fumarates and Burkitt-Lymphoma

fumarates has been researched along with Burkitt-Lymphoma* in 1 studies

Other Studies

1 other study(ies) available for fumarates and Burkitt-Lymphoma

Article	Year
DMF, but not other fumarates, inhibits NF-κB activity in vitro in an Nrf2-independent manner. Journal of neuroimmunology, 2015, Jun-15, Volume: 283 Fumarate-containing pharmaceuticals are potent therapeutic agents that influence multiple cellular pathways. Despite proven clinical efficacy, there is a significant lack of data that directly defines the molecular mechanisms of action of related, yet distinct fumarate compounds. We systematically compared the impact of dimethyl fumarate (DMF), monomethyl fumarate (MMF) and a mixture of monoethyl fumarate salts (Ca(++), Mg(++), Zn(++); MEF) on defined cellular responses. We demonstrate that DMF inhibited NF-κB-driven cytokine production and nuclear translocation of p65 and p52 in an Nrf2-independent manner. Equivalent doses of MMF and MEF did not affect NF-κB signaling. These results highlight a key difference in the biological impact of related, yet distinct fumarate compounds. Topics: Active Transport, Cell Nucleus; Animals; Bone Neoplasms; Burkitt Lymphoma; Cations; Cell Line, Tumor; Cells, Cultured; Cytokines; Dimethyl Fumarate; Fumarates; Humans; In Vitro Techniques; Lymphocytes; Maleates; Mice; Mice, Knockout; Molecular Structure; Neoplasm Proteins; NF-E2-Related Factor 2; NF-kappa B; NF-kappa B p52 Subunit; Osteosarcoma; Signal Transduction; Spleen; Transcription Factor RelA	2015

Article

Year

DMF, but not other fumarates, inhibits NF-κB activity in vitro in an Nrf2-independent manner.

Journal of neuroimmunology, 2015, Jun-15, Volume: 283

Fumarate-containing pharmaceuticals are potent therapeutic agents that influence multiple cellular pathways. Despite proven clinical efficacy, there is a significant lack of data that directly defines the molecular mechanisms of action of related, yet distinct fumarate compounds. We systematically compared the impact of dimethyl fumarate (DMF), monomethyl fumarate (MMF) and a mixture of monoethyl fumarate salts (Ca(++), Mg(++), Zn(++); MEF) on defined cellular responses. We demonstrate that DMF inhibited NF-κB-driven cytokine production and nuclear translocation of p65 and p52 in an Nrf2-independent manner. Equivalent doses of MMF and MEF did not affect NF-κB signaling. These results highlight a key difference in the biological impact of related, yet distinct fumarate compounds.

Topics: Active Transport, Cell Nucleus; Animals; Bone Neoplasms; Burkitt Lymphoma; Cations; Cell Line, Tumor; Cells, Cultured; Cytokines; Dimethyl Fumarate; Fumarates; Humans; In Vitro Techniques; Lymphocytes; Maleates; Mice; Mice, Knockout; Molecular Structure; Neoplasm Proteins; NF-E2-Related Factor 2; NF-kappa B; NF-kappa B p52 Subunit; Osteosarcoma; Signal Transduction; Spleen; Transcription Factor RelA

2015