fumaric-acid and Lymphopenia

Fumaric acid esters (FAEs) are used to treat psoriasis and are known to cause lymphopenia in roughly 60% of the patients. Much remains to be elucidated about the biological effects of FAEs on lymphocytes.. To evaluate the influence of long-term FAE (Fumaderm. In this single-centre retrospective observational subcohort study, we obtained leucocyte and lymphocyte subset counts before initiating FAE therapy in 371 psoriasis patients (mean age, 47.8 years; 63.3% males) and monitored them during treatment (mean treatment duration, 2.9 years). Multiparametric flow cytometry was used for immunophenotyping.. FAEs significantly reduced the numbers of CD4. Monitoring distinct T-cell subsets rather than just absolute lymphocyte counts may provide more meaningful insights into both the FAE treatment safety and efficacy. We therefore suggest optimizing pharmacovigilance by additionally monitoring CD4

Topics: Adolescent; Adult; Aged; Aged, 80 and over; Child; Dermatologic Agents; Esters; Female; Fumarates; Humans; Immunophenotyping; Lymphopenia; Male; Middle Aged; Psoriasis; Retrospective Studies; T-Lymphocytes; Young Adult