frax597 and Breast-Neoplasms

frax597 has been researched along with Breast-Neoplasms* in 1 studies

Other Studies

1 other study(ies) available for frax597 and Breast-Neoplasms

Article	Year
Design, synthesis and biological evaluation of 2-indolinone derivatives as PAK1 inhibitors in MDA-MB-231 cells. Bioorganic & medicinal chemistry letters, 2020, 09-01, Volume: 30, Issue:17 P21-activated kinase 1 (PAK1) plays a vital role in the proliferation, survival and migration of cancer cells, which has emerged as a promising drug target for cancer therapy. In this study, a series of 2-indolinone derivatives were designed and synthesized through a structure-based strategy. A potent PAK1 inhibitor (ZMF-005) was discovered, which presented an IC Topics: Apoptosis; Binding Sites; Breast Neoplasms; Cell Line, Tumor; Cell Movement; Drug Design; Female; Humans; Molecular Docking Simulation; Oxindoles; p21-Activated Kinases; Protein Binding; Protein Kinase Inhibitors; Structure-Activity Relationship; Thermodynamics	2020

Article

Year

Design, synthesis and biological evaluation of 2-indolinone derivatives as PAK1 inhibitors in MDA-MB-231 cells.

Bioorganic & medicinal chemistry letters, 2020, 09-01, Volume: 30, Issue:17

P21-activated kinase 1 (PAK1) plays a vital role in the proliferation, survival and migration of cancer cells, which has emerged as a promising drug target for cancer therapy. In this study, a series of 2-indolinone derivatives were designed and synthesized through a structure-based strategy. A potent PAK1 inhibitor (ZMF-005) was discovered, which presented an IC

Topics: Apoptosis; Binding Sites; Breast Neoplasms; Cell Line, Tumor; Cell Movement; Drug Design; Female; Humans; Molecular Docking Simulation; Oxindoles; p21-Activated Kinases; Protein Binding; Protein Kinase Inhibitors; Structure-Activity Relationship; Thermodynamics

2020