fumarates and Anaphylaxis

We report on two cases of adverse reactions to topical treatment with monoethyl fumarate. One patient suffering from atopic dermatitis reacted with contact dermatitis; the other, suffering from psoriasis, developed a generalized, partly pustulous exanthema as well as signs of systemic involvement, such as tachycardia and dyspnea. As the causative mechanism we suggest non-immunological contact urticaria syndrome.

Topics: Administration, Topical; Adult; Anaphylaxis; Drug Eruptions; Eczema; Female; Fumarates; Humans; Male; Psoriasis

Topics: Anaphylaxis; Anti-Inflammatory Agents; Arsenicals; Carbohydrate Metabolism; Dextrans; Edema; Fluorides; Fumarates; Inflammation; Insulin; Maleates; Malonates; Models, Theoretical; Pharmacology; Rats; Research; Succinates

Topics: Adenosine Triphosphatases; Anaphylaxis; Animals; Antigen-Antibody Reactions; Calcium; Carbohydrate Metabolism; Cattle; Chemical Phenomena; Chemistry; Electron Transport Complex II; Enzymes; Fumarates; Hypersensitivity; Keto Acids; Liver; Lung; Peptide Hydrolases; Rabbits; Research; Serum Albumin; Serum Albumin, Bovine; Succinate Dehydrogenase; Trypsin