fumaric-acid and Muscular-Atrophy

Comparison of hindlimb muscles of rats flown on Spacelab-3 or tail-traction-suspended showed that 11-17 h reloading post-flight might have altered the results. Soleus atrophied, plantaris, gastrocnemius and extensor digitorum longus grew slower, and tibialis anterior grew normally. In both flight and simulated soleus and plantaris, higher tyrosine and greater glutamine/glutamate ratio indicated negative protein balance and increased glutamine production, respectively, relative to controls. Aspartate was lower in these muscles. Reloading generally decreased tyrosine, but increased aspartate and glutamine/glutamate. These data showed that at 12 h of reloading after flight is characterized by reversal to varying extents of effects of unloading.

Topics: Adaptation, Physiological; Amino Acids, Dicarboxylic; Animals; Fumarates; Glycogen; Hindlimb Suspension; Male; Muscle Proteins; Muscle, Skeletal; Muscular Atrophy; Rats; Research Design; Space Flight; Tail; Tyrosine; Weightlessness; Weightlessness Simulation