Page last updated: 2024-08-26

fpl 55712 and Muscle Contraction

fpl 55712 has been researched along with Muscle Contraction in 110 studies

Research

Studies (110)

TimeframeStudies, this research(%)All Research%
pre-199095 (86.36)18.7374
1990's15 (13.64)18.2507
2000's0 (0.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Bernstein, PR; Brown, FJ; Cronk, LA; Dosset, DL; Hebbel, KC; Maduskuie, TP; Shapiro, HS; Vacek, EP; Willard, AK; Yee, YK1
Crowley, HJ; Levitan, P; Lind, J; O'Donnell, M; Tilley, JW; Tobias, LD; Welton, AF1
Brown, DL; Carson, M; Crowley, HJ; Han, RJ; LeMahieu, RA; Nason, WC; O'Donnell, M; Welton, AF1
Carr, FP; Dillard, RD; Fleisch, JH; Haisch, KD; McCullough, D; Rinkema, LE1
Crooke, ST; Erhard, KF; Frazee, JS; Gleason, JG; Hall, RF; Kondrad, K; Ku, TW; McCarthy, ME; Mong, S; Perchonock, CD1
Bélanger, P; Champion, E; DeHaven, RN; Denis, D; Ford-Hutchinson, AW; Fortin, R; Frenette, R; Gauthier, JY; Gillard, J; Young, RN1
Sato, F; Timmerman, H; Wada, Y; Zhang, MQ1
Onogi, K; Tamura, M; Timmerman, H; Tohma, T; Wada, Y; Zhang, MQ; Zwaagstra, ME1
Nakahata, N; Nakanishi, H; Ono, T1
Krell, RD; Snyder, DW2
Bach, MK; Hanna, CJ; Pare, PD; Schellenberg, RR1
Burka, JF; Paterson, NA1
Cade, JF; Clancy, RL; Pain, MC; Walker, SE1
Feniuk, L; Kennedy, I; Whelan, CJ1
Kulkarni, PS; Srinivason, BD1
Casey, FB; Chakrin, LW; Hardy, TM; Regal, JF1
Iwamoto, T; Koda, A; Nagai, H; Nishiyori, T; Takizawa, T; Tsuchiya, H1
Buckner, CK; Fishleder, RI1
Bantick, JR; Ghelani, AM; Holroyde, MC; Lee, TB; Sheard, P1
Borgeat, P; Girard, G; Jeanson, A; Roy, S; Sirois, P1
Hoffer, BJ; Mathews, WR; Murphy, RC; Palmer, MR1
Cromwell, O; Kay, AB; Morris, HR; O'Driscoll, BR; Taylor, GW; Walport, MJ1
Barone, M; Berdoulay, A; Giles, RE; Krell, RD; Tsai, BS1
Denis, D; Ethier, D; Hall, R; Jones, T1
Hugli, TE; Marceau, F1
Bloor, CM; Erickson, BW; Huey, R; Hugli, TE1
Butler, J; Downes, H; Hanifin, JM; Hirshman, CA; Peters, J1
Cirino, M; Ford-Hutchinson, AW; Hamel, R; Lord, A1
Mathias, MM; Murphy, RC; Reeves, JT; Stenmark, KR; Voelkel, NF1
Regal, JF2
Burka, JF; Saad, MH1
Daniel, EE; Davis, C; Jones, TR2
O'Flaherty, JT; Stimler, NP1
Goldenberg, MM; Subers, EM1
Wang, SM; Wang, SR; Yang, CM1
Brunet, G; Girard, Y; Holme, G; Masson, P; Piechuta, H; Rokach, J1
Fleisch, JH; Haisch, KD; Spaethe, SM1
Bodach, E; Borgeat, P; Coceani, F; Jhamandas, VM; Labuc, J; Olley, PM1
Ghelani, AM; Holroyde, MC1
Bryan, D; Falcone, K; Gleason, J; Kinzig, C; Krell, RD; O'Donnell, M; Osborn, R; Vickery, L1
Falcone, K; Krell, RD; Osborn, R; Vickery, L1
Bernstein, P; Conaty, J; Krell, RD; Macia, RA; Tsai, BS1
Andersson, RG; Hedman, SE1
Hodgson, WC; Hopkins, BJ; Sutherland, SK1
Timmerman, H; Zhang, MQ1
Jakschik, BA; Kulczycki, A; MacDonald, HH; Parker, CW1
Horiba, M; Inoue, K; Ohata, K; Ohkawa, E; Watanabe-Kohno, S; Yamamura, H; Yasui, K1
Gonzales, J; Lawson, DL; Mehta, JL; Nichols, WW; Nicolini, FA1
Horiba, M; Nabe, T; Ohata, K; Watanabe-Kohno, S; Yamamura, H1
Dahlén, SE; Nicolaou, KC; Westlund, P; Wikström, E1
Lindén, A; Löfdahl, CG; Skoogh, BE; Ullman, A1
Napier, FE; Shearer, MA; Temple, DM1
Becherucci, C; Mugridge, KG; Parente, L; Perretti, M1
Shikada, K; Tanaka, S; Yamamoto, A2
Kobayashi, T; Yamane, K1
Cregge, RJ; Gieske, TH; Raddatz, R; Sabol, JS; Weintraub, PM1
Aizawa, H; Hakoda, H; Hirose, T; Ito, I; Suzuki, H1
Assem, ES; Ezeamuzie, IC1
Clark, MA; Cook, M; Crooke, ST; Mong, S1
Creese, BR; Temple, DM1
Coutts, S; Gordon, R; Jolly, S; Khandwala, A; Sonnino, P; Van Inwegen, RG1
Luck, W; Peskar, BA; Schmidt, EW; Simmet, T1
Braquet, P; Jancar, S; Lauzière, M; Sirois, P; Thériault, P1
Luck, W; Simmet, T1
Brouwer, F; van Amsterdam, RG; Zaagsma, J1
Baba, K; Ito, M; Satake, T; Takagi, K; Tomita, T1
Aizawa, H; Hakoda, H; Hirose, T; Ito, Y; Suzuki, H1
Hamilton, JT; Miller, DS; Paterson, NA; Yaghi, A1
Drazen, JM; Israel, E; Robin, JL1
Hay, DW; Muccitelli, RM; Torphy, TJ; Tucker, SS; Wasserman, MA1
Buckner, CK; Castleman, WL; Saban, R; Will, JA1
Charette, L; Denis, D; Jones, TR1
Cuthbert, NJ; Gardiner, PJ1
Crea, AE; Jacques, CA; Lee, TH; Spur, BW1
Cordeiro, R; Garcez Do Carmo, L; Lagente, V; Lefort, J; Randon, J; Vargaftig, BB1
Drazen, JM; Shore, SA; Smith, E; Stimler-Gerard, NP1
Burka, JF2
DeVan, JF; Erhard, KF; Gleason, JG; Kirchner, T; McCarthy, ME; Muccitelli, RM; Perchonock, CD; Tucker, SS; Vickery, LM; Wasserman, MA1
Crooke, ST; Lewis, MA; Mong, S; Vessella, RL1
Bernstein, PR; Buckner, CK; Coursin, DB; Krell, RD; Laravuso, RB; Will, JA1
Tucker, SS; Weichman, BM2
Borgeat, P; Braquet, P; Etienne, A; Sirois, P; Touvay, C; Vilain, B1
Braquet, P; Clostre, F; Etienne, A; Touvay, C; Vilain, B1
Bernstein, PR; Snyder, DW1
Hageman, WE; Persico, FJ; Rose, MP1
Kulkarni, PS; Srinivasan, BD1
Hoppe, U; Kleemeyer, K; Peskar, BA; Peskar, BM; Wittenberg, HR1
Sakoda, R; Shikada, K; Tanaka, S; Yamamoto, A1
Benveniste, J; Brink, C; Haye-Legrand, I; Labat, C; Norel, X1
Cristol, JP; Sirois, P1
Okamoto, M; Terao, M; Tokumura, A; Tsukatani, H; Yoshida, K1
Carnathan, GW; Miyano, M; Prusa, CM; Sanner, JH; Thompson, JM1
Piper, PJ; Stewart, AG1
Robichaud, LJ; Thueson, DO; Webster, K1
DeVan, JF; Muccitelli, RM; Tucker, SS; Weichman, BM1
Detsouli, A; Lefort, J; Vargaftig, BB1
Fujinuma, S; Kamikawa, Y; Shimo, Y1
Appleton, RA; Bantick, JR; Chamberlain, TR; Hardern, DN; Lee, TB; Pratt, AD1
DeVan, JF; Erhard, KF; Gleason, JG; McCarthy, ME; Muccitelli, RM; Perchonock, CD; Tucker, SS; Uzinskas, I; Vickery, LM; Wasserman, MA1
Cullinan, GJ; Fleisch, JH; Goodson, T; Haisch, KD; Marshall, WS; Rinkema, LE; Swanson-Bean, D1
Arai, Y; Katsube, N; Konno, M; Kosuge, S; Miyamoto, T; Nakai, H; Obata, T; Okegawa, T; Sakuyama, S; Toda, M1
Bell, SC; Carlson, RP; Chang, JY; Hand, JM; Klaubert, DH; Kreft, AF; Lewis, AJ; Pattison, TW; Yardley, JP1
Ashack, RJ; Goodman, FR; Malek, RS; McCarty, LP; Peet, NP1
Crowley, HJ; Levitan, P; Tilley, JW; Welton, AF1

Other Studies

110 other study(ies) available for fpl 55712 and Muscle Contraction

ArticleYear
Hydroxyacetophenone-derived antagonists of the peptidoleukotrienes.
    Journal of medicinal chemistry, 1989, Volume: 32, Issue:4

    Topics: Acetophenones; Animals; Benzoates; Biological Assay; Chemical Phenomena; Chemistry; Chromones; Guinea Pigs; Hydroxylation; Ketones; Methylation; Muscle Contraction; Nitrogen; Phenols; SRS-A; Structure-Activity Relationship; Trachea

1989
N-(heterocyclic alkyl)pyrido[2,1-b]quinazoline-8-carboxamides as orally active antiallergy agents.
    Journal of medicinal chemistry, 1987, Volume: 30, Issue:1

    Topics: Administration, Oral; Animals; Blood Platelets; Bronchi; Guinea Pigs; Histamine H1 Antagonists; Humans; In Vitro Techniques; Indicators and Reagents; Leukotriene E4; Magnetic Resonance Spectroscopy; Mass Spectrometry; Muscle Contraction; Pyridines; Quinazolines; Spectrophotometry, Infrared; SRS-A; Structure-Activity Relationship; Thromboxane-A Synthase

1987
Substituted (aryloxy)alkanoic acids as antagonists of slow-reacting substance of anaphylaxis.
    Journal of medicinal chemistry, 1987, Volume: 30, Issue:1

    Topics: Animals; Bronchi; Fatty Acids; Guinea Pigs; In Vitro Techniques; Indicators and Reagents; Leukotriene E4; Magnetic Resonance Spectroscopy; Male; Mass Spectrometry; Muscle Contraction; Muscle, Smooth; Phenyl Ethers; Spectrophotometry; SRS-A; Structure-Activity Relationship

1987
Leukotriene receptor antagonists. 2. The [[(tetrazol-5-ylaryl)oxy]methyl]acetophenone derivatives.
    Journal of medicinal chemistry, 1987, Volume: 30, Issue:5

    Topics: Acetophenones; Animals; Azoles; Bronchi; Chemical Phenomena; Chemistry; Guinea Pigs; Ileum; Muscle Contraction; Receptors, Leukotriene; Receptors, Prostaglandin; SRS-A; Structure-Activity Relationship; Tetrazoles; Trachea

1987
High-affinity leukotriene receptor antagonists. Synthesis and pharmacological characterization of 2-hydroxy-3-[(2-carboxyethyl)thio]-3-[2-(8-phenyloctyl)phenyl] propanoic acid.
    Journal of medicinal chemistry, 1987, Volume: 30, Issue:6

    Topics: Animals; Bronchi; Dicarboxylic Acids; Guinea Pigs; Humans; Muscle Contraction; Receptors, Leukotriene; Receptors, Prostaglandin; SRS-A; Structure-Activity Relationship

1987
Design and synthesis of sodium (beta R*, gamma S*)-4-[[3-(4-acetyl-3-hydroxy-2-propylphenoxy)propyl] thio]-gamma-hydroxy-beta-methylbenzenebutanoate: a novel, selective, and orally active receptor antagonist of leukotriene D4.
    Journal of medicinal chemistry, 1986, Volume: 29, Issue:9

    Topics: Animals; Biological Assay; Bronchi; Chemical Phenomena; Chemistry; Guinea Pigs; Ileum; Muscle Contraction; Phenylbutyrates; SRS-A; Trachea

1986
(Piperidinylalkoxy)chromones: novel antihistamines with additional antagonistic activity against leukotriene D4.
    Journal of medicinal chemistry, 1995, Jun-23, Volume: 38, Issue:13

    Topics: Animals; Capillary Permeability; Cerebral Cortex; Chromones; Drug Antagonism; Guinea Pigs; Histamine H1 Antagonists; Ileum; In Vitro Techniques; Leukotriene D4; Lung; Mice; Muscle Contraction; Pyrilamine

1995
Synthesis and structure-activity relationships of carboxylated chalcones: a novel series of CysLT1 (LTD4) receptor antagonists.
    Journal of medicinal chemistry, 1997, Mar-28, Volume: 40, Issue:7

    Topics: Animals; Chalcone; Guinea Pigs; Ileum; In Vitro Techniques; Leukotriene Antagonists; Lung; Magnetic Resonance Spectroscopy; Male; Mass Spectrometry; Membrane Proteins; Muscle Contraction; Receptors, Leukotriene; Structure-Activity Relationship; Trachea

1997
Possible involvement of a product of the 5-lipoxygenase pathway in mediation of indomethacin-induced inhibition of cholinergic transmission in guinea-pig ileum.
    European journal of pharmacology, 1984, Sep-03, Volume: 104, Issue:1-2

    Topics: Acetylcholine; Animals; Arachidonic Acid; Arachidonic Acids; Chromones; Dinoprostone; Electric Stimulation; Female; Guinea Pigs; Hydroxyeicosatetraenoic Acids; Ileum; In Vitro Techniques; Indomethacin; Lipoxygenase; Male; Muscle Contraction; Muscle, Smooth; Prostaglandins E; SRS-A; Synaptic Transmission

1984
Pharmacological evidence for a distinct leukotriene C4 receptor in guinea-pig trachea.
    The Journal of pharmacology and experimental therapeutics, 1984, Volume: 231, Issue:3

    Topics: Animals; Chromones; Cysteine; Guinea Pigs; In Vitro Techniques; Leukotriene E4; Male; Muscle Contraction; Receptors, Cell Surface; Receptors, Leukotriene; Receptors, Prostaglandin; Serine; SRS-A; Trachea

1984
Slow-reacting substances (leukotrienes) contract human airway and pulmonary vascular smooth muscle in vitro.
    Nature, 1981, Mar-26, Volume: 290, Issue:5804

    Topics: Airway Resistance; Arachidonic Acids; Autacoids; Carbachol; Chromones; Ethers; Histamine; Humans; In Vitro Techniques; Kinetics; Muscle Contraction; Muscle, Smooth; Pulmonary Circulation; SRS-A; Vascular Resistance

1981
The effects of SRS-A and histamine antagonists on antigen-induced contraction of guinea pig trachea.
    European journal of pharmacology, 1981, Apr-09, Volume: 70, Issue:4

    Topics: Airway Resistance; Animals; Antigens; Atropine; Autacoids; Chromones; Drug Interactions; Ethers; Guinea Pigs; Histamine H1 Antagonists; Histamine H2 Antagonists; Indomethacin; Male; Muscle Contraction; Trachea

1981
Slow-reacting substance from alveolar macrophages--a mechanism of asthma?
    The Australian journal of experimental biology and medical science, 1981, Volume: 59, Issue:4

    Topics: Animals; Asthma; Atropine; Autacoids; Chromones; Cimetidine; Ethers; Guinea Pigs; Indomethacin; Macrophages; Methysergide; Muscle Contraction; Muscle, Smooth; Pyrilamine; Trachea

1981
The contractile action of slow reacting substance of anaphylaxis (SRS-A) on rat isolated fundic strip and guinea-pig isolated ileum and its antagonism by FPL 55712.
    The Journal of pharmacy and pharmacology, 1982, Volume: 34, Issue:9

    Topics: Animals; Chromones; Gastric Fundus; Ileum; In Vitro Techniques; Indomethacin; Muscle Contraction; Muscle, Smooth; Rats; SRS-A

1982
Synthesis of slow reacting substance-like activity in rabbit conjunctiva and anterior uvea.
    Investigative ophthalmology & visual science, 1983, Volume: 24, Issue:8

    Topics: 4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine; Animals; Arachidonic Acids; Autacoids; Catechols; Chromones; Conjunctiva; Enzyme Activation; Guinea Pigs; Ileum; Lipoxygenase; Lipoxygenase Inhibitors; Masoprocol; Muscle Contraction; Pyrazoles; Rabbits; Tissue Extracts; Uvea

1983
Effects of C5a on guinea pig lung: histamine release and mechanism of contraction.
    Immunopharmacology, 1983, Volume: 5, Issue:4

    Topics: Animals; Aspirin; Atropine; Chromones; Complement C5; Complement C5a; Dose-Response Relationship, Immunologic; Guinea Pigs; Histamine H1 Antagonists; Histamine Release; Indomethacin; Lung; Male; Muscle Contraction; Muscle, Smooth

1983
Pharmacological studies on newly synthesized anti-allergic agents, 2-methyl-3-piperidino-beta-propionaphtone hydrochloride (KZ-111) and 3-isobutyryl-2-isopropylpyrazole-[1, 5-a] pyridine (KC-404).
    Japanese journal of pharmacology, 1983, Volume: 33, Issue:6

    Topics: Animals; Asthma; Chromones; Guinea Pigs; Histamine H1 Antagonists; Histamine Release; Hypersensitivity; In Vitro Techniques; Male; Muscle Contraction; Passive Cutaneous Anaphylaxis; Piperidines; Pyridines; Rats; Rats, Inbred Strains; SRS-A

1983
Studies on the relationship between contraction and mediator release produced by ovalbumin in superfused trachea isolated from the actively sensitized guinea pig.
    The Journal of pharmacology and experimental therapeutics, 1984, Volume: 230, Issue:3

    Topics: 5,8,11,14-Eicosatetraynoic Acid; Animals; Carbachol; Chromones; Dose-Response Relationship, Drug; Female; Guinea Pigs; Histamine Release; Indomethacin; Muscle Contraction; Muscle, Smooth; Ovalbumin; SRS-A; Time Factors; Trachea

1984
Antagonists of SRS-A and leukotrienes.
    Advances in prostaglandin, thromboxane, and leukotriene research, 1982, Volume: 9

    Topics: Animals; Bronchi; Chromones; Guinea Pigs; Humans; Lung; Muscle Contraction; Muscle, Smooth; SRS-A; Structure-Activity Relationship; Trachea

1982
The action of leukotriene B4 (LTB4) on the lung.
    Prostaglandins and medicine, 1980, Volume: 5, Issue:6

    Topics: Animals; Arachidonic Acids; Chromones; Ethers; Guinea Pigs; Histamine; Humans; In Vitro Techniques; Indomethacin; Leukotriene B4; Lung; Muscle Contraction; Muscle, Smooth; Perfusion; Polyphloretin Phosphate; Prostaglandins; Rabbits; Rats; SRS-A; Thromboxanes

1980
Electrophysiological response of cerebellar Purkinje neurons to leukotriene D4 and B4.
    The Journal of pharmacology and experimental therapeutics, 1981, Volume: 219, Issue:1

    Topics: Action Potentials; Animals; Arachidonic Acids; Chromones; Ethers; Guinea Pigs; In Vitro Techniques; Leukotriene B4; Male; Muscle Contraction; Muscle, Smooth; Purkinje Cells; Rats; Rats, Inbred Strains; SRS-A

1981
Identification of leukotrienes in the sputum of patients with cystic fibrosis.
    Advances in prostaglandin, thromboxane, and leukotriene research, 1982, Volume: 9

    Topics: Adolescent; Adult; Animals; Arachidonic Acids; Biological Assay; Chemotaxis; Chromones; Cystic Fibrosis; Female; Guinea Pigs; Humans; Ileum; Leukotriene B4; Male; Muscle Contraction; Neutrophils; Sputum; SRS-A

1982
Heterogeneity of leukotriene receptors in guinea-pig trachea.
    Prostaglandins, 1983, Volume: 25, Issue:2

    Topics: Animals; Chromones; Guinea Pigs; Kinetics; Leukotriene E4; Male; Muscle Contraction; Receptors, Cell Surface; Receptors, Leukotriene; SRS-A; Structure-Activity Relationship; Trachea

1983
Pharmacological study of the effects of leukotrienes C4, D4, E4 & F4 on guinea pig trachealis: interaction with FPL-55712.
    Prostaglandins, 1983, Volume: 26, Issue:5

    Topics: Animals; Chromones; Guinea Pigs; Leukotriene E4; Male; Muscle Contraction; SRS-A; Trachea

1983
Effect of C3a and C5a anaphylatoxins on guinea-pig isolated blood vessels.
    The Journal of pharmacology and experimental therapeutics, 1984, Volume: 230, Issue:3

    Topics: Anaphylatoxins; Animals; Aspirin; Blood Vessels; Chromones; Complement C3; Complement C3a; Complement C5; Complement C5a; Dose-Response Relationship, Drug; Female; Guinea Pigs; Hemolysis; Histamine; Indomethacin; Male; Muscle Contraction; Norepinephrine; Peptides; Pyrilamine; Tachyphylaxis

1984
Contraction of guinea pig lung by synthetic oligopeptides related to human C3a.
    Immunopharmacology, 1984, Volume: 8, Issue:1

    Topics: Acetylcholine; Animals; Chromones; Complement C3; Complement C3a; Guinea Pigs; In Vitro Techniques; Indomethacin; Lung; Muscle Contraction; Oligopeptides; Pyrilamine; SRS-A; Tachyphylaxis

1984
Role of mediators in allergic and nonallergic asthma in dogs with hyperreactive airways.
    Journal of applied physiology: respiratory, environmental and exercise physiology, 1983, Volume: 54, Issue:4

    Topics: Airway Resistance; Animals; Asthma; Bronchial Provocation Tests; Chromones; Citrates; Citric Acid; Dogs; Guinea Pigs; Histamine; Hypersensitivity; Lung Compliance; Methacholine Chloride; Methacholine Compounds; Muscle Contraction; Respiratory Tract Diseases; Tissue Extracts

1983
Bronchoconstriction induced by N-formyl-methionyl-leucyl-phenylalanine in the guinea pig; involvement of arachidonic acid metabolites.
    Prostaglandins, 1984, Volume: 28, Issue:1

    Topics: Animals; Arachidonic Acid; Arachidonic Acids; Blood Pressure; Bronchi; Chromones; Dose-Response Relationship, Drug; Guinea Pigs; Indomethacin; Injections, Intravenous; Male; Muscle Contraction; N-Formylmethionine Leucyl-Phenylalanine; Prostaglandin-Endoperoxide Synthases; SRS-A; Time Factors

1984
Actions of lipoxygenase metabolites in isolated rat lungs.
    Journal of applied physiology: respiratory, environmental and exercise physiology, 1984, Volume: 57, Issue:3

    Topics: Animals; Arachidonic Acid; Arachidonic Acids; Chromatography, High Pressure Liquid; Chromones; Diethylcarbamazine; Hydroxyeicosatetraenoic Acids; Indomethacin; Lung; Male; Muscle Contraction; Muscle, Smooth; Perfusion; Pressure; Pulmonary Circulation; Rats; Rats, Inbred Strains; Serum Albumin, Bovine; SRS-A

1984
IgG vs IgE: mediators of antigen-induced guinea pig tracheal contraction.
    Immunopharmacology, 1984, Volume: 8, Issue:3-4

    Topics: Animals; Antigens; Catechols; Chromones; Diphenhydramine; Guinea Pigs; Immunoglobulin E; Immunoglobulin G; In Vitro Techniques; Male; Masoprocol; Muscle Contraction; Muscle, Smooth; Respiratory Hypersensitivity; SRS-A; Time Factors; Trachea

1984
Isolation of leukotriene C4 from human seminal fluid.
    Prostaglandins, 1983, Volume: 26, Issue:6

    Topics: Animals; Biological Assay; Chromatography, High Pressure Liquid; Chromones; Dinoprostone; Guinea Pigs; Humans; Ileum; Lung; Male; Muscle Contraction; Prostaglandins B; Prostaglandins E; Semen; Spectrophotometry, Ultraviolet; SRS-A

1983
Studies of the mechanism of passive anaphylaxis in human airway smooth muscle.
    Canadian journal of physiology and pharmacology, 1983, Volume: 61, Issue:7

    Topics: Anaphylaxis; Antigens; Arachidonic Acids; Bronchi; Chromones; Histamine; Humans; Immunoglobulin E; In Vitro Techniques; Indomethacin; Muscle Contraction; Muscle, Smooth; SRS-A; Trachea

1983
Spasmogenic properties of platelet-activating factor: evidence for a direct mechanism in the contractile response of pulmonary tissues.
    The American journal of pathology, 1983, Volume: 113, Issue:1

    Topics: 5,8,11,14-Eicosatetraynoic Acid; Animals; Aspirin; Blood Platelets; Catechols; Chromones; Dose-Response Relationship, Drug; Guinea Pigs; Indomethacin; Lung; Masoprocol; Muscle Contraction; Muscle, Smooth; Platelet Activating Factor; Rats; Sulfinpyrazone; Thromboxane B2

1983
The effect of leukotriene D4 on the isolated stomach and colon of the rat.
    Life sciences, 1983, Nov-21, Volume: 33, Issue:21

    Topics: Animals; Chromones; Colon; Dose-Response Relationship, Drug; Indomethacin; Male; Muscle Contraction; Prostaglandins; Rats; Rats, Inbred Strains; SRS-A; Stomach

1983
[Characterization of slow reacting substance of anaphylaxis in asthmatic sputum].
    Zhonghua Minguo wei sheng wu ji mian yi xue za zhi = Chinese journal of microbiology and immunology, 1984, Volume: 17, Issue:1

    Topics: Adult; Animals; Arylsulfatases; Asthma; Chromones; Diphenhydramine; Female; Guinea Pigs; Histamine; Hot Temperature; Humans; In Vitro Techniques; Male; Middle Aged; Muscle Contraction; Sputum; SRS-A

1984
The activity of synthetic leukotriene C-1 on guinea pig trachea and ileum.
    Prostaglandins, 1980, Volume: 20, Issue:4

    Topics: Animals; Arachidonic Acids; Chromones; Dose-Response Relationship, Drug; Ethers; Guinea Pigs; Histamine; Ileum; Lipoxygenase; Male; Muscle Contraction; Trachea

1980
Slow reacting substance of anaphylaxis (SRS-A) release from guinea-pig lung parenchyma during antigen- or ionophore-induced contraction.
    The Journal of pharmacology and experimental therapeutics, 1982, Volume: 221, Issue:1

    Topics: Animals; Calcimycin; Chromones; Guinea Pigs; Histamine; Hypersensitivity; In Vitro Techniques; Lung; Male; Muscle Contraction; Muscle, Smooth; Ovalbumin; SRS-A; Time Factors

1982
Evidence against a role for lipoxygenase-derived products of arachidonic acid in the lamb ductus arteriosus.
    Canadian journal of physiology and pharmacology, 1982, Volume: 60, Issue:3

    Topics: 4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine; Animals; Arachidonic Acid; Arachidonic Acids; Chromones; Ductus Arteriosus; Female; Lipoxygenase; Muscle Contraction; Pregnancy; Pyrazoles; Sheep; SRS-A

1982
Kinetics of action of two leukotriene antagonists on guinea pig ileum.
    European journal of pharmacology, 1983, Jun-03, Volume: 90, Issue:2-3

    Topics: Animals; Chromones; Guinea Pigs; Ileum; In Vitro Techniques; Kinetics; Male; Muscle Contraction; Muscle, Smooth; SRS-A

1983
Contraction of isolated airway smooth muscle by synthetic leukotrienes C4 and D4.
    Prostaglandins, 1981, Volume: 22, Issue:3

    Topics: Animals; Arachidonic Acids; Bronchi; Chromones; Ethers; Guinea Pigs; In Vitro Techniques; Indomethacin; Lung; Male; Muscle Contraction; Muscle, Smooth; Rats; Rats, Inbred Strains; SRS-A; Trachea

1981
Enhancement of isolated airway responses to bronchoconstrictive agonists by the slow-reacting substance of anaphylaxis antagonist FPL 55712.
    Prostaglandins, 1981, Volume: 22, Issue:3

    Topics: Animals; Arachidonic Acids; Carbachol; Chromones; Ethers; Guinea Pigs; Histamine; In Vitro Techniques; Lung; Male; Muscle Contraction; Muscle, Smooth; Respiratory System; SRS-A; Trachea

1981
Pharmacological study of the contractile activity of leukotriene C4 and D4 on isolated human airway smooth muscle.
    Canadian journal of physiology and pharmacology, 1982, Volume: 60, Issue:5

    Topics: Bronchi; Chromones; Histamine; Humans; In Vitro Techniques; Muscle Contraction; SRS-A; Trachea

1982
Comparative potency and pharmacology of isomers of leukotriene D4 on guinea-pig trachea: requirement for a 5(S)6(R) configuration.
    Prostaglandins, 1982, Volume: 23, Issue:4

    Topics: Animals; Chromones; Guinea Pigs; Indomethacin; Isomerism; Male; Muscle Contraction; Muscle, Smooth; SRS-A; Trachea

1982
Effects of SRS (slow reacting substance) on cyclic nucleotides in guinea pig tracheal muscle.
    Acta pharmacologica et toxicologica, 1982, Volume: 50, Issue:1

    Topics: Animals; Chromones; Female; Guinea Pigs; Hypersensitivity; Indomethacin; Male; Muscle Contraction; Muscle, Smooth; Nucleotides, Cyclic; Ovalbumin; SRS-A; Tartrazine; Trachea

1982
Pharmacological studies of stonefish (Synanceja trachynis) venom.
    Toxicon : official journal of the International Society on Toxinology, 1994, Volume: 32, Issue:10

    Topics: Animals; Biphenyl Compounds; Blood Pressure; Captopril; Chromones; Dose-Response Relationship, Drug; Fish Venoms; Fishes; Guinea Pigs; Heptanoic Acids; Histamine; Ileum; Imidazoles; In Vitro Techniques; Indomethacin; Losartan; Male; Mecamylamine; Muscle Contraction; Muscle, Smooth; Phospholipases A; Phospholipases A2; Quinacrine; Rats; Receptors, Thromboxane; Serotonin; SRS-A; Tetrazoles; Vas Deferens

1994
Leukotriene cysLT1 (LTD4) receptor antagonism of H1-antihistamines: an in vitro study.
    Inflammation research : official journal of the European Histamine Research Society ... [et al.], 1997, Volume: 46 Suppl 1

    Topics: Animals; Butyrophenones; Cell Membrane; Chromones; Cyproheptadine; Guinea Pigs; Histamine H1 Antagonists; Ileum; Leukotriene Antagonists; Leukotriene D4; Lung; Membrane Proteins; Muscle Contraction; Phthalazines; Piperidines; Receptors, Leukotriene

1997
Release of slow reacting substance (SRS) from rat basophilic leukemia (RBL-1) cells.
    Journal of immunology (Baltimore, Md. : 1950), 1977, Volume: 119, Issue:2

    Topics: Animals; Anti-Bacterial Agents; Arylsulfatases; Basophils; Benzopyrans; Calcimycin; Cells, Cultured; Chromones; Chymotrypsin; Dose-Response Relationship, Drug; Ethers; Guinea Pigs; In Vitro Techniques; Indomethacin; Leukemia, Experimental; Muscle Contraction; Muscle, Smooth; Rats; SRS-A

1977
Effect of AS-35 on agonist-induced contractions and the resting tonus of airway smooth muscles and the in vitro release of chemical mediators from passively sensitized lung fragments from humans and guinea pigs.
    Japanese journal of pharmacology, 1992, Volume: 59, Issue:2

    Topics: Animals; Chromones; Guinea Pigs; Histamine Release; Humans; In Vitro Techniques; Leukotrienes; Lung; Male; Muscle Contraction; Muscle, Smooth; Passive Cutaneous Anaphylaxis; Pyridines; Pyrimidinones; Respiratory Muscles; SRS-A; Tetrazoles

1992
Variable effects of human and canine polymorphonuclear leucocytes on vascular smooth muscle tone.
    Cardiovascular research, 1992, Volume: 26, Issue:8

    Topics: Animals; Arginine; Arteries; Chromones; Culture Techniques; Dogs; Endothelium; Humans; Indomethacin; Muscle Contraction; Muscle, Smooth, Vascular; Neutrophils; Nitric Oxide; omega-N-Methylarginine; Oxyhemoglobins; Prostaglandin Endoperoxides, Synthetic; Species Specificity; SRS-A; Superoxide Dismutase

1992
MCI-826 is a potent and selective antagonist of peptide leukotrienes (p-LTs) and has characteristics distinctive from those of FPL 55712.
    Japanese journal of pharmacology, 1992, Volume: 60, Issue:1

    Topics: Acetylcholine; Animals; Bronchi; Chromones; Guinea Pigs; Humans; Leukotriene Antagonists; Leukotrienes; Muscle Contraction; Muscle, Smooth; Prostaglandin D2; Respiratory Physiological Phenomena; Respiratory System; SRS-A; Thiazoles; Trachea

1992
Lipoxin A4-induced release of thromboxane in the guinea-pig lung: studies of its characteristics using lipoxin A4-methyl ester.
    Journal of lipid mediators, 1992, Volume: 5, Issue:3

    Topics: Animals; Chromones; Esters; Female; Guinea Pigs; Hydroxyeicosatetraenoic Acids; In Vitro Techniques; Leukotriene Antagonists; Lipoxins; Lung; Male; Muscle Contraction; Muscle, Smooth; Radioimmunoassay; Thromboxane A2

1992
In vitro characteristics of spontaneous airway tone in the guinea-pig.
    Acta physiologica Scandinavica, 1991, Volume: 142, Issue:3

    Topics: Animals; Bronchi; Chromones; Cyclooxygenase Inhibitors; Guinea Pigs; In Vitro Techniques; Indomethacin; Keto Acids; Male; Muscle Contraction; Muscle Tonus; Parasympatholytics; Receptors, Immunologic; Receptors, Leukotriene; Respiratory Physiological Phenomena; Respiratory System; SRS-A; Sulfones; Sympathetic Nervous System; Trachea

1991
Nedocromil sodium inhibits antigen-induced contraction of human lung parenchymal and bronchial strips, and the release of sulphidopeptide-leukotriene and histamine from human lung fragments.
    British journal of pharmacology, 1990, Volume: 100, Issue:2

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Antigens; Asthma; Bronchi; Chromones; Histamine Release; Humans; In Vitro Techniques; Leukotrienes; Lung; Mites; Muscle Contraction; Muscle, Smooth; Nedocromil; Quinolones; SRS-A

1990
Persistent effects of interleukin-1 on smooth muscle preparations from adrenalectomized rats: implications for increased phospholipase-A2 activity via stimulation of 5-lipoxygenase.
    The Journal of pharmacology and experimental therapeutics, 1991, Volume: 256, Issue:1

    Topics: Adrenalectomy; Animals; Arachidonate 5-Lipoxygenase; Arachidonic Acid; Arachidonic Acids; Aspirin; Chromatography, High Pressure Liquid; Chromones; Humans; Indomethacin; Interleukin-1; Leukotrienes; Lipoxygenase Inhibitors; Male; Masoprocol; Muscle Contraction; Muscle, Smooth; Phospholipases A; Phospholipases A2; Rats; Rats, Inbred Strains; Recombinant Proteins; SRS-A; Stimulation, Chemical; Stomach; Time Factors

1991
Arachidonate lipoxygenase inhibitors in guinea-pig isolated trachea. Effects on contractions to antigen and various agonists.
    Prostaglandins, 1990, Volume: 40, Issue:6

    Topics: 5,8,11,14-Eicosatetraynoic Acid; Animals; Antigens; Arachidonate Lipoxygenases; Calcimycin; Chromones; Guinea Pigs; In Vitro Techniques; Male; Masoprocol; Muscle Contraction; Pyrazoles; Receptors, Immunologic; Receptors, Leukotriene; SRS-A; Trachea

1990
Endogenous AA metabolites and their possible role in tracheal smooth muscle tone in guinea pigs.
    Journal of applied physiology (Bethesda, Md. : 1985), 1990, Volume: 69, Issue:1

    Topics: Animals; Arachidonic Acid; Arachidonic Acids; Benzoquinones; Chromones; Dibenz(b,f)(1,4)oxazepine-10(11H)-carboxylic acid, 8-chloro-, 2-acetylhydrazide; Guinea Pigs; Histamine; In Vitro Techniques; Indomethacin; Lipoxygenase Inhibitors; Methacrylates; Muscle Contraction; Muscle, Smooth; Quinones; SRS-A; Thromboxane-A Synthase; Trachea

1990
Conformationally restricted leukotriene receptor antagonists: [(octahydro-2-oxo-7-tetradecylidene-2H-1-benzopyran-8-yl)thio]ace tic acids.
    Pharmacology, 1990, Volume: 40, Issue:5

    Topics: Animals; Chromones; Dose-Response Relationship, Drug; Guinea Pigs; Ileum; Injections, Intravenous; Lactones; Leukotriene E4; Male; Muscle Contraction; Muscle, Smooth; Receptors, Immunologic; Receptors, Leukotriene; SRS-A; Sulfides

1990
Pre-junctional inhibitory action of prostaglandin E2 on excitatory neuro-effector transmission in the human bronchus.
    Prostaglandins, 1990, Volume: 39, Issue:6

    Topics: Bronchi; Chromones; Dinoprostone; Electric Stimulation; Humans; In Vitro Techniques; Indomethacin; Isoproterenol; Membrane Potentials; Microelectrodes; Muscle Contraction; Muscle, Smooth; Neuromuscular Junction; SRS-A

1990
Release of slow reacting substance (SRS) from human leucocytes by lymphokine.
    International journal of immunopharmacology, 1985, Volume: 7, Issue:4

    Topics: Animals; Autacoids; Chromones; Guinea Pigs; Histamine Release; Humans; Kinetics; Leukocytes; Lymphokines; Muscle Contraction; Muscle, Smooth; Neutrophils; Radioimmunoassay; SRS-A

1985
The binding of leukotriene C4 and leukotriene D4 to membranes of a smooth muscle cell line (BC3H1) and evidence that leukotriene induced contraction in these cells is mediated by thromboxane, protein and RNA syntheses.
    European journal of pharmacology, 1985, Oct-22, Volume: 116, Issue:3

    Topics: Animals; Binding, Competitive; Cell Line; Cell Membrane; Chromones; Cyclooxygenase Inhibitors; Kinetics; Mice; Muscle Contraction; Muscle Proteins; Muscle, Smooth; Radioimmunoassay; RNA; SRS-A; Thromboxanes

1985
IgG vs IgE: mediators of antigen-induced guinea pig lung parenchymal contraction.
    Immunopharmacology, 1985, Volume: 10, Issue:3

    Topics: Animals; Antigens; Atropine; Chromones; Guinea Pigs; Histamine Release; Immunoglobulin E; Immunoglobulin G; Indomethacin; Lung; Male; Muscle Contraction; Pyrilamine; SRS-A

1985
The effect of indomethacin on anaphylactic contraction and histamine release in guinea-pig lung parenchymal strips.
    Archives internationales de pharmacodynamie et de therapie, 1986, Volume: 281, Issue:2

    Topics: 4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine; Anaphylaxis; Animals; Chromones; Female; Guinea Pigs; Histamine Release; In Vitro Techniques; Indomethacin; Lung; Muscle Contraction; Muscle, Smooth; Ovalbumin; Pyrazoles; SRS-A

1986
REV 5901: an orally effective peptidoleukotriene antagonist, detailed biochemical/pharmacological profile.
    The Journal of pharmacology and experimental therapeutics, 1987, Volume: 241, Issue:1

    Topics: 1-Methyl-3-isobutylxanthine; Animals; Chromones; Coronary Circulation; Dose-Response Relationship, Drug; Guinea Pigs; Histamine; Hydroxyquinolines; Kinetics; Lung; Male; Methacholine Chloride; Methacholine Compounds; Muscle Contraction; Myocardial Contraction; Quinolines; Regional Blood Flow; SRS-A

1987
Formation of cysteinyl-leukotrienes by human bronchial mucosa in chronic obstructive bronchitis.
    Progress in clinical and biological research, 1989, Volume: 301

    Topics: Animals; Bronchi; Bronchitis; Calcimycin; Chromones; Female; Guinea Pigs; Humans; Ileum; In Vitro Techniques; Leukotrienes; Lung Diseases, Obstructive; Male; Mucous Membrane; Muscle Contraction; SRS-A

1989
Paf-induced release of spasmogens from guinea-pig lungs.
    British journal of pharmacology, 1989, Volume: 96, Issue:1

    Topics: Animals; Aspirin; Bronchi; Chromones; Diterpenes; Ginkgolides; Guinea Pigs; In Vitro Techniques; Indoles; Indomethacin; Lactones; Leukotriene B4; Lung; Masoprocol; Muscle Contraction; Muscle, Smooth; Platelet Activating Factor; SRS-A; Trachea

1989
Clotting of whole human blood induces cysteinyl-leukotriene formation.
    Thrombosis research, 1989, Jun-01, Volume: 54, Issue:5

    Topics: Adult; Animals; Biological Assay; Blood Coagulation; Chromatography, High Pressure Liquid; Chromones; Citrates; Citric Acid; Edetic Acid; Guinea Pigs; Heparin; Humans; Ileum; Kinetics; Leukotriene E4; Male; Masoprocol; Muscle Contraction; SRS-A; Thromboxane B2

1989
Analysis of the beta-adrenoceptor mediated inhibition of IgG1 and IgE dependent guinea-pig anaphylactic tracheal smooth muscle contraction.
    Agents and actions, 1989, Volume: 26, Issue:1-2

    Topics: Anaphylaxis; Animals; Chromones; Dibenz(b,f)(1,4)oxazepine-10(11H)-carboxylic acid, 8-chloro-, 2-acetylhydrazide; Female; Fenoterol; Guinea Pigs; Immunoglobulin E; Immunoglobulin G; Indomethacin; Leukotrienes; Male; Muscle Contraction; Muscle, Smooth; Prostaglandins; Receptors, Adrenergic, beta; SRS-A; Trachea

1989
Some properties of calcium-induced contraction in the isolated human and guinea-pig tracheal smooth muscle.
    Respiration physiology, 1985, Volume: 59, Issue:2

    Topics: Aged; Animals; Aspirin; Calcium; Chromones; Female; Guinea Pigs; Humans; Indomethacin; Ion Channels; Male; Middle Aged; Muscle Contraction; Muscle Tonus; Muscle, Smooth; SRS-A; Trachea; Verapamil

1985
The spontaneous electrical and mechanical activity of human bronchial smooth muscle: its modulation by drugs.
    British journal of pharmacology, 1989, Volume: 98, Issue:4

    Topics: Adult; Aged; Aged, 80 and over; Atropine; Bronchi; Chromones; Electric Stimulation; Electrophysiology; Female; Humans; In Vitro Techniques; Indomethacin; Isoproterenol; Male; Membrane Potentials; Middle Aged; Muscle Contraction; Muscle, Smooth; Physostigmine

1989
Role of arachidonic acid metabolites in hypoxic contractions of isolated porcine pulmonary artery and vein.
    Experimental lung research, 1989, Volume: 15, Issue:2

    Topics: Animals; Arachidonic Acids; Chromones; Histamine; Hypoxia; In Vitro Techniques; Indomethacin; Muscle Contraction; Muscle, Smooth, Vascular; Pulmonary Artery; Pulmonary Veins; Pyrazoles; Swine

1989
Differential effects of calcium channel blockers on leukotriene C4- and D4-induced contractions in guinea pig pulmonary parenchymal strips.
    The Journal of pharmacology and experimental therapeutics, 1987, Volume: 243, Issue:2

    Topics: Animals; Calcium Channel Blockers; Chromones; Dose-Response Relationship, Drug; Guinea Pigs; In Vitro Techniques; Lung; Male; Muscle Contraction; Receptors, Leukotriene; Receptors, Prostaglandin; SRS-A; Trachea

1987
Is the guinea pig trachea a good in vitro model of human large and central airways? Comparison on leukotriene-, methacholine-, histamine- and antigen-induced contractions.
    The Journal of pharmacology and experimental therapeutics, 1987, Volume: 243, Issue:2

    Topics: Adult; Animals; Antigens; Borates; Bronchi; Child; Chromones; Dicarboxylic Acids; Female; Guinea Pigs; Histamine; Humans; In Vitro Techniques; Male; Methacholine Chloride; Methacholine Compounds; Models, Biological; Muscle Contraction; Receptors, Leukotriene; Receptors, Prostaglandin; Serine; SRS-A; Trachea

1987
Analysis of leukotriene receptor antagonists on isolated human intralobar airways.
    Annals of the New York Academy of Sciences, 1988, Volume: 524

    Topics: Acetophenones; Azoles; Barium; Bronchi; Chromones; Humans; Indazoles; Muscle Contraction; Muscle, Smooth; Pyrazoles; Receptors, Leukotriene; Receptors, Prostaglandin; SRS-A; Tetrazoles

1988
Leukotriene and anti-IgE induced contractions of human isolated trachea: studies with leukotriene receptor antagonists and a novel 5-lipoxygenase inhibitor.
    Canadian journal of physiology and pharmacology, 1988, Volume: 66, Issue:6

    Topics: Animals; Antibodies, Anti-Idiotypic; Arachidonate Lipoxygenases; Atropine; Benzofurans; Chromones; Goats; Humans; In Vitro Techniques; Indomethacin; Keto Acids; Lipoxygenase Inhibitors; Muscle Contraction; Phenylbutyrates; Pyrilamine; Receptors, Leukotriene; Receptors, Prostaglandin; SRS-A; Sulfones; Trachea

1988
Characterisation of the leukotriene receptor(s) on human isolated lung strips.
    Agents and actions. Supplements, 1988, Volume: 23

    Topics: Chromones; Humans; In Vitro Techniques; Lung; Muscle Contraction; Receptors, Leukotriene; Receptors, Prostaglandin; SRS-A

1988
The contractile activities of lipoxin A4 and lipoxin B4 for guinea-pig airway tissues.
    British journal of pharmacology, 1988, Volume: 95, Issue:2

    Topics: Animals; Chromones; Guinea Pigs; Hydroxyeicosatetraenoic Acids; In Vitro Techniques; Leukotriene B4; Lipoxins; Lipoxygenase Inhibitors; Male; Muscle Contraction; Muscle, Smooth; SRS-A; Stereoisomerism; Trachea

1988
Failure of a combined anti-histamine and anti-leukotriene treatment to suppress passive anaphylaxis in the guinea-pig.
    International journal of immunopharmacology, 1986, Volume: 8, Issue:8

    Topics: Anaphylaxis; Animals; Aspirin; Chromones; Female; Guinea Pigs; Histamine H1 Antagonists; In Vitro Techniques; Lung; Male; Muscle Contraction; Ovalbumin; Propranolol; Pyrilamine; SRS-A

1986
A formyl peptide contracts guinea pig lung: role of arachidonic acid metabolites.
    Journal of applied physiology (Bethesda, Md. : 1985), 1987, Volume: 63, Issue:6

    Topics: Acetophenones; Animals; Arachidonic Acids; Autacoids; Chromones; Guinea Pigs; Histamine; Leukotriene B4; Lung; Male; Muscle Contraction; Muscle, Smooth; N-Formylmethionine Leucyl-Phenylalanine; Prostaglandins; Receptors, Leukotriene; Receptors, Prostaglandin; SRS-A; Tachyphylaxis; Tetrazoles

1987
Pharmacological modulation of responses of guinea-pig airways contracted with arachidonic acid.
    British journal of pharmacology, 1985, Volume: 85, Issue:2

    Topics: Animals; Arachidonate Lipoxygenases; Arachidonic Acid; Arachidonic Acids; Catechols; Chromones; Epoprostenol; Guinea Pigs; Indomethacin; Lipoxygenase Inhibitors; Lung; Male; Masoprocol; Muscle Contraction; Propionates; Pyrazoles; Pyrazolones; Receptors, Leukotriene; Receptors, Prostaglandin; Trachea

1985
Synthesis and pharmacological characterization of 5-(2-dodecylphenyl)-4,6-dithianonanedioic acid and 5-[2-(8-phenyloctyl)phenyl]-4,6-dithianonanedioic acid: prototypes of a novel class of leukotriene antagonists.
    Journal of medicinal chemistry, 1985, Volume: 28, Issue:9

    Topics: Airway Resistance; Animals; Chemical Phenomena; Chemistry; Chromones; Dicarboxylic Acids; Dose-Response Relationship, Drug; Guinea Pigs; Lung Compliance; Muscle Contraction; Receptors, Leukotriene; Receptors, Prostaglandin; SRS-A; Trachea

1985
Identification and characterization of leukotriene D4 receptors in adult and fetal human lung.
    Biochemical pharmacology, 1985, Dec-15, Volume: 34, Issue:24

    Topics: Adult; Binding, Competitive; Chromones; Female; Fetus; Humans; In Vitro Techniques; Lung; Muscle Contraction; Pregnancy; Radioligand Assay; Receptors, Cell Surface; Receptors, Leukotriene; Receptors, Prostaglandin; SRS-A; Tritium

1985
Pharmacological evidence that human intralobar airways do not contain different receptors that mediate contractions to leukotriene C4 and leukotriene D4.
    The Journal of pharmacology and experimental therapeutics, 1986, Volume: 237, Issue:2

    Topics: Arachidonic Acid; Arachidonic Acids; Borates; Chromones; Cysteine; Dose-Response Relationship, Drug; Humans; In Vitro Techniques; Leukotriene E4; Lung; Muscle Contraction; Receptors, Cell Surface; Receptors, Leukotriene; Receptors, Prostaglandin; Regression Analysis; Serine; SRS-A

1986
Differential rank order of potency for antagonism of LTC4- and LTD4-induced contractions of guinea pig trachea.
    Prostaglandins, leukotrienes, and medicine, 1986, Volume: 23, Issue:1

    Topics: Animals; Borates; Chromones; Guinea Pigs; In Vitro Techniques; Male; Muscle Contraction; Receptors, Leukotriene; Receptors, Prostaglandin; Serine; SRS-A; Trachea

1986
Characterization of platelet activating factor (PAF)-acether-induced contractions of guinea-pig lung strips by selected inhibitors of arachidonic acid metabolism and by PAF-acether antagonists.
    Immunopharmacology, 1986, Volume: 12, Issue:2

    Topics: Animals; Aspirin; Benzofurans; Chromones; Diterpenes; Ginkgolides; Guinea Pigs; Histamine; Imidazoles; Lactones; Leukotriene B4; Lignans; Lung; Male; Methacrylates; Muscle Contraction; Muscle, Smooth; Plant Extracts; Platelet Activating Factor; Prostaglandin Antagonists; Pyrilamine; SRS-A

1986
Comparative effects of drugs on leukotrienes-, PAF-acether- and histamine- induced contractions of guinea-pig lung parenchymal strips.
    Pharmacological research communications, 1986, Volume: 18 Suppl

    Topics: Animals; Chromones; Drug Interactions; Guinea Pigs; Histamine; In Vitro Techniques; Leukotriene B4; Lung; Muscle Contraction; Muscle, Smooth; Platelet Activating Factor; SRS-A

1986
Pharmacology of peptide leukotrienes on ferret isolated airway smooth muscle.
    Prostaglandins, 1986, Volume: 32, Issue:2

    Topics: Animals; Borates; Carbachol; Chromones; Ferrets; In Vitro Techniques; Leukotriene E4; Muscle Contraction; Muscle, Smooth; Receptors, Leukotriene; Receptors, Prostaglandin; Serine; SRS-A; Trachea

1986
Pharmacologic profile of chemically stable analogs of peptide leukotrienes.
    European journal of pharmacology, 1987, Jun-26, Volume: 138, Issue:3

    Topics: Animals; Chromones; Dose-Response Relationship, Drug; Guinea Pigs; In Vitro Techniques; Leukotriene E4; Male; Muscle Contraction; Receptors, Leukotriene; Receptors, Prostaglandin; SRS-A; Structure-Activity Relationship; Trachea

1987
Antagonism by ETYA of the effects of leukotrienes on ileum and lung parenchymal strips independent of effects on arachidonic acid metabolism.
    Prostaglandins, 1986, Volume: 32, Issue:4

    Topics: 5,8,11,14-Eicosatetraynoic Acid; Animals; Arachidonic Acid; Arachidonic Acids; Chromones; Fatty Acids, Unsaturated; Guinea Pigs; Histamine; Ileum; In Vitro Techniques; Indomethacin; Lung; Male; Muscle Contraction; Pyrazoles; SRS-A

1986
Synthesis of slow-reacting substance-like activity in human anterior uvea.
    Investigative ophthalmology & visual science, 1987, Volume: 28, Issue:7

    Topics: 4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine; Chromones; Humans; Ileum; Muscle Contraction; Pyrazoles; Radioimmunoassay; SRS-A; Uvea

1987
Release of eicosanoids from human synovial tissue and the effect of anti-inflammatory drugs.
    Progress in clinical and biological research, 1987, Volume: 242

    Topics: Aminosalicylic Acids; Animals; Calcimycin; Chromones; Guinea Pigs; Humans; In Vitro Techniques; Indomethacin; Mesalamine; Muscle Contraction; Prostaglandins; SRS-A; Sulfanilamides; Sulfapyridine; Synovial Membrane

1987
Prostaglandin F2 stimulates the generation of lipoxygenase products in guinea pig isolated trachea.
    Prostaglandins, 1987, Volume: 34, Issue:2

    Topics: Animals; Chromones; Guinea Pigs; In Vitro Techniques; Indomethacin; Lipoxygenase; Male; Masoprocol; Muscle Contraction; Prostaglandins F; Pyrazoles; SRS-A; Trachea

1987
Antigenic contraction of guinea pig tracheal preparations passively sensitized with monoclonal IgE: pharmacological modulation.
    International archives of allergy and applied immunology, 1988, Volume: 87, Issue:4

    Topics: Animals; Antibodies, Monoclonal; Antigens; Atropine; Chromones; Dinitrophenols; Dose-Response Relationship, Immunologic; Guinea Pigs; Immunization, Passive; Immunoglobulin E; Male; Mice; Mice, Inbred BALB C; Muscle Contraction; Phenothiazines; Serum Albumin, Bovine; Trachea; Tripelennamine

1988
Inhibitory effects of a lipoxygenase inhibitor nordihydroguaiaretic acid on antagonism of leukotriene C4-induced contractions of isolated guinea-pig trachea.
    Prostaglandins, 1988, Volume: 36, Issue:4

    Topics: Animals; Catechols; Chromones; Guinea Pigs; In Vitro Techniques; Indomethacin; Masoprocol; Muscle Contraction; Muscle, Smooth; SRS-A; Trachea

1988
Comparative activity of leukotriene D4, 5,6-dihydroxy-eicosatetraenoic acid and lipoxin A on guinea pig lung parenchyma and ileum smooth muscle.
    Research communications in chemical pathology and pharmacology, 1988, Volume: 59, Issue:3

    Topics: Animals; Chromones; Guinea Pigs; Hydroxyeicosatetraenoic Acids; Ileum; In Vitro Techniques; Lipoxins; Lung; Muscle Contraction; SRS-A; Stereoisomerism; Structure-Activity Relationship

1988
Study of platelet activating factor and its antagonists on rat colon strip with a new method avoiding tachyphylaxis.
    European journal of pharmacology, 1988, Apr-13, Volume: 148, Issue:3

    Topics: Animals; Atropine; Chlorpheniramine; Chromones; Colon; In Vitro Techniques; Indomethacin; Male; Methysergide; Muscle Contraction; Platelet Activating Factor; Rats; Rats, Inbred Strains; Serum Albumin; SRS-A; Tachyphylaxis

1988
Antagonism of the in vivo and in vitro effects of leukotriene D4 by SC-39070 in guinea pigs.
    Agents and actions, 1987, Volume: 20, Issue:1-2

    Topics: Animals; Bronchial Provocation Tests; Capillary Permeability; Chromones; Dimethyl Sulfoxide; Dose-Response Relationship, Drug; Drug Interactions; Guinea Pigs; Ileum; Muscle Contraction; SRS-A

1987
Actions of platelet-activating factor in the coronary circulation of the guinea pig in vitro.
    Progress in clinical and biological research, 1987, Volume: 242

    Topics: Animals; Blood Pressure; Chromones; Coronary Circulation; Guinea Pigs; In Vitro Techniques; Indomethacin; Male; Muscle Contraction; Muscle, Smooth; Myocardial Contraction; Platelet Activating Factor; SRS-A

1987
Repeatable antigen-induced contractions of isolated guinea pig lung strips are mediated by leukotriene.
    International archives of allergy and applied immunology, 1986, Volume: 80, Issue:4

    Topics: Animals; Antigens; Catechols; Chromones; Desensitization, Immunologic; Guinea Pigs; In Vitro Techniques; Lung; Male; Masoprocol; Muscle Contraction; Ovalbumin; SRS-A; Time Factors

1986
Differentiation of the mechanisms by which leukotrienes C4 and D4 elicit contraction of the guinea pig trachea.
    Prostaglandins, 1985, Volume: 29, Issue:4

    Topics: Airway Resistance; Animals; Borates; Chromones; Guinea Pigs; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth; Serine; SRS-A; Trachea

1985
Pharmacological modulation of responses of guinea-pig airways contracted with antigen and calcium ionophore A23187.
    British journal of pharmacology, 1985, Volume: 85, Issue:2

    Topics: 4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine; Animals; Arachidonate Lipoxygenases; Calcimycin; Catechols; Chromones; Drug Interactions; Epoprostenol; Guinea Pigs; Indomethacin; Lipoxygenase Inhibitors; Lung; Male; Masoprocol; Muscle Contraction; Ovalbumin; Pyrazoles; Pyrazolones; Trachea

1985
Effect of calcium antagonists on the biosynthesis and contractile effects of peptidoleukotrienes in rhesus monkey lung.
    The Journal of pharmacology and experimental therapeutics, 1985, Volume: 233, Issue:2

    Topics: Animals; Calcium Channel Blockers; Chromatography, High Pressure Liquid; Chromones; Gallic Acid; Immunoglobulin E; In Vitro Techniques; Lung; Macaca mulatta; Male; Muscle Contraction; Nifedipine; SRS-A; Trachea; Verapamil

1985
Histamine and leukotriene-independent guinea-pig anaphylactic shock unaccounted for by Paf-acether.
    British journal of pharmacology, 1985, Volume: 84, Issue:4

    Topics: Acetophenones; Anaphylaxis; Animals; Catechols; Chromones; Female; Guinea Pigs; Histamine; In Vitro Techniques; Lung; Male; Masoprocol; Muscle Contraction; Platelet Activating Factor; SRS-A

1985
Contractile responses of the guinea-pig esophageal muscularis mucosae in vitro to arachidonic acid and its metabolites.
    European journal of pharmacology, 1985, Aug-07, Volume: 114, Issue:1

    Topics: Animals; Arachidonic Acids; Chromones; Esophagus; Guinea Pigs; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth; Polyphloretin Phosphate; Prostaglandins; SRS-A; Thromboxanes

1985
Antagonists of slow reacting substance of anaphylaxis. Synthesis of a series of chromone-2-carboxylic acids.
    Journal of medicinal chemistry, 1977, Volume: 20, Issue:3

    Topics: Animals; Chromones; Guinea Pigs; In Vitro Techniques; Methods; Muscle Contraction; Muscle, Smooth; SRS-A; Structure-Activity Relationship

1977
Synthesis and structure-activity relationship studies of a series of 5-aryl-4,6-dithianonanedioic acids and related compounds: a novel class of leukotriene antagonists.
    Journal of medicinal chemistry, 1986, Volume: 29, Issue:8

    Topics: Alkynes; Animals; Binding, Competitive; Bronchi; Dicarboxylic Acids; Guinea Pigs; Magnetic Resonance Spectroscopy; Muscle Contraction; Receptors, Leukotriene; Receptors, Prostaglandin; SRS-A; Stereoisomerism; Structure-Activity Relationship; Sulfides; Trachea

1986
Leukotriene receptor antagonists. 1. Synthesis and structure-activity relationships of alkoxyacetophenone derivatives.
    Journal of medicinal chemistry, 1987, Volume: 30, Issue:4

    Topics: Acetophenones; Alkylation; Animals; Bronchi; Guinea Pigs; Muscle Contraction; Muscle, Smooth; Receptors, Leukotriene; Receptors, Prostaglandin; SRS-A; Structure-Activity Relationship

1987
New potent antagonists of leukotrienes C4 and D4. 1. Synthesis and structure-activity relationships.
    Journal of medicinal chemistry, 1988, Volume: 31, Issue:1

    Topics: Animals; Bronchodilator Agents; Cinnamates; Guinea Pigs; Ileum; In Vitro Techniques; Magnetic Resonance Spectroscopy; Mass Spectrometry; Muscle Contraction; ortho-Aminobenzoates; SRS-A; Structure-Activity Relationship

1988
Novel 1,3-bis(aryloxy)propanes as leukotriene D4 antagonists.
    Journal of medicinal chemistry, 1986, Volume: 29, Issue:7

    Topics: Animals; Guinea Pigs; Indicators and Reagents; Magnetic Resonance Spectroscopy; Muscle Contraction; Muscle, Smooth; Phenyl Ethers; Spectrophotometry, Infrared; SRS-A; Structure-Activity Relationship

1986
Evaluation of rotenone and related compounds as antagonists of slow-reacting substance of anaphylaxis.
    Journal of medicinal chemistry, 1980, Volume: 23, Issue:9

    Topics: Acetylcholine; Anaphylaxis; Animals; Guinea Pigs; Histamine H1 Antagonists; In Vitro Techniques; Muscle Contraction; Muscle, Smooth; Rotenone; Serotonin Antagonists; SRS-A

1980
Antagonists of slow-reacting substance of anaphylaxis. 1. Pyrido[2,1-b]quinazolinecarboxylic acid derivatives.
    Journal of medicinal chemistry, 1983, Volume: 26, Issue:11

    Topics: Animals; Biological Assay; Guinea Pigs; Ileum; Indicators and Reagents; Leukotriene E4; Muscle Contraction; Quinazolines; Rats; SRS-A; Structure-Activity Relationship

1983