fps-zm1 and Diabetes-Mellitus--Type-2

To investigate restorative effects of the receptor for advanced glycation end products (RAGE)-specific inhibitor FPS-ZM1 on abnormal amyloid β (Aβ) influx across the blood brain-barrier (BBB) and cognitive deficits in db/db mice.. Aβ influx across the BBB was determined by intra-arterial infusion of. Downregulation of abnormal Aβ influx across the BBB by FPS-ZM1 at higher dosage contributes to reduced neuronal apoptosis, improved hippocampal plasticity and cognitive impairment in db/db mice.

Topics: Amyloid beta-Peptides; Animals; bcl-2-Associated X Protein; Benzamides; Blood-Brain Barrier; Brain; Caspase 3; Cognition Disorders; Diabetes Mellitus, Type 2; Disease Models, Animal; Exploratory Behavior; Male; Maze Learning; Mice; Microvessels; Peptide Fragments; Proto-Oncogene Proteins c-bcl-2; Receptor for Advanced Glycation End Products; Receptors, Leptin; Synaptic Transmission