fp 83 and Complication, Postoperative studies

Research Excerpts

Excerpt	Relevance	Reference
"Flurbiprofen axetil (FA) is a commonly prescribed agent to relieve perioperative pain, but the relationship between FA and postoperative acute kidney injury (AKI) remains unclear."	7.96	Low dose of flurbiprofen axetil decrease the rate of acute kidney injury after operation: a retrospective clinical data analysis of 9915 cases. ( Liao, Q; Ou-Yang, W; Tang, YZ; Wang, D; Yang, SK; Zhang, H; Zhao, MX, 2020)
" The pain intensity, consumed sufentanil dosage of the PCA, and the side effects was not different between groups."	6.90	Effect of flurbiprofen axetil on postoperative delirium for elderly patients. ( Chen, H; Han, F; Hu, Y; Wang, L; Wang, X; Wang, Y; Wei, L; Zhao, W, 2019)
"Flurbiprofen axetil (FA) is a commonly prescribed agent to relieve perioperative pain, but the relationship between FA and postoperative acute kidney injury (AKI) remains unclear."	3.96	Low dose of flurbiprofen axetil decrease the rate of acute kidney injury after operation: a retrospective clinical data analysis of 9915 cases. ( Liao, Q; Ou-Yang, W; Tang, YZ; Wang, D; Yang, SK; Zhang, H; Zhao, MX, 2020)
" The pain intensity, consumed sufentanil dosage of the PCA, and the side effects was not different between groups."	2.90	Effect of flurbiprofen axetil on postoperative delirium for elderly patients. ( Chen, H; Han, F; Hu, Y; Wang, L; Wang, X; Wang, Y; Wei, L; Zhao, W, 2019)
"EA intervention combined with anesthetics is effective in reducing the dosage of the supplemented Sauteralgyl and the degree of postoperative nausea, and in improving postoperative gastrointestinal functional recovery in patients undergoing pneumectomy."	2.80	[Electroacupuncture Intervention Combined with Anesthetics for Analgesia and Post-surgical Gastrointestinal Recovery in Pneumectomy Patients]. ( Chen, TY; Ma, W; Wang, K; Wu, YY; Xu, JJ; Zhou, J, 2015)

Research

Studies (6)

Authors

Clinical Trials (1)

Trial Overview

Trial Outcomes

Association by Multiple Regression Between Changes in Internal Carotid Artery Blood Flow, Mean Arterial Pressure and Cardiac Output by Treatment of Anaesthesia-induced Hypotension.

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	0 (0.00)	29.6817
2010's	5 (83.33)	24.3611
2020's	1 (16.67)	2.80

Authors	Studies
Wang, D	1
Yang, SK	1
Zhao, MX	1
Tang, YZ	1
Ou-Yang, W	1
Zhang, H	1
Liao, Q	1
Huang, S	1
Cao, X	1
Li, J	1
Han, Y	1
Wang, X	1
Wang, Y	1
Hu, Y	1
Wang, L	1
Zhao, W	1
Wei, L	1
Chen, H	1
Han, F	1
Chen, TY	1
Zhou, J	1
Wang, K	1
Xu, JJ	1
Ma, W	1
Wu, YY	1
Sun, W	1
Pei, L	1
Fujimoto, Y	1
Nomura, Y	1
Hirakawa, K	1
Hotta, A	1
Nakamoto, A	1
Yoshikawa, N	1
Ohira, N	1
Tatekawa, S	1

Trial	Phase	Enrollment	Study Type	Start Date	Status
Cerebral Blood Flow During Propofol Anaesthesia[NCT02951273]		30 participants (Actual)	Observational	2016-12-08	Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

"Association by multiple regression between changes in unilateral internal carotid artery blood flow [ml/min] as outcome variable and changes in mean arterial pressure [mmHg] and cardiac output [l/min] as covariates.~Internal carotid artery blood flow [ml/min] was assessed by duplex ultrasound. Mean arterial pressure [mmHg] was recorded by a transducer connected to an arterial line. Cardiac output [l/min] was evaluated by pulse contour analysis (Modelflow) that estimates cardiac output by analysis of the arterial pressure curve taking age, gender, height and weigth into account." (NCT02951273)
Timeframe: Two measurements; one measurement during anaesthesia-induced hypotension (mean arterial pressure < 65 mmHg) before administration of phenylephrine and one measurement 3-5 min after administration of phenylephrine.

Changes in Cardiac Output From Baseline Before Induction of Anaesthesia.

Intervention	ml/min (Least Squares Mean)
Study of Cerebral Blood Flow	376

Cardiac output [l/min] as evaluated continuously by pulse contour analysis of the arterial pressure curve (Modelflow). (NCT02951273)
Timeframe: Continuous measurements from before induction of anaesthesia and until 2 hours after start of surgery.

Changes in Forehead Skin Blood Flow by Development of Mesenteric Traction Syndrome (MTS).

Intervention	l/min (Mean)
Study of Cerebral Blood Flow	-2.7

Forehead skin blood flow [PU] assessed by laser Doppler flowmetry as compared between those patients who develop mesenteric traction syndrome (defined as flushing within 60 min after the start of surgery) and those who do not. Laser Doppler flowmetry applies a laser placed on the forehead that penetrates the skin and is scattered with a Doppler shift by the red blood cells and return to a detector that evaluates the amount of backscattered light and Doppler shift. An effect of a MTS was evaluated by a repeated measure mixed model with the fixed effects time point, group according to development of MTS, and interaction between time and group. The reported result is the interaction factor for the time point 0 min after flushing and 20 min after the start of surgery in patients who did not develop MTS. (NCT02951273)
Timeframe: Six measurements during anaesthesia; 5 min before and after incision and 0, 20, 40, and 70 min after flushing and 20, 40, 60, and 90 min after the start of surgery in those patients who do not develop mesenteric traction syndrome.

Changes in Forehead Skin Oxygenation by Development of Mesenteric Traction Syndrome (MTS).

Intervention	PU (Mean)
Study of Cerebral Blood Flow	126

Forehead skin oxygenation [%] assessed by laser Doppler flowmetry as compared between those patients who develop a MTS (defined as flushing within 60 min after the start of surgery) and those who do not. An effect of a MTS was evaluated by a repeated measure mixed model with the fixed effects time point, group according to development of MTS, and interaction between time and group. The reported result is the interaction factor for the time point 0 min after flushing and 20 min after the start of surgery in patients who did not develop MTS. (NCT02951273)
Timeframe: Six measurements during anaesthesia; 5 min before and after incision and 0, 20, 40, and 70 min after flushing and 20, 40, 60, and 90 min after the start of surgery in those patients who do not develop mesenteric traction syndrome.

Changes in Frontal Lobe Oxygenation by Development of Mesenteric Traction Syndrome (MTS).

Intervention	oxygenation [%] (Mean)
Study of Cerebral Blood Flow	-2

Near-infrared spectroscopy determined frontal lobe oxygenation [%] as compared between those patients who develop a MTS (defined as flushing within 60 min after the start of surgery) and those who do not. An effect of a MTS was evaluated by a repeated measure mixed model with the fixed effects time point, group according to development of MTS, and interaction between time and group. The reported result is the interaction factor for the time point 0 min after flushing and 20 min after the start of surgery in patients who did not develop MTS. (NCT02951273)
Timeframe: Six measurements during anaesthesia; 5 min before and after incision and 0, 20, 40, and 70 min after flushing and 20, 40, 60, and 90 min after the start of surgery in those patients who do not develop mesenteric traction syndrome.

Changes in Heart Rate From Baseline Before Induction of Anaesthesia.

Intervention	oxygenation [%] (Mean)
Study of Cerebral Blood Flow	2

Heart rate [bpm] as recorded continuously by a transducer connected to an arterial line. (NCT02951273)
Timeframe: Continuous measurements from before induction of anaesthesia and until 2 hours after start of surgery.

Changes in Internal Carotid Artery Blood Flow by Development of Mesenteric Traction Syndrome (MTS).

Intervention	beats/min (Mean)
Study of Cerebral Blood Flow	-13

Unilateral internal carotid artery blood flow [ml/min] assessed by duplex ultrasound as compared between those patients who develop a MTS (defined as flushing within 60 min after the start of surgery) and those who do not. An effect of a MTS was evaluated by a repeated measure mixed model with the fixed effects time point, group according to development of MTS, and interaction between time and group. The reported result is the interaction factor for the time point 0 min after flushing and 20 min after the start of surgery in patients who did not develop MTS. (NCT02951273)
Timeframe: Six measurements during anaesthesia; 5 min before and after incision and 0, 20, 40, and 70 min after flushing and 20, 40, 60, and 90 min after the start of surgery in those patients who do not develop mesenteric traction syndrome.

Changes in Internal Carotid Artery Blood Flow by Induction of Anaesthesia.

Intervention	ml/min (Mean)
Study of Cerebral Blood Flow	-3

Unilateral internal carotid artery blood flow [ml/min] assessed by duplex ultrasound. (NCT02951273)
Timeframe: Two measurements; one measurement 5-10 min before induction of anaesthesia and one measurement 5-20 min after induction of anaesthesia.

Changes in Internal Carotid Artery Blood Flow by Treatment of Anaesthesia-induced Hypotension

Intervention	ml/min (Mean)
Study of Cerebral Blood Flow	-144

Unilateral internal carotid artery blood flow [ml/min] assessed by duplex ultrasound. (NCT02951273)
Timeframe: Two measurements; one measurement during anaesthesia-induced hypotension (mean arterial pressure < 65 mmHg) before administration of phenylephrine and one measurement 3-5 min after administration of phenylephrine.

Changes in Mean Arterial Pressure From Baseline Before Induction of Anaesthesia.

Intervention	ml/min (Mean)
Study of Cerebral Blood Flow	27

Mean arterial pressure [mmHg] as recorded continuously by a transducer connected to an arterial line. (NCT02951273)
Timeframe: Continuous measurements from before induction of anaesthesia and until 2 hours after start of surgery.

Changes in Stroke Volume From Baseline Before Induction of Anaesthesia.

Intervention	mmHg (Mean)
Study of Cerebral Blood Flow	-41

Stroke volume [ml] as evaluated continuously by pulse contour analysis of the arterial pressure curve (Modelflow). (NCT02951273)
Timeframe: Continuous measurements from before induction of anaesthesia and until 2 hours after start of surgery.

Changes in the CO2 Reactivity of the Internal Carotid Artery From Before to After Induction of Anaesthesia.

Intervention	ml (Mean)
Study of Cerebral Blood Flow	-24

"Unilateral internal carotid artery blood flow [ml/min] assessed by duplex ultrasound and arterial CO2 tension (PaCO2) [kPa] was evaluated by gas analysis. Changes in PaCO2 are guided by evaluation of end-tidal CO2 tension.~The CO2 reactivity to hypocapnia when awake and during anaesthesia is calculated as the percentage change in internal carotid artery blood flow per kPa change in PaCO2. The CO2 reactivity when awake and when anaesthetized is compared." (NCT02951273)
Timeframe: Four measurements; before induction of anaesthesia during normoventilation and during hyperventilation to reduce PaCO2 by 1.5 kPa and during anaesthesia at a PaCO2 at the value before induction of anaesthesia and 1.5 kPa below that value.

Article	Year
Analgesic effect of flurbiprofen axetil in treatment of single hole thoracoscopic surgery for pneumothorax. Pakistan journal of pharmaceutical sciences, 2017, Volume: 30, Issue:5(Special) Topics: Anti-Inflammatory Agents, Non-Steroidal; China; Female; Flurbiprofen; Glucagon; Humans; Hydrocortiso	2017
Effect of flurbiprofen axetil on postoperative delirium for elderly patients. Brain and behavior, 2019, Volume: 9, Issue:6 Topics: Aged; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal; Delirium; Double-Blind Method; Dr	2019
[Electroacupuncture Intervention Combined with Anesthetics for Analgesia and Post-surgical Gastrointestinal Recovery in Pneumectomy Patients]. Zhen ci yan jiu = Acupuncture research, 2015, Volume: 40, Issue:6 Topics: Acupuncture Analgesia; Acupuncture Points; Adolescent; Adult; Aged; Aged, 80 and over; Anesthetics;	2015
Flurbiprofen axetil provides a prophylactic benefit against mesenteric traction syndrome associated with remifentanil infusion during laparotomy. Journal of anesthesia, 2012, Volume: 26, Issue:4 Topics: 6-Ketoprostaglandin F1 alpha; Abdomen; Aged; Anesthesia, General; Anesthetics, Intravenous; Anti-Inf	2012

Article	Year
Low dose of flurbiprofen axetil decrease the rate of acute kidney injury after operation: a retrospective clinical data analysis of 9915 cases. BMC nephrology, 2020, 02-14, Volume: 21, Issue:1 Topics: Acute Kidney Injury; Adult; Anti-Inflammatory Agents, Non-Steroidal; Data Analysis; Female; Flurbipr	2020
Flurbiprofen axetil, nasal polyps, and status asthmaticus: an unusual case report. The Journal of asthma : official journal of the Association for the Care of Asthma, 2011, Volume: 48, Issue:6 Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Asthma, Aspirin-Induced; Endoscopy; Flurbiprofen; He	2011

fp 83 and Complication, Postoperative