of folic acid-treated guinea pigs. ( Gourgiotis, D; Kavazarakis, E; Messaritaki, A; Moustaki, M; Nakopoulou, L; Nicolaidou, P; Tzaki, M; Zeis, MP; Zeis, PM, 2000)
"An analysis was made in 22 patients with glomerulonephritis taking furosemide as to occurrence of acute renal failure."	3.69	[Acute kidney failure in patients with glomerulonephritis related to the use of furosemide]. ( Dzgoeva, FU; Milovanov, IuS; Nikolaev, AIu; Trofimova, EI, 1995)
"A case of rhabdomyolysis with acute renal failure associated with bezafibrate and furosemide treatment is reported."	3.68	[A case of acute rhabdomyolysis and acute renal insufficiency caused by the simultaneous use of furosemide and bezafibrate]. ( Cordi, GC; Corsi, L; Dapelo, M; De Micheli, A; Grimaldi, GP; Venzano, C, 1990)
"A patient with congestive heart failure and moderate renal insufficiency developed severe reversible non-oliguric renal failure while on frusemide and enalapril."	3.67	Reversible renal failure after combined treatment with enalapril and frusemide in a patient with congestive heart failure. ( Alexandre, JM; Chatellier, G; Funck-Brentano, C, 1986)
"To clarify the diuretic response to furosemide in a diseased state, the urinary excretion of furosemide, water, and electrolytes was examined after a single intravenous injection of furosemide in control rats and rats with mild acute renal failure (ARF) induced by glycerol."	3.67	Increased diuretic response to furosemide in rats with glycerol-induced acute renal failure. ( Hayashi, Y; Hori, R; Huang, Y; Inui, K; Kamiya, A; Kikkoji, T, 1988)
" Acute volume depletion (2% body weight; by furosemide injection or by hemorrhage) or volume expansion (10% body weight; by saline infusion) was induced in Sprague-Dawley rats."	3.67	Alterations of intravascular volume: influence on renal susceptibility to ischemic injury. ( Zager, RA, 1986)
" min-1 furosemide in 5% body wt normal saline for the 60 min preceding 60 min of total renal ischemia."	3.66	Prior mannitol and furosemide infusion in a model of ischemic acute renal failure. ( Davidson, K; Hanley, MJ, 1981)
"High dose of intravenous furosemide (2 g/24 hr) was given to six patients with acute renal failure due to leptospirosis."	3.66	Furosemide and acute renal failure. ( Borirakchanyavat, V; Sitprija, V; Vongsthongsri, M, 1978)
" Two patients with acute pulmonary edema and oliguric renal failure were treated with a combined therapy of sorbitol and furosemide."	3.66	The treatment of pulmonary edema in the absence of renal function. A role for sorbitol and furosemide. ( Anderson, CC; Shahvari, MB; Zimmerman, JE, 1979)
" Under these conditions ketoacidosis causes impaired renal uric acid excretion and hyperuricemia."	3.65	[Acute kidney failure as a complication of fasting therapy]. ( Binswanger, U; Huber, M; Lämmli, J; Meier, HR; Wick, A; Zürcher, HU, 1977)
"31% of patients had type 2 diabetes mellitus (DM2)."	3.30	The use of Dapagliflozin in Acute Decompensated Heart Failure: Results of the Randomized Study. ( Andreev, DA; Charaya, KV; Dimchishina, AS; Kusova, ZR; Mesitskaya, DF; Nikiforova, TV; Novikova, NA; Schekochikhin, DIY; Shkliarov, AM; Soboleva, TV, 2023)
"31% of patients had type 2 diabetes mellitus (DM2)."	3.30	The use of Dapagliflozin in Acute Decompensated Heart Failure: Results of the Randomized Study. ( Andreev, DA; Charaya, KV; Dimchishina, AS; Kusova, ZR; Mesitskaya, DF; Nikiforova, TV; Novikova, NA; Schekochikhin, DY; Shkliarov, AM; Soboleva, TV, 2023)
"We can assume that PMMA-CHDF in the treatment of septic shock patients with ARF is clinically relevant."	2.76	Comparison of efficacy between continuous hemodiafiltration with a PMMA high-performance membrane dialyzer and a PAN membrane hemofilter in the treatment of septic shock patients with acute renal failure. ( Harada, D; Harii, N; Matsuda, K; Moriguchi, T; Sugawara, H; Yanagisawa, M, 2011)
"Furosemide is known to increase renal prostaglandin synthesis."	2.75	Effect of furosemide on ductal closure and renal function in indomethacin-treated preterm infants during the early neonatal period. ( Byun, SY; Chang, JY; Chung, ML; Kim, EA; Kim, HY; Kim, KS; Lee, BS; Pi, SY, 2010)
"Loop diuretics are commonly used in acute renal failure."	2.71	Differential effects of human atrial natriuretic peptide and furosemide on glomerular filtration rate and renal oxygen consumption in humans. ( Ricksten, SE; Sellgren, J; Swärd, K; Valsson, F, 2005)
"Torsemide has a longer duration of action and does not accumulate in renal failure."	2.71	Torsemide versus furosemide after continuous renal replacement therapy due to acute renal failure in cardiac surgery patients. ( Martin, M; Morgera, S; Spies, C; Staegemann, M; Vargas Hein, O; von Heymann, C; Wagner, D, 2005)
"Because development of acute renal failure is one of the most potent predictors of outcome in cardiac surgery patients, the prevention of renal dysfunction is of utmost importance in perioperative care."	2.69	Lack of renoprotective effects of dopamine and furosemide during cardiac surgery. ( Donner, E; Druml, W; Grubhofer, G; Hiesmayr, M; Lassnigg, A; Presterl, E, 2000)
"Gallopamil was infused into each kidney at the rate of 40 to 80 micrograms/min for 4 hours."	2.67	Intrarenal infusion of gallopamil in acute renal failure. A preliminary report. ( Conger, JD; Hundagoon, P; Keoplung, M; Lumlertgul, D; Schrier, RW; Sirivanichai, C; Wongmekiat, O, 1991)
"Fifty-eight patients in established acute renal failure following trauma or surgery were allocated in a prospective and random fashion to two different diuretic regimes."	2.65	High dose frusemide in acute renal failure: a controlled trial. ( Brown, CB; Cameron, JS; Ogg, CS, 1981)
"A pharmacokinetic study with high doses of frusemide has been performed in nine patients with acute tubulopathy, treated by hemodialysis."	2.64	[Pharmacokinetic characteristics of a massive dose of furosemide in acute kidney failure]. ( Le Gall, JR; Lucas, A; Meignan, M; Rapin, M; Tillement, JP, 1976)
"The furosemide dose was 20-60 mg."	2.64	The effect of prophylactic use of furosemide on renal function during open heart surgery. ( Hollmén, A; Nuutinen, L, 1976)
" Even if the diuretic response to furosemide is expressed by a steep dose-response curve positively correlated with renal function, pharmacodynamic limitations occur when creatinine clearance is < 20 ml/min or urine output is < 500 ml/12 h."	2.61	Furosemide as a functional marker of acute kidney injury in ICU patients: a new role for an old drug. ( Biancone, L; Mariano, F; Mella, A; Vincenti, M, 2019)
"The furosemide stress test has been demonstrated to be a useful clinical tool to ascertain tubular integrity in the setting of acute kidney injury."	2.55	Use of stress tests in evaluating kidney disease. ( Chawla, LS; Koyner, JL, 2017)
"Furosemide is a commonly used loop diuretic in neonatal intensive care."	2.44	Furosemide and acute kidney injury in neonates. ( Moghal, NE; Shenoy, M, 2008)
" In congestive heart failure, the difference is greater between oral and intravenous doses than apparent from the bioavailability of the drugs."	2.38	[Loop diuretics. Rational pharmacotherapy]. ( Bülow, HH; Ladefoged, SD, 1993)
"Acute renal failure is a known complication of cardiovascular surgery and is associated with a high mortality."	2.37	Acute renal failure in the cardiovascular surgical patient. ( Joob, AW; Kron, IL; Van Meter, C, 1985)
" In this study, we compared the effectiveness and safety of a continuous infusion with that of a bolus injection when an increased loop diuretic dosage is required in intensive care unit (ICU) patients."	1.91	Comparative effectiveness and safety of bolus vs. continuous infusion of loop diuretics: Results from the MIMIC-III Database. ( Chen, Q; Feng, P; He, C; Huo, Y; Jiang, J; Li, J; Li, Y; Nie, X; Sun, W; Weng, H; Zhang, Y; Zhao, F, 2023)
"Hypertension is modeled as overactive renal sympathetic nervous activity."	1.72	Determining risk factors for triple whammy acute kidney injury. ( Layton, AT; Leete, J; López-Hernández, FJ; Wang, C, 2022)
"Methyl bromide is a pre-plant soil fumigant that is widely used to control nematodes, insects, and fungi in farmlands."	1.72	Severe methyl bromide poisoning causing early acute renal failure and anuria: a case report. ( Jian, X; Kan, B; Li, Y; Shi, L; Wang, W; Wen, Z; Yu, G; Zhao, L, 2022)
" The incidence of AKI increased significantly when the cumulative dosage of furosemide exceeded 110 mg (odds ratio [OR] 6."	1.62	Preoperative use of furosemide may increase the incidence of acute kidney injury after coronary artery bypass grafting: a propensity score-matched study. ( Chang, B; Fan, G; Liu, L; Liu, Z; Wang, Z; Zheng, H, 2021)
"Furosemide was associated with reduced in-hospital mortality [hazard ratio (HR) 0."	1.56	Association between furosemide administration and outcomes in critically ill patients with acute kidney injury. ( Hong, GL; Li, MF; Lü, WB; Lu, ZQ; Wu, B; Xu, C; Yao, YM; Ying, JC; Zhao, GJ, 2020)
"L-carnitine or furosemide was administered, and serial blood samples were collected and analyzed to assess the effects of hydronephrosis on the pharmacokinetic parameters."	1.56	Rats with congenital hydronephrosis show increased susceptibility to renal ischemia-reperfusion injury. ( Cirule, H; Dambrova, M; Liepinsh, E; Sevostjanovs, E; Videja, M; Vilks, K; Vilskersts, R; Zharkova-Malkova, O, 2020)
"The paper describes a case of severe preranal acute renal failure that was induced by the uncontrolled long-term use of furosemide and that was reversible after infusion therapy."	1.40	[The specific features of kidney injury due to abuse of saluretics and uncontrollable fasting in anorexia nervosa]. ( Nikolaev, AIu; Tareeva, AB; Zakharova, EV, 2014)
"Severe hemolysis and acute renal failure are extremely rare complications that may be aggravated by the presence of an acute EBV infection."	1.39	Acute renal failure in a child with thrombocytopenic purpura caused by acute Epstein-Barr virus infection after treatment with anti-D immunoglobulin. ( Garoufi, A; Kossiva, L; Kyriakou, D; Mitsioni, A, 2013)
"In patients with congestive heart failure (CHF), use of loop diuretic therapy may result in acute kidney insufficiency (AKI)."	1.39	Predisposing factors for acute kidney injury in Hispanic patients treated with diuretics for decompensated heart failure. ( Cangiano, JL; López, JE; Marmorato, R; Pagán, P; Ramírez, T; Ricci, F; Soto-Salgado, M; Vega, J, 2013)
"We identified 423 patients with severe sepsis and electronically recorded continuous hemodynamic data in the prospective observational FINNAKI study."	1.39	Hemodynamic variables and progression of acute kidney injury in critically ill patients with severe sepsis: data from the prospective observational FINNAKI study. ( Hautamäki, R; Hovilehto, S; Inkinen, O; Karlsson, S; Kaukonen, KM; Korhonen, AM; Kuitunen, A; Laru-Sompa, R; Pettilä, V; Poukkanen, M; Uusaro, A; Vaara, ST; Wilkman, E, 2013)
"Age, use of furosemide, and septic shock were predictors of AKI in critically ill patients."	1.38	Furosemide is associated with acute kidney injury in critically ill patients. ( Almeida, DN; Cruz, CM; Levi, TM; Martins, RT; Rocha, MS; Sanjuan, IT; Santana, NC; Silva, MG, 2012)
" Dosing of diuretics is difficult in these patients."	1.37	Management of diuretic treatment: a challenge in the obese patient. ( Jespersen, B; Lassen, CK, 2011)
"Furosemide has no effect on both FENa and FE UN."	1.36	The fractional excretion of urea in the differential diagnosis of prerenal failure and acute tubular necrosis in neonates. ( Jungthirapanich, J; Khositseth, S; Srithipsukho, P; Techasatid, W, 2010)
"Acute renal failure was caused by D."	1.35	The effects of the nonsteroidal anti-inflammatory drug diclofenac sodium on the rat kidney, and alteration by furosemide. ( Balal, M; Besen, A; Dogan, A; Gonlusen, G; Inal, T; Kibar, M; Kose, F; Paydas, S, 2009)
"9%) and by bolus dosing (43."	1.34	Diuretics in the management of acute kidney injury: a multinational survey. ( Bagshaw, SM; Bellomo, R; Delaney, A; Jones, D; Ronco, C, 2007)
"Treatment with furosemide significantly (p < 0."	1.34	Furosemide prevents apoptosis and associated gene expression in a rat model of surgical ischemic acute renal failure. ( Aravindan, N; Aravindan, S; Riedel, BJ; Shaw, AD; Weng, HR, 2007)
"Treatment with furosemide was used to study HIF expression under conditions of ameliorated tissue injury."	1.33	Up-regulation of HIF in experimental acute renal failure: evidence for a protective transcriptional response to hypoxia. ( Bachmann, S; Eckardt, KU; Frei, U; Goldfarb, M; Griethe, W; Heyman, SN; Reinke, P; Rosen, S; Rosenberger, C; Shina, A, 2005)
"We report a case of an acute renal failure secondary to povidone iodine exposure in a 37-year-old woman."	1.33	[Acute renal failure following mucosal administration of povidone iodine]. ( Abderrahim, E; Béji, S; Ben Hamida, F; Ben Maiz, H; Ben Moussa, F; Kaaroud, H; Kheder, A; Zghidi, S, 2006)
"In patients with congestive heart failure (CHF), continuous diuretic therapy may result in acute renal insufficiency (ARI)."	1.33	Risk factors for acute renal insufficiency induced by diuretics in patients with congestive heart failure. ( Chou, SY; Reiser, IW; Sun, WY, 2006)
"ARF with eclampsia is a frequent situation that required intensive management when risks factors were present."	1.32	Acute renal failure during eclampsia: incidence risks factors and outcome in intensive care unit. ( Alaoui, SY; Barrou, L; Mjahed, K, 2004)
"Furosemide pretreatment to reduce the imbalance between oxygen supply and demand markedly attenuated the basal-medullary hypoxia produced in the presence of indomethacin and RSR13 (P < 0."	1.31	Effects of enhanced oxygen release from hemoglobin by RSR13 in an acute renal failure model. ( Burke, TJ; Malhotra, D; Shapiro, JI, 2001)
"Renal recovery is much better when acute renal failure is caused by nephrotic syndrome."	1.30	[Severe nephrotic syndrome with reversible acute kidney failure in lupus-associated membranous nephropathy]. ( Kuhlmann, U; Mettang, T; Pauli-Magnus, C, 1999)
"We describe a case of rapidly appearing acute renal failure following a single intramuscular dose of ketorolac."	1.29	Ketorolac induced acute renal failure following a single dose. ( Kayser, SR; Quan, DJ, 1994)
"Using various models of acute renal failure (ARF) in rats, the diuretic effects of 8-(noradamantan-3-yl)-1,3-dipropylxanthine (KW-3902), a novel adenosine A1-receptor antagonist (0."	1.29	Diuretic effects of KW-3902, a novel adenosine A1-receptor antagonist, in various models of acute renal failure in rats. ( Karasawa, A; Kusaka, H; Sano, J; Sato, K; Yao, K, 1994)
"Septic shock is frequently associated with acute renal failure."	1.28	Effects of naloxone infusion in patients with septic shock and renal failure: a limited experience. ( Ali, MM; Duarte, RR; Grace, BW; Nayak, P; Sayegh, NY, 1992)
"Furosemide was well tolerated."	1.28	High doses of furosemide in children with acute renal failure. A preliminary retrospective study. ( Prandota, J, 1991)
"This report concerns two boys with minimal change nephrotic syndrome progressed to renal failure."	1.28	[Rapid deterioration of renal function in minimal change nephrotic syndrome]. ( Matsutani, H; Narumi, F; Niimura, F; Oogushi, H; Shimoda, M; Takeda, A; Yoneshima, H, 1991)
" Plasma level-diuretic response relationship was extensively shifted to the right in HgCl2-treated dogs, while urinary dose-response relationship did not change significantly between two groups."	1.28	The pharmacokinetics and pharmacodynamics of furosemide in anesthetized dogs with normal and experimentally decreased renal function. ( Hirai, J; Miyazaki, H; Taneike, T, 1990)
"Treatment with furosemide and/or normal saline prevented both the decline in renal function and mTAL injury."	1.28	Protective role of furosemide and saline in radiocontrast-induced acute renal failure in the rat. ( Brezis, M; Greenfeld, Z; Heyman, SN; Rosen, S, 1989)
"Administration of diuretics during acute renal failure in animals has been demonstrated to be of value with mannitol and/or loop-blocking diuretics, furosemide or ethacrynic acid."	1.27	The use of diuretics in varying degrees of renal impairment: an overview. ( Dickerman, D; Lowenthal, DT, 1983)
" Electrolytes, blood urea nitrogen, and serum creatinine levels need to be monitored in high-risk patients with predisposing factors and for chronic, long-term use of drugs that inhibit prostaglandin synthesis."	1.27	Reversible renal failure associated with ibuprofen: case report and review of the literature. ( Poirier, TI, 1984)
"Renal ischemia has been implicated as a major factor in the pathogenesis of acute renal failure."	1.27	Renal ischemic injury in the dog: characterization and effect of various pharmacologic agents. ( Barnes, JL; Fried, T; Lewis, RM; Nickel, AE; Osgood, RW; Patton, MK; Rice, JH; Stein, JH, 1984)
"Acute renal failure is a rare complication of acute polymyositis."	1.27	Acute renal failure and polymyositis: case report. ( Bailey, RR; Lynn, KL; Swainson, CP, 1984)
"The courses of the acute renal failure observed in all three study groups were similar; however, there was a suggestion in the surviving animals that these maneuvers may have contributed to a more rapid return in renal function among rats not dying of DDP induced acute renal failure."	1.27	Cis-diamminedichloroplatinum (DDP) induced acute renal failure (ARF): attempts at amelioration. ( Chopra, S; Flamenbaum, W; Kaufman, J, 1983)
"Into 24 oliguric patients with acute renal failure (ARF) for whom mannitol and high-dose frusemide had failed to promote a diuresis, dopamine (3 micrograms/kg/min) plus frusemide (10-15 mg/kg/h) were infused for 6-24 h."	1.27	Dopamine and frusemide in oliguric acute renal failure. ( Aroldi, A; Brancaccio, D; Cantaluppi, A; Casati, S; Citterio, A; Graziani, G; Ponticelli, C; Scalamogna, A; Silenzio, R, 1984)
"Two of them, which were both polytraumatized, suffered from adult respiratory distress syndrome (ARDS)."	1.27	Renin-angiotensin system in sepsis. ( Hilgenfeldt, U; Kellermann, W; Kienapfel, G; Schmidt, M; Schott, R, 1987)
"The case of vasomotor parenchymal acute renal failure is reported in a patient a few days after the initiation of treatment by Enalapril which is a new converting enzyme inhibitor."	1.27	[Acute renal insufficiency caused by observed a combination of enalapril, furosemide and flurbiprofen in a patient with retroperitoneal fibrosis]. ( Coevoet, B; Demontis, R; Fournier, A; Guellal, A, 1987)
"Because the pathogenesis of acute renal failure is multifactorial, clinical evaluation and ancillary studies must be performed systematically to reliably differentiate the various disorders."	1.27	Acute renal failure. II. Management of suspected and established disease. ( Feld, LG; Fildes, RD; Springate, JE, 1986)
"We conclude that: acute renal failure in kidney graft recipients with TRAS is frequent, but not mandatory; sodium depletion induced by diuretics enhances the fall in GFR; acute effect of captopril must be assessed in patients with TRAS before the use of this product as long term antihypertensive treatment."	1.27	[Hypertension and stenosis of the graft artery: effects of conversion enzyme inhibition]. ( Argiles, A; Mimran, A; Mion, C; Mourad, G; Ribstein, J, 1986)
" The urinary excretion profile of furosemide was not significantly changed by concurrent dosing of tenoxicam."	1.27	Study on the possible interaction between tenoxicam and furosemide. ( Hartmann, D; Kleinbloesem, CH; Lücker, PW; Vetter, G, 1987)
"Treatment with muzolimine by food (in a concentration of 800 ppm for four days) and additional oral gavage one hour prior to ischemia prevented the sequelae of ischemia to a great extent."	1.27	Beneficial effect of muzolimine in postischemic acute renal failure in rats. ( Garthoff, B, 1985)
" Urinary Hg excretion was variable during the first 24 h after HgCl2 injection and tended to be higher with higher dosage unless the animals became anuric early on."	1.27	Renal mercury content in HgCl2-induced acute renal failure in furosemide/saline-protected and nonprotected rats. ( Brunner, FP; de Rougemont, D; Robbiani, M; Seiler, H; Thiel, G, 1985)
"In rats with 1 mg/kg HgCl2-induced acute renal failure, azosemide at doses ranging from 10 to 40 mg/kg p."	1.26	[Pharmacological studies on diuretic action of azosemide [5-(4'-chloro-5'-sulfamoyl-2'-thenylamino)-phenyltetrazole], a new diuretic (2). Diuretic action of azosemide in HgCl2-induced acute renal failure in rats]. ( Ito, M; Komura, T; Suzuki, Y, 1982)
"Acute renal failure was induced in rats by subcutaneous injection of 200 mg/kg body weight gentamicin on 3 consecutive days."	1.26	Gentamicin-induced acute renal failure in the rat. Effect of dehydration, DOCA-saline and furosemide. ( Brunner, FP; de Rougemont, D; Konrad, L; Oeschger, A; Thiel, G; Torhorst, J; Wenk, M; Wunderlich, P, 1981)
"Furosemide (20 mg/kg) was injected intraperitoneally daily and for the first time 24 h after injection of glycerol Mortality and azotemia of acute renal failure was not improved by this drug."	1.26	[Action of furosemide in experimental acute renal failure (author's transl)]. ( Greven, J; Kölling, B, 1978)
" We believe that repeated renograms, a reduction in azathioprine dosage and careful dialysis is the only treatment necessary."	1.26	Etiology and prognosis in acute post-transplant renal failure. ( Buselmeier, TJ; Casali, RE; Kjellstrand, CM; Najarian, JS; Shideman, JR; Simmons, RL, 1976)
"The renal effects of furosemide in acute renal failure of the rat were studied using clearance and micropuncture techniques."	1.26	Renal effects of furosemide in glycerol induced acute renal failure of the rat. ( Greven, J; Klein, H, 1976)
"Fifty-two cases of acute renal failure at Livingstone Hospital were studied."	1.26	Acute renal failure. Experience with 52 patients treated at Livingstone Hospital. ( Naidoo, PM, 1976)
"Post-transplant acute renal failure was reduced from 58 to 21 per cent in those kidneys protected with furosemide and methylprednisolone."	1.25	Reduction of acute tubular necrosis (ATN) by furosemide and steroids in cadaveric kidney recovery. ( Hashim, GM; Lattes, C; McCabe, R; Stevens, LE; Subramamian, A, 1975)
"In a sixth patient with nonoliguric acute renal failure, urine volume increased with a gradual decrease in blood urea nitrogen and creatinine during the week after study."	1.25	Effect of intrarenal furosemide on renal function and intratenal hemodynamics in acute renal failure. ( Befeler, B; Epstein, M; Schneider, NS, 1975)
"The mean duration of acute renal failure in survivors of the present series was 11."	1.25	Clinical determinants of survival from postoperative renal failure. ( Baek, SM; Makabali, GG; Shoemaker, WC, 1975)
"Six of the diabetic patients with acute renal failure recovered; two required hemodialysis, never regaining self-sustaining renal function."	1.25	Acute renal failure after excretory urography in diabetic patients. ( Diaz-Buxo, JA; Hattery, RR; Palumbo, PJ; Wagoner, RD, 1975)
"The use of potent diuretics in acute renal failure remains controversial."	1.25	Effects of furosemide on low-dose mercuric chloride acute renal failure in the rat. ( Freeman, RB; Jaenike, JR; Pabico, RC; Ufferman, RC, 1975)
"Twelve patients with acute renal failure underwent L."	1.25	Renal hemodynamic response to l-dopa during acute renal failure in man. ( Berthoux, F; Beruard, M; Collard, M; Guey, A; Pinet, A; Plantier, J; Traeger, J; Zech, P, 1975)
"Acute anuric renal failure complicating systemic lupus erythematosus does not usually respond to treatment with corticosteroids and immunosuppressive agents."	1.25	Acute renal failure in systemic lupus erythematosus. ( Brancaccio, D; Imbasciati, E; Ponticelli, C; Rivolta, E; Tarantino, A, 1974)

Research

Studies (507)

Authors

Clinical Trials (30)

Trial Overview

Trial Outcomes

Change in Brain Natriuretic Peptide (BNP) Levels From Admission to the Discharge

Timeframe	Studies, this research(%)	All Research%
pre-1990	262 (51.68)	18.7374
1990's	52 (10.26)	18.2507
2000's	51 (10.06)	29.6817
2010's	93 (18.34)	24.3611
2020's	49 (9.66)	2.80

Authors	Studies
Suzuki, F	1
Shimada, J	1
Mizumoto, H	1
Karasawa, A	6
Kubo, K	1
Nonaka, H	1
Ishii, A	1
Kawakita, T	1
Gu, Z	1
Huang, Z	1
Mo, M	1
Huang, H	2
Khera, D	1
Paul, B	1
Goyal, JP	1
Rameshkumar, R	2
Leete, J	1
Wang, C	2
López-Hernández, FJ	2
Layton, AT	2
Yang, WH	1
Xue, FS	1
Wan, L	1
Shen, J	2
Chu, Y	1
Yan, S	1
Wu, J	2
Wang, W	2
Jiang, N	1
Jin, H	1
Che, X	1
Ni, Z	1
Fang, Y	1
Mou, S	1
Kaul, A	1
Fursule, A	1
Shiwarkar, G	1
Shah, S	1
Roughead, EE	1
Kerr, M	1
Moffat, A	1
Kassie, GM	1
Pratt, N	1
Huang, J	1
Chen, E	1
Zheng, X	1
Li, Y	3
Yu, G	1
Shi, L	1
Zhao, L	2
Wen, Z	1
Kan, B	1
Jian, X	1
Giorgi, ME	1
Mochel, JP	1
Yuan, L	1
Adin, DB	1
Ward, JL	1
Xie, CM	1
Yao, YT	1
Yang, K	1
Shen, MQ	1
He, LX	1
Dai, Z	1
Hu, C	2
Fu, Y	1
Han, Z	1
Cao, M	1
Fu, G	1
Weng, H	1
Nie, X	1
He, C	1
Feng, P	1
Zhao, F	1
Chen, Q	1
Sun, W	1
Jiang, J	1
Zhang, Y	1
Huo, Y	2
Li, J	2
Jiang, M	1
Pan, CQ	1
Xu, LG	1
Li, CL	1
John, JS	1
Deepthi, RV	1
Rebekah, G	1
Prabhu, SB	1
Ajitkumar, P	1
Mathew, G	1
Agarwal, I	1
Khandelwal, P	1
McLean, N	1
Menon, S	1
Cai, L	1
Shu, L	1
Yujun, Z	1
Ke, C	1
Qiang, W	1
Meersch, M	1
Weiss, R	1
Gerss, J	1
Albert, F	1
Gruber, J	1
Kellum, JA	4
Chawla, L	1
Forni, LG	2
Koyner, JL	6
von Groote, T	1
Zarbock, A	1
Hasson, DC	1
Zhang, B	1
Krallman, K	1
Rose, JE	1
Kempton, KM	1
Steele, P	1
Devarajan, P	1
Goldstein, SL	2
Alder, MN	1
Zhang, K	1
Zhang, H	1
Zhao, C	2
Hu, Z	1
Shang, J	1
Chen, Y	1
Li, B	1
Guo, S	1
Tagaya, T	1
Hayashi, H	1
Ogata, S	1
Takahashi, K	1
Koide, S	1
Inaguma, D	1
Hasegawa, M	1
Yuzawa, Y	1
Tsuboi, N	1
Okamura, K	1
Lu, S	1
He, Z	1
Altmann, C	1
Montford, JR	1
Li, AS	1
Lucia, MS	1
Orlicky, DJ	1
Weiser-Evans, M	1
Faubel, S	1
Li, C	2
Ren, Q	1
Li, X	1
Han, H	1
Xie, K	1
Wang, G	1
Guan, C	1
Xu, L	1
Che, L	1
Wang, Y	1
Yang, C	1
Zhang, N	1
Liu, Z	3
Zhou, B	1
Man, X	1
Luan, H	1
Xu, Y	1
Charaya, KV	2
Schekochikhin, DIY	1
Nikiforova, TV	2
Dimchishina, AS	2
Soboleva, TV	2
Shkliarov, AM	2
Kusova, ZR	2
Mesitskaya, DF	2
Novikova, NA	2
Andreev, DA	2
Schekochikhin, DY	1
Liu, K	1
Zhou, LY	1
Li, DY	1
Cheng, WJ	1
Yin, WJ	1
Xie, YL	1
Wang, JL	1
Zuo, SR	1
Chen, LH	1
Zhou, G	1
Zuo, XC	1
Winther-Olesen, M	1
Møller, MH	1
Johansen, KK	1
Aasvang, EK	1
Reis, T	1
Zhao, GJ	1
Xu, C	1
Ying, JC	1
Lü, WB	1
Hong, GL	1
Li, MF	1
Wu, B	1
Yao, YM	1
Lu, ZQ	1
Coca, A	1
Aller, C	1
Reinaldo Sánchez, J	1
Valencia, AL	1
Bustamante-Munguira, E	1
Bustamante-Munguira, J	1
Chen, JJ	1
Chang, CH	1
Huang, YT	1
Kuo, G	1
Gao, S	1
Yang, L	1
Wang, Z	2
Prieto-García, L	1
Vicente-Vicente, L	1
Blanco-Gozalo, V	1
Hidalgo-Thomas, O	1
García-Macías, MC	1
Kurtz, A	1
Sanz, AB	1
Morales, AI	1
Martínez-Salgado, C	1
Pericacho, M	1
Sancho-Martínez, SM	1
Pettit, KA	1
Schreiter, NA	1
Lushaj, EB	1
Hermsen, JL	1
Wilhelm, M	1
Mahon, ACR	1
Nelson, KL	1
DeGrave, JJ	1
Marka, N	1
Anagnostopoulos, PV	1
Hu, M	1
Yan, G	1
Tang, H	1
Wang, L	2
Zhang, Q	1
Gong, J	1
Tang, C	1
Vilskersts, R	1
Vilks, K	1
Videja, M	1
Cirule, H	1
Zharkova-Malkova, O	1
Sevostjanovs, E	1
Dambrova, M	1
Liepinsh, E	1
Zheng, H	1
Liu, L	1
Fan, G	1
Chang, B	1
Casas-Aparicio, GA	1
León-Rodríguez, I	1
Alvarado-de la Barrera, C	1
González-Navarro, M	1
Peralta-Prado, AB	1
Luna-Villalobos, Y	1
Velasco-Morales, A	1
Calderón-Dávila, N	1
Ormsby, CE	1
Ávila-Ríos, S	1
Bolgiaghi, L	1
Umbrello, M	1
Formenti, P	1
Coppola, S	1
Sabbatini, G	1
Massaro, C	1
Damiani, M	1
Chiumello, D	1
Ostermann, M	1
Lumlertgul, N	2
Zheng, Z	1
Jiang, X	1
Chen, J	1
He, D	1
Xie, X	1
Lu, Y	1
Abraham, S	1
Chidambaram, M	1
Soundravally, R	1
Subramani, S	1
Bhowmick, R	1
Sheriff, A	1
Maulik, K	1
Mahadevan, S	1
Geoffroy, S	1
Fremery, A	1
Lambert, Y	1
Marty, C	1
Elenga, N	1
McMahon, BA	2
Chawla, LS	6
Hu, MJ	1
Luo, EF	1
Tang, CC	1
Zhang, QG	1
Gong, JB	1
Kang, Z	1
Li, Z	1
Yang, Y	1
Liu, Q	1
Zhou, S	1
Chorin, E	1
Konigstein, M	2
Ben-Assa, E	2
Banai, S	2
Bagshaw, SM	6
Gibney, RTN	1
Kruger, P	1
Hassan, I	1
McAlister, FA	1
Bellomo, R	6
Chae, MS	1
Lee, N	1
Park, DH	1
Lee, J	2
Jung, HS	1
Park, CS	1
Choi, JH	1
Hong, SH	1
Bauer, F	1
Wald, J	1
Bauer, FJ	1
Dahlkamp, LM	1
Seibert, FS	1
Pagonas, N	1
Gedat, E	1
Babel, N	1
Zidek, W	1
von Bodman, C	1
Noldus, J	1
Liermann, D	1
Westhoff, TH	1
Kindgen-Milles, D	1
Slowinski, T	1
Dimski, T	1
Ma, YR	1
Luo, X	1
Wu, YF	1
Zhang, T	1
Zhang, F	1
Zhang, GQ	1
Wu, XA	1
Raurich, JM	1
Llompart-Pou, JA	1
Novo, MA	1
Talavera, C	1
Ferreruela, M	1
Ayestarán, I	1
Borasino, S	1
Wall, KM	1
Crawford, JH	1
Hock, KM	1
Cleveland, DC	1
Rahman, F	1
Martin, KD	1
Alten, JA	1
Peerapornratana, S	1
Trakarnvanich, T	1
Pongsittisak, W	1
Surasit, K	1
Chuasuwan, A	1
Tankee, P	1
Tiranathanagul, K	1
Praditpornsilpa, K	1
Tungsanga, K	1
Eiam-Ong, S	1
Srisawat, N	1
Bove, T	1
Belletti, A	2
Putzu, A	2
Pappacena, S	1
Denaro, G	1
Landoni, G	1
Zangrillo, A	1
Burns, AR	1
Ho, KM	5
Shen, Y	1
Wu, M	1
Mariano, F	2
Leporati, M	1
Carignano, P	1
Stella, M	1
Vincenti, M	2
Biancone, L	3
Bolt, LJJ	1
Sigterman, TA	1
Krasznai, AG	1
Sikkink, CJM	1
Schurink, GH	1
Bouwman, LH	1
Jeon, J	1
Kim, DH	1
Baeg, SI	1
Lee, EJ	1
Chung, CR	1
Jeon, K	1
Lee, JE	1
Huh, W	1
Suh, GY	1
Kim, YG	1
Kim, DJ	1
Oh, HY	1
Jang, HR	1
Penk, J	1
Gist, KM	1
Wald, EL	1
Kitzmiller, L	1
Webb, TN	1
Cooper, DS	1
Basu, RK	1
Prasad, BS	1
Kumar, M	1
Dabas, A	1
Mishra, K	1
Roy, N	1
Schmid, SM	1
Cianciolo, RE	1
Drobatz, KJ	1
Sanchez, M	1
Price, JM	1
King, LG	1
Kikura, M	1
Nishino, J	1
Suzuki, Y	3
Uraoka, M	1
Rewa, OG	1
Wang, X	1
Wald, R	1
Smith, O	1
Shapiro, J	1
McMahon, B	1
Liu, KD	2
Trevino, SA	3
Mella, A	1
Iguchi, N	2
Lankadeva, YR	2
Mori, TA	3
Osawa, EA	2
Cutuli, SL	2
Evans, RG	2
May, CN	2
Mose, FH	1
Jörgensen, AN	1
Vrist, MH	1
Ekelöf, NP	1
Pedersen, EB	1
Bech, JN	1
Bitker, L	1
Canet, E	1
Cioccari, L	1
Eastwood, GM	1
Legrand, M	1
Payen, D	1
Kossiva, L	1
Kyriakou, D	1
Mitsioni, A	1
Garoufi, A	1
Ricci, F	1
Ramírez, T	1
Marmorato, R	1
Vega, J	1
Pagán, P	1
López, JE	1
Soto-Salgado, M	1
Cangiano, JL	1
Kim, WH	1
Lee, SM	1
Choi, JW	1
Kim, EH	1
Lee, JH	1
Jung, JW	1
Ahn, JH	1
Sung, KI	1
Kim, CS	1
Cho, HS	1
Davison, DL	2
Brasha-Mitchell, E	2
Arthur, JM	2
Shaw, AD	3
Tumlin, JA	2
Kimmel, PL	2
Seneff, MG	2
Quintavalle, C	1
Donnarumma, E	2
Fiore, D	1
Briguori, C	4
Condorelli, G	4
Thajudeen, B	1
Rubin, MF	1
Axelrod, DM	1
Anglemyer, AT	1
Sherman-Levine, SF	1
Zhu, A	1
Grimm, PC	1
Roth, SJ	1
Sutherland, SM	1
Solomon, R	2
Poukkanen, M	1

Trial	Phase	Enrollment	Study Type	Start Date	Status
A Phase II Randomized Blinded Controlled Trial of the Effect of furoSemide in Critically Ill Patients With eARly Acute Kidney Injury (The SPARK Study)[NCT00978354]	Phase 2/Phase 3	72 participants (Actual)	Interventional	2009-09-30	Terminated (stopped due to Feasibility of target enrollment within the context of available funding resources.)
Does Early Initiation of Renal Replacement Therapy Have an Impact on 7-day Fluid Balance in Critically Ill Patients With Acute Kidney Injury With Positive Furosemide Stress Test?: a Multicenter Randomized Controlled Trial[NCT02730117]		118 participants (Actual)	Interventional	2016-03-31	Completed
Can Urinary Partial Oxygen Pressure be an Indicator of Acute Kidney Injury in Patients With Sepsis?[NCT06124105]		68 participants (Anticipated)	Interventional	2023-11-06	Not yet recruiting
Impact of Renin-Angiotensin System Inhibitors Continuation on Outcome After Major Surgery : a Multicenter, Prospective, Randomized and Controlled Trial[NCT03374449]		2,222 participants (Actual)	Interventional	2018-02-06	Active, not recruiting
Furosemide Stress Test as a Predictor of Tubular Atrophy and Interstitial Fibrosis in Patients With Chronic Kidney Disease[NCT02417883]	Phase 3	100 participants (Anticipated)	Interventional	2015-04-30	Recruiting
Early Versus Late Renal Replacement Therapy In Mechanically Ventilated Patients With Acute Kidney Injury[NCT05382598]		94 participants (Actual)	Interventional	2022-06-28	Completed
Evaluation of the Furosemide Stress Test to Predict Successful Liberation From Renal Replacement Therapy in Critically Ill Patients[NCT05612490]		60 participants (Anticipated)	Observational	2023-01-17	Recruiting
Continuous Versus Intermittent Loop Diuretics Infusion Dosing in Acute Heart Failure: Effects on Renal Function, Outcome and BNP Levels[NCT01441245]	Phase 4	57 participants (Actual)	Interventional	2010-04-30	Completed
Continuous Versus Bolus Intermittent Loop Diuretic Infusion in Acutely Decompensated Heart Failure: Evaluation of Renal Function, Congestion Signs, BNP and Outcome[NCT02638142]		116 participants (Actual)	Observational	2015-12-31	Active, not recruiting
Reducing Acute Kidney Injury in TAVI Patients (REDUCE Trial)[NCT01866800]	Phase 4	136 participants (Actual)	Interventional	2013-06-01	Completed
Predicting Acute Kidney Injury in Infants Exposed to Nephrotoxic Drugs: A Big Data Approach to Predict NEOnatal Acute Kidney Injury in Newborns expoSed to nephroTOxic Drugs. (NeoAKI STOP)[NCT05851222]		4,200 participants (Anticipated)	Observational	2023-08-01	Not yet recruiting
Forced Diuresis Vs Observation in Resolving Renal Failure After Haemofiltration in Critically Ill Patients (Fodorefh)[NCT00298454]	Phase 3	72 participants	Interventional	2005-12-31	Terminated (stopped due to Number included has been reached)
Prevention of Contrast-Induced Nephropathy: a Randomized Controlled Trial of Saline + Furosemide + Mannitol in High Risk Patients Undergoing Cardiac Angiography[NCT00175227]		200 participants (Anticipated)	Interventional	1996-05-31	Completed
Reducing Empiric VAncomycin Use in Pediatric Suspected Sepsis (REVAMP-Sepsis)[NCT05975671]		52,500 participants (Anticipated)	Interventional	2023-08-21	Recruiting
Agreement Test of Intravascular Volume Assessment Between Inferior Vena Cava (IVC) Diameter and Vascular Pedicle Width (VPW)[NCT03535038]		35 participants (Actual)	Interventional	2018-05-31	Completed
Renal Insufficiency Following Contrast Media Administration Trial II (Remedial II): The RenalGuard System in High-Risk Patients for Contrast-Induced Acute Kidney Injury[NCT01098032]	Phase 3	294 participants (Actual)	Interventional	2009-01-31	Completed
Pirfenidone Effect on the Recovery of Renal Function in Patients With Septic Acute Kidney Injury[NCT02530359]	Phase 4	90 participants (Anticipated)	Interventional	2015-10-31	Not yet recruiting
Renal Insufficiency Following Contrast Media Administration Trial IV: Contrast Media Volume Control for Limiting Contrast-Induced Acute Kidney in Acute Coronary Syndrome.[NCT04714736]		522 participants (Anticipated)	Interventional	2020-02-10	Recruiting
Renal Insufficiency Following Contrast Media Administration Trial III (REMEDIAL III): Renalguard System Versus Left-ventricular End-diastolic Pressure-guided Hydration in High-risk Patients for Contrast-induced Acute Kidney Injury[NCT02489669]		700 participants (Anticipated)	Interventional	2015-07-15	Enrolling by invitation
A Study to Evaluate the Effectiveness of Induced Diuresis With Matched Hydration Therapy Compared to Standard Overnight Hydration in the Prevention of Contrast Induced Nephropathy -MYTHOS Study[NCT00702728]	Phase 3	120 participants (Anticipated)	Interventional	2008-06-30	Recruiting
Effect of Hydration Guided by Vigileo on the Prevention of Contrast Induced Nephropathy After Emergency PCI for Patients With Acute Myocardial Infarction[NCT04382313]		344 participants (Actual)	Interventional	2020-07-10	Completed
Chinese People's Liberation Army General Hospital[NCT02405377]		264 participants (Actual)	Interventional	2014-02-28	Completed
Predictive Value of CHA2DS2-VASC Score and Contrast Volume to Creatinine Clearance Ratio in Relation to Mehran Score for Contrast-Induced Nephropathy In ST- Elevation Myocardial Infarction Patients Undergoing Primary Percutaneous Coronary Intervention[NCT03266458]		210 participants (Anticipated)	Observational [Patient Registry]	2018-01-01	Not yet recruiting
The Prevention Contrast-Induced Acute Kidney Injury With the Triple Combination of Hydration With Physiological Saline, N-Acetylcysteine and Sodium Bicarbonate[NCT01210456]	Phase 3	458 participants (Anticipated)	Interventional	2009-10-31	Enrolling by invitation
Sodium Bicarbonate to Treat Severe Acidosis in the Critically Ill : A Multiple Center Randomized Clinical Trial (BICAR-ICU)[NCT02476253]	Phase 3	400 participants (Anticipated)	Interventional	2015-05-05	Recruiting
Ischemic Preconditioning for Prevention of Contrast Nephropathy in The Emergency Department: Randomised, Double Blind Clinical Trial[NCT03238391]		350 participants (Anticipated)	Interventional	2017-08-15	Not yet recruiting
Investigation of Relationship Between Contrast Nephropathy and Caval Index Measurement in Patients With Suspected Ileus in Emergency Department[NCT03261518]		250 participants (Anticipated)	Observational	2017-08-24	Not yet recruiting
Bioequivalence Study of Furosemide in Indonesian Healthy Volunteers[NCT04982874]		24 participants (Actual)	Interventional	2019-12-13	Completed
Hemodynamics and Extravascular Lung Water in Acute Lung Injury: A Prospective Randomized Controlled Multicentered Trial of Goal Directed Treatment of EVLW Versus Standard Management for the Treatment of Acute Lung Injury[NCT00624650]	Phase 2	33 participants (Actual)	Interventional	2008-02-29	Completed
Single Dose of Furosemide to Improve Respiratory Distress in Moderate to Severe Bronchiolitis[NCT02469597]	Phase 2	46 participants (Actual)	Interventional	2013-10-31	Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

(NCT01441245)
Timeframe: participants were followed for the duration of hospital stay, an average of 13 days

Dopamine Infusion During Hospitalization

Evaluation of B-type Natriuretic Peptide (BNP) Levels From Admission to the End of Treatment

Evaluation of Mean Urine Output Volume During the Infusion Period

Intervention	pg/mL (Mean)
BNP Change in cIV	-525
BNP Change in iIV	-148

Intervention	percentage of partecipants (Number)
Dopamine Infusion in cIV	50
Dopamine Infusion in iIV	26

Intervention	pg/ml (Mean)
BNP Levels at Discharge in cIV Group	679
BNP Levels at Discharge in iIV Group	949

this study aimed to evaluate the effects of continuous infusion of furosemide in comparison to twice daily regimens at similar doses with respect to changes in renal function in terms of creatinine levels and GFR, urine output and BNP levels from admission to discharge (NCT01441245)
Timeframe: time period ranging from 72 h to 120 h.

Evaluation of Renal Function in Terms of Changes in Creatinine Levels

Intervention	mL (Mean)
Urine Output in cIV	2505
Urine Output in iIV	2140

evaluation of renal function in terms of changes in creatinine levels during hospitalization in the two arms. (NCT01441245)
Timeframe: participants were followed for the duration of hospital stay, an average of 13 days

Evaluation of Renal Function in Terms of Changes in GFR

Evaluation of Renal Function in Terms of Creatinine Levels at Discharge

Evaluation of Renal Function in Terms of GFR Values at Discharge

Length of Hospitalization in the Two Groups

Intervention	mg/dL (Mean)
Changes in Creatinine in cIV Group	-0.10
Changes in Creatinine in iIV Group	-0.50

Intervention	(ml/min·1.73 m2) (Mean)
GFR Change in cIV	-3.18
GFR Change in iIV	-1.93

Intervention	mg/dL (Mean)
Creatinine at Discharge in cIV	1.78
Creatinine at Discharge in iIV	1.51

Intervention	(ml/min·1.73 m2) (Mean)
GFR at Discharge in cIV	44.8
GFR at Discharge in iIV	46.7

percentage of participants with hospital stay > 10 days (NCT01441245)
Timeframe: in-hospital

Number of Participants With Contrast-induced Acute Kidney Injury

Intervention	percentage of partecipants (Number)
Lenght of Hospitalization in cIV	80
Lenght of Hospitalization in iIV	44

The primary outcome measure will be the rate of development of CI-AKI in the 2 study arms (number of participants). CI-AKI is defined as an increase in the serum creatinine concentration >=0.3 mg/dL from the baseline value at 48 hours after administration of the contrast media or the need for dialysis. (NCT01098032)
Timeframe: at 48 hours following contrast exposure

Geometric Mean Ratio of Area Under Curve

Intervention	participants (Number)
Systemic Alone Therapy Group	146
RenalGuard System Group	146

The ratio between test drug and reference drug (NCT04982874)
Timeframe: before dosing (0 h) and at 0.25, 0.5, 1, 1.5, 2, 2.5, 3, 4, 5, 6, 8, 10, 12, 16 and 24 hours after drug administration

Geometric Mean Ratio of Maximum Concentration

Intervention	percentage (Geometric Mean)
Furosemide 40 mg Tablet	101.79

The ratio between test drug and reference drug (NCT04982874)
Timeframe: before dosing (0 h) and at 0.25, 0.5, 1, 1.5, 2, 2.5, 3, 4, 5, 6, 8, 10, 12, 16 and 24 hours after drug administration

Pharmacokinetics Parameter

Intervention	percentage (Geometric Mean)
Furosemide 40 mg Tablet	104.51

Area Under Curve from 0 to 24 hours (NCT04982874)
Timeframe: before dosing (0 h) and at 0.25, 0.5, 1, 1.5, 2, 2.5, 3, 4, 5, 6, 8, 10, 12, 16 and 24 hours after drug administration

Pharmacokinetics Parameter

Intervention	ng*h/mL (Mean)
Furosemide 40 mg Tablet	4938.79
Lasix® 40 mg Tablet	4921.94

Maximum plasma concentration (NCT04982874)
Timeframe: before dosing (0 h) and at 0.25, 0.5, 1, 1.5, 2, 2.5, 3, 4, 5, 6, 8, 10, 12, 16 and 24 hours after drug administration

Length of Hospital Stay

Intervention	ng/mL (Mean)
Furosemide 40 mg Tablet	1893.09
Lasix® 40 mg Tablet	1907.32

(NCT02469597)
Timeframe: Participants will be followed for the duration of hospital stay up to 1 week

Intervention	Percentage change in oxygen saturation (Least Squares Mean)
Single Dose of Furosemide	-0.19
Placebo	0.29

Intervention	Percentage change in respiratory rate (Least Squares Mean)
Single Dose of Furosemide	-3.7
Placebo	-1.7

Intervention	Percentage change in respiratory rate (Least Squares Mean)
Single Dose of Furosemide	-2.8
Placebo	-5.4

Article	Year
Furosemide does not reduce the incidence of postoperative acute kidney injury in adult patients undergoing cardiac surgery: A PRISMA-compliant systematic review and meta-analysis. Journal of cardiac surgery, 2022, Volume: 37, Issue:12 Topics: Acute Kidney Injury; Adult; Cardiac Surgical Procedures; Furosemide; Humans; Incidence; Renal Replac	2022
Update on Pediatric Acute Kidney Injury. Pediatric clinics of North America, 2022, Volume: 69, Issue:6 Topics: Acute Kidney Injury; Child; Furosemide; Humans	2022
Effects of post-operative furosemide in adult surgical patients: A systematic review and meta-analysis of randomised clinical trials. Acta anaesthesiologica Scandinavica, 2020, Volume: 64, Issue:3 Topics: Acute Kidney Injury; Diuretics; Furosemide; Humans; Postoperative Care	2020
Acute kidney injury. Revista da Associacao Medica Brasileira (1992), 2020, Jan-13, Volume: 66Suppl 1, Issue:Suppl 1 Topics: Acute Kidney Injury; Biomarkers; Diuretics; Furosemide; Glomerular Filtration Rate; Humans; Renal Re	2020
Role of the Furosemide Stress Test in Renal Injury Prognosis. International journal of molecular sciences, 2020, Apr-27, Volume: 21, Issue:9 Topics: Acute Kidney Injury; Biomarkers; Clinical Decision-Making; Disease Management; Furosemide; Humans; K	2020
Furosemide stress test as a predictive marker of acute kidney injury progression or renal replacement therapy: a systemic review and meta-analysis. Critical care (London, England), 2020, 05-07, Volume: 24, Issue:1 Topics: Acute Kidney Injury; Disease Progression; Exercise Test; Furosemide; Humans; Predictive Value of Tes	2020
The furosemide stress test: current use and future potential. Renal failure, 2021, Volume: 43, Issue:1 Topics: Acute Kidney Injury; Critical Illness; Diuretics; Electrolytes; Exercise Test; Furosemide; Humans; R	2021
Meta-analysis of the effects of furosemide combined with hydration therapy on contrast-induced acute kidney injury after coronary intervention. European review for medical and pharmacological sciences, 2021, Volume: 25, Issue:14 Topics: Acute Kidney Injury; Fluid Therapy; Furosemide; Humans; Percutaneous Coronary Intervention	2021
[New kidney function tests: Renal functional reserve and furosemide stress test]. Medizinische Klinik, Intensivmedizin und Notfallmedizin, 2020, Volume: 115, Issue:1 Topics: Acute Kidney Injury; Creatinine; Diuretics; Furosemide; Humans; Kidney; Kidney Function Tests; Renal	2020
Furosemide as a functional marker of acute kidney injury in ICU patients: a new role for an old drug. Journal of nephrology, 2019, Volume: 32, Issue:6 Topics: Acute Kidney Injury; Biomarkers; Creatinine; Diuretics; Furosemide; Humans; Infusions, Intravenous;	2019
Therapeutic strategies to prevent contrast-induced acute kidney injury. Current opinion in cardiology, 2013, Volume: 28, Issue:6 Topics: Acetylcysteine; Acute Kidney Injury; Antioxidants; Calcium Channel Blockers; Contrast Media; Diureti	2013
Forced diuresis with the RenalGuard system: impact on contrast induced acute kidney injury. Journal of cardiology, 2014, Volume: 63, Issue:1 Topics: Acute Kidney Injury; Contrast Media; Diuresis; Diuretics; Furosemide; Humans; Pilot Projects; Random	2014
[Planning of cardiothoracic surgery for chronic kidney disease patients]. Masui. The Japanese journal of anesthesiology, 2013, Volume: 62, Issue:11 Topics: Acute Kidney Injury; Aortic Aneurysm; Atrial Natriuretic Factor; Cardiopulmonary Bypass; Cardiovascu	2013
Question 1: Is the use of furosemide beneficial in the treatment of acute kidney injury in the paediatric population including neonates? Archives of disease in childhood, 2015, Volume: 100, Issue:7 Topics: Acute Kidney Injury; Child, Preschool; Diuretics; Evidence-Based Medicine; Furosemide; Humans; Infan	2015
Risk Stratification for Acute Kidney Injury: Are Biomarkers Enough? Advances in chronic kidney disease, 2016, Volume: 23, Issue:3 Topics: Acute Kidney Injury; Biomarkers; Critical Care; Diuretics; Early Diagnosis; Furosemide; Humans; Insu	2016
Use of stress tests in evaluating kidney disease. Current opinion in nephrology and hypertension, 2017, Volume: 26, Issue:1 Topics: Acute Kidney Injury; Furosemide; Glomerular Filtration Rate; Humans; Kidney Function Tests; Kidney G	2017
Prevention of Contrast-Induced Acute Kidney Injury by Furosemide With Matched Hydration in Patients Undergoing Interventional Procedures: A Systematic Review and Meta-Analysis of Randomized Trials. JACC. Cardiovascular interventions, 2017, 02-27, Volume: 10, Issue:4 Topics: Acute Kidney Injury; Chi-Square Distribution; Contrast Media; Diuretics; Evidence-Based Medicine; Fu	2017
Diuretics in acute kidney injury. Minerva anestesiologica, 2009, Volume: 75, Issue:5 Topics: Acute Kidney Injury; Animals; Cohort Studies; Combined Modality Therapy; Contraindications; Critical	2009
Forced euvolemic diuresis with mannitol and furosemide for prevention of contrast-induced nephropathy in patients with CKD undergoing coronary angiography: a randomized controlled trial. American journal of kidney diseases : the official journal of the National Kidney Foundation, 2009, Volume: 54, Issue:4 Topics: Acute Kidney Injury; Adult; Aged; Biomarkers; Contrast Media; Coronary Angiography; Creatinine; Diur	2009
Benefits and risks of furosemide in acute kidney injury. Anaesthesia, 2010, Volume: 65, Issue:3 Topics: Acute Kidney Injury; Diuretics; Evidence-Based Medicine; Furosemide; Humans; Randomized Controlled T	2010
Renal insufficiency following contrast media administration trial II (REMEDIAL II): RenalGuard system in high-risk patients for contrast-induced acute kidney injury: rationale and design. EuroIntervention : journal of EuroPCR in collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology, 2011, Volume: 6, Issue:9 Topics: Acetylcysteine; Acute Kidney Injury; Biomarkers; Chi-Square Distribution; Chronic Disease; Contrast	2011
Does perioperative furosemide usage reduce the need for renal replacement therapy in cardiac surgery patients? Interactive cardiovascular and thoracic surgery, 2012, Volume: 15, Issue:4 Topics: Acute Kidney Injury; Aged; Benchmarking; Cardiac Surgical Procedures; Diuretics; Drug Administration	2012
Diuretics in acute renal failure? Contributions to nephrology, 2004, Volume: 144 Topics: Acute Kidney Injury; Animals; Diuretics; Furosemide; Humans; Ischemia; Randomized Controlled Trials	2004
Meta-analysis of frusemide to prevent or treat acute renal failure. BMJ (Clinical research ed.), 2006, Aug-26, Volume: 333, Issue:7565 Topics: Acute Kidney Injury; Adult; Diuretics; Furosemide; Humans; Randomized Controlled Trials as Topic	2006
[Anuric acute renal failure due to acetazolamide]. Nefrologia : publicacion oficial de la Sociedad Espanola Nefrologia, 2006, Volume: 26, Issue:6 Topics: Acetazolamide; Acute Kidney Injury; Anuria; Back Pain; Diagnosis, Differential; Fluid Therapy; Furos	2006
Loop diuretics in the management of acute renal failure: a systematic review and meta-analysis. Critical care and resuscitation : journal of the Australasian Academy of Critical Care Medicine, 2007, Volume: 9, Issue:1 Topics: Acid-Base Equilibrium; Acute Kidney Injury; Creatinine; Critical Illness; Data Interpretation, Stati	2007
Meta-analysis: effectiveness of drugs for preventing contrast-induced nephropathy. Annals of internal medicine, 2008, Feb-19, Volume: 148, Issue:4 Topics: Acetylcysteine; Acute Kidney Injury; Ascorbic Acid; Bicarbonates; Clinical Trials as Topic; Contrast	2008
Meta-analysis: effectiveness of drugs for preventing contrast-induced nephropathy. Annals of internal medicine, 2008, Feb-19, Volume: 148, Issue:4 Topics: Acetylcysteine; Acute Kidney Injury; Ascorbic Acid; Bicarbonates; Clinical Trials as Topic; Contrast	2008
Meta-analysis: effectiveness of drugs for preventing contrast-induced nephropathy. Annals of internal medicine, 2008, Feb-19, Volume: 148, Issue:4 Topics: Acetylcysteine; Acute Kidney Injury; Ascorbic Acid; Bicarbonates; Clinical Trials as Topic; Contrast	2008
Meta-analysis: effectiveness of drugs for preventing contrast-induced nephropathy. Annals of internal medicine, 2008, Feb-19, Volume: 148, Issue:4 Topics: Acetylcysteine; Acute Kidney Injury; Ascorbic Acid; Bicarbonates; Clinical Trials as Topic; Contrast	2008
Meta-analysis: effectiveness of drugs for preventing contrast-induced nephropathy. Annals of internal medicine, 2008, Feb-19, Volume: 148, Issue:4 Topics: Acetylcysteine; Acute Kidney Injury; Ascorbic Acid; Bicarbonates; Clinical Trials as Topic; Contrast	2008
Meta-analysis: effectiveness of drugs for preventing contrast-induced nephropathy. Annals of internal medicine, 2008, Feb-19, Volume: 148, Issue:4 Topics: Acetylcysteine; Acute Kidney Injury; Ascorbic Acid; Bicarbonates; Clinical Trials as Topic; Contrast	2008
Meta-analysis: effectiveness of drugs for preventing contrast-induced nephropathy. Annals of internal medicine, 2008, Feb-19, Volume: 148, Issue:4 Topics: Acetylcysteine; Acute Kidney Injury; Ascorbic Acid; Bicarbonates; Clinical Trials as Topic; Contrast	2008
Meta-analysis: effectiveness of drugs for preventing contrast-induced nephropathy. Annals of internal medicine, 2008, Feb-19, Volume: 148, Issue:4 Topics: Acetylcysteine; Acute Kidney Injury; Ascorbic Acid; Bicarbonates; Clinical Trials as Topic; Contrast	2008
Meta-analysis: effectiveness of drugs for preventing contrast-induced nephropathy. Annals of internal medicine, 2008, Feb-19, Volume: 148, Issue:4 Topics: Acetylcysteine; Acute Kidney Injury; Ascorbic Acid; Bicarbonates; Clinical Trials as Topic; Contrast	2008
Meta-analysis: effectiveness of drugs for preventing contrast-induced nephropathy. Annals of internal medicine, 2008, Feb-19, Volume: 148, Issue:4 Topics: Acetylcysteine; Acute Kidney Injury; Ascorbic Acid; Bicarbonates; Clinical Trials as Topic; Contrast	2008
Meta-analysis: effectiveness of drugs for preventing contrast-induced nephropathy. Annals of internal medicine, 2008, Feb-19, Volume: 148, Issue:4 Topics: Acetylcysteine; Acute Kidney Injury; Ascorbic Acid; Bicarbonates; Clinical Trials as Topic; Contrast	2008
Meta-analysis: effectiveness of drugs for preventing contrast-induced nephropathy. Annals of internal medicine, 2008, Feb-19, Volume: 148, Issue:4 Topics: Acetylcysteine; Acute Kidney Injury; Ascorbic Acid; Bicarbonates; Clinical Trials as Topic; Contrast	2008
Meta-analysis: effectiveness of drugs for preventing contrast-induced nephropathy. Annals of internal medicine, 2008, Feb-19, Volume: 148, Issue:4 Topics: Acetylcysteine; Acute Kidney Injury; Ascorbic Acid; Bicarbonates; Clinical Trials as Topic; Contrast	2008
Meta-analysis: effectiveness of drugs for preventing contrast-induced nephropathy. Annals of internal medicine, 2008, Feb-19, Volume: 148, Issue:4 Topics: Acetylcysteine; Acute Kidney Injury; Ascorbic Acid; Bicarbonates; Clinical Trials as Topic; Contrast	2008
Meta-analysis: effectiveness of drugs for preventing contrast-induced nephropathy. Annals of internal medicine, 2008, Feb-19, Volume: 148, Issue:4 Topics: Acetylcysteine; Acute Kidney Injury; Ascorbic Acid; Bicarbonates; Clinical Trials as Topic; Contrast	2008
Meta-analysis: effectiveness of drugs for preventing contrast-induced nephropathy. Annals of internal medicine, 2008, Feb-19, Volume: 148, Issue:4 Topics: Acetylcysteine; Acute Kidney Injury; Ascorbic Acid; Bicarbonates; Clinical Trials as Topic; Contrast	2008
Meta-analysis: effectiveness of drugs for preventing contrast-induced nephropathy. Annals of internal medicine, 2008, Feb-19, Volume: 148, Issue:4 Topics: Acetylcysteine; Acute Kidney Injury; Ascorbic Acid; Bicarbonates; Clinical Trials as Topic; Contrast	2008
Meta-analysis: effectiveness of drugs for preventing contrast-induced nephropathy. Annals of internal medicine, 2008, Feb-19, Volume: 148, Issue:4 Topics: Acetylcysteine; Acute Kidney Injury; Ascorbic Acid; Bicarbonates; Clinical Trials as Topic; Contrast	2008
Meta-analysis: effectiveness of drugs for preventing contrast-induced nephropathy. Annals of internal medicine, 2008, Feb-19, Volume: 148, Issue:4 Topics: Acetylcysteine; Acute Kidney Injury; Ascorbic Acid; Bicarbonates; Clinical Trials as Topic; Contrast	2008
Meta-analysis: effectiveness of drugs for preventing contrast-induced nephropathy. Annals of internal medicine, 2008, Feb-19, Volume: 148, Issue:4 Topics: Acetylcysteine; Acute Kidney Injury; Ascorbic Acid; Bicarbonates; Clinical Trials as Topic; Contrast	2008
Meta-analysis: effectiveness of drugs for preventing contrast-induced nephropathy. Annals of internal medicine, 2008, Feb-19, Volume: 148, Issue:4 Topics: Acetylcysteine; Acute Kidney Injury; Ascorbic Acid; Bicarbonates; Clinical Trials as Topic; Contrast	2008
Meta-analysis: effectiveness of drugs for preventing contrast-induced nephropathy. Annals of internal medicine, 2008, Feb-19, Volume: 148, Issue:4 Topics: Acetylcysteine; Acute Kidney Injury; Ascorbic Acid; Bicarbonates; Clinical Trials as Topic; Contrast	2008
Meta-analysis: effectiveness of drugs for preventing contrast-induced nephropathy. Annals of internal medicine, 2008, Feb-19, Volume: 148, Issue:4 Topics: Acetylcysteine; Acute Kidney Injury; Ascorbic Acid; Bicarbonates; Clinical Trials as Topic; Contrast	2008
Meta-analysis: effectiveness of drugs for preventing contrast-induced nephropathy. Annals of internal medicine, 2008, Feb-19, Volume: 148, Issue:4 Topics: Acetylcysteine; Acute Kidney Injury; Ascorbic Acid; Bicarbonates; Clinical Trials as Topic; Contrast	2008
Meta-analysis: effectiveness of drugs for preventing contrast-induced nephropathy. Annals of internal medicine, 2008, Feb-19, Volume: 148, Issue:4 Topics: Acetylcysteine; Acute Kidney Injury; Ascorbic Acid; Bicarbonates; Clinical Trials as Topic; Contrast	2008
Furosemide and acute kidney injury in neonates. Archives of disease in childhood. Fetal and neonatal edition, 2008, Volume: 93, Issue:4 Topics: Acute Kidney Injury; Diuretics; Furosemide; Humans; Infant, Newborn; Infant, Premature; Infant, Prem	2008
Oliguria, volume overload, and loop diuretics. Critical care medicine, 2008, Volume: 36, Issue:4 Suppl Topics: Acute Kidney Injury; Critical Care; Fluid Therapy; Furosemide; Humans; Intensive Care Units; Oliguri	2008
Disease-induced modifications of drug pharmacokinetics. International journal of clinical pharmacology research, 1983, Volume: 3, Issue:4 Topics: Acute Kidney Injury; Blood Proteins; Disease; Furosemide; Glomerular Filtration Rate; Heart Failure;	1983
Diuretics. International anesthesiology clinics, 1984,Spring, Volume: 22, Issue:1 Topics: Acetazolamide; Acute Kidney Injury; Chlorothiazide; Diuretics; Diuretics, Osmotic; Ethacrynic Acid;	1984
[Clinical application of diuretics: acute kidney failure]. Nihon rinsho. Japanese journal of clinical medicine, 1984, Volume: 42, Issue:9 Topics: Acute Kidney Injury; Animals; Furosemide; Humans; Loop of Henle; Mannitol; Sodium Chloride	1984
Are diuretics useful in the treatment or prevention of acute renal failure? Southern medical journal, 1982, Volume: 75, Issue:3 Topics: Acute Kidney Injury; Animals; Diuretics; Dogs; Ethacrynic Acid; Furosemide; Humans; Mannitol; Models	1982
Studies on acute disease models. Kidney international, 1982, Volume: 22, Issue:5 Topics: Acute Kidney Injury; Animals; Disease Models, Animal; Female; Furosemide; In Vitro Techniques; Ische	1982
[Loop diuretics. Rational pharmacotherapy]. Ugeskrift for laeger, 1993, Nov-01, Volume: 155, Issue:44 Topics: Acute Kidney Injury; Bumetanide; Diuresis; Diuretics; Dose-Response Relationship, Drug; Drug Therapy	1993
[Emergency therapy of acute kidney failure and water-electrolyte imbalance]. Nihon Naika Gakkai zasshi. The Journal of the Japanese Society of Internal Medicine, 1995, Nov-10, Volume: 84, Issue:11 Topics: Acute Kidney Injury; Blood Component Removal; Calcium Gluconate; Diagnosis, Differential; Diuretics;	1995
[Contrast medium induced nephropathy: pathogenesis, clinical aspects, prevention]. Deutsche medizinische Wochenschrift (1946), 1999, Mar-19, Volume: 124, Issue:11 Topics: Acute Kidney Injury; Contrast Media; Diagnosis, Differential; Diuretics; Diuretics, Osmotic; Furosem	1999
Acute renal failure. Pediatric clinics of North America, 1976, Volume: 23, Issue:4 Topics: Acute Kidney Injury; Blood Urea Nitrogen; Dehydration; Diarrhea, Infantile; Ethacrynic Acid; Furosem	1976
Diagnostic possibilities in acute renal failure. Geriatrics, 1976, Volume: 31, Issue:8 Topics: Acute Kidney Injury; Blood Circulation; Blood Urea Nitrogen; Blood Volume; Extracellular Space; Furo	1976
[Kidney and pregnancy]. Zeitschrift fur Urologie und Nephrologie, 1976, Volume: 69, Issue:02 Topics: Acute Kidney Injury; Adrenal Cortex Hormones; Adult; Anti-Bacterial Agents; Chloramphenicol; Creatin	1976
Radiocontrast-induced nephropathy. Prevention is better than cure. Postgraduate medicine, 1992, Volume: 92, Issue:8 Topics: Acute Kidney Injury; Comorbidity; Contrast Media; Creatinine; Dose-Response Relationship, Drug; Drug	1992
The efficacy of diuretics in acute and chronic renal failure. Focus on torasemide. Drugs, 1991, Volume: 41 Suppl 3 Topics: Acute Kidney Injury; Diuretics; Furosemide; Humans; Kidney Failure, Chronic; Sulfonamides; Torsemide	1991
Diuretic and vasopressor usage in acute renal failure: a synopsis. Critical care nursing quarterly, 1992, Volume: 14, Issue:4 Topics: Acute Kidney Injury; Critical Care; Diuretics; Dopamine; Furosemide; Humans; Mannitol; Vasoconstrict	1992
Acute renal failure: prevention and treatment. Archivio italiano di urologia, nefrologia, andrologia : organo ufficiale dell'Associazione per la ricerca in urologia = Urological, nephrological, and andrological sciences, 1990, Volume: 62, Issue:1 Topics: Acute Kidney Injury; Dopamine; Furosemide; Glomerular Filtration Rate; Humans; Kidney Transplantatio	1990
Furosemide (frusemide). A pharmacokinetic/pharmacodynamic review (Part I). Clinical pharmacokinetics, 1990, Volume: 18, Issue:5 Topics: Acute Kidney Injury; Furosemide; Heart Failure; Humans; Hypertension; Liver Diseases	1990
The pharmacologic basis of diuretic therapy in the newborn. Clinics in perinatology, 1987, Volume: 14, Issue:4 Topics: Acute Kidney Injury; Diuretics; Furosemide; Humans; Infant, Newborn; Pulmonary Edema; Respiratory Di	1987
Acute renal failure in the intensive care unit today. Intensive care medicine, 1986, Volume: 12, Issue:2 Topics: Acute Kidney Injury; Dopamine; Furosemide; Humans; Infections; Intensive Care Units; Postoperative C	1986
Acute renal failure in the cardiovascular surgical patient. The Annals of thoracic surgery, 1985, Volume: 39, Issue:6 Topics: Acute Kidney Injury; Aneurysm; Animals; Cardiac Surgical Procedures; Diuretics; Dogs; Dopamine; Furo	1985
Non-dialytic therapy of acute renal failure: a review. The International journal of artificial organs, 1985, Volume: 8, Issue:5 Topics: Acute Kidney Injury; Adenosine Triphosphate; Amino Acids, Essential; Animals; Calcium Channel Blocke	1985
Acute renal failure. The Medical clinics of North America, 1973, Volume: 57, Issue:6 Topics: Acute Kidney Injury; Angiotensin II; Anuria; Blood Pressure; Blood Urea Nitrogen; Blood Volume; Card	1973
The clinical use of diuretics. 2. The New England journal of medicine, 1973, Mar-01, Volume: 288, Issue:9 Topics: Acute Kidney Injury; Diabetes Insipidus; Diuretics; Ethacrynic Acid; Furosemide; Humans; Hypertensio	1973
[Furosemide in renal insufficiency. Physiopathological and pharmacodynamic data]. La Nouvelle presse medicale, 1974, Jun-08, Volume: 3, Issue:23 Topics: Acute Kidney Injury; Diuresis; Edema; Furosemide; Humans; Kidney Failure, Chronic; Nephrotic Syndrom	1974
[Effects of potent diuretics in renal failure]. Nihon rinsho. Japanese journal of clinical medicine, 1974, Volume: 32, Issue:8 Topics: Acute Kidney Injury; Benzoates; Butylamines; Diuresis; Diuretics; Dose-Response Relationship, Drug;	1974
Acute renal failure in children: principles of management. Clinical pediatrics, 1974, Volume: 13, Issue:8 Topics: Acute Kidney Injury; Anemia; Child; Furosemide; Humans; Hypertension, Renal; Infections; Infusions,	1974
[Accident and insurance medicine]. Munchener medizinische Wochenschrift (1950), 1969, Feb-07, Volume: 111, Issue:6 Topics: Accidents; Acute Kidney Injury; Athletic Injuries; Bites and Stings; Burns; Embolism, Fat; First Aid	1969
[Advances in nephrology. Glomerulonephritis]. Polskie Archiwum Medycyny Wewnetrznej, 1969, Volume: 42, Issue:6 Topics: Acute Kidney Injury; Diuretics; Furosemide; Glomerulonephritis; Humans; Kidney Failure, Chronic	1969
Furosemide and ethacrynic acid in renal insufficiency. The Medical clinics of North America, 1971, Volume: 55, Issue:1 Topics: Acute Kidney Injury; Adult; Animals; Dogs; Ethacrynic Acid; Furosemide; Humans; Kidney; Kidney Failu	1971
Surgical aspects of acute renal failure. British medical bulletin, 1971, Volume: 27, Issue:2 Topics: Acute Kidney Injury; Diagnosis, Differential; Furosemide; Humans; Jaundice; Kidney Transplantation;	1971

Article	Year
Trial of Furosemide to Prevent Acute Kidney Injury in Critically Ill Children: A Double-Blind, Randomized, Controlled Trial: Correspondence. Indian journal of pediatrics, 2022, Volume: 89, Issue:5 Topics: Acute Kidney Injury; Child; Critical Illness; Diuretics; Double-Blind Method; Furosemide; Humans	2022
Trial of Furosemide to Prevent Acute Kidney Injury in Critically Ill Children: A Double-Blind, Randomized, Controlled Trial: Author's Reply. Indian journal of pediatrics, 2022, Volume: 89, Issue:5 Topics: Acute Kidney Injury; Child; Critical Illness; Diuretics; Double-Blind Method; Furosemide; Humans	2022
Rosiglitazone Alleviates Contrast-Induced Acute Kidney Injury in Rats via the PPAR Disease markers, 2022, Volume: 2022 Topics: Acute Kidney Injury; Animals; Caspase 3; Creatinine; Furosemide; Interleukin-10; Iohexol; Kidney; Ni	2022
The furosemide stress test predicts the timing of continuous renal replacement therapy initiation in critically ill patients with acute kidney injury: a double-blind prospective intervention cohort study. European journal of medical research, 2023, Apr-05, Volume: 28, Issue:1 Topics: Acute Kidney Injury; Cohort Studies; Continuous Renal Replacement Therapy; Critical Illness; Exercis	2023
The use of Dapagliflozin in Acute Decompensated Heart Failure: Results of the Randomized Study. Kardiologiia, 2023, Aug-31, Volume: 63, Issue:8 Topics: Acute Kidney Injury; Aged; Aged, 80 and over; Diabetes Mellitus, Type 2; Female; Furosemide; Heart F	2023
The use of Dapagliflozin in Acute Decompensated Heart Failure: Results of the Randomized Study. Kardiologiia, 2023, Aug-31, Volume: 63, Issue:8 Topics: Acute Kidney Injury; Aged; Aged, 80 and over; Diabetes Mellitus, Type 2; Female; Furosemide; Heart F	2023
Trial of Furosemide to Prevent Acute Kidney Injury in Critically Ill Children: A Double-Blind, Randomized, Controlled Trial. Indian journal of pediatrics, 2021, Volume: 88, Issue:11 Topics: Acute Kidney Injury; Child; Child, Preschool; Critical Illness; Double-Blind Method; Furosemide; Hum	2021
The effect of low-dose furosemide in critically ill patients with early acute kidney injury: A pilot randomized blinded controlled trial (the SPARK study). Journal of critical care, 2017, Volume: 42 Topics: Acute Disease; Acute Kidney Injury; Aged; Critical Illness; Diuretics; Double-Blind Method; Female;	2017
Early versus standard initiation of renal replacement therapy in furosemide stress test non-responsive acute kidney injury patients (the FST trial). Critical care (London, England), 2018, Apr-19, Volume: 22, Issue:1 Topics: Acute Kidney Injury; Aged; Aged, 80 and over; Analysis of Variance; APACHE; Chi-Square Distribution;	2018
Intermittent furosemide administration in patients with or at risk for acute kidney injury: Meta-analysis of randomized trials. PloS one, 2018, Volume: 13, Issue:4 Topics: Acute Kidney Injury; Creatinine; Diuretics; Electronic Health Records; Furosemide; Humans; Length of	2018
Prevention of postcontrast acute kidney injury after percutaneous transluminal angioplasty by inducing RenalGuard controlled furosemide forced diuresis with matched hydration: study protocol for a randomised controlled trial. BMJ open, 2018, 10-04, Volume: 8, Issue:9 Topics: Acute Kidney Injury; Angioplasty, Balloon, Coronary; Biomarkers; Combined Modality Therapy; Contrast	2018
Effect of 3% saline and furosemide on biomarkers of kidney injury and renal tubular function and GFR in healthy subjects - a randomized controlled trial. BMC nephrology, 2019, 06-03, Volume: 20, Issue:1 Topics: Acute Kidney Injury; Adult; Aldosterone; Aquaporin 2; Biomarkers; Chlorides; Female; Furosemide; Glo	2019
Continuous versus bolus intermittent loop diuretic infusion in acutely decompensated heart failure: a prospective randomized trial. Critical care (London, England), 2014, Jun-28, Volume: 18, Issue:3 Topics: Acute Kidney Injury; Aged; Aged, 80 and over; Creatinine; Diuretics; Double-Blind Method; Female; Fu	2014
Continuous versus bolus intermittent loop diuretic infusion in acutely decompensated heart failure: a prospective randomized trial. Critical care (London, England), 2014, Jun-28, Volume: 18, Issue:3 Topics: Acute Kidney Injury; Aged; Aged, 80 and over; Creatinine; Diuretics; Double-Blind Method; Female; Fu	2014
Continuous versus bolus intermittent loop diuretic infusion in acutely decompensated heart failure: a prospective randomized trial. Critical care (London, England), 2014, Jun-28, Volume: 18, Issue:3 Topics: Acute Kidney Injury; Aged; Aged, 80 and over; Creatinine; Diuretics; Double-Blind Method; Female; Fu	2014
Continuous versus bolus intermittent loop diuretic infusion in acutely decompensated heart failure: a prospective randomized trial. Critical care (London, England), 2014, Jun-28, Volume: 18, Issue:3 Topics: Acute Kidney Injury; Aged; Aged, 80 and over; Creatinine; Diuretics; Double-Blind Method; Female; Fu	2014
Forced diuresis with matched hydration in reducing acute kidney injury during transcatheter aortic valve implantation (Reduce-AKI): study protocol for a randomized sham-controlled trial. Trials, 2014, Jul-02, Volume: 15 Topics: Acetylcysteine; Acute Kidney Injury; Antioxidants; Cardiac Catheterization; Clinical Protocols; Cont	2014
Furosemide Stress Test and Biomarkers for the Prediction of AKI Severity. Journal of the American Society of Nephrology : JASN, 2015, Volume: 26, Issue:8 Topics: Acute Kidney Injury; Acute-Phase Proteins; Aged; Albuminuria; Biomarkers; Creatinine; Disease Progre	2015
Acute Kidney Injury With the RenalGuard System in Patients Undergoing Transcatheter Aortic Valve Replacement: The PROTECT-TAVI Trial (PROphylactic effecT of furosEmide-induCed diuresis with matched isotonic intravenous hydraTion in Transcatheter Aortic Va JACC. Cardiovascular interventions, 2015, Volume: 8, Issue:12 Topics: Acute Kidney Injury; Aged; Aged, 80 and over; Aortic Valve; Aortic Valve Stenosis; Cardiac Catheteri	2015
AKIGUARD (Acute Kidney Injury GUARding Device) trial: in-hospital and one-year outcomes. Journal of cardiovascular medicine (Hagerstown, Md.), 2016, Volume: 17, Issue:7 Topics: Acute Kidney Injury; Aged; Aged, 80 and over; Contrast Media; Coronary Angiography; Creatinine; Fema	2016
Determinants of Urinary Output Response to IV Furosemide in Acute Kidney Injury: A Pharmacokinetic/Pharmacodynamic Study. Critical care medicine, 2016, Volume: 44, Issue:10 Topics: Acute Kidney Injury; Creatinine; Diuretics; Female; Furosemide; Humans; Injections, Intravenous; Mal	2016
Effects of mannitol alone and mannitol plus furosemide on renal oxygen consumption, blood flow and glomerular filtration after cardiac surgery. Intensive care medicine, 2009, Volume: 35, Issue:1 Topics: Acute Kidney Injury; Cardiac Surgical Procedures; Diuretics; Drug Therapy, Combination; Furosemide;	2009
Furosemide does not improve renal recovery after hemofiltration for acute renal failure in critically ill patients: a double blind randomized controlled trial. Critical care medicine, 2009, Volume: 37, Issue:2 Topics: Acute Kidney Injury; Aged; Aged, 80 and over; Critical Care; Diuretics; Double-Blind Method; Female;	2009
Forced euvolemic diuresis with mannitol and furosemide for prevention of contrast-induced nephropathy in patients with CKD undergoing coronary angiography: a randomized controlled trial. American journal of kidney diseases : the official journal of the National Kidney Foundation, 2009, Volume: 54, Issue:4 Topics: Acute Kidney Injury; Adult; Aged; Biomarkers; Contrast Media; Coronary Angiography; Creatinine; Diur	2009
Effect of furosemide on ductal closure and renal function in indomethacin-treated preterm infants during the early neonatal period. Neonatology, 2010, Volume: 98, Issue:2 Topics: Acute Kidney Injury; Creatinine; Cyclooxygenase Inhibitors; Drug Interactions; Ductus Arteriosus, Pa	2010
Renal insufficiency following contrast media administration trial II (REMEDIAL II): RenalGuard system in high-risk patients for contrast-induced acute kidney injury: rationale and design. EuroIntervention : journal of EuroPCR in collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology, 2011, Volume: 6, Issue:9 Topics: Acetylcysteine; Acute Kidney Injury; Biomarkers; Chi-Square Distribution; Chronic Disease; Contrast	2011
Renal Insufficiency After Contrast Media Administration Trial II (REMEDIAL II): RenalGuard System in high-risk patients for contrast-induced acute kidney injury. Circulation, 2011, Sep-13, Volume: 124, Issue:11 Topics: Acetylcysteine; Acute Kidney Injury; Aged; Aged, 80 and over; Carbonates; Contrast Media; Female; Fl	2011
Renal Insufficiency After Contrast Media Administration Trial II (REMEDIAL II): RenalGuard System in high-risk patients for contrast-induced acute kidney injury. Circulation, 2011, Sep-13, Volume: 124, Issue:11 Topics: Acetylcysteine; Acute Kidney Injury; Aged; Aged, 80 and over; Carbonates; Contrast Media; Female; Fl	2011
Renal Insufficiency After Contrast Media Administration Trial II (REMEDIAL II): RenalGuard System in high-risk patients for contrast-induced acute kidney injury. Circulation, 2011, Sep-13, Volume: 124, Issue:11 Topics: Acetylcysteine; Acute Kidney Injury; Aged; Aged, 80 and over; Carbonates; Contrast Media; Female; Fl	2011
Renal Insufficiency After Contrast Media Administration Trial II (REMEDIAL II): RenalGuard System in high-risk patients for contrast-induced acute kidney injury. Circulation, 2011, Sep-13, Volume: 124, Issue:11 Topics: Acetylcysteine; Acute Kidney Injury; Aged; Aged, 80 and over; Carbonates; Contrast Media; Female; Fl	2011
Renal Insufficiency After Contrast Media Administration Trial II (REMEDIAL II): RenalGuard System in high-risk patients for contrast-induced acute kidney injury. Circulation, 2011, Sep-13, Volume: 124, Issue:11 Topics: Acetylcysteine; Acute Kidney Injury; Aged; Aged, 80 and over; Carbonates; Contrast Media; Female; Fl	2011
Renal Insufficiency After Contrast Media Administration Trial II (REMEDIAL II): RenalGuard System in high-risk patients for contrast-induced acute kidney injury. Circulation, 2011, Sep-13, Volume: 124, Issue:11 Topics: Acetylcysteine; Acute Kidney Injury; Aged; Aged, 80 and over; Carbonates; Contrast Media; Female; Fl	2011
Renal Insufficiency After Contrast Media Administration Trial II (REMEDIAL II): RenalGuard System in high-risk patients for contrast-induced acute kidney injury. Circulation, 2011, Sep-13, Volume: 124, Issue:11 Topics: Acetylcysteine; Acute Kidney Injury; Aged; Aged, 80 and over; Carbonates; Contrast Media; Female; Fl	2011
Renal Insufficiency After Contrast Media Administration Trial II (REMEDIAL II): RenalGuard System in high-risk patients for contrast-induced acute kidney injury. Circulation, 2011, Sep-13, Volume: 124, Issue:11 Topics: Acetylcysteine; Acute Kidney Injury; Aged; Aged, 80 and over; Carbonates; Contrast Media; Female; Fl	2011
Renal Insufficiency After Contrast Media Administration Trial II (REMEDIAL II): RenalGuard System in high-risk patients for contrast-induced acute kidney injury. Circulation, 2011, Sep-13, Volume: 124, Issue:11 Topics: Acetylcysteine; Acute Kidney Injury; Aged; Aged, 80 and over; Carbonates; Contrast Media; Female; Fl	2011
Renal Insufficiency After Contrast Media Administration Trial II (REMEDIAL II): RenalGuard System in high-risk patients for contrast-induced acute kidney injury. Circulation, 2011, Sep-13, Volume: 124, Issue:11 Topics: Acetylcysteine; Acute Kidney Injury; Aged; Aged, 80 and over; Carbonates; Contrast Media; Female; Fl	2011
Renal Insufficiency After Contrast Media Administration Trial II (REMEDIAL II): RenalGuard System in high-risk patients for contrast-induced acute kidney injury. Circulation, 2011, Sep-13, Volume: 124, Issue:11 Topics: Acetylcysteine; Acute Kidney Injury; Aged; Aged, 80 and over; Carbonates; Contrast Media; Female; Fl	2011
Renal Insufficiency After Contrast Media Administration Trial II (REMEDIAL II): RenalGuard System in high-risk patients for contrast-induced acute kidney injury. Circulation, 2011, Sep-13, Volume: 124, Issue:11 Topics: Acetylcysteine; Acute Kidney Injury; Aged; Aged, 80 and over; Carbonates; Contrast Media; Female; Fl	2011
Renal Insufficiency After Contrast Media Administration Trial II (REMEDIAL II): RenalGuard System in high-risk patients for contrast-induced acute kidney injury. Circulation, 2011, Sep-13, Volume: 124, Issue:11 Topics: Acetylcysteine; Acute Kidney Injury; Aged; Aged, 80 and over; Carbonates; Contrast Media; Female; Fl	2011
Renal Insufficiency After Contrast Media Administration Trial II (REMEDIAL II): RenalGuard System in high-risk patients for contrast-induced acute kidney injury. Circulation, 2011, Sep-13, Volume: 124, Issue:11 Topics: Acetylcysteine; Acute Kidney Injury; Aged; Aged, 80 and over; Carbonates; Contrast Media; Female; Fl	2011
Renal Insufficiency After Contrast Media Administration Trial II (REMEDIAL II): RenalGuard System in high-risk patients for contrast-induced acute kidney injury. Circulation, 2011, Sep-13, Volume: 124, Issue:11 Topics: Acetylcysteine; Acute Kidney Injury; Aged; Aged, 80 and over; Carbonates; Contrast Media; Female; Fl	2011
Renal Insufficiency After Contrast Media Administration Trial II (REMEDIAL II): RenalGuard System in high-risk patients for contrast-induced acute kidney injury. Circulation, 2011, Sep-13, Volume: 124, Issue:11 Topics: Acetylcysteine; Acute Kidney Injury; Aged; Aged, 80 and over; Carbonates; Contrast Media; Female; Fl	2011
Comparison of efficacy between continuous hemodiafiltration with a PMMA high-performance membrane dialyzer and a PAN membrane hemofilter in the treatment of septic shock patients with acute renal failure. Contributions to nephrology, 2011, Volume: 173 Topics: Acrylic Resins; Acute Kidney Injury; Adsorption; Aged; Body Water; Combined Modality Therapy; Diuret	2011
Prevention of contrast nephropathy by furosemide with matched hydration: the MYTHOS (Induced Diuresis With Matched Hydration Compared to Standard Hydration for Contrast Induced Nephropathy Prevention) trial. JACC. Cardiovascular interventions, 2012, Volume: 5, Issue:1 Topics: Acute Kidney Injury; Aged; Confidence Intervals; Contrast Media; Creatinine; Diuretics; Female; Flui	2012
Prevention of contrast nephropathy by furosemide with matched hydration: the MYTHOS (Induced Diuresis With Matched Hydration Compared to Standard Hydration for Contrast Induced Nephropathy Prevention) trial. JACC. Cardiovascular interventions, 2012, Volume: 5, Issue:1 Topics: Acute Kidney Injury; Aged; Confidence Intervals; Contrast Media; Creatinine; Diuretics; Female; Flui	2012
Prevention of contrast nephropathy by furosemide with matched hydration: the MYTHOS (Induced Diuresis With Matched Hydration Compared to Standard Hydration for Contrast Induced Nephropathy Prevention) trial. JACC. Cardiovascular interventions, 2012, Volume: 5, Issue:1 Topics: Acute Kidney Injury; Aged; Confidence Intervals; Contrast Media; Creatinine; Diuretics; Female; Flui	2012
Prevention of contrast nephropathy by furosemide with matched hydration: the MYTHOS (Induced Diuresis With Matched Hydration Compared to Standard Hydration for Contrast Induced Nephropathy Prevention) trial. JACC. Cardiovascular interventions, 2012, Volume: 5, Issue:1 Topics: Acute Kidney Injury; Aged; Confidence Intervals; Contrast Media; Creatinine; Diuretics; Female; Flui	2012
Prevention of contrast nephropathy by furosemide with matched hydration: the MYTHOS (Induced Diuresis With Matched Hydration Compared to Standard Hydration for Contrast Induced Nephropathy Prevention) trial. JACC. Cardiovascular interventions, 2012, Volume: 5, Issue:1 Topics: Acute Kidney Injury; Aged; Confidence Intervals; Contrast Media; Creatinine; Diuretics; Female; Flui	2012
Prevention of contrast nephropathy by furosemide with matched hydration: the MYTHOS (Induced Diuresis With Matched Hydration Compared to Standard Hydration for Contrast Induced Nephropathy Prevention) trial. JACC. Cardiovascular interventions, 2012, Volume: 5, Issue:1 Topics: Acute Kidney Injury; Aged; Confidence Intervals; Contrast Media; Creatinine; Diuretics; Female; Flui	2012
Prevention of contrast nephropathy by furosemide with matched hydration: the MYTHOS (Induced Diuresis With Matched Hydration Compared to Standard Hydration for Contrast Induced Nephropathy Prevention) trial. JACC. Cardiovascular interventions, 2012, Volume: 5, Issue:1 Topics: Acute Kidney Injury; Aged; Confidence Intervals; Contrast Media; Creatinine; Diuretics; Female; Flui	2012
Prevention of contrast nephropathy by furosemide with matched hydration: the MYTHOS (Induced Diuresis With Matched Hydration Compared to Standard Hydration for Contrast Induced Nephropathy Prevention) trial. JACC. Cardiovascular interventions, 2012, Volume: 5, Issue:1 Topics: Acute Kidney Injury; Aged; Confidence Intervals; Contrast Media; Creatinine; Diuretics; Female; Flui	2012
Prevention of contrast nephropathy by furosemide with matched hydration: the MYTHOS (Induced Diuresis With Matched Hydration Compared to Standard Hydration for Contrast Induced Nephropathy Prevention) trial. JACC. Cardiovascular interventions, 2012, Volume: 5, Issue:1 Topics: Acute Kidney Injury; Aged; Confidence Intervals; Contrast Media; Creatinine; Diuretics; Female; Flui	2012
Prevention of contrast nephropathy by furosemide with matched hydration: the MYTHOS (Induced Diuresis With Matched Hydration Compared to Standard Hydration for Contrast Induced Nephropathy Prevention) trial. JACC. Cardiovascular interventions, 2012, Volume: 5, Issue:1 Topics: Acute Kidney Injury; Aged; Confidence Intervals; Contrast Media; Creatinine; Diuretics; Female; Flui	2012
Prevention of contrast nephropathy by furosemide with matched hydration: the MYTHOS (Induced Diuresis With Matched Hydration Compared to Standard Hydration for Contrast Induced Nephropathy Prevention) trial. JACC. Cardiovascular interventions, 2012, Volume: 5, Issue:1 Topics: Acute Kidney Injury; Aged; Confidence Intervals; Contrast Media; Creatinine; Diuretics; Female; Flui	2012
Prevention of contrast nephropathy by furosemide with matched hydration: the MYTHOS (Induced Diuresis With Matched Hydration Compared to Standard Hydration for Contrast Induced Nephropathy Prevention) trial. JACC. Cardiovascular interventions, 2012, Volume: 5, Issue:1 Topics: Acute Kidney Injury; Aged; Confidence Intervals; Contrast Media; Creatinine; Diuretics; Female; Flui	2012
Prevention of contrast nephropathy by furosemide with matched hydration: the MYTHOS (Induced Diuresis With Matched Hydration Compared to Standard Hydration for Contrast Induced Nephropathy Prevention) trial. JACC. Cardiovascular interventions, 2012, Volume: 5, Issue:1 Topics: Acute Kidney Injury; Aged; Confidence Intervals; Contrast Media; Creatinine; Diuretics; Female; Flui	2012
Prevention of contrast nephropathy by furosemide with matched hydration: the MYTHOS (Induced Diuresis With Matched Hydration Compared to Standard Hydration for Contrast Induced Nephropathy Prevention) trial. JACC. Cardiovascular interventions, 2012, Volume: 5, Issue:1 Topics: Acute Kidney Injury; Aged; Confidence Intervals; Contrast Media; Creatinine; Diuretics; Female; Flui	2012
Prevention of contrast nephropathy by furosemide with matched hydration: the MYTHOS (Induced Diuresis With Matched Hydration Compared to Standard Hydration for Contrast Induced Nephropathy Prevention) trial. JACC. Cardiovascular interventions, 2012, Volume: 5, Issue:1 Topics: Acute Kidney Injury; Aged; Confidence Intervals; Contrast Media; Creatinine; Diuretics; Female; Flui	2012
Prevention of contrast nephropathy by furosemide with matched hydration: the MYTHOS (Induced Diuresis With Matched Hydration Compared to Standard Hydration for Contrast Induced Nephropathy Prevention) trial. JACC. Cardiovascular interventions, 2012, Volume: 5, Issue:1 Topics: Acute Kidney Injury; Aged; Confidence Intervals; Contrast Media; Creatinine; Diuretics; Female; Flui	2012
A randomized trial of saline hydration to prevent contrast-induced nephropathy in patients on regular captopril or furosemide therapy undergoing percutaneous coronary intervention. Saudi journal of kidney diseases and transplantation : an official publication of the Saudi Center for Organ Transplantation, Saudi Arabia, 2012, Volume: 23, Issue:2 Topics: Acute Kidney Injury; Adult; Aged; Angiotensin-Converting Enzyme Inhibitors; Captopril; Contrast Medi	2012
Continuous renal replacement therapy versus furosemide for management of kidney impairment in heart transplant recipients with volume overload. Interactive cardiovascular and thoracic surgery, 2013, Volume: 16, Issue:3 Topics: Acute Kidney Injury; Adult; Chi-Square Distribution; Diuretics; Female; Furosemide; Glomerular Filtr	2013
Determinants of serum creatinine trajectory in acute contrast nephropathy. Journal of interventional cardiology, 2002, Volume: 15, Issue:5 Topics: Acute Kidney Injury; Aged; Cardiotonic Agents; Contrast Media; Creatinine; Crystalloid Solutions; Di	2002
High-dose furosemide for established ARF: a prospective, randomized, double-blind, placebo-controlled, multicenter trial. American journal of kidney diseases : the official journal of the National Kidney Foundation, 2004, Volume: 44, Issue:3 Topics: Acute Kidney Injury; Aged; Diuretics; Double-Blind Method; Female; Furosemide; Humans; Male; Middle	2004
Fenoldopam mesylate and renal function in patients undergoing liver transplantation: a randomized, controlled pilot trial. Anesthesia and analgesia, 2004, Volume: 99, Issue:6 Topics: Acute Kidney Injury; Adult; Aged; Blood Urea Nitrogen; Blood Volume; Cyclosporine; Diuretics; Dopami	2004
Differential effects of human atrial natriuretic peptide and furosemide on glomerular filtration rate and renal oxygen consumption in humans. Intensive care medicine, 2005, Volume: 31, Issue:1 Topics: Acute Kidney Injury; Aged; Atrial Natriuretic Factor; Blood Pressure; Coronary Artery Bypass; Diuret	2005
Torsemide versus furosemide after continuous renal replacement therapy due to acute renal failure in cardiac surgery patients. Renal failure, 2005, Volume: 27, Issue:4 Topics: Acute Kidney Injury; Adult; Aged; Chi-Square Distribution; Combined Modality Therapy; Dose-Response	2005
High dose frusemide in acute renal failure: a controlled trial. Clinical nephrology, 1981, Volume: 15, Issue:2 Topics: Acute Kidney Injury; Administration, Oral; Clinical Trials as Topic; Female; Furosemide; Humans; Inj	1981
A simple prognostic index for patients with acute renal failure requiring dialysis. French Multicentric Prospective Study on Furosemide in Acute Renal Failure Requiring Dialysis. Renal failure, 1996, Volume: 18, Issue:4 Topics: Acute Kidney Injury; Age Factors; Bilirubin; Diuretics; Double-Blind Method; Female; Follow-Up Studi	1996
Increased toxicity of high-dose furosemide versus low-dose dopamine in the treatment of refractory congestive heart failure. Clinical pharmacology and therapeutics, 1997, Volume: 62, Issue:2 Topics: Acute Kidney Injury; Administration, Oral; Aged; Blood Pressure; Diuretics; Dopamine; Drug Therapy,	1997
Acute renal failure following cardiac surgery is reverted by administration of Urodilatin (INN: Ularitide). European journal of medical research, 1996, Feb-22, Volume: 1, Issue:5 Topics: Acute Kidney Injury; Adult; Aged; Aged, 80 and over; Anuria; Atrial Natriuretic Factor; Cardiac Surg	1996
Loop diuretics in the management of acute renal failure: a prospective, double-blind, placebo-controlled, randomized study. Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, 1997, Volume: 12, Issue:12 Topics: Acute Kidney Injury; Adult; Aged; Creatinine; Diuresis; Diuretics; Double-Blind Method; Female; Furo	1997
Concomitant treatment with urodilatin (ularitide) does not improve renal function in patients with acute renal failure after major abdominal surgery--a randomized controlled trial. Wiener klinische Wochenschrift, 1999, Feb-26, Volume: 111, Issue:4 Topics: Abdomen; Acute Kidney Injury; Adult; Aged; Atrial Natriuretic Factor; Critical Care; Diuretics; Dopa	1999
Lack of renoprotective effects of dopamine and furosemide during cardiac surgery. Journal of the American Society of Nephrology : JASN, 2000, Volume: 11, Issue:1 Topics: Acute Kidney Injury; Adult; Aged; Analysis of Variance; Cardiac Surgical Procedures; Cardiotonic Age	2000
Mannitol, furosemide, and dopamine infusion in postoperative renal failure complicating cardiac surgery. The Annals of thoracic surgery, 2000, Volume: 69, Issue:2 Topics: Acute Kidney Injury; Aged; Cardiac Surgical Procedures; Cardiotonic Agents; Diuretics; Dopamine; Dru	2000
Effect of polymyxin B-immobilized fiber hemoperfusion on sepsis-induced rhabdomyolysis with acute renal failure. Nephron, 2000, Volume: 86, Issue:2 Topics: Acute Kidney Injury; APACHE; Bacteremia; Furosemide; Gram-Negative Bacterial Infections; Hemoperfusi	2000
Intraplatelet calcium levels in patients with acute renal failure before and after the administration of loop diuretics. Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, 2001, Volume: 16, Issue:3 Topics: Acute Kidney Injury; Adult; Arginine Vasopressin; Blood Platelets; Calcium; Chelating Agents; Diuret	2001
[Pharmacokinetic characteristics of a massive dose of furosemide in acute kidney failure]. Biomedicine / [publiee pour l'A.A.I.C.I.G.], 1976, Volume: 24, Issue:1 Topics: Acute Kidney Injury; Adult; Aged; Anuria; Blood Proteins; Clinical Trials as Topic; Creatinine; Fema	1976
Furosemide in acute oliguric renal failure. A controlled trial. Nephron, 1976, Volume: 17, Issue:1 Topics: Acute Kidney Injury; Anuria; Clinical Trials as Topic; Diuresis; Female; Furosemide; Humans; Male; O	1976
The effect of prophylactic use of furosemide on renal function during open heart surgery. Annales chirurgiae et gynaecologiae, 1976, Volume: 65, Issue:4 Topics: Acute Kidney Injury; Adult; Cardiac Surgical Procedures; Creatinine; Diuresis; Extracorporeal Circul	1976
Potential deleterious effect of furosemide in radiocontrast nephropathy. Nephron, 1992, Volume: 62, Issue:4 Topics: Acute Kidney Injury; Adult; Angiography; Contrast Media; Furosemide; Humans; Prospective Studies; Wa	1992
Urodilatin: a new peptide with beneficial effects in the postoperative therapy of cardiac transplant recipients. The Clinical investigator, 1992, Volume: 70, Issue:8 Topics: Acute Kidney Injury; Adult; Atrial Natriuretic Factor; Blood Pressure; Catecholamines; Cyclosporine;	1992
The efficacy of diuretics in acute and chronic renal failure. Focus on torasemide. Drugs, 1991, Volume: 41 Suppl 3 Topics: Acute Kidney Injury; Diuretics; Furosemide; Humans; Kidney Failure, Chronic; Sulfonamides; Torsemide	1991
Intrarenal infusion of gallopamil in acute renal failure. A preliminary report. Drugs, 1991, Volume: 42 Suppl 1 Topics: Acute Kidney Injury; Adolescent; Adult; Aged; Blood Urea Nitrogen; Creatinine; Drug Administration R	1991
Furosemide and dopamine in malarial acute renal failure. Nephron, 1989, Volume: 52, Issue:1 Topics: Acute Kidney Injury; Adult; Animals; Dopamine; Drug Therapy, Combination; Female; Furosemide; Humans	1989
High dose frusemide in acute reversible intrinsic renal failure. A preliminary communication. Scottish medical journal, 1974, Volume: 19 Suppl 1 Topics: Acute Kidney Injury; Adult; Clinical Trials as Topic; Deafness; Furosemide; Gentamicins; Humans; Kan	1974
Clinical trial of a new diuretic, bumetanide, in seriously ill patients. Annals of clinical research, 1974, Volume: 6, Issue:5 Topics: Acute Kidney Injury; Adolescent; Adult; Aged; Benzoates; Butylamines; Clinical Trials as Topic; Diur	1974
Bumetanide, a new diuretic. International urology and nephrology, 1974, Volume: 6, Issue:1 Topics: Acute Kidney Injury; Adolescent; Adult; Aged; Benzoates; Bumetanide; Butylamines; Chlorides; Clinica	1974
High dose frusemide in established acute renal failure. British medical journal, 1973, Nov-24, Volume: 4, Issue:5890 Topics: Acute Kidney Injury; Anuria; Diuresis; Female; Furosemide; Genital Diseases, Female; Humans; Length	1973
Letter: High-dose frusemide in renal failure. British medical journal, 1974, Feb-09, Volume: 1, Issue:5901 Topics: Acute Kidney Injury; Furosemide; Humans; Urea; Urination	1974
Letter: High-dose frusemide in renal failure. British medical journal, 1974, May-04, Volume: 2, Issue:5913 Topics: Acute Kidney Injury; Diuresis; Furosemide; Humans	1974
Frusemide in high doses in the treatment of acute renal failure. Postgraduate medical journal, 1971, Volume: 47 Topics: Abortion, Septic; Acute Kidney Injury; Creatinine; Female; Furosemide; Humans; Kidney; Metabolic Cle	1971

furosemide and Acute Kidney Failure

Research Excerpts

Research

Studies (507)

Authors

Clinical Trials (30)

Trial Overview

Trial Outcomes

Change in Brain Natriuretic Peptide (BNP) Levels From Admission to the Discharge

Dopamine Infusion During Hospitalization

Evaluation of B-type Natriuretic Peptide (BNP) Levels From Admission to the End of Treatment

Evaluation of Mean Urine Output Volume During the Infusion Period

Evaluation of Renal Function in Terms of Changes in Creatinine Levels

Evaluation of Renal Function in Terms of Changes in GFR

Evaluation of Renal Function in Terms of Creatinine Levels at Discharge

Evaluation of Renal Function in Terms of GFR Values at Discharge

Length of Hospitalization in the Two Groups

Number of Participants With Contrast-induced Acute Kidney Injury

Geometric Mean Ratio of Area Under Curve

Geometric Mean Ratio of Maximum Concentration

Pharmacokinetics Parameter

Pharmacokinetics Parameter

Length of Hospital Stay

Oxygen Saturation

Oxygen Saturation

Patient Needing Endotracheal Intubation

Respiratory Rate

Respiratory Rate

Reviews

Trials

Other Studies