fr 74366 has been researched along with Alloxan Diabetes in 7 studies
| Excerpt | Relevance | Reference |
|---|---|---|
| " One of these toxic findings was cataract, and we have found that cataract appeared in rats dosed orally with FK506 for 13 weeks and more." | 5.30 | Cataract development induced by repeated oral dosing with FK506 (tacrolimus) in adult rats. ( Fukuhara, Y; Hisatomi, A; Ishida, H; Mitamura, T; Murato, K; Ohara, K; Takahashi, Y, 1997) |
| "45 mug equiv/g, respectively, when dosed with [(14)C]lidorestat at 10 mg/kg po)." | 1.33 | Discovery of 3-[(4,5,7-trifluorobenzothiazol-2-yl)methyl]indole-N-acetic acid (lidorestat) and congeners as highly potent and selective inhibitors of aldose reductase for treatment of chronic diabetic complications. ( Dicioccio, AT; Geraci, LS; Gunn, DE; Jacot, JL; Jones, JH; Jones, ML; Mitschler, A; Petrova, T; Podjarny, AD; Sawicki, DR; Sredy, J; Van Zandt, MC, 2005) |
| " One of these toxic findings was cataract, and we have found that cataract appeared in rats dosed orally with FK506 for 13 weeks and more." | 1.30 | Cataract development induced by repeated oral dosing with FK506 (tacrolimus) in adult rats. ( Fukuhara, Y; Hisatomi, A; Ishida, H; Mitamura, T; Murato, K; Ohara, K; Takahashi, Y, 1997) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 3 (42.86) | 18.2507 |
| 2000's | 3 (42.86) | 29.6817 |
| 2010's | 1 (14.29) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Van Zandt, MC | 1 |
| Jones, ML | 1 |
| Gunn, DE | 1 |
| Geraci, LS | 1 |
| Jones, JH | 1 |
| Sawicki, DR | 1 |
| Sredy, J | 1 |
| Jacot, JL | 1 |
| Dicioccio, AT | 1 |
| Petrova, T | 1 |
| Mitschler, A | 1 |
| Podjarny, AD | 1 |
| Shimoshige, Y | 2 |
| Minoura, K | 1 |
| Matsuoka, N | 2 |
| Takakura, S | 2 |
| Mutoh, S | 1 |
| Kamijo, M | 1 |
| Enomoto, R | 1 |
| Aoki, T | 1 |
| Kaneko, S | 1 |
| Ishida, H | 1 |
| Mitamura, T | 1 |
| Takahashi, Y | 1 |
| Hisatomi, A | 1 |
| Fukuhara, Y | 1 |
| Murato, K | 1 |
| Ohara, K | 1 |
| Yamamoto, T | 1 |
| Kawamura, I | 1 |
| Seki, J | 1 |
| Goto, T | 1 |
| Ao, S | 1 |
| Kikuchi, C | 1 |
| Ono, T | 1 |
| Notsu, Y | 1 |
| Mori, K | 1 |
| Terubayashi, H | 1 |
| Akagi, Y | 1 |
| Okamoto, S | 1 |
| Tsutsumi, M | 1 |
| Ikebe, H | 1 |
| Yoshizaki, K | 1 |
| Nishikawa, H | 1 |
7 other studies available for fr 74366 and Alloxan Diabetes
| Article | Year |
|---|---|
Discovery of 3-[(4,5,7-trifluorobenzothiazol-2-yl)methyl]indole-N-acetic acid (lidorestat) and congeners as highly potent and selective inhibitors of aldose reductase for treatment of chronic diabetic complications.
Topics: Aldehyde Reductase; Animals; Cataract; Chronic Disease; Crystallography, X-Ray; Diabetes Complicatio | 2005 |
Thirteen-month inhibition of aldose reductase by zenarestat prevents morphological abnormalities in the dorsal root ganglia of streptozotocin-induced diabetic rats.
Topics: Aldehyde Reductase; Animals; Axons; Cell Death; Diabetes Mellitus, Experimental; Diabetic Neuropathi | 2009 |
The involvement of aldose reductase in alterations to neurotrophin receptors and neuronal cytoskeletal protein mRNA levels in the dorsal root ganglion of streptozotocin-induced diabetic rats.
Topics: Aldehyde Reductase; Animals; Cytoskeletal Proteins; Diabetes Mellitus, Experimental; Diabetic Nephro | 2010 |
Cataract development induced by repeated oral dosing with FK506 (tacrolimus) in adult rats.
Topics: Administration, Oral; Aldehyde Reductase; Animals; Blood Glucose; Body Weight; Cataract; Diabetes Me | 1997 |
The effects of zenarestat, an aldose reductase inhibitor, on minimal F-wave latency and nerve blood flow in streptozotocin-induced diabetic rats.
Topics: Aldehyde Reductase; Animals; Blood Flow Velocity; Diabetes Mellitus, Experimental; Diabetic Neuropat | 2001 |
Effect of instillation of aldose reductase inhibitor FR74366 on diabetic cataract.
Topics: Administration, Topical; Aldehyde Reductase; Animals; Cataract; Diabetes Mellitus, Experimental; Len | 1991 |
[Quantitative study of rat diabetic cataract, by the relaxation times of nuclear magnetic resonance].
Topics: Aldehyde Reductase; Animals; Cataract; Diabetes Mellitus, Experimental; Magnetic Resonance Spectrosc | 1991 |