frondoside-a has been researched along with Carcinoma--Ehrlich-Tumor* in 1 studies
1 other study(ies) available for frondoside-a and Carcinoma--Ehrlich-Tumor
Article | Year |
---|---|
Inhibition of tumor cells multidrug resistance by cucumarioside A2-2, frondoside A and their complexes with cholesterol.
In non-cytotoxic concentrations, frondoside A (1) from the sea cucumber Cucumaria okhotensis and cucumarioside A2-2 (2) from C. japonica, as well as their complexes with cholesterol block the activity of membrane transport P-glycoprotein in cells of the ascite form of mouse Ehrlich carcinoma. They prevent in this way an efflux of fluorescent probe Calcein from the cells. Since the blocking of P-glycoprotein activity results in decrease of multidrug resistance, these glycosides and their complexes with cholesterol may be considered as potential inhibitors of multidrug resistance of tumor cells. Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Carcinoma, Ehrlich Tumor; Cholesterol; Cucumaria; Drug Resistance, Neoplasm; Drug Screening Assays, Antitumor; Female; Fluoresceins; Glycosides; Male; Mice; Saponins; Triterpenes | 2013 |