fr-264205 and Seizures

fr-264205 has been researched along with Seizures* in 1 studies

Other Studies

1 other study(ies) available for fr-264205 and Seizures

Article	Year
Synthesis and SAR of novel parenteral anti-pseudomonal cephalosporins: discovery of FR264205. Bioorganic & medicinal chemistry letters, 2008, Sep-01, Volume: 18, Issue:17 We describe herein the synthesis and biological evaluation of a series of novel cephalosporins with potent activity against Pseudomonas aeruginosa. Introduction of various amino groups to the 4-position of a 3-amino-2-methylpyrazole cephalosporin 3-side chain resulted in enhanced MIC values against multiple Pseudomonas aeruginosa strains and ultimately led to the discovery of FR264205 (15) with excellent anti-bacterial activity and weak convulsion effect by direct intracerebroventricular injection assay. Topics: Animals; Anti-Bacterial Agents; Ceftazidime; Cephalosporins; Drug Design; Drug Evaluation, Preclinical; Mice; Pseudomonas aeruginosa; Seizures; Structure-Activity Relationship	2008

Article

Year

Synthesis and SAR of novel parenteral anti-pseudomonal cephalosporins: discovery of FR264205.

Bioorganic & medicinal chemistry letters, 2008, Sep-01, Volume: 18, Issue:17

We describe herein the synthesis and biological evaluation of a series of novel cephalosporins with potent activity against Pseudomonas aeruginosa. Introduction of various amino groups to the 4-position of a 3-amino-2-methylpyrazole cephalosporin 3-side chain resulted in enhanced MIC values against multiple Pseudomonas aeruginosa strains and ultimately led to the discovery of FR264205 (15) with excellent anti-bacterial activity and weak convulsion effect by direct intracerebroventricular injection assay.

Topics: Animals; Anti-Bacterial Agents; Ceftazidime; Cephalosporins; Drug Design; Drug Evaluation, Preclinical; Mice; Pseudomonas aeruginosa; Seizures; Structure-Activity Relationship

2008