fumagillin and Leukemia-P388

fumagillin has been researched along with Leukemia-P388* in 2 studies

Other Studies

2 other study(ies) available for fumagillin and Leukemia-P388

Article	Year
Total synthesis and antiangiogenic activity of cyclopentane analogues of fumagillol. Bioorganic & medicinal chemistry letters, 2005, Aug-01, Volume: 15, Issue:15 Novel cyclopentane analogues of fumagillol were synthesized and their endothelial cell proliferation inhibitory activities were evaluated. The cyclopentane-fumagillol derivatives were synthesized from (-)-2,3-O-isopropylidene-D-erythronolactone via stereoselective glycolate Claisen rearrangement and intramolecular ester enolate alkylation as key steps. Topics: Alkenes; Alkylation; Angiogenesis Inhibitors; Animals; Cell Line, Tumor; Cell Proliferation; Cyclohexanes; Cyclopentanes; Endothelium, Vascular; Glycolates; Lactones; Leukemia P388; Sesquiterpenes; Stereoisomerism; Structure-Activity Relationship	2005
Design and synthesis of highly potent fumagillin analogues from homology modeling for a human MetAP-2. Bioorganic & medicinal chemistry letters, 2000, Jan-03, Volume: 10, Issue:1 New fumagillin analogues were designed through structure-based molecular modeling with a human methionine aminopeptidase-2. Among the fumagillin analogues, cinnamic acid ester derivative CKD-731 showed 1000-fold more potent proliferation inhibitory activity on endothelial cell than TNP-470. Topics: Amino Acid Sequence; Aminopeptidases; Angiogenesis Inhibitors; Animals; Cattle; Cell Line; Cinnamates; Cyclohexanes; Drug Design; Epoxy Compounds; Fatty Acids, Unsaturated; Growth Inhibitors; Humans; Leukemia P388; Metalloendopeptidases; Mice; Models, Molecular; Molecular Sequence Data; Sequence Homology, Amino Acid; Sesquiterpenes; Structure-Activity Relationship	2000

Article

Year

Total synthesis and antiangiogenic activity of cyclopentane analogues of fumagillol.

Bioorganic & medicinal chemistry letters, 2005, Aug-01, Volume: 15, Issue:15

Novel cyclopentane analogues of fumagillol were synthesized and their endothelial cell proliferation inhibitory activities were evaluated. The cyclopentane-fumagillol derivatives were synthesized from (-)-2,3-O-isopropylidene-D-erythronolactone via stereoselective glycolate Claisen rearrangement and intramolecular ester enolate alkylation as key steps.

Topics: Alkenes; Alkylation; Angiogenesis Inhibitors; Animals; Cell Line, Tumor; Cell Proliferation; Cyclohexanes; Cyclopentanes; Endothelium, Vascular; Glycolates; Lactones; Leukemia P388; Sesquiterpenes; Stereoisomerism; Structure-Activity Relationship

2005

Design and synthesis of highly potent fumagillin analogues from homology modeling for a human MetAP-2.

Bioorganic & medicinal chemistry letters, 2000, Jan-03, Volume: 10, Issue:1

New fumagillin analogues were designed through structure-based molecular modeling with a human methionine aminopeptidase-2. Among the fumagillin analogues, cinnamic acid ester derivative CKD-731 showed 1000-fold more potent proliferation inhibitory activity on endothelial cell than TNP-470.

Topics: Amino Acid Sequence; Aminopeptidases; Angiogenesis Inhibitors; Animals; Cattle; Cell Line; Cinnamates; Cyclohexanes; Drug Design; Epoxy Compounds; Fatty Acids, Unsaturated; Growth Inhibitors; Humans; Leukemia P388; Metalloendopeptidases; Mice; Models, Molecular; Molecular Sequence Data; Sequence Homology, Amino Acid; Sesquiterpenes; Structure-Activity Relationship

2000