fr-148083 has been researched along with Inflammation* in 1 studies
1 other study(ies) available for fr-148083 and Inflammation
| Article | Year |
|---|---|
Synthesis and anti-tumor activity of imidazopyrazines as TAK1 inhibitors.
Transforming growth factor-β activated kinase-1 (TAK1) is a potential therapeutic target for cancers and inflammatory diseases. We synthesized a series of novel imidazopyrazine derivatives, which were found to exhibit potent inhibitory effect against TAK1. Compound 22a, which possesses a good pharmacokinetic profile, showed excellent in vitro kinase activity and significant in vivo efficacy in mice xenografted with SW620, a KRAS-dependent colon cancer cell line. Topics: Animals; Cell Line, Tumor; Colonic Neoplasms; Heterografts; Humans; Inflammation; MAP Kinase Kinase Kinases; Mice; Neoplasms; Protein Kinase Inhibitors; Pyrazines | 2019 |