Page last updated: 2024-10-27

furosemide and Acute Brain Injuries

furosemide has been researched along with Acute Brain Injuries in 14 studies

Furosemide: A benzoic-sulfonamide-furan. It is a diuretic with fast onset and short duration that is used for EDEMA and chronic RENAL INSUFFICIENCY.
furosemide : A chlorobenzoic acid that is 4-chlorobenzoic acid substituted by a (furan-2-ylmethyl)amino and a sulfamoyl group at position 2 and 5 respectively. It is a diuretic used in the treatment of congestive heart failure.

Research Excerpts

ExcerptRelevanceReference
"Continuous infusion of 3% hypertonic saline + furosemide is effective and safe for intracranial pressure control."1.42Efficacy and Safety of Continuous Micro-Pump Infusion of 3% Hypertonic Saline combined with Furosemide to Control Elevated Intracranial Pressure. ( Cheng, H; Fang, W; Gao, G; Gao, L; Li, L; Li, M; Li, Y; Li, Z; Wang, B; Yang, Y; Zhang, X; Zhao, B, 2015)
"Seventeen had Glasgow Coma Scales of 3 to 4 and 23 scales of 5 to 7."1.27Early prediction of outcome after severe head injury in children. ( Pfenninger, J, 1984)

Research

Studies (14)

TimeframeStudies, this research(%)All Research%
pre-19909 (64.29)18.7374
1990's1 (7.14)18.2507
2000's2 (14.29)29.6817
2010's2 (14.29)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Cragoe, EJ1
Gould, NP1
Woltersdorf, OW1
Ziegler, C1
Bourke, RS1
Nelson, LR1
Kimelberg, HK1
Waldman, JB1
Popp, AJ1
Sedransk, N1
Li, Y1
Li, Z1
Li, M1
Yang, Y1
Wang, B2
Gao, L1
Zhang, X1
Cheng, H1
Fang, W1
Zhao, B1
Gao, G1
Li, L1
Tang, ME1
Lobel, DA1
Mtchedlishvili, Z1
Lepsveridze, E1
Xu, H1
Kharlamov, EA1
Lu, B1
Kelly, KM1
Todd, MM1
Cutkomp, J1
Brian, JE1
Millet, A1
Pfenninger, J1
McNamara, M1
Quinn, C1
Kirdan, KP1
Kuberger, MB1
Ivanov, LB1
Dabrowska, E1
JagodziƄski, Z1
Michalak, W1
Baethmann, A1
Lanksch, W1
Schmiedek, P1
Hayakawa, I1
Cabrini, GP1
Giovanelli, M1
Infuso, L1
Nicola, GC1
Galle, P1
Staudacher, M1

Clinical Trials (2)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Comparison of Mannitol Alone Versus Different Doses of Mannitol in Combination With Furosemide on Brain Relaxation in Supratentorial Mass Resection Surgery[NCT02712476]47 participants (Actual)Interventional2013-07-31Completed
The Effect of Furosemide Versus Placebo on Brain Relaxation and Incidence of Significant Intravascular Volume Depletion in Human Subjects Receiving Mannitol[NCT01054404]23 participants (Actual)Interventional2010-02-28Terminated (stopped due to Concern for volume depletion and electrolyte abnormalities in furosemide arm.)
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

Acceptable vs. Unacceptable Brain Relaxation at Dural Opening

"Rating of brain relaxation will be on a 4-point scale:~0 = brain very relaxed under dura, acceptable~= brain adequately relaxed under dura, acceptable~= brain slightly tense under dura, acceptable~= brain very tense under bulging dura, unacceptable" (NCT01054404)
Timeframe: just prior to dural opening for each subject

Interventionunits on a scale 0-3 (Mean)
Furosemide1.5
Placebo1.3

Reviews

3 reviews available for furosemide and Acute Brain Injuries

ArticleYear
Severe traumatic brain injury: maximizing outcomes.
    The Mount Sinai journal of medicine, New York, 2009, Volume: 76, Issue:2

    Topics: Bacterial Infections; Brain Injuries; Cerebrovascular Circulation; Diuretics; Furosemide; Humans; Hy

2009
[Effect of osmotic diuretics, enzyme-inhibiting diuretics and neuroleptics on cerebral perfusion pressure].
    Agressologie: revue internationale de physio-biologie et de pharmacologie appliquees aux effets de l'agression, 1983, Volume: 24, Issue:9

    Topics: Acetazolamide; Adrenal Cortex Hormones; Animals; Antipsychotic Agents; Brain Edema; Brain Injuries;

1983
Epidural intracranial pressure monitoring: theory and clinical application.
    Journal of neurosurgical nursing, 1981, Volume: 13, Issue:5

    Topics: Barbiturates; Brain; Brain Diseases; Brain Edema; Brain Injuries; Cerebrovascular Circulation; Epidu

1981

Trials

1 trial available for furosemide and Acute Brain Injuries

ArticleYear
[Effect of glucose and lasix on the functional state of the brain in craniocerebral injury in children].
    Voprosy okhrany materinstva i detstva, 1976, Volume: 21, Issue:12

    Topics: Adolescent; Brain; Brain Injuries; Child; Clinical Trials as Topic; Drug Evaluation; Electroencephal

1976

Other Studies

10 other studies available for furosemide and Acute Brain Injuries

ArticleYear
Agents for the treatment of brain injury. 1. (Aryloxy)alkanoic acids.
    Journal of medicinal chemistry, 1982, Volume: 25, Issue:5

    Topics: Animals; Astrocytes; Bicarbonates; Brain Injuries; Carboxylic Acids; Cats; Cerebral Cortex; Chemical

1982
Efficacy and Safety of Continuous Micro-Pump Infusion of 3% Hypertonic Saline combined with Furosemide to Control Elevated Intracranial Pressure.
    Medical science monitor : international medical journal of experimental and clinical research, 2015, Jun-17, Volume: 21

    Topics: Aged; Brain Injuries; Female; Furosemide; Humans; Infusion Pumps; Intracranial Hypertension; Male; M

2015
Increase of GABAA receptor-mediated tonic inhibition in dentate granule cells after traumatic brain injury.
    Neurobiology of disease, 2010, Volume: 38, Issue:3

    Topics: Animals; Brain Injuries; Dentate Gyrus; Diazepam; Furosemide; GABA Agonists; GABA Modulators; GABA-A

2010
Influence of mannitol and furosemide, alone and in combination, on brain water content after fluid percussion injury.
    Anesthesiology, 2006, Volume: 105, Issue:6

    Topics: Animals; Blood Gas Analysis; Blood Pressure; Body Water; Brain Chemistry; Brain Edema; Brain Injurie

2006
Influence of mannitol and furosemide, alone and in combination, on brain water content after fluid percussion injury.
    Anesthesiology, 2006, Volume: 105, Issue:6

    Topics: Animals; Blood Gas Analysis; Blood Pressure; Body Water; Brain Chemistry; Brain Edema; Brain Injurie

2006
Influence of mannitol and furosemide, alone and in combination, on brain water content after fluid percussion injury.
    Anesthesiology, 2006, Volume: 105, Issue:6

    Topics: Animals; Blood Gas Analysis; Blood Pressure; Body Water; Brain Chemistry; Brain Edema; Brain Injurie

2006
Influence of mannitol and furosemide, alone and in combination, on brain water content after fluid percussion injury.
    Anesthesiology, 2006, Volume: 105, Issue:6

    Topics: Animals; Blood Gas Analysis; Blood Pressure; Body Water; Brain Chemistry; Brain Edema; Brain Injurie

2006
Early prediction of outcome after severe head injury in children.
    Zeitschrift fur Kinderchirurgie : organ der Deutschen, der Schweizerischen und der Osterreichischen Gesellschaft fur Kinderchirurgie = Surgery in infancy and childhood, 1984, Volume: 39, Issue:4

    Topics: Adolescent; Blood Coagulation Tests; Brain Death; Brain Injuries; Child; Child, Preschool; Coma; Dex

1984
[Remarks on conservative treatment of cerebral hematoma].
    Neurologia i neurochirurgia polska, 1992, Volume: Suppl 1

    Topics: Accidental Falls; Accidents, Traffic; Adolescent; Adult; Aged; Brain Injuries; Cerebral Hemorrhage;

1992
Formation and treatment of cerebral edema.
    Neurochirurgia, 1974, Volume: 17, Issue:2

    Topics: Aldosterone; Animals; Blood-Brain Barrier; Brain Edema; Brain Injuries; Dexamethasone; Ethacrynic Ac

1974
[Clinical studies on a new intracranial pressure reducing agent].
    Zentralblatt fur Neurochirurgie, 1967, Volume: 28, Issue:1

    Topics: Adolescent; Adult; Aged; Astrocytoma; Brain Diseases; Brain Injuries; Brain Neoplasms; Craniopharyng

1967
[Changes in cerebrospinal fluid pressure in closed cranial injuries as related to drug therapy].
    Minerva neurochirurgica, 1967, Volume: 11, Issue:3

    Topics: Brain Edema; Brain Injuries; Caffeine; Contusions; Dexamethasone; Furosemide; Hematoma, Subdural; In

1967
[On the influence of dehydrated drug preparations on cerebrospinal fluid pressure in head-brain injuries].
    Klinische Medizin; osterreichische Zeitschrift fur wissenschaftliche und praktische Medizin, 1967, Volume: 22, Issue:9

    Topics: Brain Injuries; Cerebrospinal Fluid; Furosemide; Humans; Phytotherapy; Plants, Medicinal; Pressure

1967