fumarates and Pruritus

The new antihistamine, HC20-511 (Sandoz), was compared with Dimetinden (Fenistil retard) in a single-blind comparative study in 42 patients with dermatoses, 28 of whom suffered from chronic urticaria. HC20-511 had a better effect, especially in chronic urticaria, where pruritus, erythema and papules quickly disappeared. The effect appeared somewhat faster than and lasted as long as that of Dimetinden, although HC20-511 is not a retard-preparation unlike the Dimetinden preparation used for comparison. HC20-511 also caused less side effects.

Topics: Adolescent; Adult; Aged; Chronic Disease; Clinical Trials as Topic; Dimethindene; Drug Therapy, Combination; Female; Fumarates; Histamine H1 Antagonists; Humans; Male; Middle Aged; Piperidines; Pruritus; Skin Diseases; Thiophenes; Urticaria; Vomiting

Topics: Clinical Trials as Topic; Dermatitis, Contact; Drug Eruptions; Exanthema; Female; Fumarates; Histamine H1 Antagonists; Humans; Male; Mycosis Fungoides; Neurodermatitis; Pruritus; Pyrrolidines; Scabies; Skin Diseases; Skin Neoplasms; Urticaria

Topics: Clinical Trials as Topic; Eczema; Fumarates; Histamine H1 Antagonists; Humans; Placebos; Pruritus; Pyrrolidines; Rhinitis, Allergic, Seasonal; Urticaria

For the first time in Argentina, we describe an outbreak of contact dermatitis. New pairs of shoes caused intense pruritus, pain, and eruption, followed by edema, blisters, and a severe negative impact on the epidermal barrier of the feet. We identify dimethylfumarate as the causal agent and suggest an analytical method for its fast identification.

Topics: Adult; Animals; Anti-Bacterial Agents; Argentina; Blister; Dermatitis, Contact; Dimethyl Fumarate; Epidemics; Erythema; Female; Foot; Fumarates; Fungicides, Industrial; Gentamicins; Humans; Hypersensitivity; Miconazole; Patch Tests; Pruritus; Rabbits; Shoes

Topics: Adult; Blister; Edema; Erythema; Fumarates; Humans; Irritants; Male; Nitriles; Pruritus; Skin Diseases; Water