fr-901379 has been researched along with Disease-Models--Animal* in 2 studies
2 other study(ies) available for fr-901379 and Disease-Models--Animal
| Article | Year |
|---|---|
FR131535, a novel water-soluble echinocandin-like lipopeptide: synthesis and biological properties.
The synthesis and biological properties of a novel water-soluble echinocandin-like lipopeptide, FR131535, are described. This compound displayed potent in vitro and in vivo antifungal activities. The hemolytic activity of FR901379 was reduced by replacing the acyl side chain. This compound showed good water-solubility, comparable to the natural product FR901379. Topics: Animals; Anti-Bacterial Agents; Antifungal Agents; Bronchogenic Cyst; Candida albicans; Candidiasis; Disease Models, Animal; Echinocandins; Female; Fungal Proteins; Glucosyltransferases; Hemolysis; Membrane Proteins; Mice; Mice, Nude; Peptides; Peptides, Cyclic; Pneumonia, Pneumocystis; Schizosaccharomyces pombe Proteins; Solubility | 2001 |
Therapeutic effects of water-soluble echinocandin compounds on Pneumocystis pneumonia in mice.
The therapeutic effectiveness of water-soluble echinocandin compounds obtained from Coleophoma empetri F-11899, which has a strong inhibitory effect on the growth of fungi, was examined in nude mice with experimental Pneumocystis pneumonia. The studies demonstrated the potential usefulness of the compounds. Topics: Animals; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Female; Mice; Mice, Inbred BALB C; Mice, Nude; Microbial Sensitivity Tests; Peptides, Cyclic; Pneumocystis; Pneumonia, Pneumocystis; Rats | 1998 |