fructooligosaccharide and Inflammatory-Bowel-Diseases

The dysbiosis of gut microbiota is closely related to the occurrence and development of inflammatory bowel disease (IBD). The manipulation of intestinal flora through prebiotics or probiotics is expected to induce and maintain the remission of IBD symptoms. 6-week-old C57BL/J mice were daily gavaged with fructooligosaccharides (FOS) or the synbiotic two weeks before the administration of dextran sulfate sodium (DSS). The supplementation of FOS or synbiotic could significantly ameliorate the body weight loss and colon histological damage in DSS-induced acute colitis mice. The altered composition of gut microbiota in acute colitis mice was reversed by FOS or Synbiotic supplementation, with a characteristic of decreased abundance of

Topics: Animals; Colitis; Colon; Cytokines; Dextran Sulfate; Disease Models, Animal; Dysbiosis; Gastrointestinal Microbiome; Immunity; Inflammatory Bowel Diseases; Interleukin-10; Intestinal Mucosa; Lactobacillus; Male; Mice; Mice, Inbred C57BL; Oligosaccharides; Prebiotics; Probiotics; Synbiotics; Tight Junction Proteins