fullerene-c70 and Lung-Neoplasms

fullerene-c70 has been researched along with Lung-Neoplasms* in 1 studies

Other Studies

1 other study(ies) available for fullerene-c70 and Lung-Neoplasms

Article	Year
Enhanced photodynamic efficiency of an aptamer-guided fullerene photosensitizer toward tumor cells. Chemistry, an Asian journal, 2013, Volume: 8, Issue:10 Fullerene-based photosensitizers exhibit great potential in photodynamic therapy (PDT). Based on the high photodynamic efficacy of trimalonic acid-modified C70 fullerene (TF70), we constructed an aptamer-guided TF70 photosensitizer and investigated its photodynamic effect. Conjugation of the novel aptamer (named R13) could effectively enhance the PDT efficiency of TF70 against A549 lung cancer cells in the presence of serum. The lysosomal location of the TF70-R13 conjugate inside cells facilitates the production of intracellular reactive oxygen species (ROS), which can efficiently kill cells, under light irradiation. The enhanced photodynamic efficiency, along with its good biocompatibility in the dark, makes TF70-R13 a highly promising photosensitizer for tumor-specific PDT. Topics: Aptamers, Nucleotide; Cell Line, Tumor; Cell Survival; Fullerenes; Humans; Light; Lung Neoplasms; Photochemotherapy; Photosensitizing Agents; Reactive Oxygen Species	2013

Article

Year

Enhanced photodynamic efficiency of an aptamer-guided fullerene photosensitizer toward tumor cells.

Chemistry, an Asian journal, 2013, Volume: 8, Issue:10

Fullerene-based photosensitizers exhibit great potential in photodynamic therapy (PDT). Based on the high photodynamic efficacy of trimalonic acid-modified C70 fullerene (TF70), we constructed an aptamer-guided TF70 photosensitizer and investigated its photodynamic effect. Conjugation of the novel aptamer (named R13) could effectively enhance the PDT efficiency of TF70 against A549 lung cancer cells in the presence of serum. The lysosomal location of the TF70-R13 conjugate inside cells facilitates the production of intracellular reactive oxygen species (ROS), which can efficiently kill cells, under light irradiation. The enhanced photodynamic efficiency, along with its good biocompatibility in the dark, makes TF70-R13 a highly promising photosensitizer for tumor-specific PDT.

Topics: Aptamers, Nucleotide; Cell Line, Tumor; Cell Survival; Fullerenes; Humans; Light; Lung Neoplasms; Photochemotherapy; Photosensitizing Agents; Reactive Oxygen Species

2013