fucoxanthin and Adenomatous-Polyposis-Coli

A xanthophyll of fucoxanthin (Fx) is a potential chemopreventive agent. Familial adenomatous polyposis (FAP) is an inherited disease that is associated with a high risk of developing colorectal cancer. However, it remains unclear whether Fx can modify colorectal tumorigenesis in Apc. We investigated the chemopreventive effect of Fx in dextran sodium sulfate (DSS)-treated Apc. Administration of Fx in the diet for 5 weeks significantly suppressed the number of colorectal adenocarcinomas in DSS-treated male Apc. Fx possesses chemopreventive potential against progression of colorectal carcinogenesis in Apc

Topics: Adenomatous Polyposis Coli; Animals; Anticarcinogenic Agents; Colorectal Neoplasms; Cyclin D1; Dextran Sulfate; Disease Models, Animal; Male; Mice; Xanthophylls