fumarates and Bone-Diseases

fumarates has been researched along with Bone-Diseases* in 2 studies

Other Studies

2 other study(ies) available for fumarates and Bone-Diseases

Article	Year
Thiol-ene Hydrogels for Local Delivery of PTH for Bone Regeneration in Critical Size defects. Journal of orthopaedic research : official publication of the Orthopaedic Research Society, 2020, Volume: 38, Issue:3 Neither allograft nor commercially available bone graft substitutes provide the same quality of bone healing as autograft. Incorporation of bioactive molecules like parathyroid hormone (PTH) within bone graft substitute materials may provide similar, if not better treatment options to grafting. The goal of this work was to develop a biomaterial system for the local delivery of PTH to large bone defects for promoting bone regeneration. PTH was loaded in a thiol-ene hydrogel at several concentrations and polymerized in and around an osteoconductive poly(propylene fumarate) (PPF) scaffold. PTH was shown to be bioactive when released from the hydrogel for up to 21 days. Eighty percent of the PTH was released by day 3 with the remaining 20% released by day 14. Bone healing was quantified in rat critical size femoral defects that were treated with hydrogel/PPF and 0, 1, 3, 10, or 30 µg of PTH. Although complete osseous healing was not observed in all samples in any one treatment group, all samples in the 10 µg PTH group were bridged fully by bone or a combination of bone and cartilage containing hypertrophic chondrocytes and endochondral ossification. Outcome measures indicated improved defect bridging by a combination of bony and cartilaginous tissue in the 10 μg treatment group compared with empty bone defects and defects treated with only hydrogel/PPF (i.e., without PTH). Given the tailorability of the hydrogel, future studies will investigate the effects of prolonged gradual PTH release on bone healing. © 2019 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 38:536-544, 2020. Topics: Animals; Biocompatible Materials; Bone and Bones; Bone Diseases; Bone Regeneration; Bone Substitutes; Chondrocytes; Drug Delivery Systems; Femur; Fumarates; Hydrogels; Kinetics; Male; Osteogenesis; Parathyroid Hormone; Polypropylenes; Rats; Rats, Sprague-Dawley; Sulfhydryl Compounds; Treatment Outcome; Ursidae; X-Ray Microtomography	2020
EFFECTS OF INCREASING DOSES OF AMINOPROPIO-NITRILE FUMARATE ON RODENT BONES. The Indian journal of medical research, 1963, Volume: 51 Topics: Bone and Bones; Bone Diseases; Cyanides; Fumarates; Lathyrism; Nitriles; Pharmacology; Rats; Research; Toxicology	1963

Article

Year

Thiol-ene Hydrogels for Local Delivery of PTH for Bone Regeneration in Critical Size defects.

Journal of orthopaedic research : official publication of the Orthopaedic Research Society, 2020, Volume: 38, Issue:3

Neither allograft nor commercially available bone graft substitutes provide the same quality of bone healing as autograft. Incorporation of bioactive molecules like parathyroid hormone (PTH) within bone graft substitute materials may provide similar, if not better treatment options to grafting. The goal of this work was to develop a biomaterial system for the local delivery of PTH to large bone defects for promoting bone regeneration. PTH was loaded in a thiol-ene hydrogel at several concentrations and polymerized in and around an osteoconductive poly(propylene fumarate) (PPF) scaffold. PTH was shown to be bioactive when released from the hydrogel for up to 21 days. Eighty percent of the PTH was released by day 3 with the remaining 20% released by day 14. Bone healing was quantified in rat critical size femoral defects that were treated with hydrogel/PPF and 0, 1, 3, 10, or 30 µg of PTH. Although complete osseous healing was not observed in all samples in any one treatment group, all samples in the 10 µg PTH group were bridged fully by bone or a combination of bone and cartilage containing hypertrophic chondrocytes and endochondral ossification. Outcome measures indicated improved defect bridging by a combination of bony and cartilaginous tissue in the 10 μg treatment group compared with empty bone defects and defects treated with only hydrogel/PPF (i.e., without PTH). Given the tailorability of the hydrogel, future studies will investigate the effects of prolonged gradual PTH release on bone healing. © 2019 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 38:536-544, 2020.

Topics: Animals; Biocompatible Materials; Bone and Bones; Bone Diseases; Bone Regeneration; Bone Substitutes; Chondrocytes; Drug Delivery Systems; Femur; Fumarates; Hydrogels; Kinetics; Male; Osteogenesis; Parathyroid Hormone; Polypropylenes; Rats; Rats, Sprague-Dawley; Sulfhydryl Compounds; Treatment Outcome; Ursidae; X-Ray Microtomography

2020

EFFECTS OF INCREASING DOSES OF AMINOPROPIO-NITRILE FUMARATE ON RODENT BONES.

The Indian journal of medical research, 1963, Volume: 51

Topics: Bone and Bones; Bone Diseases; Cyanides; Fumarates; Lathyrism; Nitriles; Pharmacology; Rats; Research; Toxicology

1963