fumarates and Hidradenitis-Suppurativa

The management of hidradenitis suppurativa is multidisciplinary, involving general measures, medical treatment and surgery. Non-surgical treatments, often first-line procedures, mainly concern forms of low-to-moderate severity or, conversely, very severe forms in non-operable patients or those refusing surgery. While many treatments have been attempted, few randomized controlled trials have been conducted, so the choice of treatments is most often based on the personal experience of the clinicians. The objective of this systematic review is to propose a synthetic analysis of the currently available non-surgical procedures.. This systematic review of the literature was conducted in accordance with the PRISMA criteria. We searched for articles in the Medline. Sixty-four articles were included. They generally had a low level of evidence; indeed, the majority of them were retrospective observational studies. They involved biotherapy (44%), dynamic phototherapy (16%), antibiotics (11%), Laser (8%), retinoids (6%) and immunosuppressive therapies, anti-inflammatory drugs, zinc, metformin, gammaglobulins and fumarates.. None of the non-surgical treatments can treat all stages of the disease and offer long-term remission. Antibiotics and biotherapy seem to have real effectiveness but their effect remains suspensive and the disease is almost certain to reappear once they are stopped. As regards antibiotics, no association has shown their superiority in a study with a high level of evidence. And while some biotherapies seem quite effective, due to their side effects they should be reserved for moderate-to-severe, resistant or inoperable forms of the disease. Randomized controlled studies are needed before valid conclusions can be drawn. In the resistant or disabling forms, it is consequently advisable to orientate to the greatest possible extent towards radical surgery, which is the only treatment allowing hope for cure.

Topics: Androgen Antagonists; Anti-Bacterial Agents; Anti-Inflammatory Agents; Biological Products; Dermatologic Agents; Fumarates; Hidradenitis Suppurativa; Humans; Hypoglycemic Agents; Immunoglobulins; Immunosuppressive Agents; Laser Therapy; Metformin; Phototherapy; Retinoids

Topics: Adult; Anti-Inflammatory Agents; Dermatologic Agents; Drug Resistance; Female; Fumarates; Hidradenitis Suppurativa; Humans; Male; Middle Aged; Pilot Projects; Prospective Studies; Treatment Outcome