fumarates and Hand-Dermatoses

Fumaric acid esters (FAEs) have proven efficacy in the treatment of psoriasis and have been in use for decades. More recently, as their mechanism of action and abundant immunomodulatory effects become clearer, the potential benefits of treating other inflammatory skin conditions using FAEs are increasingly being recognized. The use of FAEs as combination systemic therapy has not been well studied and data are lacking regarding the safety and efficacy of this type of therapy. In this case report, three patients with severe, extensive and recalcitrant cutaneous manifestations of systemic lupus erythematosus (SLE) (one case of disseminated discoid lesions and two with severe chilblain lesions) were treated with Fumaderm

Topics: Adult; Chronic Disease; Dermatologic Agents; Facial Dermatoses; Female; Fumarates; Hand Dermatoses; Humans; Lupus Erythematosus, Cutaneous; Middle Aged; Treatment Outcome