frondosin-a has been researched along with Neoplasms* in 1 studies
1 other study(ies) available for frondosin-a and Neoplasms
Article | Year |
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Reactivity of acyclic (pentadienyl)iron(1+) cations: synthetic studies directed toward the frondosins.
A short, 4-step route to the scaffold of frondosin A and B is reported. The [1-methoxycarbonyl-5-(2',5'-dimethoxyphenyl)pentadienyl]Fe(CO)(3)(+) cation was prepared in two steps from (methyl 6-oxo-2,4-hexadienoate)Fe(CO)(3). Reaction of this cation with isopropenyl Grignard or cyclohexenyllithium reagents affords (2-alkenyl-5-aryl-1-methoxycarbonyl-3-pentene-1,5-diyl)Fe(CO)(3) along with other addition products. Oxidative decomplexation of these (pentenediyl)iron complexes, utilizing CuCl(2), affords 6-aryl-3-methoxycarbonyl-1,4-cycloheptadienes via the presumed intermediacy of a cis-divinylcyclopropane. Topics: Alkadienes; Animals; Aquatic Organisms; Autoimmune Diseases; Bridged Bicyclo Compounds; Cations; Chemistry, Pharmaceutical; Ferric Compounds; Humans; Interleukin-8; Iron; Magnetic Resonance Spectroscopy; Models, Molecular; Neoplasms; Oxidation-Reduction; Porifera; Receptors, Interleukin-8 | 2011 |