fpl 55712 has been researched along with Muscle Contraction in 110 studies
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 95 (86.36) | 18.7374 |
1990's | 15 (13.64) | 18.2507 |
2000's | 0 (0.00) | 29.6817 |
2010's | 0 (0.00) | 24.3611 |
2020's | 0 (0.00) | 2.80 |
Authors | Studies |
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Bernstein, PR; Brown, FJ; Cronk, LA; Dosset, DL; Hebbel, KC; Maduskuie, TP; Shapiro, HS; Vacek, EP; Willard, AK; Yee, YK | 1 |
Crowley, HJ; Levitan, P; Lind, J; O'Donnell, M; Tilley, JW; Tobias, LD; Welton, AF | 1 |
Brown, DL; Carson, M; Crowley, HJ; Han, RJ; LeMahieu, RA; Nason, WC; O'Donnell, M; Welton, AF | 1 |
Carr, FP; Dillard, RD; Fleisch, JH; Haisch, KD; McCullough, D; Rinkema, LE | 1 |
Crooke, ST; Erhard, KF; Frazee, JS; Gleason, JG; Hall, RF; Kondrad, K; Ku, TW; McCarthy, ME; Mong, S; Perchonock, CD | 1 |
Bélanger, P; Champion, E; DeHaven, RN; Denis, D; Ford-Hutchinson, AW; Fortin, R; Frenette, R; Gauthier, JY; Gillard, J; Young, RN | 1 |
Sato, F; Timmerman, H; Wada, Y; Zhang, MQ | 1 |
Onogi, K; Tamura, M; Timmerman, H; Tohma, T; Wada, Y; Zhang, MQ; Zwaagstra, ME | 1 |
Nakahata, N; Nakanishi, H; Ono, T | 1 |
Krell, RD; Snyder, DW | 2 |
Bach, MK; Hanna, CJ; Pare, PD; Schellenberg, RR | 1 |
Burka, JF; Paterson, NA | 1 |
Cade, JF; Clancy, RL; Pain, MC; Walker, SE | 1 |
Feniuk, L; Kennedy, I; Whelan, CJ | 1 |
Kulkarni, PS; Srinivason, BD | 1 |
Casey, FB; Chakrin, LW; Hardy, TM; Regal, JF | 1 |
Iwamoto, T; Koda, A; Nagai, H; Nishiyori, T; Takizawa, T; Tsuchiya, H | 1 |
Buckner, CK; Fishleder, RI | 1 |
Bantick, JR; Ghelani, AM; Holroyde, MC; Lee, TB; Sheard, P | 1 |
Borgeat, P; Girard, G; Jeanson, A; Roy, S; Sirois, P | 1 |
Hoffer, BJ; Mathews, WR; Murphy, RC; Palmer, MR | 1 |
Cromwell, O; Kay, AB; Morris, HR; O'Driscoll, BR; Taylor, GW; Walport, MJ | 1 |
Barone, M; Berdoulay, A; Giles, RE; Krell, RD; Tsai, BS | 1 |
Denis, D; Ethier, D; Hall, R; Jones, T | 1 |
Hugli, TE; Marceau, F | 1 |
Bloor, CM; Erickson, BW; Huey, R; Hugli, TE | 1 |
Butler, J; Downes, H; Hanifin, JM; Hirshman, CA; Peters, J | 1 |
Cirino, M; Ford-Hutchinson, AW; Hamel, R; Lord, A | 1 |
Mathias, MM; Murphy, RC; Reeves, JT; Stenmark, KR; Voelkel, NF | 1 |
Regal, JF | 2 |
Burka, JF; Saad, MH | 1 |
Daniel, EE; Davis, C; Jones, TR | 2 |
O'Flaherty, JT; Stimler, NP | 1 |
Goldenberg, MM; Subers, EM | 1 |
Wang, SM; Wang, SR; Yang, CM | 1 |
Brunet, G; Girard, Y; Holme, G; Masson, P; Piechuta, H; Rokach, J | 1 |
Fleisch, JH; Haisch, KD; Spaethe, SM | 1 |
Bodach, E; Borgeat, P; Coceani, F; Jhamandas, VM; Labuc, J; Olley, PM | 1 |
Ghelani, AM; Holroyde, MC | 1 |
Bryan, D; Falcone, K; Gleason, J; Kinzig, C; Krell, RD; O'Donnell, M; Osborn, R; Vickery, L | 1 |
Falcone, K; Krell, RD; Osborn, R; Vickery, L | 1 |
Bernstein, P; Conaty, J; Krell, RD; Macia, RA; Tsai, BS | 1 |
Andersson, RG; Hedman, SE | 1 |
Hodgson, WC; Hopkins, BJ; Sutherland, SK | 1 |
Timmerman, H; Zhang, MQ | 1 |
Jakschik, BA; Kulczycki, A; MacDonald, HH; Parker, CW | 1 |
Horiba, M; Inoue, K; Ohata, K; Ohkawa, E; Watanabe-Kohno, S; Yamamura, H; Yasui, K | 1 |
Gonzales, J; Lawson, DL; Mehta, JL; Nichols, WW; Nicolini, FA | 1 |
Horiba, M; Nabe, T; Ohata, K; Watanabe-Kohno, S; Yamamura, H | 1 |
Dahlén, SE; Nicolaou, KC; Westlund, P; Wikström, E | 1 |
Lindén, A; Löfdahl, CG; Skoogh, BE; Ullman, A | 1 |
Napier, FE; Shearer, MA; Temple, DM | 1 |
Becherucci, C; Mugridge, KG; Parente, L; Perretti, M | 1 |
Shikada, K; Tanaka, S; Yamamoto, A | 2 |
Kobayashi, T; Yamane, K | 1 |
Cregge, RJ; Gieske, TH; Raddatz, R; Sabol, JS; Weintraub, PM | 1 |
Aizawa, H; Hakoda, H; Hirose, T; Ito, I; Suzuki, H | 1 |
Assem, ES; Ezeamuzie, IC | 1 |
Clark, MA; Cook, M; Crooke, ST; Mong, S | 1 |
Creese, BR; Temple, DM | 1 |
Coutts, S; Gordon, R; Jolly, S; Khandwala, A; Sonnino, P; Van Inwegen, RG | 1 |
Luck, W; Peskar, BA; Schmidt, EW; Simmet, T | 1 |
Braquet, P; Jancar, S; Lauzière, M; Sirois, P; Thériault, P | 1 |
Luck, W; Simmet, T | 1 |
Brouwer, F; van Amsterdam, RG; Zaagsma, J | 1 |
Baba, K; Ito, M; Satake, T; Takagi, K; Tomita, T | 1 |
Aizawa, H; Hakoda, H; Hirose, T; Ito, Y; Suzuki, H | 1 |
Hamilton, JT; Miller, DS; Paterson, NA; Yaghi, A | 1 |
Drazen, JM; Israel, E; Robin, JL | 1 |
Hay, DW; Muccitelli, RM; Torphy, TJ; Tucker, SS; Wasserman, MA | 1 |
Buckner, CK; Castleman, WL; Saban, R; Will, JA | 1 |
Charette, L; Denis, D; Jones, TR | 1 |
Cuthbert, NJ; Gardiner, PJ | 1 |
Crea, AE; Jacques, CA; Lee, TH; Spur, BW | 1 |
Cordeiro, R; Garcez Do Carmo, L; Lagente, V; Lefort, J; Randon, J; Vargaftig, BB | 1 |
Drazen, JM; Shore, SA; Smith, E; Stimler-Gerard, NP | 1 |
Burka, JF | 2 |
DeVan, JF; Erhard, KF; Gleason, JG; Kirchner, T; McCarthy, ME; Muccitelli, RM; Perchonock, CD; Tucker, SS; Vickery, LM; Wasserman, MA | 1 |
Crooke, ST; Lewis, MA; Mong, S; Vessella, RL | 1 |
Bernstein, PR; Buckner, CK; Coursin, DB; Krell, RD; Laravuso, RB; Will, JA | 1 |
Tucker, SS; Weichman, BM | 2 |
Borgeat, P; Braquet, P; Etienne, A; Sirois, P; Touvay, C; Vilain, B | 1 |
Braquet, P; Clostre, F; Etienne, A; Touvay, C; Vilain, B | 1 |
Bernstein, PR; Snyder, DW | 1 |
Hageman, WE; Persico, FJ; Rose, MP | 1 |
Kulkarni, PS; Srinivasan, BD | 1 |
Hoppe, U; Kleemeyer, K; Peskar, BA; Peskar, BM; Wittenberg, HR | 1 |
Sakoda, R; Shikada, K; Tanaka, S; Yamamoto, A | 1 |
Benveniste, J; Brink, C; Haye-Legrand, I; Labat, C; Norel, X | 1 |
Cristol, JP; Sirois, P | 1 |
Okamoto, M; Terao, M; Tokumura, A; Tsukatani, H; Yoshida, K | 1 |
Carnathan, GW; Miyano, M; Prusa, CM; Sanner, JH; Thompson, JM | 1 |
Piper, PJ; Stewart, AG | 1 |
Robichaud, LJ; Thueson, DO; Webster, K | 1 |
DeVan, JF; Muccitelli, RM; Tucker, SS; Weichman, BM | 1 |
Detsouli, A; Lefort, J; Vargaftig, BB | 1 |
Fujinuma, S; Kamikawa, Y; Shimo, Y | 1 |
Appleton, RA; Bantick, JR; Chamberlain, TR; Hardern, DN; Lee, TB; Pratt, AD | 1 |
DeVan, JF; Erhard, KF; Gleason, JG; McCarthy, ME; Muccitelli, RM; Perchonock, CD; Tucker, SS; Uzinskas, I; Vickery, LM; Wasserman, MA | 1 |
Cullinan, GJ; Fleisch, JH; Goodson, T; Haisch, KD; Marshall, WS; Rinkema, LE; Swanson-Bean, D | 1 |
Arai, Y; Katsube, N; Konno, M; Kosuge, S; Miyamoto, T; Nakai, H; Obata, T; Okegawa, T; Sakuyama, S; Toda, M | 1 |
Bell, SC; Carlson, RP; Chang, JY; Hand, JM; Klaubert, DH; Kreft, AF; Lewis, AJ; Pattison, TW; Yardley, JP | 1 |
Ashack, RJ; Goodman, FR; Malek, RS; McCarty, LP; Peet, NP | 1 |
Crowley, HJ; Levitan, P; Tilley, JW; Welton, AF | 1 |
110 other study(ies) available for fpl 55712 and Muscle Contraction
Article | Year |
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Hydroxyacetophenone-derived antagonists of the peptidoleukotrienes.
Topics: Acetophenones; Animals; Benzoates; Biological Assay; Chemical Phenomena; Chemistry; Chromones; Guinea Pigs; Hydroxylation; Ketones; Methylation; Muscle Contraction; Nitrogen; Phenols; SRS-A; Structure-Activity Relationship; Trachea | 1989 |
N-(heterocyclic alkyl)pyrido[2,1-b]quinazoline-8-carboxamides as orally active antiallergy agents.
Topics: Administration, Oral; Animals; Blood Platelets; Bronchi; Guinea Pigs; Histamine H1 Antagonists; Humans; In Vitro Techniques; Indicators and Reagents; Leukotriene E4; Magnetic Resonance Spectroscopy; Mass Spectrometry; Muscle Contraction; Pyridines; Quinazolines; Spectrophotometry, Infrared; SRS-A; Structure-Activity Relationship; Thromboxane-A Synthase | 1987 |
Substituted (aryloxy)alkanoic acids as antagonists of slow-reacting substance of anaphylaxis.
Topics: Animals; Bronchi; Fatty Acids; Guinea Pigs; In Vitro Techniques; Indicators and Reagents; Leukotriene E4; Magnetic Resonance Spectroscopy; Male; Mass Spectrometry; Muscle Contraction; Muscle, Smooth; Phenyl Ethers; Spectrophotometry; SRS-A; Structure-Activity Relationship | 1987 |
Leukotriene receptor antagonists. 2. The [[(tetrazol-5-ylaryl)oxy]methyl]acetophenone derivatives.
Topics: Acetophenones; Animals; Azoles; Bronchi; Chemical Phenomena; Chemistry; Guinea Pigs; Ileum; Muscle Contraction; Receptors, Leukotriene; Receptors, Prostaglandin; SRS-A; Structure-Activity Relationship; Tetrazoles; Trachea | 1987 |
High-affinity leukotriene receptor antagonists. Synthesis and pharmacological characterization of 2-hydroxy-3-[(2-carboxyethyl)thio]-3-[2-(8-phenyloctyl)phenyl] propanoic acid.
Topics: Animals; Bronchi; Dicarboxylic Acids; Guinea Pigs; Humans; Muscle Contraction; Receptors, Leukotriene; Receptors, Prostaglandin; SRS-A; Structure-Activity Relationship | 1987 |
Design and synthesis of sodium (beta R*, gamma S*)-4-[[3-(4-acetyl-3-hydroxy-2-propylphenoxy)propyl] thio]-gamma-hydroxy-beta-methylbenzenebutanoate: a novel, selective, and orally active receptor antagonist of leukotriene D4.
Topics: Animals; Biological Assay; Bronchi; Chemical Phenomena; Chemistry; Guinea Pigs; Ileum; Muscle Contraction; Phenylbutyrates; SRS-A; Trachea | 1986 |
(Piperidinylalkoxy)chromones: novel antihistamines with additional antagonistic activity against leukotriene D4.
Topics: Animals; Capillary Permeability; Cerebral Cortex; Chromones; Drug Antagonism; Guinea Pigs; Histamine H1 Antagonists; Ileum; In Vitro Techniques; Leukotriene D4; Lung; Mice; Muscle Contraction; Pyrilamine | 1995 |
Synthesis and structure-activity relationships of carboxylated chalcones: a novel series of CysLT1 (LTD4) receptor antagonists.
Topics: Animals; Chalcone; Guinea Pigs; Ileum; In Vitro Techniques; Leukotriene Antagonists; Lung; Magnetic Resonance Spectroscopy; Male; Mass Spectrometry; Membrane Proteins; Muscle Contraction; Receptors, Leukotriene; Structure-Activity Relationship; Trachea | 1997 |
Possible involvement of a product of the 5-lipoxygenase pathway in mediation of indomethacin-induced inhibition of cholinergic transmission in guinea-pig ileum.
Topics: Acetylcholine; Animals; Arachidonic Acid; Arachidonic Acids; Chromones; Dinoprostone; Electric Stimulation; Female; Guinea Pigs; Hydroxyeicosatetraenoic Acids; Ileum; In Vitro Techniques; Indomethacin; Lipoxygenase; Male; Muscle Contraction; Muscle, Smooth; Prostaglandins E; SRS-A; Synaptic Transmission | 1984 |
Pharmacological evidence for a distinct leukotriene C4 receptor in guinea-pig trachea.
Topics: Animals; Chromones; Cysteine; Guinea Pigs; In Vitro Techniques; Leukotriene E4; Male; Muscle Contraction; Receptors, Cell Surface; Receptors, Leukotriene; Receptors, Prostaglandin; Serine; SRS-A; Trachea | 1984 |
Slow-reacting substances (leukotrienes) contract human airway and pulmonary vascular smooth muscle in vitro.
Topics: Airway Resistance; Arachidonic Acids; Autacoids; Carbachol; Chromones; Ethers; Histamine; Humans; In Vitro Techniques; Kinetics; Muscle Contraction; Muscle, Smooth; Pulmonary Circulation; SRS-A; Vascular Resistance | 1981 |
The effects of SRS-A and histamine antagonists on antigen-induced contraction of guinea pig trachea.
Topics: Airway Resistance; Animals; Antigens; Atropine; Autacoids; Chromones; Drug Interactions; Ethers; Guinea Pigs; Histamine H1 Antagonists; Histamine H2 Antagonists; Indomethacin; Male; Muscle Contraction; Trachea | 1981 |
Slow-reacting substance from alveolar macrophages--a mechanism of asthma?
Topics: Animals; Asthma; Atropine; Autacoids; Chromones; Cimetidine; Ethers; Guinea Pigs; Indomethacin; Macrophages; Methysergide; Muscle Contraction; Muscle, Smooth; Pyrilamine; Trachea | 1981 |
The contractile action of slow reacting substance of anaphylaxis (SRS-A) on rat isolated fundic strip and guinea-pig isolated ileum and its antagonism by FPL 55712.
Topics: Animals; Chromones; Gastric Fundus; Ileum; In Vitro Techniques; Indomethacin; Muscle Contraction; Muscle, Smooth; Rats; SRS-A | 1982 |
Synthesis of slow reacting substance-like activity in rabbit conjunctiva and anterior uvea.
Topics: 4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine; Animals; Arachidonic Acids; Autacoids; Catechols; Chromones; Conjunctiva; Enzyme Activation; Guinea Pigs; Ileum; Lipoxygenase; Lipoxygenase Inhibitors; Masoprocol; Muscle Contraction; Pyrazoles; Rabbits; Tissue Extracts; Uvea | 1983 |
Effects of C5a on guinea pig lung: histamine release and mechanism of contraction.
Topics: Animals; Aspirin; Atropine; Chromones; Complement C5; Complement C5a; Dose-Response Relationship, Immunologic; Guinea Pigs; Histamine H1 Antagonists; Histamine Release; Indomethacin; Lung; Male; Muscle Contraction; Muscle, Smooth | 1983 |
Pharmacological studies on newly synthesized anti-allergic agents, 2-methyl-3-piperidino-beta-propionaphtone hydrochloride (KZ-111) and 3-isobutyryl-2-isopropylpyrazole-[1, 5-a] pyridine (KC-404).
Topics: Animals; Asthma; Chromones; Guinea Pigs; Histamine H1 Antagonists; Histamine Release; Hypersensitivity; In Vitro Techniques; Male; Muscle Contraction; Passive Cutaneous Anaphylaxis; Piperidines; Pyridines; Rats; Rats, Inbred Strains; SRS-A | 1983 |
Studies on the relationship between contraction and mediator release produced by ovalbumin in superfused trachea isolated from the actively sensitized guinea pig.
Topics: 5,8,11,14-Eicosatetraynoic Acid; Animals; Carbachol; Chromones; Dose-Response Relationship, Drug; Female; Guinea Pigs; Histamine Release; Indomethacin; Muscle Contraction; Muscle, Smooth; Ovalbumin; SRS-A; Time Factors; Trachea | 1984 |
Antagonists of SRS-A and leukotrienes.
Topics: Animals; Bronchi; Chromones; Guinea Pigs; Humans; Lung; Muscle Contraction; Muscle, Smooth; SRS-A; Structure-Activity Relationship; Trachea | 1982 |
The action of leukotriene B4 (LTB4) on the lung.
Topics: Animals; Arachidonic Acids; Chromones; Ethers; Guinea Pigs; Histamine; Humans; In Vitro Techniques; Indomethacin; Leukotriene B4; Lung; Muscle Contraction; Muscle, Smooth; Perfusion; Polyphloretin Phosphate; Prostaglandins; Rabbits; Rats; SRS-A; Thromboxanes | 1980 |
Electrophysiological response of cerebellar Purkinje neurons to leukotriene D4 and B4.
Topics: Action Potentials; Animals; Arachidonic Acids; Chromones; Ethers; Guinea Pigs; In Vitro Techniques; Leukotriene B4; Male; Muscle Contraction; Muscle, Smooth; Purkinje Cells; Rats; Rats, Inbred Strains; SRS-A | 1981 |
Identification of leukotrienes in the sputum of patients with cystic fibrosis.
Topics: Adolescent; Adult; Animals; Arachidonic Acids; Biological Assay; Chemotaxis; Chromones; Cystic Fibrosis; Female; Guinea Pigs; Humans; Ileum; Leukotriene B4; Male; Muscle Contraction; Neutrophils; Sputum; SRS-A | 1982 |
Heterogeneity of leukotriene receptors in guinea-pig trachea.
Topics: Animals; Chromones; Guinea Pigs; Kinetics; Leukotriene E4; Male; Muscle Contraction; Receptors, Cell Surface; Receptors, Leukotriene; SRS-A; Structure-Activity Relationship; Trachea | 1983 |
Pharmacological study of the effects of leukotrienes C4, D4, E4 & F4 on guinea pig trachealis: interaction with FPL-55712.
Topics: Animals; Chromones; Guinea Pigs; Leukotriene E4; Male; Muscle Contraction; SRS-A; Trachea | 1983 |
Effect of C3a and C5a anaphylatoxins on guinea-pig isolated blood vessels.
Topics: Anaphylatoxins; Animals; Aspirin; Blood Vessels; Chromones; Complement C3; Complement C3a; Complement C5; Complement C5a; Dose-Response Relationship, Drug; Female; Guinea Pigs; Hemolysis; Histamine; Indomethacin; Male; Muscle Contraction; Norepinephrine; Peptides; Pyrilamine; Tachyphylaxis | 1984 |
Contraction of guinea pig lung by synthetic oligopeptides related to human C3a.
Topics: Acetylcholine; Animals; Chromones; Complement C3; Complement C3a; Guinea Pigs; In Vitro Techniques; Indomethacin; Lung; Muscle Contraction; Oligopeptides; Pyrilamine; SRS-A; Tachyphylaxis | 1984 |
Role of mediators in allergic and nonallergic asthma in dogs with hyperreactive airways.
Topics: Airway Resistance; Animals; Asthma; Bronchial Provocation Tests; Chromones; Citrates; Citric Acid; Dogs; Guinea Pigs; Histamine; Hypersensitivity; Lung Compliance; Methacholine Chloride; Methacholine Compounds; Muscle Contraction; Respiratory Tract Diseases; Tissue Extracts | 1983 |
Bronchoconstriction induced by N-formyl-methionyl-leucyl-phenylalanine in the guinea pig; involvement of arachidonic acid metabolites.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Blood Pressure; Bronchi; Chromones; Dose-Response Relationship, Drug; Guinea Pigs; Indomethacin; Injections, Intravenous; Male; Muscle Contraction; N-Formylmethionine Leucyl-Phenylalanine; Prostaglandin-Endoperoxide Synthases; SRS-A; Time Factors | 1984 |
Actions of lipoxygenase metabolites in isolated rat lungs.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Chromatography, High Pressure Liquid; Chromones; Diethylcarbamazine; Hydroxyeicosatetraenoic Acids; Indomethacin; Lung; Male; Muscle Contraction; Muscle, Smooth; Perfusion; Pressure; Pulmonary Circulation; Rats; Rats, Inbred Strains; Serum Albumin, Bovine; SRS-A | 1984 |
IgG vs IgE: mediators of antigen-induced guinea pig tracheal contraction.
Topics: Animals; Antigens; Catechols; Chromones; Diphenhydramine; Guinea Pigs; Immunoglobulin E; Immunoglobulin G; In Vitro Techniques; Male; Masoprocol; Muscle Contraction; Muscle, Smooth; Respiratory Hypersensitivity; SRS-A; Time Factors; Trachea | 1984 |
Isolation of leukotriene C4 from human seminal fluid.
Topics: Animals; Biological Assay; Chromatography, High Pressure Liquid; Chromones; Dinoprostone; Guinea Pigs; Humans; Ileum; Lung; Male; Muscle Contraction; Prostaglandins B; Prostaglandins E; Semen; Spectrophotometry, Ultraviolet; SRS-A | 1983 |
Studies of the mechanism of passive anaphylaxis in human airway smooth muscle.
Topics: Anaphylaxis; Antigens; Arachidonic Acids; Bronchi; Chromones; Histamine; Humans; Immunoglobulin E; In Vitro Techniques; Indomethacin; Muscle Contraction; Muscle, Smooth; SRS-A; Trachea | 1983 |
Spasmogenic properties of platelet-activating factor: evidence for a direct mechanism in the contractile response of pulmonary tissues.
Topics: 5,8,11,14-Eicosatetraynoic Acid; Animals; Aspirin; Blood Platelets; Catechols; Chromones; Dose-Response Relationship, Drug; Guinea Pigs; Indomethacin; Lung; Masoprocol; Muscle Contraction; Muscle, Smooth; Platelet Activating Factor; Rats; Sulfinpyrazone; Thromboxane B2 | 1983 |
The effect of leukotriene D4 on the isolated stomach and colon of the rat.
Topics: Animals; Chromones; Colon; Dose-Response Relationship, Drug; Indomethacin; Male; Muscle Contraction; Prostaglandins; Rats; Rats, Inbred Strains; SRS-A; Stomach | 1983 |
[Characterization of slow reacting substance of anaphylaxis in asthmatic sputum].
Topics: Adult; Animals; Arylsulfatases; Asthma; Chromones; Diphenhydramine; Female; Guinea Pigs; Histamine; Hot Temperature; Humans; In Vitro Techniques; Male; Middle Aged; Muscle Contraction; Sputum; SRS-A | 1984 |
The activity of synthetic leukotriene C-1 on guinea pig trachea and ileum.
Topics: Animals; Arachidonic Acids; Chromones; Dose-Response Relationship, Drug; Ethers; Guinea Pigs; Histamine; Ileum; Lipoxygenase; Male; Muscle Contraction; Trachea | 1980 |
Slow reacting substance of anaphylaxis (SRS-A) release from guinea-pig lung parenchyma during antigen- or ionophore-induced contraction.
Topics: Animals; Calcimycin; Chromones; Guinea Pigs; Histamine; Hypersensitivity; In Vitro Techniques; Lung; Male; Muscle Contraction; Muscle, Smooth; Ovalbumin; SRS-A; Time Factors | 1982 |
Evidence against a role for lipoxygenase-derived products of arachidonic acid in the lamb ductus arteriosus.
Topics: 4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine; Animals; Arachidonic Acid; Arachidonic Acids; Chromones; Ductus Arteriosus; Female; Lipoxygenase; Muscle Contraction; Pregnancy; Pyrazoles; Sheep; SRS-A | 1982 |
Kinetics of action of two leukotriene antagonists on guinea pig ileum.
Topics: Animals; Chromones; Guinea Pigs; Ileum; In Vitro Techniques; Kinetics; Male; Muscle Contraction; Muscle, Smooth; SRS-A | 1983 |
Contraction of isolated airway smooth muscle by synthetic leukotrienes C4 and D4.
Topics: Animals; Arachidonic Acids; Bronchi; Chromones; Ethers; Guinea Pigs; In Vitro Techniques; Indomethacin; Lung; Male; Muscle Contraction; Muscle, Smooth; Rats; Rats, Inbred Strains; SRS-A; Trachea | 1981 |
Enhancement of isolated airway responses to bronchoconstrictive agonists by the slow-reacting substance of anaphylaxis antagonist FPL 55712.
Topics: Animals; Arachidonic Acids; Carbachol; Chromones; Ethers; Guinea Pigs; Histamine; In Vitro Techniques; Lung; Male; Muscle Contraction; Muscle, Smooth; Respiratory System; SRS-A; Trachea | 1981 |
Pharmacological study of the contractile activity of leukotriene C4 and D4 on isolated human airway smooth muscle.
Topics: Bronchi; Chromones; Histamine; Humans; In Vitro Techniques; Muscle Contraction; SRS-A; Trachea | 1982 |
Comparative potency and pharmacology of isomers of leukotriene D4 on guinea-pig trachea: requirement for a 5(S)6(R) configuration.
Topics: Animals; Chromones; Guinea Pigs; Indomethacin; Isomerism; Male; Muscle Contraction; Muscle, Smooth; SRS-A; Trachea | 1982 |
Effects of SRS (slow reacting substance) on cyclic nucleotides in guinea pig tracheal muscle.
Topics: Animals; Chromones; Female; Guinea Pigs; Hypersensitivity; Indomethacin; Male; Muscle Contraction; Muscle, Smooth; Nucleotides, Cyclic; Ovalbumin; SRS-A; Tartrazine; Trachea | 1982 |
Pharmacological studies of stonefish (Synanceja trachynis) venom.
Topics: Animals; Biphenyl Compounds; Blood Pressure; Captopril; Chromones; Dose-Response Relationship, Drug; Fish Venoms; Fishes; Guinea Pigs; Heptanoic Acids; Histamine; Ileum; Imidazoles; In Vitro Techniques; Indomethacin; Losartan; Male; Mecamylamine; Muscle Contraction; Muscle, Smooth; Phospholipases A; Phospholipases A2; Quinacrine; Rats; Receptors, Thromboxane; Serotonin; SRS-A; Tetrazoles; Vas Deferens | 1994 |
Leukotriene cysLT1 (LTD4) receptor antagonism of H1-antihistamines: an in vitro study.
Topics: Animals; Butyrophenones; Cell Membrane; Chromones; Cyproheptadine; Guinea Pigs; Histamine H1 Antagonists; Ileum; Leukotriene Antagonists; Leukotriene D4; Lung; Membrane Proteins; Muscle Contraction; Phthalazines; Piperidines; Receptors, Leukotriene | 1997 |
Release of slow reacting substance (SRS) from rat basophilic leukemia (RBL-1) cells.
Topics: Animals; Anti-Bacterial Agents; Arylsulfatases; Basophils; Benzopyrans; Calcimycin; Cells, Cultured; Chromones; Chymotrypsin; Dose-Response Relationship, Drug; Ethers; Guinea Pigs; In Vitro Techniques; Indomethacin; Leukemia, Experimental; Muscle Contraction; Muscle, Smooth; Rats; SRS-A | 1977 |
Effect of AS-35 on agonist-induced contractions and the resting tonus of airway smooth muscles and the in vitro release of chemical mediators from passively sensitized lung fragments from humans and guinea pigs.
Topics: Animals; Chromones; Guinea Pigs; Histamine Release; Humans; In Vitro Techniques; Leukotrienes; Lung; Male; Muscle Contraction; Muscle, Smooth; Passive Cutaneous Anaphylaxis; Pyridines; Pyrimidinones; Respiratory Muscles; SRS-A; Tetrazoles | 1992 |
Variable effects of human and canine polymorphonuclear leucocytes on vascular smooth muscle tone.
Topics: Animals; Arginine; Arteries; Chromones; Culture Techniques; Dogs; Endothelium; Humans; Indomethacin; Muscle Contraction; Muscle, Smooth, Vascular; Neutrophils; Nitric Oxide; omega-N-Methylarginine; Oxyhemoglobins; Prostaglandin Endoperoxides, Synthetic; Species Specificity; SRS-A; Superoxide Dismutase | 1992 |
MCI-826 is a potent and selective antagonist of peptide leukotrienes (p-LTs) and has characteristics distinctive from those of FPL 55712.
Topics: Acetylcholine; Animals; Bronchi; Chromones; Guinea Pigs; Humans; Leukotriene Antagonists; Leukotrienes; Muscle Contraction; Muscle, Smooth; Prostaglandin D2; Respiratory Physiological Phenomena; Respiratory System; SRS-A; Thiazoles; Trachea | 1992 |
Lipoxin A4-induced release of thromboxane in the guinea-pig lung: studies of its characteristics using lipoxin A4-methyl ester.
Topics: Animals; Chromones; Esters; Female; Guinea Pigs; Hydroxyeicosatetraenoic Acids; In Vitro Techniques; Leukotriene Antagonists; Lipoxins; Lung; Male; Muscle Contraction; Muscle, Smooth; Radioimmunoassay; Thromboxane A2 | 1992 |
In vitro characteristics of spontaneous airway tone in the guinea-pig.
Topics: Animals; Bronchi; Chromones; Cyclooxygenase Inhibitors; Guinea Pigs; In Vitro Techniques; Indomethacin; Keto Acids; Male; Muscle Contraction; Muscle Tonus; Parasympatholytics; Receptors, Immunologic; Receptors, Leukotriene; Respiratory Physiological Phenomena; Respiratory System; SRS-A; Sulfones; Sympathetic Nervous System; Trachea | 1991 |
Nedocromil sodium inhibits antigen-induced contraction of human lung parenchymal and bronchial strips, and the release of sulphidopeptide-leukotriene and histamine from human lung fragments.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Antigens; Asthma; Bronchi; Chromones; Histamine Release; Humans; In Vitro Techniques; Leukotrienes; Lung; Mites; Muscle Contraction; Muscle, Smooth; Nedocromil; Quinolones; SRS-A | 1990 |
Persistent effects of interleukin-1 on smooth muscle preparations from adrenalectomized rats: implications for increased phospholipase-A2 activity via stimulation of 5-lipoxygenase.
Topics: Adrenalectomy; Animals; Arachidonate 5-Lipoxygenase; Arachidonic Acid; Arachidonic Acids; Aspirin; Chromatography, High Pressure Liquid; Chromones; Humans; Indomethacin; Interleukin-1; Leukotrienes; Lipoxygenase Inhibitors; Male; Masoprocol; Muscle Contraction; Muscle, Smooth; Phospholipases A; Phospholipases A2; Rats; Rats, Inbred Strains; Recombinant Proteins; SRS-A; Stimulation, Chemical; Stomach; Time Factors | 1991 |
Arachidonate lipoxygenase inhibitors in guinea-pig isolated trachea. Effects on contractions to antigen and various agonists.
Topics: 5,8,11,14-Eicosatetraynoic Acid; Animals; Antigens; Arachidonate Lipoxygenases; Calcimycin; Chromones; Guinea Pigs; In Vitro Techniques; Male; Masoprocol; Muscle Contraction; Pyrazoles; Receptors, Immunologic; Receptors, Leukotriene; SRS-A; Trachea | 1990 |
Endogenous AA metabolites and their possible role in tracheal smooth muscle tone in guinea pigs.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Benzoquinones; Chromones; Dibenz(b,f)(1,4)oxazepine-10(11H)-carboxylic acid, 8-chloro-, 2-acetylhydrazide; Guinea Pigs; Histamine; In Vitro Techniques; Indomethacin; Lipoxygenase Inhibitors; Methacrylates; Muscle Contraction; Muscle, Smooth; Quinones; SRS-A; Thromboxane-A Synthase; Trachea | 1990 |
Conformationally restricted leukotriene receptor antagonists: [(octahydro-2-oxo-7-tetradecylidene-2H-1-benzopyran-8-yl)thio]ace tic acids.
Topics: Animals; Chromones; Dose-Response Relationship, Drug; Guinea Pigs; Ileum; Injections, Intravenous; Lactones; Leukotriene E4; Male; Muscle Contraction; Muscle, Smooth; Receptors, Immunologic; Receptors, Leukotriene; SRS-A; Sulfides | 1990 |
Pre-junctional inhibitory action of prostaglandin E2 on excitatory neuro-effector transmission in the human bronchus.
Topics: Bronchi; Chromones; Dinoprostone; Electric Stimulation; Humans; In Vitro Techniques; Indomethacin; Isoproterenol; Membrane Potentials; Microelectrodes; Muscle Contraction; Muscle, Smooth; Neuromuscular Junction; SRS-A | 1990 |
Release of slow reacting substance (SRS) from human leucocytes by lymphokine.
Topics: Animals; Autacoids; Chromones; Guinea Pigs; Histamine Release; Humans; Kinetics; Leukocytes; Lymphokines; Muscle Contraction; Muscle, Smooth; Neutrophils; Radioimmunoassay; SRS-A | 1985 |
The binding of leukotriene C4 and leukotriene D4 to membranes of a smooth muscle cell line (BC3H1) and evidence that leukotriene induced contraction in these cells is mediated by thromboxane, protein and RNA syntheses.
Topics: Animals; Binding, Competitive; Cell Line; Cell Membrane; Chromones; Cyclooxygenase Inhibitors; Kinetics; Mice; Muscle Contraction; Muscle Proteins; Muscle, Smooth; Radioimmunoassay; RNA; SRS-A; Thromboxanes | 1985 |
IgG vs IgE: mediators of antigen-induced guinea pig lung parenchymal contraction.
Topics: Animals; Antigens; Atropine; Chromones; Guinea Pigs; Histamine Release; Immunoglobulin E; Immunoglobulin G; Indomethacin; Lung; Male; Muscle Contraction; Pyrilamine; SRS-A | 1985 |
The effect of indomethacin on anaphylactic contraction and histamine release in guinea-pig lung parenchymal strips.
Topics: 4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine; Anaphylaxis; Animals; Chromones; Female; Guinea Pigs; Histamine Release; In Vitro Techniques; Indomethacin; Lung; Muscle Contraction; Muscle, Smooth; Ovalbumin; Pyrazoles; SRS-A | 1986 |
REV 5901: an orally effective peptidoleukotriene antagonist, detailed biochemical/pharmacological profile.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Chromones; Coronary Circulation; Dose-Response Relationship, Drug; Guinea Pigs; Histamine; Hydroxyquinolines; Kinetics; Lung; Male; Methacholine Chloride; Methacholine Compounds; Muscle Contraction; Myocardial Contraction; Quinolines; Regional Blood Flow; SRS-A | 1987 |
Formation of cysteinyl-leukotrienes by human bronchial mucosa in chronic obstructive bronchitis.
Topics: Animals; Bronchi; Bronchitis; Calcimycin; Chromones; Female; Guinea Pigs; Humans; Ileum; In Vitro Techniques; Leukotrienes; Lung Diseases, Obstructive; Male; Mucous Membrane; Muscle Contraction; SRS-A | 1989 |
Paf-induced release of spasmogens from guinea-pig lungs.
Topics: Animals; Aspirin; Bronchi; Chromones; Diterpenes; Ginkgolides; Guinea Pigs; In Vitro Techniques; Indoles; Indomethacin; Lactones; Leukotriene B4; Lung; Masoprocol; Muscle Contraction; Muscle, Smooth; Platelet Activating Factor; SRS-A; Trachea | 1989 |
Clotting of whole human blood induces cysteinyl-leukotriene formation.
Topics: Adult; Animals; Biological Assay; Blood Coagulation; Chromatography, High Pressure Liquid; Chromones; Citrates; Citric Acid; Edetic Acid; Guinea Pigs; Heparin; Humans; Ileum; Kinetics; Leukotriene E4; Male; Masoprocol; Muscle Contraction; SRS-A; Thromboxane B2 | 1989 |
Analysis of the beta-adrenoceptor mediated inhibition of IgG1 and IgE dependent guinea-pig anaphylactic tracheal smooth muscle contraction.
Topics: Anaphylaxis; Animals; Chromones; Dibenz(b,f)(1,4)oxazepine-10(11H)-carboxylic acid, 8-chloro-, 2-acetylhydrazide; Female; Fenoterol; Guinea Pigs; Immunoglobulin E; Immunoglobulin G; Indomethacin; Leukotrienes; Male; Muscle Contraction; Muscle, Smooth; Prostaglandins; Receptors, Adrenergic, beta; SRS-A; Trachea | 1989 |
Some properties of calcium-induced contraction in the isolated human and guinea-pig tracheal smooth muscle.
Topics: Aged; Animals; Aspirin; Calcium; Chromones; Female; Guinea Pigs; Humans; Indomethacin; Ion Channels; Male; Middle Aged; Muscle Contraction; Muscle Tonus; Muscle, Smooth; SRS-A; Trachea; Verapamil | 1985 |
The spontaneous electrical and mechanical activity of human bronchial smooth muscle: its modulation by drugs.
Topics: Adult; Aged; Aged, 80 and over; Atropine; Bronchi; Chromones; Electric Stimulation; Electrophysiology; Female; Humans; In Vitro Techniques; Indomethacin; Isoproterenol; Male; Membrane Potentials; Middle Aged; Muscle Contraction; Muscle, Smooth; Physostigmine | 1989 |
Role of arachidonic acid metabolites in hypoxic contractions of isolated porcine pulmonary artery and vein.
Topics: Animals; Arachidonic Acids; Chromones; Histamine; Hypoxia; In Vitro Techniques; Indomethacin; Muscle Contraction; Muscle, Smooth, Vascular; Pulmonary Artery; Pulmonary Veins; Pyrazoles; Swine | 1989 |
Differential effects of calcium channel blockers on leukotriene C4- and D4-induced contractions in guinea pig pulmonary parenchymal strips.
Topics: Animals; Calcium Channel Blockers; Chromones; Dose-Response Relationship, Drug; Guinea Pigs; In Vitro Techniques; Lung; Male; Muscle Contraction; Receptors, Leukotriene; Receptors, Prostaglandin; SRS-A; Trachea | 1987 |
Is the guinea pig trachea a good in vitro model of human large and central airways? Comparison on leukotriene-, methacholine-, histamine- and antigen-induced contractions.
Topics: Adult; Animals; Antigens; Borates; Bronchi; Child; Chromones; Dicarboxylic Acids; Female; Guinea Pigs; Histamine; Humans; In Vitro Techniques; Male; Methacholine Chloride; Methacholine Compounds; Models, Biological; Muscle Contraction; Receptors, Leukotriene; Receptors, Prostaglandin; Serine; SRS-A; Trachea | 1987 |
Analysis of leukotriene receptor antagonists on isolated human intralobar airways.
Topics: Acetophenones; Azoles; Barium; Bronchi; Chromones; Humans; Indazoles; Muscle Contraction; Muscle, Smooth; Pyrazoles; Receptors, Leukotriene; Receptors, Prostaglandin; SRS-A; Tetrazoles | 1988 |
Leukotriene and anti-IgE induced contractions of human isolated trachea: studies with leukotriene receptor antagonists and a novel 5-lipoxygenase inhibitor.
Topics: Animals; Antibodies, Anti-Idiotypic; Arachidonate Lipoxygenases; Atropine; Benzofurans; Chromones; Goats; Humans; In Vitro Techniques; Indomethacin; Keto Acids; Lipoxygenase Inhibitors; Muscle Contraction; Phenylbutyrates; Pyrilamine; Receptors, Leukotriene; Receptors, Prostaglandin; SRS-A; Sulfones; Trachea | 1988 |
Characterisation of the leukotriene receptor(s) on human isolated lung strips.
Topics: Chromones; Humans; In Vitro Techniques; Lung; Muscle Contraction; Receptors, Leukotriene; Receptors, Prostaglandin; SRS-A | 1988 |
The contractile activities of lipoxin A4 and lipoxin B4 for guinea-pig airway tissues.
Topics: Animals; Chromones; Guinea Pigs; Hydroxyeicosatetraenoic Acids; In Vitro Techniques; Leukotriene B4; Lipoxins; Lipoxygenase Inhibitors; Male; Muscle Contraction; Muscle, Smooth; SRS-A; Stereoisomerism; Trachea | 1988 |
Failure of a combined anti-histamine and anti-leukotriene treatment to suppress passive anaphylaxis in the guinea-pig.
Topics: Anaphylaxis; Animals; Aspirin; Chromones; Female; Guinea Pigs; Histamine H1 Antagonists; In Vitro Techniques; Lung; Male; Muscle Contraction; Ovalbumin; Propranolol; Pyrilamine; SRS-A | 1986 |
A formyl peptide contracts guinea pig lung: role of arachidonic acid metabolites.
Topics: Acetophenones; Animals; Arachidonic Acids; Autacoids; Chromones; Guinea Pigs; Histamine; Leukotriene B4; Lung; Male; Muscle Contraction; Muscle, Smooth; N-Formylmethionine Leucyl-Phenylalanine; Prostaglandins; Receptors, Leukotriene; Receptors, Prostaglandin; SRS-A; Tachyphylaxis; Tetrazoles | 1987 |
Pharmacological modulation of responses of guinea-pig airways contracted with arachidonic acid.
Topics: Animals; Arachidonate Lipoxygenases; Arachidonic Acid; Arachidonic Acids; Catechols; Chromones; Epoprostenol; Guinea Pigs; Indomethacin; Lipoxygenase Inhibitors; Lung; Male; Masoprocol; Muscle Contraction; Propionates; Pyrazoles; Pyrazolones; Receptors, Leukotriene; Receptors, Prostaglandin; Trachea | 1985 |
Synthesis and pharmacological characterization of 5-(2-dodecylphenyl)-4,6-dithianonanedioic acid and 5-[2-(8-phenyloctyl)phenyl]-4,6-dithianonanedioic acid: prototypes of a novel class of leukotriene antagonists.
Topics: Airway Resistance; Animals; Chemical Phenomena; Chemistry; Chromones; Dicarboxylic Acids; Dose-Response Relationship, Drug; Guinea Pigs; Lung Compliance; Muscle Contraction; Receptors, Leukotriene; Receptors, Prostaglandin; SRS-A; Trachea | 1985 |
Identification and characterization of leukotriene D4 receptors in adult and fetal human lung.
Topics: Adult; Binding, Competitive; Chromones; Female; Fetus; Humans; In Vitro Techniques; Lung; Muscle Contraction; Pregnancy; Radioligand Assay; Receptors, Cell Surface; Receptors, Leukotriene; Receptors, Prostaglandin; SRS-A; Tritium | 1985 |
Pharmacological evidence that human intralobar airways do not contain different receptors that mediate contractions to leukotriene C4 and leukotriene D4.
Topics: Arachidonic Acid; Arachidonic Acids; Borates; Chromones; Cysteine; Dose-Response Relationship, Drug; Humans; In Vitro Techniques; Leukotriene E4; Lung; Muscle Contraction; Receptors, Cell Surface; Receptors, Leukotriene; Receptors, Prostaglandin; Regression Analysis; Serine; SRS-A | 1986 |
Differential rank order of potency for antagonism of LTC4- and LTD4-induced contractions of guinea pig trachea.
Topics: Animals; Borates; Chromones; Guinea Pigs; In Vitro Techniques; Male; Muscle Contraction; Receptors, Leukotriene; Receptors, Prostaglandin; Serine; SRS-A; Trachea | 1986 |
Characterization of platelet activating factor (PAF)-acether-induced contractions of guinea-pig lung strips by selected inhibitors of arachidonic acid metabolism and by PAF-acether antagonists.
Topics: Animals; Aspirin; Benzofurans; Chromones; Diterpenes; Ginkgolides; Guinea Pigs; Histamine; Imidazoles; Lactones; Leukotriene B4; Lignans; Lung; Male; Methacrylates; Muscle Contraction; Muscle, Smooth; Plant Extracts; Platelet Activating Factor; Prostaglandin Antagonists; Pyrilamine; SRS-A | 1986 |
Comparative effects of drugs on leukotrienes-, PAF-acether- and histamine- induced contractions of guinea-pig lung parenchymal strips.
Topics: Animals; Chromones; Drug Interactions; Guinea Pigs; Histamine; In Vitro Techniques; Leukotriene B4; Lung; Muscle Contraction; Muscle, Smooth; Platelet Activating Factor; SRS-A | 1986 |
Pharmacology of peptide leukotrienes on ferret isolated airway smooth muscle.
Topics: Animals; Borates; Carbachol; Chromones; Ferrets; In Vitro Techniques; Leukotriene E4; Muscle Contraction; Muscle, Smooth; Receptors, Leukotriene; Receptors, Prostaglandin; Serine; SRS-A; Trachea | 1986 |
Pharmacologic profile of chemically stable analogs of peptide leukotrienes.
Topics: Animals; Chromones; Dose-Response Relationship, Drug; Guinea Pigs; In Vitro Techniques; Leukotriene E4; Male; Muscle Contraction; Receptors, Leukotriene; Receptors, Prostaglandin; SRS-A; Structure-Activity Relationship; Trachea | 1987 |
Antagonism by ETYA of the effects of leukotrienes on ileum and lung parenchymal strips independent of effects on arachidonic acid metabolism.
Topics: 5,8,11,14-Eicosatetraynoic Acid; Animals; Arachidonic Acid; Arachidonic Acids; Chromones; Fatty Acids, Unsaturated; Guinea Pigs; Histamine; Ileum; In Vitro Techniques; Indomethacin; Lung; Male; Muscle Contraction; Pyrazoles; SRS-A | 1986 |
Synthesis of slow-reacting substance-like activity in human anterior uvea.
Topics: 4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine; Chromones; Humans; Ileum; Muscle Contraction; Pyrazoles; Radioimmunoassay; SRS-A; Uvea | 1987 |
Release of eicosanoids from human synovial tissue and the effect of anti-inflammatory drugs.
Topics: Aminosalicylic Acids; Animals; Calcimycin; Chromones; Guinea Pigs; Humans; In Vitro Techniques; Indomethacin; Mesalamine; Muscle Contraction; Prostaglandins; SRS-A; Sulfanilamides; Sulfapyridine; Synovial Membrane | 1987 |
Prostaglandin F2 stimulates the generation of lipoxygenase products in guinea pig isolated trachea.
Topics: Animals; Chromones; Guinea Pigs; In Vitro Techniques; Indomethacin; Lipoxygenase; Male; Masoprocol; Muscle Contraction; Prostaglandins F; Pyrazoles; SRS-A; Trachea | 1987 |
Antigenic contraction of guinea pig tracheal preparations passively sensitized with monoclonal IgE: pharmacological modulation.
Topics: Animals; Antibodies, Monoclonal; Antigens; Atropine; Chromones; Dinitrophenols; Dose-Response Relationship, Immunologic; Guinea Pigs; Immunization, Passive; Immunoglobulin E; Male; Mice; Mice, Inbred BALB C; Muscle Contraction; Phenothiazines; Serum Albumin, Bovine; Trachea; Tripelennamine | 1988 |
Inhibitory effects of a lipoxygenase inhibitor nordihydroguaiaretic acid on antagonism of leukotriene C4-induced contractions of isolated guinea-pig trachea.
Topics: Animals; Catechols; Chromones; Guinea Pigs; In Vitro Techniques; Indomethacin; Masoprocol; Muscle Contraction; Muscle, Smooth; SRS-A; Trachea | 1988 |
Comparative activity of leukotriene D4, 5,6-dihydroxy-eicosatetraenoic acid and lipoxin A on guinea pig lung parenchyma and ileum smooth muscle.
Topics: Animals; Chromones; Guinea Pigs; Hydroxyeicosatetraenoic Acids; Ileum; In Vitro Techniques; Lipoxins; Lung; Muscle Contraction; SRS-A; Stereoisomerism; Structure-Activity Relationship | 1988 |
Study of platelet activating factor and its antagonists on rat colon strip with a new method avoiding tachyphylaxis.
Topics: Animals; Atropine; Chlorpheniramine; Chromones; Colon; In Vitro Techniques; Indomethacin; Male; Methysergide; Muscle Contraction; Platelet Activating Factor; Rats; Rats, Inbred Strains; Serum Albumin; SRS-A; Tachyphylaxis | 1988 |
Antagonism of the in vivo and in vitro effects of leukotriene D4 by SC-39070 in guinea pigs.
Topics: Animals; Bronchial Provocation Tests; Capillary Permeability; Chromones; Dimethyl Sulfoxide; Dose-Response Relationship, Drug; Drug Interactions; Guinea Pigs; Ileum; Muscle Contraction; SRS-A | 1987 |
Actions of platelet-activating factor in the coronary circulation of the guinea pig in vitro.
Topics: Animals; Blood Pressure; Chromones; Coronary Circulation; Guinea Pigs; In Vitro Techniques; Indomethacin; Male; Muscle Contraction; Muscle, Smooth; Myocardial Contraction; Platelet Activating Factor; SRS-A | 1987 |
Repeatable antigen-induced contractions of isolated guinea pig lung strips are mediated by leukotriene.
Topics: Animals; Antigens; Catechols; Chromones; Desensitization, Immunologic; Guinea Pigs; In Vitro Techniques; Lung; Male; Masoprocol; Muscle Contraction; Ovalbumin; SRS-A; Time Factors | 1986 |
Differentiation of the mechanisms by which leukotrienes C4 and D4 elicit contraction of the guinea pig trachea.
Topics: Airway Resistance; Animals; Borates; Chromones; Guinea Pigs; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth; Serine; SRS-A; Trachea | 1985 |
Pharmacological modulation of responses of guinea-pig airways contracted with antigen and calcium ionophore A23187.
Topics: 4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine; Animals; Arachidonate Lipoxygenases; Calcimycin; Catechols; Chromones; Drug Interactions; Epoprostenol; Guinea Pigs; Indomethacin; Lipoxygenase Inhibitors; Lung; Male; Masoprocol; Muscle Contraction; Ovalbumin; Pyrazoles; Pyrazolones; Trachea | 1985 |
Effect of calcium antagonists on the biosynthesis and contractile effects of peptidoleukotrienes in rhesus monkey lung.
Topics: Animals; Calcium Channel Blockers; Chromatography, High Pressure Liquid; Chromones; Gallic Acid; Immunoglobulin E; In Vitro Techniques; Lung; Macaca mulatta; Male; Muscle Contraction; Nifedipine; SRS-A; Trachea; Verapamil | 1985 |
Histamine and leukotriene-independent guinea-pig anaphylactic shock unaccounted for by Paf-acether.
Topics: Acetophenones; Anaphylaxis; Animals; Catechols; Chromones; Female; Guinea Pigs; Histamine; In Vitro Techniques; Lung; Male; Masoprocol; Muscle Contraction; Platelet Activating Factor; SRS-A | 1985 |
Contractile responses of the guinea-pig esophageal muscularis mucosae in vitro to arachidonic acid and its metabolites.
Topics: Animals; Arachidonic Acids; Chromones; Esophagus; Guinea Pigs; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth; Polyphloretin Phosphate; Prostaglandins; SRS-A; Thromboxanes | 1985 |
Antagonists of slow reacting substance of anaphylaxis. Synthesis of a series of chromone-2-carboxylic acids.
Topics: Animals; Chromones; Guinea Pigs; In Vitro Techniques; Methods; Muscle Contraction; Muscle, Smooth; SRS-A; Structure-Activity Relationship | 1977 |
Synthesis and structure-activity relationship studies of a series of 5-aryl-4,6-dithianonanedioic acids and related compounds: a novel class of leukotriene antagonists.
Topics: Alkynes; Animals; Binding, Competitive; Bronchi; Dicarboxylic Acids; Guinea Pigs; Magnetic Resonance Spectroscopy; Muscle Contraction; Receptors, Leukotriene; Receptors, Prostaglandin; SRS-A; Stereoisomerism; Structure-Activity Relationship; Sulfides; Trachea | 1986 |
Leukotriene receptor antagonists. 1. Synthesis and structure-activity relationships of alkoxyacetophenone derivatives.
Topics: Acetophenones; Alkylation; Animals; Bronchi; Guinea Pigs; Muscle Contraction; Muscle, Smooth; Receptors, Leukotriene; Receptors, Prostaglandin; SRS-A; Structure-Activity Relationship | 1987 |
New potent antagonists of leukotrienes C4 and D4. 1. Synthesis and structure-activity relationships.
Topics: Animals; Bronchodilator Agents; Cinnamates; Guinea Pigs; Ileum; In Vitro Techniques; Magnetic Resonance Spectroscopy; Mass Spectrometry; Muscle Contraction; ortho-Aminobenzoates; SRS-A; Structure-Activity Relationship | 1988 |
Novel 1,3-bis(aryloxy)propanes as leukotriene D4 antagonists.
Topics: Animals; Guinea Pigs; Indicators and Reagents; Magnetic Resonance Spectroscopy; Muscle Contraction; Muscle, Smooth; Phenyl Ethers; Spectrophotometry, Infrared; SRS-A; Structure-Activity Relationship | 1986 |
Evaluation of rotenone and related compounds as antagonists of slow-reacting substance of anaphylaxis.
Topics: Acetylcholine; Anaphylaxis; Animals; Guinea Pigs; Histamine H1 Antagonists; In Vitro Techniques; Muscle Contraction; Muscle, Smooth; Rotenone; Serotonin Antagonists; SRS-A | 1980 |
Antagonists of slow-reacting substance of anaphylaxis. 1. Pyrido[2,1-b]quinazolinecarboxylic acid derivatives.
Topics: Animals; Biological Assay; Guinea Pigs; Ileum; Indicators and Reagents; Leukotriene E4; Muscle Contraction; Quinazolines; Rats; SRS-A; Structure-Activity Relationship | 1983 |